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The map label for this gene is hemB [H]

Identifier: 134302460

GI number: 134302460

Start: 1513148

End: 1514122

Strand: Reverse

Name: hemB [H]

Synonym: FTW_1608

Alternate gene names: 134302460

Gene position: 1514122-1513148 (Counterclockwise)

Preceding gene: 134302461

Following gene: 134302459

Centisome position: 79.75

GC content: 37.13

Gene sequence:

>975_bases
ATGAGCTTTCCAATATCACGTCCACGTAGACTTAGGGTTACACAAGCTTTTCGCGATATCGTTGCTGAGACAACTTTAAG
CCTTGATGACTTAATGTATCCAATATTTGTTGTGCATGGTCAAGGAGTTAAAAAAGAAATTTCAAGTATGCCAAATCAAT
ATCATTGGTCAGTTGACATGCTTGATGAGTTAGTAGATCAAGTTGTCAAGGCTGGAATAAGGAGTCTAATGATATTTGGC
GTGCCAAAAATCAAAGATCTTGTTTCATCGGAGAATTATGATCCTAATGGAATAACACAGCAAGCAATTAGAAAGATTAA
ACAACTTGCTCCTGAGCTTGTGATAGCTACAGATGTATGTATGTGTAGTTTTACACCACATGGTCATTGTGGAATTTTAG
ATGAGCATGATTATGTTGATAACGATCAAACATTAGAAATATTACAAAAAACGGCTGTTTCTCATGCTCAAGCTGGAGCA
GATATTGTAGCACCAAGTGGGATGATGGATGGTATGATAATTGCGATGCGTCAGGCACTAGATGAGGCAAGCTTTGAGAA
TGTGAGTATTATGTCATACTCAGTTAAATATGCATCGGCATATTATGGACCATTTAGAAGTGCTTGTAGTTCGTCACTTA
AGGGAGATCGTAAAACTTATCAGATGGATTATCGCAATAAGAAAGAGGCAATCTGTGAGGCGCTTGCAGATATTGAGCAG
GGTGCAGATTTTATTATGGTTAAACCAGCTTTGAGTTATCTGGATATTGTCAATGAGTTAAGTCATATTATAGATTTACC
AATAGCAGCATATCATGTCAGTGGTGAATATGCGATGATAAAAGCTGCTGCTAGTGCTGGTTTAGTTGATGAAAAAGCAA
TCACTATAGAAACACTCATATCAATGAAAAGAGCAGGTGCTAAAGTGATACTTACATATACTGCGTTGGATGTGGCTAAT
TGGTTAAAGGTTTAA

Upstream 100 bases:

>100_bases
GAAATTACTCAGGCGACAAGGTTAGAGCTTGTACAGATTATTGGTAATATTCTAGTCTTATACAGAAGAAATCCAAACAA
AGAAAAAATATAGGTGAAAT

Downstream 100 bases:

>100_bases
AATATGATAAGTATTGCTTTATACGAGCCAGAAATCCCACCTAATACTGGCAATATAATTAGGTTGTGTGCAAATGTAGG
AGCAAAGTTACATTTAATAG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSFPISRPRRLRVTQAFRDIVAETTLSLDDLMYPIFVVHGQGVKKEISSMPNQYHWSVDMLDELVDQVVKAGIRSLMIFG
VPKIKDLVSSENYDPNGITQQAIRKIKQLAPELVIATDVCMCSFTPHGHCGILDEHDYVDNDQTLEILQKTAVSHAQAGA
DIVAPSGMMDGMIIAMRQALDEASFENVSIMSYSVKYASAYYGPFRSACSSSLKGDRKTYQMDYRNKKEAICEALADIEQ
GADFIMVKPALSYLDIVNELSHIIDLPIAAYHVSGEYAMIKAAASAGLVDEKAITIETLISMKRAGAKVILTYTALDVAN
WLKV

Sequences:

>Translated_324_residues
MSFPISRPRRLRVTQAFRDIVAETTLSLDDLMYPIFVVHGQGVKKEISSMPNQYHWSVDMLDELVDQVVKAGIRSLMIFG
VPKIKDLVSSENYDPNGITQQAIRKIKQLAPELVIATDVCMCSFTPHGHCGILDEHDYVDNDQTLEILQKTAVSHAQAGA
DIVAPSGMMDGMIIAMRQALDEASFENVSIMSYSVKYASAYYGPFRSACSSSLKGDRKTYQMDYRNKKEAICEALADIEQ
GADFIMVKPALSYLDIVNELSHIIDLPIAAYHVSGEYAMIKAAASAGLVDEKAITIETLISMKRAGAKVILTYTALDVAN
WLKV
>Mature_323_residues
SFPISRPRRLRVTQAFRDIVAETTLSLDDLMYPIFVVHGQGVKKEISSMPNQYHWSVDMLDELVDQVVKAGIRSLMIFGV
PKIKDLVSSENYDPNGITQQAIRKIKQLAPELVIATDVCMCSFTPHGHCGILDEHDYVDNDQTLEILQKTAVSHAQAGAD
IVAPSGMMDGMIIAMRQALDEASFENVSIMSYSVKYASAYYGPFRSACSSSLKGDRKTYQMDYRNKKEAICEALADIEQG
ADFIMVKPALSYLDIVNELSHIIDLPIAAYHVSGEYAMIKAAASAGLVDEKAITIETLISMKRAGAKVILTYTALDVANW
LKV

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=308, Percent_Identity=41.2337662337662, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI87081728, Length=316, Percent_Identity=51.8987341772152, Blast_Score=315, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6321398, Length=312, Percent_Identity=41.025641025641, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI21358291, Length=288, Percent_Identity=38.8888888888889, Blast_Score=208, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35812; Mature: 35681

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPISRPRRLRVTQAFRDIVAETTLSLDDLMYPIFVVHGQGVKKEISSMPNQYHWSVDM
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCHHHHHHHCCCCEECCHHH
LDELVDQVVKAGIRSLMIFGVPKIKDLVSSENYDPNGITQQAIRKIKQLAPELVIATDVC
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
MCSFTPHGHCGILDEHDYVDNDQTLEILQKTAVSHAQAGADIVAPSGMMDGMIIAMRQAL
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHH
DEASFENVSIMSYSVKYASAYYGPFRSACSSSLKGDRKTYQMDYRNKKEAICEALADIEQ
HHCCCCCEEEEEEEHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHC
GADFIMVKPALSYLDIVNELSHIIDLPIAAYHVSGEYAMIKAAASAGLVDEKAITIETLI
CCCEEEECHHHHHHHHHHHHHHHHHCCHHEEEECCCHHEEEHHHHCCCCCCHHHHHHHHH
SMKRAGAKVILTYTALDVANWLKV
HHHHCCCEEEEEEHHHHHHHHHCC
>Mature Secondary Structure 
SFPISRPRRLRVTQAFRDIVAETTLSLDDLMYPIFVVHGQGVKKEISSMPNQYHWSVDM
CCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCHHHHHHHCCCCEECCHHH
LDELVDQVVKAGIRSLMIFGVPKIKDLVSSENYDPNGITQQAIRKIKQLAPELVIATDVC
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
MCSFTPHGHCGILDEHDYVDNDQTLEILQKTAVSHAQAGADIVAPSGMMDGMIIAMRQAL
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHH
DEASFENVSIMSYSVKYASAYYGPFRSACSSSLKGDRKTYQMDYRNKKEAICEALADIEQ
HHCCCCCEEEEEEEHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHC
GADFIMVKPALSYLDIVNELSHIIDLPIAAYHVSGEYAMIKAAASAGLVDEKAITIETLI
CCCEEEECHHHHHHHHHHHHHHHHHCCHHEEEECCCHHEEEHHHHCCCCCCHHHHHHHHH
SMKRAGAKVILTYTALDVANWLKV
HHHHCCCEEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]