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The map label for this gene is sucA2 [H]

Identifier: 134302425

GI number: 134302425

Start: 1469146

End: 1470018

Strand: Direct

Name: sucA2 [H]

Synonym: FTW_1562

Alternate gene names: 134302425

Gene position: 1469146-1470018 (Clockwise)

Preceding gene: 134302424

Following gene: 134302426

Centisome position: 77.39

GC content: 40.32

Gene sequence:

>873_bases
ATGAGCGTATTAGTTGATAAAAATACAAAAGTTTTAGTACAGGGTTTTACTGGTAAAAATGGTACTTTCCATTCAGAACA
AGCTATTGCTTATGGTACAAATATTGTAGGTGGCGTAACTCCTGGTAAAGGTGGCACTACTCACTTAGATAGACCAGTGT
TCAATACAATGGCTGAAGCTGTAGCAGCTACTGGTGCTGATGCGTCTGTAATCTATGTTCCAGCTCCATTTGTAAAAGAC
TCTGCAATTGAAGCGATCGATTCTGGTGTTAAGCTAGTAGTAATCATTACAGAAGGTGTCCCTACTCTAGATATGCTAGT
AGTTAAAGAGTACTTAAAAGATAAAGATGTGAGAGTAATTGGTCCTAACTGTCCAGGGATCATCACTCCAGGTGAGTGTA
AGATTGGTATTATGCCGGGTCATATTCATATGAAAGGTAAAGTTGGTATCATTTCTCGTTCTGGTACTTTAACTTACGAA
GCAGTTGCTCAAACTACTAAACTAGGCTTTGGTCAATCTACTTGTATTGGTATAGGCGGAGACCCTATCCCAGGTATGAA
CCAAATCGAAGCTCTTAAACTTTTAGAGAATGACCCACAAACTGAAGCTATCATCTTAATCGGTGAAATTGGTGGTACAG
CTGAAGAAGAAGCTGCTGAATATATCAAGCACAATGTAACTAAGCCTGTTATTGGATATATCGCTGGTGTTACAGCTCCT
CCAGGAAAGCGTATGGGTCATGCTGGTGCTATTATCTCTGGTGGTAAAGGTACCGCTGAAGAAAAATTTGCCGCATTCGA
AGCTGCTGGTATTGCTTATACTAGATCACCTGCTGAGATCGGCAAGAAGCTTAAAGAAGTTACTGGCTGGTAA

Upstream 100 bases:

>100_bases
GGTTTAAAACTAATACCTGCTGATGGTTTAGCTGATGCTGCTGATAAAGTTGTGAAATCACTAGGTTAATAAATTAAAAC
AGTTAAAAGGATATTAAATA

Downstream 100 bases:

>100_bases
TTTTATTCTTTTATATTTTTCTATTACTTCTTAAAATTACATTATATTTTTTATCACCACTTAAACTTAAAATGATACTA
TAATCTTATAGATTTATAAT

Product: succinyl-CoA synthetase, alpha subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSVLVDKNTKVLVQGFTGKNGTFHSEQAIAYGTNIVGGVTPGKGGTTHLDRPVFNTMAEAVAATGADASVIYVPAPFVKD
SAIEAIDSGVKLVVIITEGVPTLDMLVVKEYLKDKDVRVIGPNCPGIITPGECKIGIMPGHIHMKGKVGIISRSGTLTYE
AVAQTTKLGFGQSTCIGIGGDPIPGMNQIEALKLLENDPQTEAIILIGEIGGTAEEEAAEYIKHNVTKPVIGYIAGVTAP
PGKRMGHAGAIISGGKGTAEEKFAAFEAAGIAYTRSPAEIGKKLKEVTGW

Sequences:

>Translated_290_residues
MSVLVDKNTKVLVQGFTGKNGTFHSEQAIAYGTNIVGGVTPGKGGTTHLDRPVFNTMAEAVAATGADASVIYVPAPFVKD
SAIEAIDSGVKLVVIITEGVPTLDMLVVKEYLKDKDVRVIGPNCPGIITPGECKIGIMPGHIHMKGKVGIISRSGTLTYE
AVAQTTKLGFGQSTCIGIGGDPIPGMNQIEALKLLENDPQTEAIILIGEIGGTAEEEAAEYIKHNVTKPVIGYIAGVTAP
PGKRMGHAGAIISGGKGTAEEKFAAFEAAGIAYTRSPAEIGKKLKEVTGW
>Mature_289_residues
SVLVDKNTKVLVQGFTGKNGTFHSEQAIAYGTNIVGGVTPGKGGTTHLDRPVFNTMAEAVAATGADASVIYVPAPFVKDS
AIEAIDSGVKLVVIITEGVPTLDMLVVKEYLKDKDVRVIGPNCPGIITPGECKIGIMPGHIHMKGKVGIISRSGTLTYEA
VAQTTKLGFGQSTCIGIGGDPIPGMNQIEALKLLENDPQTEAIILIGEIGGTAEEEAAEYIKHNVTKPVIGYIAGVTAPP
GKRMGHAGAIISGGKGTAEEKFAAFEAAGIAYTRSPAEIGKKLKEVTGW

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=284, Percent_Identity=63.3802816901408, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI38569423, Length=250, Percent_Identity=29.6, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI38569421, Length=250, Percent_Identity=29.6, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1786949, Length=287, Percent_Identity=76.6550522648084, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1786513, Length=148, Percent_Identity=31.0810810810811, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17550194, Length=288, Percent_Identity=59.7222222222222, Blast_Score=323, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI17553126, Length=290, Percent_Identity=58.6206896551724, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17551266, Length=253, Percent_Identity=31.6205533596838, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17557344, Length=253, Percent_Identity=32.0158102766798, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324716, Length=292, Percent_Identity=50.6849315068493, Blast_Score=272, Evalue=4e-74,
Organism=Drosophila melanogaster, GI21356559, Length=287, Percent_Identity=57.4912891986063, Blast_Score=336, Evalue=1e-92,
Organism=Drosophila melanogaster, GI28574296, Length=285, Percent_Identity=58.5964912280702, Blast_Score=307, Evalue=5e-84,
Organism=Drosophila melanogaster, GI281363477, Length=253, Percent_Identity=29.2490118577075, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI281363475, Length=253, Percent_Identity=29.2490118577075, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281363473, Length=253, Percent_Identity=29.2490118577075, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30095; Mature: 29964

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLVDKNTKVLVQGFTGKNGTFHSEQAIAYGTNIVGGVTPGKGGTTHLDRPVFNTMAEA
CEEEEECCCEEEEEECCCCCCCCCCCCEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHH
VAATGADASVIYVPAPFVKDSAIEAIDSGVKLVVIITEGVPTLDMLVVKEYLKDKDVRVI
HHHCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
GPNCPGIITPGECKIGIMPGHIHMKGKVGIISRSGTLTYEAVAQTTKLGFGQSTCIGIGG
CCCCCCEECCCCEEEEEECCEEEECCEEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGMNQIEALKLLENDPQTEAIILIGEIGGTAEEEAAEYIKHNVTKPVIGYIAGVTAP
CCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTAEEKFAAFEAAGIAYTRSPAEIGKKLKEVTGW
CCCCCCCCCEEEECCCCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVLVDKNTKVLVQGFTGKNGTFHSEQAIAYGTNIVGGVTPGKGGTTHLDRPVFNTMAEA
EEEEECCCEEEEEECCCCCCCCCCCCEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHH
VAATGADASVIYVPAPFVKDSAIEAIDSGVKLVVIITEGVPTLDMLVVKEYLKDKDVRVI
HHHCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
GPNCPGIITPGECKIGIMPGHIHMKGKVGIISRSGTLTYEAVAQTTKLGFGQSTCIGIGG
CCCCCCEECCCCEEEEEECCEEEECCEEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGMNQIEALKLLENDPQTEAIILIGEIGGTAEEEAAEYIKHNVTKPVIGYIAGVTAP
CCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTAEEKFAAFEAAGIAYTRSPAEIGKKLKEVTGW
CCCCCCCCCEEEECCCCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]