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The map label for this gene is sufS [H]

Identifier: 134302324

GI number: 134302324

Start: 1339445

End: 1340668

Strand: Reverse

Name: sufS [H]

Synonym: FTW_1433

Alternate gene names: 134302324

Gene position: 1340668-1339445 (Counterclockwise)

Preceding gene: 134302325

Following gene: 134302323

Centisome position: 70.62

GC content: 34.56

Gene sequence:

>1224_bases
ATGTATGATGTAAATAAAATTAGGCAAGACTTTCCATTTTTAGCACAAAAAATAAATAATAAATCGGTACTTTTTTTTGA
CACTGGTGCCTCAGCACAGAAGCCCCAAGCTGTTATTGAATGTGTAGCTGAAGCATATGCTTATAATTATGCAAATGTAC
ATAGAGGTGTATATTCTCTTAGTCAAGAAGCTAGCGAGAAGTATGAAAATGTCCGTCAAATTGTGCAAAAGTTTTTAAAC
TCTAAATCAGCAGATGAAATTGTAATAACAAAAGGAACCACAGAGGCTATTAATTTAGTTGCTAGCTCTATCGGTAAGGG
GATTATTAGGTCTGATGATGAAATAGTTGTCACAGAAATGGAGCATCATGCTAATTTTGTACCATGGCAGATGCTTTGCG
AGGACAAAAACCTAGATTTTAAAGTGGCTGCGGTCAAGGACAATGGCGAGTTAGACGTTGATAATTTATTAGCTTTAGTT
ACAGCTAAGACTAAAATTTTAGCAATTACATTATGCTCTAATGTTTTAGGAACAATCAACCCTGTGAAAGAAATTATCAA
ACAAGTTAGAGAAATTAATCCAAATATAATTGTTTTGGTAGATGGTGCTCAAGCTGTTATTCATACCAAGGTTGATGTTC
AAGATTTAGATTGTGATTTTTTTGTCTTCTCTGGGCATAAGTTATATGGACCTACTGGGGTCGGCATTTTATATGGTAAA
TATGAGTTGCTAAAACAACTTCCTCCTTATAATTATGGTGGTGATATGGTTGACGAAGTAACAATAGCAAAGACTACATT
TGCGCTACCACCATATAGGTTTGAAGCTGGAACACCAAATATAGTTGAAGCTATTGGACTTGGTAGGGCTATTGAGTATG
TTGATTCAATCGGCATGATTAACATTGAAAAACATGAGCAAAAATTATTAGAATACGCGACAGCTGAGCTTAATAAAATC
GATGGTCTAACTATATTTGGTCAGGCAAAACACAAAGCTGGAGTTATAACTTTTGATATTCAAGGTTGTAATGCTGGGGA
TATTGGTGAGCTATTGGCAATTAAGGGTATATGTGTGAGAACTGGTAAGCATTGTGCTCATCCTTTGATGTATCGAATGG
GAGTTACCTCAACAGTGCGTATGTCTTTTGGGATGTATAATACTTTTGAGGAAATAGATTTGTTCATAATAGCATTGAAA
AAAGTAATATCTCAATTAAAATAA

Upstream 100 bases:

>100_bases
AATTCATAATATTGAGATATCTCAGTTTTAAGTTAGTTTGGCAAAATTATACTAATTTAGTATAATTTAGACCGTATGAG
TTCTATAGAAATTTTTTGAT

Downstream 100 bases:

>100_bases
TTTAGCAAAAAGAGGCAAGTATGGTAGAAGTTTTTGATCCAAATGCTAGTAGCATTTTAGAAGTTACAGATGCTGCAGCT
AAACATTTCAAGAAACATCT

Product: sufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MYDVNKIRQDFPFLAQKINNKSVLFFDTGASAQKPQAVIECVAEAYAYNYANVHRGVYSLSQEASEKYENVRQIVQKFLN
SKSADEIVITKGTTEAINLVASSIGKGIIRSDDEIVVTEMEHHANFVPWQMLCEDKNLDFKVAAVKDNGELDVDNLLALV
TAKTKILAITLCSNVLGTINPVKEIIKQVREINPNIIVLVDGAQAVIHTKVDVQDLDCDFFVFSGHKLYGPTGVGILYGK
YELLKQLPPYNYGGDMVDEVTIAKTTFALPPYRFEAGTPNIVEAIGLGRAIEYVDSIGMINIEKHEQKLLEYATAELNKI
DGLTIFGQAKHKAGVITFDIQGCNAGDIGELLAIKGICVRTGKHCAHPLMYRMGVTSTVRMSFGMYNTFEEIDLFIIALK
KVISQLK

Sequences:

>Translated_407_residues
MYDVNKIRQDFPFLAQKINNKSVLFFDTGASAQKPQAVIECVAEAYAYNYANVHRGVYSLSQEASEKYENVRQIVQKFLN
SKSADEIVITKGTTEAINLVASSIGKGIIRSDDEIVVTEMEHHANFVPWQMLCEDKNLDFKVAAVKDNGELDVDNLLALV
TAKTKILAITLCSNVLGTINPVKEIIKQVREINPNIIVLVDGAQAVIHTKVDVQDLDCDFFVFSGHKLYGPTGVGILYGK
YELLKQLPPYNYGGDMVDEVTIAKTTFALPPYRFEAGTPNIVEAIGLGRAIEYVDSIGMINIEKHEQKLLEYATAELNKI
DGLTIFGQAKHKAGVITFDIQGCNAGDIGELLAIKGICVRTGKHCAHPLMYRMGVTSTVRMSFGMYNTFEEIDLFIIALK
KVISQLK
>Mature_407_residues
MYDVNKIRQDFPFLAQKINNKSVLFFDTGASAQKPQAVIECVAEAYAYNYANVHRGVYSLSQEASEKYENVRQIVQKFLN
SKSADEIVITKGTTEAINLVASSIGKGIIRSDDEIVVTEMEHHANFVPWQMLCEDKNLDFKVAAVKDNGELDVDNLLALV
TAKTKILAITLCSNVLGTINPVKEIIKQVREINPNIIVLVDGAQAVIHTKVDVQDLDCDFFVFSGHKLYGPTGVGILYGK
YELLKQLPPYNYGGDMVDEVTIAKTTFALPPYRFEAGTPNIVEAIGLGRAIEYVDSIGMINIEKHEQKLLEYATAELNKI
DGLTIFGQAKHKAGVITFDIQGCNAGDIGELLAIKGICVRTGKHCAHPLMYRMGVTSTVRMSFGMYNTFEEIDLFIIALK
KVISQLK

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI156713448, Length=437, Percent_Identity=26.0869565217391, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI32307132, Length=397, Percent_Identity=23.1738035264484, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=48.3870967741936, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1789175, Length=408, Percent_Identity=37.7450980392157, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI48994898, Length=337, Percent_Identity=24.6290801186944, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=396, Percent_Identity=23.4848484848485, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=405, Percent_Identity=24.9382716049383, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17533177, Length=344, Percent_Identity=24.4186046511628, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319831, Length=396, Percent_Identity=23.4848484848485, Blast_Score=106, Evalue=6e-24,
Organism=Drosophila melanogaster, GI20129463, Length=389, Percent_Identity=24.6786632390745, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 45054; Mature: 45054

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDVNKIRQDFPFLAQKINNKSVLFFDTGASAQKPQAVIECVAEAYAYNYANVHRGVYSL
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
SQEASEKYENVRQIVQKFLNSKSADEIVITKGTTEAINLVASSIGKGIIRSDDEIVVTEM
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEE
EHHANFVPWQMLCEDKNLDFKVAAVKDNGELDVDNLLALVTAKTKILAITLCSNVLGTIN
HHCCCCCCHHHEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCHHEEEEEHHHHHHCCCH
PVKEIIKQVREINPNIIVLVDGAQAVIHTKVDVQDLDCDFFVFSGHKLYGPTGVGILYGK
HHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCEECCCCEEEEECCEEECCCCCEEEEHH
YELLKQLPPYNYGGDMVDEVTIAKTTFALPPYRFEAGTPNIVEAIGLGRAIEYVDSIGMI
HHHHHHCCCCCCCCCHHHHEEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCE
NIEKHEQKLLEYATAELNKIDGLTIFGQAKHKAGVITFDIQGCNAGDIGELLAIKGICVR
EEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHCCHHEE
TGKHCAHPLMYRMGVTSTVRMSFGMYNTFEEIDLFIIALKKVISQLK
CCCHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYDVNKIRQDFPFLAQKINNKSVLFFDTGASAQKPQAVIECVAEAYAYNYANVHRGVYSL
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
SQEASEKYENVRQIVQKFLNSKSADEIVITKGTTEAINLVASSIGKGIIRSDDEIVVTEM
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEE
EHHANFVPWQMLCEDKNLDFKVAAVKDNGELDVDNLLALVTAKTKILAITLCSNVLGTIN
HHCCCCCCHHHEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCHHEEEEEHHHHHHCCCH
PVKEIIKQVREINPNIIVLVDGAQAVIHTKVDVQDLDCDFFVFSGHKLYGPTGVGILYGK
HHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCEECCCCEEEEECCEEECCCCCEEEEHH
YELLKQLPPYNYGGDMVDEVTIAKTTFALPPYRFEAGTPNIVEAIGLGRAIEYVDSIGMI
HHHHHHCCCCCCCCCHHHHEEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCE
NIEKHEQKLLEYATAELNKIDGLTIFGQAKHKAGVITFDIQGCNAGDIGELLAIKGICVR
EEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHCCHHEE
TGKHCAHPLMYRMGVTSTVRMSFGMYNTFEEIDLFIIALKKVISQLK
CCCHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA