Click here to switch to the map view.

The map label for this gene is parC [H]

Identifier: 134302521

GI number: 134302521

Start: 1593928

End: 1596153

Strand: Reverse

Name: parC [H]

Synonym: FTW_1678

Alternate gene names: 134302521

Gene position: 1596153-1593928 (Counterclockwise)

Preceding gene: 134302522

Following gene: 134302520

Centisome position: 84.08

GC content: 33.74

Gene sequence:

>2226_bases
ATGGATTTATTCTCAAGTTTAGAAAGTACTCGCTCTGTGGCTGAATTTTCCGAACAAGCATATCTAAATTATTCAATGTA
TGTAATCCTCGATAGAGCATTACCACATATTTCTGATGGTCTTAAGCCTGTACAAAGACGTATTATATACGCCATGAGTG
AAATTGGTTTAAGTCATTTATCTAAGTATAAAAAATCAGCACGTACAGTTGGTGATGTATTGGGTAAATATCATCCTCAT
GGTGATAGTGCTTGTTATGAAGCTATGGTTTTGATGGCACAAGACTTTTCTTATCGTTATCCTTTCATTGATGGGCAAGG
TAACTGGGGATCTATAGATGATCCAAAATCATTTGCTGCGATGCGTTATACAGAGTCGCGTTTATCTAAATATGCGGTAT
TACTTCTAGATGAATTAAAAAAAGGCACGGTTGATTGGGCCAAAAACTTTGATGGAACAATGGATGAGCCTAAGCTTTTA
CCTGCTCAAGTACCAAATATTTTACTTAATGGTGCTATGGGTATCGCTGTTGGGATGTCGACATATATTCCACCACACAA
TATTACAGAGATTATAAATGCCTGTTTGCAATTATTGTCTAAGCCTAATTCTACTATTGAAGAAATTCTAGAGATTGTTG
AGGCTCCTGACTATCCTGGTGGTGCTAATATTATCGGCAGCAAAGAAGAAATTGCTGATGTATATAAGTCAGGCAATGGA
TCGATACGCCAGCAGGCAGTTTATGAATATGATAATCATGGTAATGTTGTGATTACAAAATTACCTCATCAGGTTTCAAG
TGCTGCGGTAATGGAGCAAATCGCTAATGAACTTAAGCAACAGAAGATTACTTGGATAAAAAATATTCAAGATGAATCAG
ACGATAAAGAACCTGTGAAAATAGTTTTATATTCAGCGACGATAAAGAAGAATATCAAGAAAATAATGGGACATTTGCTA
GCAACTACAGATCTTGAGAAAAGCTTTCGTGTCAATATGAATATGATTGGTCTAGATAATCGTCCACAAGTAAAAAATCT
TTTAGATATACTTAATGAATGGCTTGAGTATCGTAAGCATACCTTACGAAGAAGACTACAGACTAGTTTGGATAAGGTTT
TAGATCGTTTACATATATTAGAAGGTTTATTGATAGCATTTCTGAATATTGATGAAGTGATTGATATCATTAGAAATTAT
GATGATTCAAGTGGCGAATTACAAACTAGATTTACACTTTCTGAAATCCAGGCTGAAGCAATTTTGAACATCAGATTACG
CAAGTTAGCAAAGATTGAAGAAATTGAGATTAAAAAAGAGCAAAAGGAATTACAAAAAGAAAGAGAGTTACTCGAGGGTT
ATTTAAATAGCGAGGTTAAGTTTAGAAACTTAATGAAGAAAGAATTTAAGCAAATATTAACAGATTTTGGTGATTCTAGA
CGCTCAAAAATTATTGTTGCAGAAAAGGCACAAGCTCTAGAAGAAAAGGATCTTATGCCTAGTGAGAAGGTAACTATTAT
TTTGTCAAAAGCTGGCTGGATTAGATGCGCTAAAGGTGAGAATATTGATCCAGCAGGTTTAAGCTATAAACCTGAGGATA
AGCCATTTTTAGTAACTACAGGTAATAGTAATATCAAGCTGGTATTTTTTAGTAAGCTTGGTAAGGCGTATTCTATGTAT
ATAGATAAATTACCATCTGCAAGAGGTTATGGTGAGCATATAACTACATATATTCCTCTAGATAAGCAAGATCAAATTAT
AAGTATGGCTTTTGTAAATGCTGCGAGGTATTTCTTAATCGCTAGTGAAAGTGGCAAAGCCTTTGTTATACCTGCTGAAG
ATCTTATTACAAATAAAGTTACAGGTAAAAATATCTTTGATGCTGATGATGTCTTTAAGTTCATACCGTATGATAAAGAT
TTGAAGATGCTTGCAGTTAGTTCGCAAGGTAGGGCGATTATTCGTGATTTTGCGAGTTTTGCATTACTTAAAAAAGGTAA
GGGTAAATCAATCATTAGGCTAGACAAAAAAGACAAACTTAAATTTATCGAGCTATTTAGAGCAAATCAAGAATTAACAC
TAAATGCTGGTAAGAGATTTATTCGTATTGATAGTAAAAATATTGAGACTTATTATAGCGATAAACCATCTGGTGGTGGT
GTGCTATTACCTCAAGGCTTCAGAAAAATAACTAAAATTGATATAGAAAATATAGAGAGTGAATAA

Upstream 100 bases:

>100_bases
AAAGTTAGTGCTTGTGATACGTACTAGCGCTTATGATCCTAGCATACTAAAAGCTGTTAATATATAATTTATAGATTAGT
TTATTATATTCCCGTAGTAT

Downstream 100 bases:

>100_bases
TGAGAAAAATTGCAATATTAGGAGCAATGGAGATAGAAATTTTACCAATTCTAGCTAAGTTAGATAACTATGAAACTATA
GAATATGCAAATAACAAATA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 741; Mature: 741

Protein sequence:

>741_residues
MDLFSSLESTRSVAEFSEQAYLNYSMYVILDRALPHISDGLKPVQRRIIYAMSEIGLSHLSKYKKSARTVGDVLGKYHPH
GDSACYEAMVLMAQDFSYRYPFIDGQGNWGSIDDPKSFAAMRYTESRLSKYAVLLLDELKKGTVDWAKNFDGTMDEPKLL
PAQVPNILLNGAMGIAVGMSTYIPPHNITEIINACLQLLSKPNSTIEEILEIVEAPDYPGGANIIGSKEEIADVYKSGNG
SIRQQAVYEYDNHGNVVITKLPHQVSSAAVMEQIANELKQQKITWIKNIQDESDDKEPVKIVLYSATIKKNIKKIMGHLL
ATTDLEKSFRVNMNMIGLDNRPQVKNLLDILNEWLEYRKHTLRRRLQTSLDKVLDRLHILEGLLIAFLNIDEVIDIIRNY
DDSSGELQTRFTLSEIQAEAILNIRLRKLAKIEEIEIKKEQKELQKERELLEGYLNSEVKFRNLMKKEFKQILTDFGDSR
RSKIIVAEKAQALEEKDLMPSEKVTIILSKAGWIRCAKGENIDPAGLSYKPEDKPFLVTTGNSNIKLVFFSKLGKAYSMY
IDKLPSARGYGEHITTYIPLDKQDQIISMAFVNAARYFLIASESGKAFVIPAEDLITNKVTGKNIFDADDVFKFIPYDKD
LKMLAVSSQGRAIIRDFASFALLKKGKGKSIIRLDKKDKLKFIELFRANQELTLNAGKRFIRIDSKNIETYYSDKPSGGG
VLLPQGFRKITKIDIENIESE

Sequences:

>Translated_741_residues
MDLFSSLESTRSVAEFSEQAYLNYSMYVILDRALPHISDGLKPVQRRIIYAMSEIGLSHLSKYKKSARTVGDVLGKYHPH
GDSACYEAMVLMAQDFSYRYPFIDGQGNWGSIDDPKSFAAMRYTESRLSKYAVLLLDELKKGTVDWAKNFDGTMDEPKLL
PAQVPNILLNGAMGIAVGMSTYIPPHNITEIINACLQLLSKPNSTIEEILEIVEAPDYPGGANIIGSKEEIADVYKSGNG
SIRQQAVYEYDNHGNVVITKLPHQVSSAAVMEQIANELKQQKITWIKNIQDESDDKEPVKIVLYSATIKKNIKKIMGHLL
ATTDLEKSFRVNMNMIGLDNRPQVKNLLDILNEWLEYRKHTLRRRLQTSLDKVLDRLHILEGLLIAFLNIDEVIDIIRNY
DDSSGELQTRFTLSEIQAEAILNIRLRKLAKIEEIEIKKEQKELQKERELLEGYLNSEVKFRNLMKKEFKQILTDFGDSR
RSKIIVAEKAQALEEKDLMPSEKVTIILSKAGWIRCAKGENIDPAGLSYKPEDKPFLVTTGNSNIKLVFFSKLGKAYSMY
IDKLPSARGYGEHITTYIPLDKQDQIISMAFVNAARYFLIASESGKAFVIPAEDLITNKVTGKNIFDADDVFKFIPYDKD
LKMLAVSSQGRAIIRDFASFALLKKGKGKSIIRLDKKDKLKFIELFRANQELTLNAGKRFIRIDSKNIETYYSDKPSGGG
VLLPQGFRKITKIDIENIESE
>Mature_741_residues
MDLFSSLESTRSVAEFSEQAYLNYSMYVILDRALPHISDGLKPVQRRIIYAMSEIGLSHLSKYKKSARTVGDVLGKYHPH
GDSACYEAMVLMAQDFSYRYPFIDGQGNWGSIDDPKSFAAMRYTESRLSKYAVLLLDELKKGTVDWAKNFDGTMDEPKLL
PAQVPNILLNGAMGIAVGMSTYIPPHNITEIINACLQLLSKPNSTIEEILEIVEAPDYPGGANIIGSKEEIADVYKSGNG
SIRQQAVYEYDNHGNVVITKLPHQVSSAAVMEQIANELKQQKITWIKNIQDESDDKEPVKIVLYSATIKKNIKKIMGHLL
ATTDLEKSFRVNMNMIGLDNRPQVKNLLDILNEWLEYRKHTLRRRLQTSLDKVLDRLHILEGLLIAFLNIDEVIDIIRNY
DDSSGELQTRFTLSEIQAEAILNIRLRKLAKIEEIEIKKEQKELQKERELLEGYLNSEVKFRNLMKKEFKQILTDFGDSR
RSKIIVAEKAQALEEKDLMPSEKVTIILSKAGWIRCAKGENIDPAGLSYKPEDKPFLVTTGNSNIKLVFFSKLGKAYSMY
IDKLPSARGYGEHITTYIPLDKQDQIISMAFVNAARYFLIASESGKAFVIPAEDLITNKVTGKNIFDADDVFKFIPYDKD
LKMLAVSSQGRAIIRDFASFALLKKGKGKSIIRLDKKDKLKFIELFRANQELTLNAGKRFIRIDSKNIETYYSDKPSGGG
VLLPQGFRKITKIDIENIESE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=247, Percent_Identity=27.5303643724696, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789396, Length=744, Percent_Identity=50.1344086021505, Blast_Score=756, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=736, Percent_Identity=34.5108695652174, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI212645845, Length=196, Percent_Identity=30.6122448979592, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=361, Percent_Identity=28.2548476454294, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83963; Mature: 83963

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLFSSLESTRSVAEFSEQAYLNYSMYVILDRALPHISDGLKPVQRRIIYAMSEIGLSHL
CCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQDFSYRYPFIDGQGNWGSIDDPKSFAA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHH
MRYTESRLSKYAVLLLDELKKGTVDWAKNFDGTMDEPKLLPAQVPNILLNGAMGIAVGMS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHCCHHHHCCCHHHHHHHH
TYIPPHNITEIINACLQLLSKPNSTIEEILEIVEAPDYPGGANIIGSKEEIADVYKSGNG
HCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCC
SIRQQAVYEYDNHGNVVITKLPHQVSSAAVMEQIANELKQQKITWIKNIQDESDDKEPVK
CHHHHHHHEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
IVLYSATIKKNIKKIMGHLLATTDLEKSFRVNMNMIGLDNRPQVKNLLDILNEWLEYRKH
EEEEHHHHHHHHHHHHHHHHHHHCCCHHHEECEEEECCCCCCHHHHHHHHHHHHHHHHHH
TLRRRLQTSLDKVLDRLHILEGLLIAFLNIDEVIDIIRNYDDSSGELQTRFTLSEIQAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHH
ILNIRLRKLAKIEEIEIKKEQKELQKERELLEGYLNSEVKFRNLMKKEFKQILTDFGDSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
RSKIIVAEKAQALEEKDLMPSEKVTIILSKAGWIRCAKGENIDPAGLSYKPEDKPFLVTT
CCEEEEEHHHHHHHHHCCCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCEEEEE
GNSNIKLVFFSKLGKAYSMYIDKLPSARGYGEHITTYIPLDKQDQIISMAFVNAARYFLI
CCCCEEEEEHHHHCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHEEEEE
ASESGKAFVIPAEDLITNKVTGKNIFDADDVFKFIPYDKDLKMLAVSSQGRAIIRDFASF
ECCCCCEEEEEHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHH
ALLKKGKGKSIIRLDKKDKLKFIELFRANQELTLNAGKRFIRIDSKNIETYYSDKPSGGG
HHHHCCCCCCEEEECCCHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCEEECCCCCCCC
VLLPQGFRKITKIDIENIESE
EECCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLFSSLESTRSVAEFSEQAYLNYSMYVILDRALPHISDGLKPVQRRIIYAMSEIGLSHL
CCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQDFSYRYPFIDGQGNWGSIDDPKSFAA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHH
MRYTESRLSKYAVLLLDELKKGTVDWAKNFDGTMDEPKLLPAQVPNILLNGAMGIAVGMS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHCCHHHHCCCHHHHHHHH
TYIPPHNITEIINACLQLLSKPNSTIEEILEIVEAPDYPGGANIIGSKEEIADVYKSGNG
HCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCC
SIRQQAVYEYDNHGNVVITKLPHQVSSAAVMEQIANELKQQKITWIKNIQDESDDKEPVK
CHHHHHHHEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
IVLYSATIKKNIKKIMGHLLATTDLEKSFRVNMNMIGLDNRPQVKNLLDILNEWLEYRKH
EEEEHHHHHHHHHHHHHHHHHHHCCCHHHEECEEEECCCCCCHHHHHHHHHHHHHHHHHH
TLRRRLQTSLDKVLDRLHILEGLLIAFLNIDEVIDIIRNYDDSSGELQTRFTLSEIQAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHH
ILNIRLRKLAKIEEIEIKKEQKELQKERELLEGYLNSEVKFRNLMKKEFKQILTDFGDSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
RSKIIVAEKAQALEEKDLMPSEKVTIILSKAGWIRCAKGENIDPAGLSYKPEDKPFLVTT
CCEEEEEHHHHHHHHHCCCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCEEEEE
GNSNIKLVFFSKLGKAYSMYIDKLPSARGYGEHITTYIPLDKQDQIISMAFVNAARYFLI
CCCCEEEEEHHHHCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHEEEEE
ASESGKAFVIPAEDLITNKVTGKNIFDADDVFKFIPYDKDLKMLAVSSQGRAIIRDFASF
ECCCCCEEEEEHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHH
ALLKKGKGKSIIRLDKKDKLKFIELFRANQELTLNAGKRFIRIDSKNIETYYSDKPSGGG
HHHHCCCCCCEEEECCCHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCEEECCCCCCCC
VLLPQGFRKITKIDIENIESE
EECCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]