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The map label for this gene is serS [H]

Identifier: 134302372

GI number: 134302372

Start: 1402013

End: 1403293

Strand: Direct

Name: serS [H]

Synonym: FTW_1496

Alternate gene names: 134302372

Gene position: 1402013-1403293 (Clockwise)

Preceding gene: 134302371

Following gene: 134302373

Centisome position: 73.85

GC content: 34.74

Gene sequence:

>1281_bases
ATGCTTGATGCTAAATATATTAAGGATAATTTACAACAAGTTGCTGAAAAGCTTGCAACTAGAGGTTATCAATTTGATAT
AGCCGAATTTGAAGCCCAAGAGCAAAAAAGAAAACATCTTCAAGAAAGAACTCAGGATCTACAATCACAACGTAATACTA
TTTCAAAAGAAATAGGCCAAAAAAAAGCTAAAGGTGAAGATACTAGTGATATCTTTGCTAAAGTTAATCAAATTAATGAA
GAACTAAAAATTATTGAAAAAGAGCTCAAAGACCTACAAGATACTATAAATCAAACACTATTATCAATGCCAAACCTTCC
TGCTGATGACGTCCCTGTTGGTAAAGATGAGAATGATAATGTAGAAATAAGAAGATGGGGAACTCCACGTGAGTTTCATC
CTGAAGCACCTGCAAAAGATCATTCTGATATTGGTGAAATCCTCAAAATGATTGATTTTAAAGCCGCTGCTAAAGTTACT
GGCAGCCGTTTTATGGTCCTGAAAAATAAGATTGCTAAACTACACCGCGCTCTATCACAGTTTATGCTTGATCTGCATAC
AGAAAAACATGGTTATGAAGAATTATATGTGCCATATCTAGTCAATAATGATAGTTTATATGGTACTGGACAATTACCAA
AATTTGCTGCTGATCTTTTTAAGCTTGAGGGAGATTTTGAATATAGTCTAATACCTACAGCAGAGGTGCCAATCACTAAT
CTAGTAAGGGATGAAATTTTAGATACAGAAACTTTACCTAGATACTATACAGCTCACACTCCTTGCTTTAGAAGTGAAGC
TGGTTCATATGGCCGTGATACTAAAGGTATGATTCGTCAACACCAGTTTGAGAAAGTCGAGTTAGTACATATCACTACTG
CAGATAAAGGTGAAGAATCTCTAGAATTACTCACATCACATGCTGAAAAAGTCTTACAAAAACTTAACTTACCATATAGA
GTGATGAAACTATGTACTGGTGATATGGGCTTTAGCGCTAAAAAAACTTATGATTTAGAAGTATGGCTCCCATCACAAAA
TACTTATAGAGAAATATCTTCATGTAGCTGGTGTGGAGATTTCCAAGCTCGTCGTATGAAAGCTCGACACAAAAATCCAA
GTATGAAGAAACCAGAATTAGTCCATACTCTAAATGGTTCTGGTTTGGCTGTAGGTAGAACATTATTAGCTATTATTGAA
AATTATCAACAAGAAGATGGTTCTATTATGGTTCCCGATGCTCTTATCAAGTATATGGGCGGAATTTCAGTTATTAAGTA
A

Upstream 100 bases:

>100_bases
ATATTGCACCAACTCTACTTAATGTCATGGGTATAGCTCAACCTAAAGAAATGACTGGTAAAACTATTTTTAACTTTGAA
AAATAAGGATTTTAGATAAA

Downstream 100 bases:

>100_bases
ATCGGATAAATTTGTTATTTTTATTTCTTTCAAAGAGTAATAATCTAAATATTATTAGTGAATAATGCTAAAATCTTTAT
ATCTAGTTTTATTGAAAAAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDAKYIKDNLQQVAEKLATRGYQFDIAEFEAQEQKRKHLQERTQDLQSQRNTISKEIGQKKAKGEDTSDIFAKVNQINE
ELKIIEKELKDLQDTINQTLLSMPNLPADDVPVGKDENDNVEIRRWGTPREFHPEAPAKDHSDIGEILKMIDFKAAAKVT
GSRFMVLKNKIAKLHRALSQFMLDLHTEKHGYEELYVPYLVNNDSLYGTGQLPKFAADLFKLEGDFEYSLIPTAEVPITN
LVRDEILDTETLPRYYTAHTPCFRSEAGSYGRDTKGMIRQHQFEKVELVHITTADKGEESLELLTSHAEKVLQKLNLPYR
VMKLCTGDMGFSAKKTYDLEVWLPSQNTYREISSCSWCGDFQARRMKARHKNPSMKKPELVHTLNGSGLAVGRTLLAIIE
NYQQEDGSIMVPDALIKYMGGISVIK

Sequences:

>Translated_426_residues
MLDAKYIKDNLQQVAEKLATRGYQFDIAEFEAQEQKRKHLQERTQDLQSQRNTISKEIGQKKAKGEDTSDIFAKVNQINE
ELKIIEKELKDLQDTINQTLLSMPNLPADDVPVGKDENDNVEIRRWGTPREFHPEAPAKDHSDIGEILKMIDFKAAAKVT
GSRFMVLKNKIAKLHRALSQFMLDLHTEKHGYEELYVPYLVNNDSLYGTGQLPKFAADLFKLEGDFEYSLIPTAEVPITN
LVRDEILDTETLPRYYTAHTPCFRSEAGSYGRDTKGMIRQHQFEKVELVHITTADKGEESLELLTSHAEKVLQKLNLPYR
VMKLCTGDMGFSAKKTYDLEVWLPSQNTYREISSCSWCGDFQARRMKARHKNPSMKKPELVHTLNGSGLAVGRTLLAIIE
NYQQEDGSIMVPDALIKYMGGISVIK
>Mature_426_residues
MLDAKYIKDNLQQVAEKLATRGYQFDIAEFEAQEQKRKHLQERTQDLQSQRNTISKEIGQKKAKGEDTSDIFAKVNQINE
ELKIIEKELKDLQDTINQTLLSMPNLPADDVPVGKDENDNVEIRRWGTPREFHPEAPAKDHSDIGEILKMIDFKAAAKVT
GSRFMVLKNKIAKLHRALSQFMLDLHTEKHGYEELYVPYLVNNDSLYGTGQLPKFAADLFKLEGDFEYSLIPTAEVPITN
LVRDEILDTETLPRYYTAHTPCFRSEAGSYGRDTKGMIRQHQFEKVELVHITTADKGEESLELLTSHAEKVLQKLNLPYR
VMKLCTGDMGFSAKKTYDLEVWLPSQNTYREISSCSWCGDFQARRMKARHKNPSMKKPELVHTLNGSGLAVGRTLLAIIE
NYQQEDGSIMVPDALIKYMGGISVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=420, Percent_Identity=35.9523809523809, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI8923421, Length=409, Percent_Identity=27.8728606356968, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI225579074, Length=326, Percent_Identity=30.3680981595092, Blast_Score=152, Evalue=8e-37,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=61.9489559164733, Blast_Score=542, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17539260, Length=418, Percent_Identity=33.0143540669856, Blast_Score=191, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17542084, Length=327, Percent_Identity=26.9113149847095, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320226, Length=391, Percent_Identity=33.7595907928389, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=393, Percent_Identity=30.7888040712468, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24581334, Length=442, Percent_Identity=32.8054298642534, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI17737985, Length=297, Percent_Identity=30.3030303030303, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48586; Mature: 48586

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDAKYIKDNLQQVAEKLATRGYQFDIAEFEAQEQKRKHLQERTQDLQSQRNTISKEIGQ
CCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKAKGEDTSDIFAKVNQINEELKIIEKELKDLQDTINQTLLSMPNLPADDVPVGKDENDN
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEIRRWGTPREFHPEAPAKDHSDIGEILKMIDFKAAAKVTGSRFMVLKNKIAKLHRALSQ
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FMLDLHTEKHGYEELYVPYLVNNDSLYGTGQLPKFAADLFKLEGDFEYSLIPTAEVPITN
HHHHHHHCCCCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCHHH
LVRDEILDTETLPRYYTAHTPCFRSEAGSYGRDTKGMIRQHQFEKVELVHITTADKGEES
HHHHHHHCCCCCCCHHHCCCCCHHHCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCHHH
LELLTSHAEKVLQKLNLPYRVMKLCTGDMGFSAKKTYDLEVWLPSQNTYREISSCSWCGD
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEEECCCHHHHHHHCCCCCCH
FQARRMKARHKNPSMKKPELVHTLNGSGLAVGRTLLAIIENYQQEDGSIMVPDALIKYMG
HHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHC
GISVIK
CCCCCC
>Mature Secondary Structure
MLDAKYIKDNLQQVAEKLATRGYQFDIAEFEAQEQKRKHLQERTQDLQSQRNTISKEIGQ
CCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKAKGEDTSDIFAKVNQINEELKIIEKELKDLQDTINQTLLSMPNLPADDVPVGKDENDN
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEIRRWGTPREFHPEAPAKDHSDIGEILKMIDFKAAAKVTGSRFMVLKNKIAKLHRALSQ
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FMLDLHTEKHGYEELYVPYLVNNDSLYGTGQLPKFAADLFKLEGDFEYSLIPTAEVPITN
HHHHHHHCCCCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCHHH
LVRDEILDTETLPRYYTAHTPCFRSEAGSYGRDTKGMIRQHQFEKVELVHITTADKGEES
HHHHHHHCCCCCCCHHHCCCCCHHHCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCHHH
LELLTSHAEKVLQKLNLPYRVMKLCTGDMGFSAKKTYDLEVWLPSQNTYREISSCSWCGD
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEEECCCHHHHHHHCCCCCCH
FQARRMKARHKNPSMKKPELVHTLNGSGLAVGRTLLAIIENYQQEDGSIMVPDALIKYMG
HHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHC
GISVIK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA