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The map label for this gene is hsrA [H]

Identifier: 134302353

GI number: 134302353

Start: 1378261

End: 1379649

Strand: Direct

Name: hsrA [H]

Synonym: FTW_1477

Alternate gene names: 134302353

Gene position: 1378261-1379649 (Clockwise)

Preceding gene: 134302351

Following gene: 134302361

Centisome position: 72.6

GC content: 32.47

Gene sequence:

>1389_bases
ATGGACAAAAACAAAATAATCGCCTATACGATAGGCTTAGTTATGCTTATTGAACTAATTGATGGCTCTGCACTAAACAC
TGCACTACCACAAATAGCAAATGACTTACATGTAAATGCTATAACTCTAAAAGTAGCAATTACTGTATATTTGCTTGCTT
TGGGATTATTTATCCCAGCATCTGGATGGATATCAGATAAAATTGGCAGTAAAAATCTATTACTACTCTCAATCACTGGC
TTTATGTTCTCATCTATAGCATGTGGACTATCGACCAATCTTATTAGCCTAGTTATCTTTAGAGCTATTCAAGGAGCTTT
TGGAGCTTTTACCGCACCTGTTGCCCGTTTAGCAATGGTTAGAATCTACAAAAATGATGTACTCACAGCAATGTCGATAG
TTGCTGTAATAGCTGCGTTAGGACCAATGCTTGGACCTTTGTTTGGAGGAGCGATTACTACTCACATTGGCTGGAGAATG
ATTTTTTTCATCAATGTCCCAATTGGTATGATAGCTATAACTTTAATTTATCTACATCTACCGAATATAACATCTCTTAC
GTTAAGAAAATTTGATTTGAAAGGTTTTATTATCATTGGCACATCTATCGCACTAATATTATTTTTTATAGACTTATTGA
TAGATACACACCTTGCTCACATAAAATGGTTGTTACTAATCTCTGCAGTTATCCTCTTTGGTATATATATACGCCATGCT
CAACGTCTCAAAGATGATGCTGTTATCAACTTAACTATTTTTAAAGACCGTTGTTTTAGATATTTCACCATAATTAGTTC
AACCTCAAGACTTTTAGTAATGGGGATGTCATTTATTTTTCCACTATACTTACAAACCAAGCAAGGCTTTAGTGCTTTTG
AATCAGGATTATTTTTAATGTTCTTTTTGATCCCTGCTTGGTTTGTTAAAAAGTTTGTAAAGCGAGTTTTAGCTAAACTA
CATTTTTATAAATTTTTTATTATTTGCCTATGTCTAATGGCAACTACATATTTAGGCATTGGCTGGGTTTTTATCCATTT
TAACTTTTTAGTTTTTGCGCTACTATTGAGTATGCTTGGTTTTTGCTTTGGTATGTTCACGATGATTAGTAATGCTGGGA
TATATAATTCTATACAAAATGATAATTATATGAGTGCGGCAACTGTTATTAATAGTTCAATAATCCAACTTACAAACGCA
TTTGCGATTTCTTGGGTTGGAATAGTTCTAGCAACTTTTTCAGGAATTAGTCATATTGATTTTAATTCAATAATATCACT
ATCAGCTTTTGCAGCAGTTCAATTTATATACTCTATCGGGCTTTTAATGATTTTAGTTTATGTAGTATTTTATAGACCTA
ATAATTTAAACAGCGTACCAATATCTTAG

Upstream 100 bases:

>100_bases
TACTCTTATAATTATAGCGCAATATAAACGATAATACTCTTTATATTACCTACTATATTTTGTTTATTTCAACATAACCA
TATTGGATCAAAATCAAAAC

Downstream 100 bases:

>100_bases
TTTAGCTAAAGTAAATCTTTAAGATACTTACCAGTGTATGATTTTTTACAGTTAATTATATCCTCTGGAGTTCCCTCAAA
AATTATCTGCCCTCCTTTAC

Product: major facilitator superfamily transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MDKNKIIAYTIGLVMLIELIDGSALNTALPQIANDLHVNAITLKVAITVYLLALGLFIPASGWISDKIGSKNLLLLSITG
FMFSSIACGLSTNLISLVIFRAIQGAFGAFTAPVARLAMVRIYKNDVLTAMSIVAVIAALGPMLGPLFGGAITTHIGWRM
IFFINVPIGMIAITLIYLHLPNITSLTLRKFDLKGFIIIGTSIALILFFIDLLIDTHLAHIKWLLLISAVILFGIYIRHA
QRLKDDAVINLTIFKDRCFRYFTIISSTSRLLVMGMSFIFPLYLQTKQGFSAFESGLFLMFFLIPAWFVKKFVKRVLAKL
HFYKFFIICLCLMATTYLGIGWVFIHFNFLVFALLLSMLGFCFGMFTMISNAGIYNSIQNDNYMSAATVINSSIIQLTNA
FAISWVGIVLATFSGISHIDFNSIISLSAFAAVQFIYSIGLLMILVYVVFYRPNNLNSVPIS

Sequences:

>Translated_462_residues
MDKNKIIAYTIGLVMLIELIDGSALNTALPQIANDLHVNAITLKVAITVYLLALGLFIPASGWISDKIGSKNLLLLSITG
FMFSSIACGLSTNLISLVIFRAIQGAFGAFTAPVARLAMVRIYKNDVLTAMSIVAVIAALGPMLGPLFGGAITTHIGWRM
IFFINVPIGMIAITLIYLHLPNITSLTLRKFDLKGFIIIGTSIALILFFIDLLIDTHLAHIKWLLLISAVILFGIYIRHA
QRLKDDAVINLTIFKDRCFRYFTIISSTSRLLVMGMSFIFPLYLQTKQGFSAFESGLFLMFFLIPAWFVKKFVKRVLAKL
HFYKFFIICLCLMATTYLGIGWVFIHFNFLVFALLLSMLGFCFGMFTMISNAGIYNSIQNDNYMSAATVINSSIIQLTNA
FAISWVGIVLATFSGISHIDFNSIISLSAFAAVQFIYSIGLLMILVYVVFYRPNNLNSVPIS
>Mature_462_residues
MDKNKIIAYTIGLVMLIELIDGSALNTALPQIANDLHVNAITLKVAITVYLLALGLFIPASGWISDKIGSKNLLLLSITG
FMFSSIACGLSTNLISLVIFRAIQGAFGAFTAPVARLAMVRIYKNDVLTAMSIVAVIAALGPMLGPLFGGAITTHIGWRM
IFFINVPIGMIAITLIYLHLPNITSLTLRKFDLKGFIIIGTSIALILFFIDLLIDTHLAHIKWLLLISAVILFGIYIRHA
QRLKDDAVINLTIFKDRCFRYFTIISSTSRLLVMGMSFIFPLYLQTKQGFSAFESGLFLMFFLIPAWFVKKFVKRVLAKL
HFYKFFIICLCLMATTYLGIGWVFIHFNFLVFALLLSMLGFCFGMFTMISNAGIYNSIQNDNYMSAATVINSSIIQLTNA
FAISWVGIVLATFSGISHIDFNSIISLSAFAAVQFIYSIGLLMILVYVVFYRPNNLNSVPIS

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=430, Percent_Identity=31.1627906976744, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1788392, Length=472, Percent_Identity=28.3898305084746, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1789042, Length=298, Percent_Identity=28.5234899328859, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788710, Length=292, Percent_Identity=28.0821917808219, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87081983, Length=325, Percent_Identity=26.7692307692308, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319770, Length=361, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51253; Mature: 51253

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS00962 RIBOSOMAL_S2_1 ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNKIIAYTIGLVMLIELIDGSALNTALPQIANDLHVNAITLKVAITVYLLALGLFIPA
CCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
SGWISDKIGSKNLLLLSITGFMFSSIACGLSTNLISLVIFRAIQGAFGAFTAPVARLAMV
CCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIYKNDVLTAMSIVAVIAALGPMLGPLFGGAITTHIGWRMIFFINVPIGMIAITLIYLHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHC
PNITSLTLRKFDLKGFIIIGTSIALILFFIDLLIDTHLAHIKWLLLISAVILFGIYIRHA
CCCCHHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRLKDDAVINLTIFKDRCFRYFTIISSTSRLLVMGMSFIFPLYLQTKQGFSAFESGLFLM
HHCCCCCEEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FFLIPAWFVKKFVKRVLAKLHFYKFFIICLCLMATTYLGIGWVFIHFNFLVFALLLSMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FCFGMFTMISNAGIYNSIQNDNYMSAATVINSSIIQLTNAFAISWVGIVLATFSGISHID
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FNSIISLSAFAAVQFIYSIGLLMILVYVVFYRPNNLNSVPIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MDKNKIIAYTIGLVMLIELIDGSALNTALPQIANDLHVNAITLKVAITVYLLALGLFIPA
CCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
SGWISDKIGSKNLLLLSITGFMFSSIACGLSTNLISLVIFRAIQGAFGAFTAPVARLAMV
CCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIYKNDVLTAMSIVAVIAALGPMLGPLFGGAITTHIGWRMIFFINVPIGMIAITLIYLHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHC
PNITSLTLRKFDLKGFIIIGTSIALILFFIDLLIDTHLAHIKWLLLISAVILFGIYIRHA
CCCCHHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRLKDDAVINLTIFKDRCFRYFTIISSTSRLLVMGMSFIFPLYLQTKQGFSAFESGLFLM
HHCCCCCEEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FFLIPAWFVKKFVKRVLAKLHFYKFFIICLCLMATTYLGIGWVFIHFNFLVFALLLSMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FCFGMFTMISNAGIYNSIQNDNYMSAATVINSSIIQLTNAFAISWVGIVLATFSGISHID
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FNSIISLSAFAAVQFIYSIGLLMILVYVVFYRPNNLNSVPIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]