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The map label for this gene is mutL [H]

Identifier: 134302436

GI number: 134302436

Start: 1485859

End: 1487661

Strand: Reverse

Name: mutL [H]

Synonym: FTW_1584

Alternate gene names: 134302436

Gene position: 1487661-1485859 (Counterclockwise)

Preceding gene: 134302437

Following gene: 134302429

Centisome position: 78.36

GC content: 34.44

Gene sequence:

>1803_bases
ATGCAACCACAACAACATGATTATCGTCAAATAAAAATTCTACCTGAGAGTTTAGCTAACCAGATAGCTGCTGGTGAGGT
TATCGAAAGACCATCTTCAGTAGTCAAAGAACTTATTGAAAATGCAATTGATGCCGGAGCAACTCAGATAATAATCGAAA
TTCAAGAGGGCGGTAAATCATTAATCAGAATTAGAGATAATGGTAAAGGAATCGCACAACAAGACTTAAAATTAGCTTTG
GCACCTCATGCAACAAGTAAGGTCTATACCTTGGATGAACTTGAAGCTGTGGCTAGTATGGGTTTTCGTGGCGAGGCTTT
GGCAAGTATAGCTTCTGTTGCTAAACTAAAAATTATCTCAAAGCATCAGAATTCACAAGATGCTTGGCAAATTAATAACC
AAACTAGAGAAGTTATGCCAGTAGCACATGTGACAGGAACAACTATAGAGGTTAGTGAGCTTTTCTATAATACTCCTGCA
CGCCGTAAGTTTCTTAAAAAAGATAATACGGAGTTTTTACATATTTATGATTTACTCAAAAAGTATATGCTTTGCTATTT
TGGTATTGCTTTTAAACTTATTCATAATGGTAAGGAAGTCAAAGATTTACTTATAGCTGAAGAAGTTCAACTTAAATATA
ATCGTGTTTTAGATTTATATAGTCGCGAGTTTATTGAAAATGCCATTTATGTAGACAAACAAGTTGGTGATGCCCATCTG
TGGGGATGGGTAGCTAGTCCAAGATTTAATCGAGCTCGAGCTGATATGCAGAGTTTCTATATAAATGGACGTATAATTAA
AGACAAAATTGTTAGCCATGCGATAAAAAATGCCTATAAAGATGTGATGTATGGCAATCGCTATCCAGCATTTTTACTTT
ACCTTGATATTGATTATTGTGAGGTTGATGTAAATGTTCATCCAGCAAAAAGTGAAGTACGTTTTAGAAATCAAAAATTC
ATCTATGACTTTCTCTTTGGTAATATCAATAAGGCGATAACTACTAGTGCGGATATAAAAGTATCTAGCCACCAACAAGT
AATCAGTCAAGAACGACAAACTAGTAATAATAATCCGCTTAATATTGGTAATATGAGTTTGGATATCAGTATTGATGATG
AAAAAGAAGAAAGCTCAAATACAAGCTTATTAGACAAGTACTTTAATAATCAAAATTCTCAAGAAAATGAAATTCGTATT
AGCCAACAGTCGAAGTCTAATGGATTAGGACAAGCTATTTGTCAAATTCATGGTATATATATTCTCTCGCAAGTTGAGGA
TGGTGTTGTACTTGTAGATATGCATGCAGCACATGAAAGAATACTTTATGAAGAGATGAAAAAAACTTGGCATGCAAATG
CTGATAAATTTAAACAAAACCTGTTAATGCCGCTTACATGTCAACTATCTAGCAGTATAGTTGCAGCTGTTGATGAGAAT
GTTGAAGTATTTAAAAAGTTGGGTTTTGAAATATCAGTAGTTGCCGATGATGCAATACTTGTACGTTCAACTCCAATATA
TGTCAAAGATAAAGACATACAAACCTTAATAACCAACATAGCTACCGAGCTGATATCTTCAAGTAAGACAAAGAGCGTCG
AATTTTACTTAAACCATATTTTAGCCACAGTATCTTGTCACGCAGCTGTACGAGCAAATGATAAGTTAAGTATACCAGAG
ATGAATCATTTACTTAGACAAATGGAGACAGTAGAGAATTCAGGGCAGTGTAATCATGGGCGACCAACTTGGGTGAAACT
TAATTTTGCTCAACTAGATAGTTTCTTTTTGAGAGGAAGGTAA

Upstream 100 bases:

>100_bases
GTCTATACTTATGAGGATAAAAACGGTAAGGTTAACAATAAAGAGCTATTTAAAGAATGTGCCACCAGAAACTTTGTAAA
AGATCCTTTATAGTGAAAAT

Downstream 100 bases:

>100_bases
CCCTCTATAAAATATTGTCATCCGATACTTGAATAGTAATCTGTTTGCTAGTTGATAAACTTTCAACTTGCTTATAAATA
TACTTAGTGTAGAATCACCT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MQPQQHDYRQIKILPESLANQIAAGEVIERPSSVVKELIENAIDAGATQIIIEIQEGGKSLIRIRDNGKGIAQQDLKLAL
APHATSKVYTLDELEAVASMGFRGEALASIASVAKLKIISKHQNSQDAWQINNQTREVMPVAHVTGTTIEVSELFYNTPA
RRKFLKKDNTEFLHIYDLLKKYMLCYFGIAFKLIHNGKEVKDLLIAEEVQLKYNRVLDLYSREFIENAIYVDKQVGDAHL
WGWVASPRFNRARADMQSFYINGRIIKDKIVSHAIKNAYKDVMYGNRYPAFLLYLDIDYCEVDVNVHPAKSEVRFRNQKF
IYDFLFGNINKAITTSADIKVSSHQQVISQERQTSNNNPLNIGNMSLDISIDDEKEESSNTSLLDKYFNNQNSQENEIRI
SQQSKSNGLGQAICQIHGIYILSQVEDGVVLVDMHAAHERILYEEMKKTWHANADKFKQNLLMPLTCQLSSSIVAAVDEN
VEVFKKLGFEISVVADDAILVRSTPIYVKDKDIQTLITNIATELISSSKTKSVEFYLNHILATVSCHAAVRANDKLSIPE
MNHLLRQMETVENSGQCNHGRPTWVKLNFAQLDSFFLRGR

Sequences:

>Translated_600_residues
MQPQQHDYRQIKILPESLANQIAAGEVIERPSSVVKELIENAIDAGATQIIIEIQEGGKSLIRIRDNGKGIAQQDLKLAL
APHATSKVYTLDELEAVASMGFRGEALASIASVAKLKIISKHQNSQDAWQINNQTREVMPVAHVTGTTIEVSELFYNTPA
RRKFLKKDNTEFLHIYDLLKKYMLCYFGIAFKLIHNGKEVKDLLIAEEVQLKYNRVLDLYSREFIENAIYVDKQVGDAHL
WGWVASPRFNRARADMQSFYINGRIIKDKIVSHAIKNAYKDVMYGNRYPAFLLYLDIDYCEVDVNVHPAKSEVRFRNQKF
IYDFLFGNINKAITTSADIKVSSHQQVISQERQTSNNNPLNIGNMSLDISIDDEKEESSNTSLLDKYFNNQNSQENEIRI
SQQSKSNGLGQAICQIHGIYILSQVEDGVVLVDMHAAHERILYEEMKKTWHANADKFKQNLLMPLTCQLSSSIVAAVDEN
VEVFKKLGFEISVVADDAILVRSTPIYVKDKDIQTLITNIATELISSSKTKSVEFYLNHILATVSCHAAVRANDKLSIPE
MNHLLRQMETVENSGQCNHGRPTWVKLNFAQLDSFFLRGR
>Mature_600_residues
MQPQQHDYRQIKILPESLANQIAAGEVIERPSSVVKELIENAIDAGATQIIIEIQEGGKSLIRIRDNGKGIAQQDLKLAL
APHATSKVYTLDELEAVASMGFRGEALASIASVAKLKIISKHQNSQDAWQINNQTREVMPVAHVTGTTIEVSELFYNTPA
RRKFLKKDNTEFLHIYDLLKKYMLCYFGIAFKLIHNGKEVKDLLIAEEVQLKYNRVLDLYSREFIENAIYVDKQVGDAHL
WGWVASPRFNRARADMQSFYINGRIIKDKIVSHAIKNAYKDVMYGNRYPAFLLYLDIDYCEVDVNVHPAKSEVRFRNQKF
IYDFLFGNINKAITTSADIKVSSHQQVISQERQTSNNNPLNIGNMSLDISIDDEKEESSNTSLLDKYFNNQNSQENEIRI
SQQSKSNGLGQAICQIHGIYILSQVEDGVVLVDMHAAHERILYEEMKKTWHANADKFKQNLLMPLTCQLSSSIVAAVDEN
VEVFKKLGFEISVVADDAILVRSTPIYVKDKDIQTLITNIATELISSSKTKSVEFYLNHILATVSCHAAVRANDKLSIPE
MNHLLRQMETVENSGQCNHGRPTWVKLNFAQLDSFFLRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=320, Percent_Identity=34.6875, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI189458898, Length=326, Percent_Identity=29.1411042944785, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI4505911, Length=326, Percent_Identity=29.1411042944785, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI310128478, Length=346, Percent_Identity=26.0115606936416, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI4505913, Length=346, Percent_Identity=26.0115606936416, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI189458896, Length=319, Percent_Identity=28.8401253918495, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI263191589, Length=231, Percent_Identity=30.3030303030303, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI310128480, Length=297, Percent_Identity=23.9057239057239, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI91992162, Length=355, Percent_Identity=24.5070422535211, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI91992160, Length=355, Percent_Identity=24.5070422535211, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1790612, Length=544, Percent_Identity=36.3970588235294, Blast_Score=343, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.0625, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17562796, Length=416, Percent_Identity=25.9615384615385, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=345, Percent_Identity=33.6231884057971, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=342, Percent_Identity=27.1929824561404, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6325093, Length=154, Percent_Identity=29.8701298701299, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6323063, Length=342, Percent_Identity=23.0994152046784, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136968, Length=323, Percent_Identity=31.2693498452012, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17136970, Length=359, Percent_Identity=25.9052924791086, Blast_Score=115, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 68045; Mature: 68045

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPQQHDYRQIKILPESLANQIAAGEVIERPSSVVKELIENAIDAGATQIIIEIQEGGKS
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEEECCCCE
LIRIRDNGKGIAQQDLKLALAPHATSKVYTLDELEAVASMGFRGEALASIASVAKLKIIS
EEEEECCCCCCCCCCCEEEECCCCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
KHQNSQDAWQINNQTREVMPVAHVTGTTIEVSELFYNTPARRKFLKKDNTEFLHIYDLLK
HCCCCCCCEEECCCCHHEEEEEEECCCEEEEHHHHHCCHHHHHHHHCCCCCEEHHHHHHH
KYMLCYFGIAFKLIHNGKEVKDLLIAEEVQLKYNRVLDLYSREFIENAIYVDKQVGDAHL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEE
WGWVASPRFNRARADMQSFYINGRIIKDKIVSHAIKNAYKDVMYGNRYPAFLLYLDIDYC
EEEECCCCCHHHHHHHHHHEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEE
EVDVNVHPAKSEVRFRNQKFIYDFLFGNINKAITTSADIKVSSHQQVISQERQTSNNNPL
EEEEEECCCHHHHHHCCCCEEEEHHHCCCCHHEECCCCEEECHHHHHHHHHHHCCCCCCE
NIGNMSLDISIDDEKEESSNTSLLDKYFNNQNSQENEIRISQQSKSNGLGQAICQIHGIY
EECCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHEE
ILSQVEDGVVLVDMHAAHERILYEEMKKTWHANADKFKQNLLMPLTCQLSSSIVAAVDEN
EEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCCHHHHHHCCC
VEVFKKLGFEISVVADDAILVRSTPIYVKDKDIQTLITNIATELISSSKTKSVEFYLNHI
HHHHHHCCCEEEEEECCEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LATVSCHAAVRANDKLSIPEMNHLLRQMETVENSGQCNHGRPTWVKLNFAQLDSFFLRGR
HHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure
MQPQQHDYRQIKILPESLANQIAAGEVIERPSSVVKELIENAIDAGATQIIIEIQEGGKS
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEEECCCCE
LIRIRDNGKGIAQQDLKLALAPHATSKVYTLDELEAVASMGFRGEALASIASVAKLKIIS
EEEEECCCCCCCCCCCEEEECCCCCCCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
KHQNSQDAWQINNQTREVMPVAHVTGTTIEVSELFYNTPARRKFLKKDNTEFLHIYDLLK
HCCCCCCCEEECCCCHHEEEEEEECCCEEEEHHHHHCCHHHHHHHHCCCCCEEHHHHHHH
KYMLCYFGIAFKLIHNGKEVKDLLIAEEVQLKYNRVLDLYSREFIENAIYVDKQVGDAHL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEE
WGWVASPRFNRARADMQSFYINGRIIKDKIVSHAIKNAYKDVMYGNRYPAFLLYLDIDYC
EEEECCCCCHHHHHHHHHHEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEE
EVDVNVHPAKSEVRFRNQKFIYDFLFGNINKAITTSADIKVSSHQQVISQERQTSNNNPL
EEEEEECCCHHHHHHCCCCEEEEHHHCCCCHHEECCCCEEECHHHHHHHHHHHCCCCCCE
NIGNMSLDISIDDEKEESSNTSLLDKYFNNQNSQENEIRISQQSKSNGLGQAICQIHGIY
EECCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHEE
ILSQVEDGVVLVDMHAAHERILYEEMKKTWHANADKFKQNLLMPLTCQLSSSIVAAVDEN
EEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCCHHHHHHCCC
VEVFKKLGFEISVVADDAILVRSTPIYVKDKDIQTLITNIATELISSSKTKSVEFYLNHI
HHHHHHCCCEEEEEECCEEEEECCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LATVSCHAAVRANDKLSIPEMNHLLRQMETVENSGQCNHGRPTWVKLNFAQLDSFFLRGR
HHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA