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The map label for this gene is glmS

Identifier: 134302528

GI number: 134302528

Start: 1600371

End: 1602209

Strand: Reverse

Name: glmS

Synonym: FTW_1686

Alternate gene names: 134302528

Gene position: 1602209-1600371 (Counterclockwise)

Preceding gene: 134302529

Following gene: 134302524

Centisome position: 84.39

GC content: 33.61

Gene sequence:

>1839_bases
ATGTGTGGAATAGTAGGTGCTAACTCTACAAGAAATGTTACTAATATCTTAATTGAAGGTTTAAAAAAACTAGAGTACAG
AGGTTATGATTCTGCTGGTTTGGCAATAATTGATGATAAAAATAATATAGATATATGTAAAGAAGTTGGTAAAGTTATTG
AACTAGAGAAATCTGTACATAACTTAGCTAATTTTAAAGGAGATATAGGTATTGCTCATACTAGATGGGCTACTCATGGT
AAACCATCTAAGAATAATTCTCACCCTCATGCTTCGGAAAGCTTTTGTATAGTCCATAATGGAGTCATAGAGAACTTTGC
TGAGCTTAAAAAAGTTCTTATTAATGATGGTTATAAATTTAAGTCAGATACTGATACTGAGGTTATCGCACATTTGCTAC
AAAAAGAATGGCGTGATAATTTTAGCATAGTTGATAATATTAAATATATTATGGCTATGCTTAAGGGAGCATATGCCGTA
GCAATAATCTCACAAAAATTCTCTGATAAAATTGTTGCGGTGCGTTCAGGTTCGCCACTTGTAATTGGTGTGGGTATAGA
TGAGAATTTTATTTCATCAGATGCATTATCATTATTACCAGTTACAAATAAATTTTCTTATCTTGATGAAGGTGACATTG
CAATTATTTCTAAAGACAATGTTGAGGTTTTTGATAATAATGGTGCAGCAAAAAATCTTGAGGTTGAGGAGTATAATTAC
TCTTCATCAAGCGCCTCTAAAGATGGTTATAAGCATTATATGCTCAAAGAAATATATGAGCAGCCAGAGGCAGTTTCAAA
TACTATCTTAGCATCATTAGCTGATGGTGAAATTAGTCTGGATAGTTTTGATAAAAGAGCTAAAGAATTATTTGAAAAAA
CCAAACATATTTGTATAGTTGCATGTGGAACTAGCTATAATGCTGGGATGACAGCAAAGTATTGGATTGAAAAATATGCA
AAAGTTCCATGTAGTGTCGAAATAGCAAGTGAGATTAGGTATAGAGATAATGTTGTGGTTGATGGTTCTTTGTTTGTCAG
TATTTCTCAATCTGGTGAAACAGCAGATACTCTAGAGTCACTTAGAAAGAGCAAAAAGCAAAATTATGTTGGCAGTATGT
GCATTTGTAATGTGCCAAATAGTTCGCTTGTGAGAGAATCTGATATTGCTTTTATGACAAAAGCTGGTGTTGAAATTGGA
GTGGCTTCAACCAAGGCATTTACAACACAGTTGGTGGCATTAGCAATATTTACATTGGTAATTGCTAAACTCAAAAATAG
TTTAACAGATCAACAGATAGCTAAATATACTGAAGAACTTAAAAATATCAGAGCTTTGGTTATGGGAGCCTTAAAACTAG
ATACTGAAATAGATCAGATAAGTGAGTATTTTTCTGATAAAGAGCATACTATCTTTTTAGGAAGAGGATTATATTATCCT
ATAGCTATTGAAGGGGCCTTAAAACTTAAAGAGATCTCTTATATCCATGCTGAAGCATACCCATCAGGAGAGTTAAAGCA
TGGTCCTCTAGCTCTAGTTGATAAGAATATGCCAATAGTTGCAGTTGTGCCAAATGATGAATTATTAGATAAAACCTTAT
CTAACTTACAGGAAGTACATGCTCGAGGCGGCAAGCTAATTCTTTTTGTTGATAAAGCTGTTAAAGAAAGAGTTAACTTT
GATAATAGTATTGTGCTAGAGTTAGATGCAGGACATGATTTTAGTGCGCCTGTGGTATTTACGATACCGCTTCAGCTGTT
GTCATATCATGTGGCTATAATCAAAGGAACGGATGTTGATCAACCTAGAAACTTAGCTAAATCTGTAACCGTTGAGTAA

Upstream 100 bases:

>100_bases
CTGATAATCTTGCAATTTCAAGAGCAAGACAGCGTCATATTGATACTTGGCAGAGATCCGTCAAGAAAACAGATAAATAA
TAAAAAATAAGGTTTGTGTT

Downstream 100 bases:

>100_bases
AAGCTAAAACTATTTTACTTTCTTATCATTTATTTTCCAAATATAATAATTGCTACTACCTAGTTAGTTTAATAAACAGT
AAGGTGGATATGAATTTTAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MCGIVGANSTRNVTNILIEGLKKLEYRGYDSAGLAIIDDKNNIDICKEVGKVIELEKSVHNLANFKGDIGIAHTRWATHG
KPSKNNSHPHASESFCIVHNGVIENFAELKKVLINDGYKFKSDTDTEVIAHLLQKEWRDNFSIVDNIKYIMAMLKGAYAV
AIISQKFSDKIVAVRSGSPLVIGVGIDENFISSDALSLLPVTNKFSYLDEGDIAIISKDNVEVFDNNGAAKNLEVEEYNY
SSSSASKDGYKHYMLKEIYEQPEAVSNTILASLADGEISLDSFDKRAKELFEKTKHICIVACGTSYNAGMTAKYWIEKYA
KVPCSVEIASEIRYRDNVVVDGSLFVSISQSGETADTLESLRKSKKQNYVGSMCICNVPNSSLVRESDIAFMTKAGVEIG
VASTKAFTTQLVALAIFTLVIAKLKNSLTDQQIAKYTEELKNIRALVMGALKLDTEIDQISEYFSDKEHTIFLGRGLYYP
IAIEGALKLKEISYIHAEAYPSGELKHGPLALVDKNMPIVAVVPNDELLDKTLSNLQEVHARGGKLILFVDKAVKERVNF
DNSIVLELDAGHDFSAPVVFTIPLQLLSYHVAIIKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_612_residues
MCGIVGANSTRNVTNILIEGLKKLEYRGYDSAGLAIIDDKNNIDICKEVGKVIELEKSVHNLANFKGDIGIAHTRWATHG
KPSKNNSHPHASESFCIVHNGVIENFAELKKVLINDGYKFKSDTDTEVIAHLLQKEWRDNFSIVDNIKYIMAMLKGAYAV
AIISQKFSDKIVAVRSGSPLVIGVGIDENFISSDALSLLPVTNKFSYLDEGDIAIISKDNVEVFDNNGAAKNLEVEEYNY
SSSSASKDGYKHYMLKEIYEQPEAVSNTILASLADGEISLDSFDKRAKELFEKTKHICIVACGTSYNAGMTAKYWIEKYA
KVPCSVEIASEIRYRDNVVVDGSLFVSISQSGETADTLESLRKSKKQNYVGSMCICNVPNSSLVRESDIAFMTKAGVEIG
VASTKAFTTQLVALAIFTLVIAKLKNSLTDQQIAKYTEELKNIRALVMGALKLDTEIDQISEYFSDKEHTIFLGRGLYYP
IAIEGALKLKEISYIHAEAYPSGELKHGPLALVDKNMPIVAVVPNDELLDKTLSNLQEVHARGGKLILFVDKAVKERVNF
DNSIVLELDAGHDFSAPVVFTIPLQLLSYHVAIIKGTDVDQPRNLAKSVTVE
>Mature_612_residues
MCGIVGANSTRNVTNILIEGLKKLEYRGYDSAGLAIIDDKNNIDICKEVGKVIELEKSVHNLANFKGDIGIAHTRWATHG
KPSKNNSHPHASESFCIVHNGVIENFAELKKVLINDGYKFKSDTDTEVIAHLLQKEWRDNFSIVDNIKYIMAMLKGAYAV
AIISQKFSDKIVAVRSGSPLVIGVGIDENFISSDALSLLPVTNKFSYLDEGDIAIISKDNVEVFDNNGAAKNLEVEEYNY
SSSSASKDGYKHYMLKEIYEQPEAVSNTILASLADGEISLDSFDKRAKELFEKTKHICIVACGTSYNAGMTAKYWIEKYA
KVPCSVEIASEIRYRDNVVVDGSLFVSISQSGETADTLESLRKSKKQNYVGSMCICNVPNSSLVRESDIAFMTKAGVEIG
VASTKAFTTQLVALAIFTLVIAKLKNSLTDQQIAKYTEELKNIRALVMGALKLDTEIDQISEYFSDKEHTIFLGRGLYYP
IAIEGALKLKEISYIHAEAYPSGELKHGPLALVDKNMPIVAVVPNDELLDKTLSNLQEVHARGGKLILFVDKAVKERVNF
DNSIVLELDAGHDFSAPVVFTIPLQLLSYHVAIIKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=35.5072463768116, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI4826742, Length=695, Percent_Identity=35.1079136690648, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI29570798, Length=261, Percent_Identity=29.5019157088123, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=53.0179445350734, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=219, Percent_Identity=31.0502283105023, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87082251, Length=316, Percent_Identity=24.0506329113924, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=722, Percent_Identity=32.9639889196676, Blast_Score=337, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17532897, Length=510, Percent_Identity=34.7058823529412, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=36.4269141531323, Blast_Score=265, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17554892, Length=252, Percent_Identity=25.7936507936508, Blast_Score=66, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322745, Length=445, Percent_Identity=36.6292134831461, Blast_Score=250, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6323731, Length=436, Percent_Identity=30.045871559633, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6323730, Length=221, Percent_Identity=41.1764705882353, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6323958, Length=184, Percent_Identity=27.7173913043478, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=35.4651162790698, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI28573187, Length=260, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_FRATT (Q5NHQ9)

Other databases:

- EMBL:   AJ749949
- RefSeq:   YP_169433.1
- ProteinModelPortal:   Q5NHQ9
- SMR:   Q5NHQ9
- IntAct:   Q5NHQ9
- GeneID:   3192352
- GenomeReviews:   AJ749949_GR
- KEGG:   ftu:FTT_0388
- HOGENOM:   HBG645312
- OMA:   PSAINSH
- ProtClustDB:   PRK00331
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67445; Mature: 67445

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 607-607

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGANSTRNVTNILIEGLKKLEYRGYDSAGLAIIDDKNNIDICKEVGKVIELEKSVH
CCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
NLANFKGDIGIAHTRWATHGKPSKNNSHPHASESFCIVHNGVIENFAELKKVLINDGYKF
HHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCEE
KSDTDTEVIAHLLQKEWRDNFSIVDNIKYIMAMLKGAYAVAIISQKFSDKIVAVRSGSPL
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEHHCCCCCEEEEECCCCE
VIGVGIDENFISSDALSLLPVTNKFSYLDEGDIAIISKDNVEVFDNNGAAKNLEVEEYNY
EEEECCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCEEEECCC
SSSSASKDGYKHYMLKEIYEQPEAVSNTILASLADGEISLDSFDKRAKELFEKTKHICIV
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHEECCCCEEHHHHHHHHHHHHHHCCCEEEE
ACGTSYNAGMTAKYWIEKYAKVPCSVEIASEIRYRDNVVVDGSLFVSISQSGETADTLES
EECCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHCCCEEECCEEEEEEECCCCHHHHHHH
LRKSKKQNYVGSMCICNVPNSSLVRESDIAFMTKAGVEIGVASTKAFTTQLVALAIFTLV
HHHHHHHCCCCCEEEEECCCCCCEECCCCCEEEECCCEEEECCHHHHHHHHHHHHHHHHH
IAKLKNSLTDQQIAKYTEELKNIRALVMGALKLDTEIDQISEYFSDKEHTIFLGRGLYYP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCEEEE
IAIEGALKLKEISYIHAEAYPSGELKHGPLALVDKNMPIVAVVPNDELLDKTLSNLQEVH
EEECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHH
ARGGKLILFVDKAVKERVNFDNSIVLELDAGHDFSAPVVFTIPLQLLSYHVAIIKGTDVD
HCCCEEEEEECHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEHHHHHCEEEEEEECCCCC
QPRNLAKSVTVE
CCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGANSTRNVTNILIEGLKKLEYRGYDSAGLAIIDDKNNIDICKEVGKVIELEKSVH
CCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
NLANFKGDIGIAHTRWATHGKPSKNNSHPHASESFCIVHNGVIENFAELKKVLINDGYKF
HHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCEE
KSDTDTEVIAHLLQKEWRDNFSIVDNIKYIMAMLKGAYAVAIISQKFSDKIVAVRSGSPL
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEHHCCCCCEEEEECCCCE
VIGVGIDENFISSDALSLLPVTNKFSYLDEGDIAIISKDNVEVFDNNGAAKNLEVEEYNY
EEEECCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCEEEECCC
SSSSASKDGYKHYMLKEIYEQPEAVSNTILASLADGEISLDSFDKRAKELFEKTKHICIV
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHEECCCCEEHHHHHHHHHHHHHHCCCEEEE
ACGTSYNAGMTAKYWIEKYAKVPCSVEIASEIRYRDNVVVDGSLFVSISQSGETADTLES
EECCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHCCCEEECCEEEEEEECCCCHHHHHHH
LRKSKKQNYVGSMCICNVPNSSLVRESDIAFMTKAGVEIGVASTKAFTTQLVALAIFTLV
HHHHHHHCCCCCEEEEECCCCCCEECCCCCEEEECCCEEEECCHHHHHHHHHHHHHHHHH
IAKLKNSLTDQQIAKYTEELKNIRALVMGALKLDTEIDQISEYFSDKEHTIFLGRGLYYP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCEEEE
IAIEGALKLKEISYIHAEAYPSGELKHGPLALVDKNMPIVAVVPNDELLDKTLSNLQEVH
EEECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHH
ARGGKLILFVDKAVKERVNFDNSIVLELDAGHDFSAPVVFTIPLQLLSYHVAIIKGTDVD
HCCCEEEEEECHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEHHHHHCEEEEEEECCCCC
QPRNLAKSVTVE
CCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA