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The map label for this gene is purCD [H]

Identifier: 134302215

GI number: 134302215

Start: 1216722

End: 1219034

Strand: Reverse

Name: purCD [H]

Synonym: FTW_1285

Alternate gene names: 134302215

Gene position: 1219034-1216722 (Counterclockwise)

Preceding gene: 134302216

Following gene: 134302214

Centisome position: 64.21

GC content: 36.14

Gene sequence:

>2313_bases
ATGCTTGATAAACAAATCATTGCTAATAATATAAAAAATGTTCTAAAATCAACAAATCTTGATATCAAGAATAAATATAT
AGGTAAAGTAAGAGATATGTACTTTACTGATGACAAAAGTATTTTGATATCTACAGATAGACAATCTGCTTTTGATAGAT
CTTTGGGTTTTATACCATTTAAGGGGCAAATCCTTGCACAATCATCAGTATGGTGGTTCAAAGAAACAGCACATATTGTC
AAAAACCACTTTATAGACTCTCCAGATCCAAATGTTGTCATCGCGAGAAAGGCAAAAGTATTGCCAATTGAGTTTGTCGT
TAGAGGTTATATAACTGGTTCAACTTCTACATCATTGTGGACACATTATAAAAACGGTAGCCGTGACTATTGTGGCAATA
TCCTGCCAGAAGGTTTAAAAAAGAATCAAAAATTACCACAAAATATCCTTACACCAACTACCAAAGAGCAAGATCATGAT
CGCCCAATTTCAGCTGAGGATATTGTCAAGGAAGGTTGGCTAACTCAGCAGCAGTGGGATTTTGCTTCACAAAAGGCTCT
AGAACTTTTTGAGTTTGGACAAAAAAAAGCCTTAGAACATGGCTTAATTTTGGCGGATACTAAATATGAGTTTGGTATTG
ATGAGCAAACTGGAGAGATTATTTTGATCGATGAGATCCATACTCCAGATAGCTCAAGATTTTGGCTAAAAGATAGCTAT
GCTACAAGATTTGAAAATGGTGAAGAACCAGAGAATATTGATAAAGAATTTTTTAGATTATGGTTTGCAAAAAATTGTGA
CCCATATAATGATGAAGTTTTACCACAAGCACCACAAGAGTTAGTTGTCGAATTATCTCAAAAATATATAGCCCTTTTTG
AAATGATAACAGGGCAAAAGTTTGAAGTACCAAGAGATTTAGAAAATATAAATCAACGTATTGTTAAAAATGTTACAGAT
TACTTAAATATGGAGAAGCCAGTGAATATTCTTCTAGTAGGATCAGGAAGTAGAGAGCATGCGATAGCAGAAGCAGTCAA
AAGAAGCTCTATTGCAAATAAGCTTTTTTGTATAAGCACAGCGATTAACCCTGCGATAGATAAGATAACGCAAGGGTATC
AAATCGCTGATATTTGTAATTGTGATGAAGTACTAGAGTATGCAAAATCACAAAGTATTGATATTGCGATTATCGGTCCT
GAAGCACCACTTGAGGCTGGTCTAGCTGATGCACTTAAGACAGCAGCAATTGGCGTAGTTGGTCCAACCAAAAAGTTAGC
ACAGCTTGAAACATCAAAAGGTTTCACTAGAGATCTGATCCGTGATTATGATATAGGCGCTAATCCTTTCTTTAGAAAGT
TTAACTCGATGGATGGAGTCGAAGAGACTCTCAAAAAATATCAAAATCAATTTGTCATAAAAGCTGATGGTTTATGTGGT
GGTAAAGGAGTGCTTGTTTGGGGCGATCATTTGCACAGCCTTGATGAGGCGATTAGACACTGTCAGTCATTGGTAGATGC
TGGCAAAGAGTTTGTTATCGAGGAGAAGCTTGTTGGCCAGGAGTTCTCGCTGATATCATTTACTGATGGCAAAAATTTTA
TCCATATGCCAGCAGTCCAAGATCATAAGCGTGCCCATGAAGGTGACAAAGGTCCTAATACCGGTGGTATGGGTACTTAT
TCTGATGCTAATCATAGTTTACCGTTTTTATCAGCTGCTGATATCGAAAGAGCAAAACAAATAAATGAGAAAGTTGTCAG
AGCTTTAGCTGATAAATTTGGTGAACCATATCAAGGTATCCTTTATGGTGGCTTTATGGCGACAAAAGATGATACTAAAG
TGATCGAGTATAATGCACGTTTTGGTGATCCAGAAGCGATGAATCTACTTACACTGTTAGAGACAGATTTTGTTGAGATT
GCTCAAGCTATTACACAGGGTAAACTTGATACGGTCAAAGCTAAGTTTAAAAATCAAGCAAGCGTATGTAAATATCTAGT
ACCGCTTGGCTATCCAAACCAATCAGTTAAAAACTTTGAGATAGATATTTCACAATGCCCTGATAATGTCGAGCTTTTCT
TAGGTGCTGTTGATTATAAAGATGGTAAGCTAATTGGTACAGGTTCTAGAGCTATAGCTGTACTTGGTTTAGGTGATACA
ATAGCTGAAGCAGAGCAAAAAGCCGAAAATGCTGTCAAAAATATTTATGGTAAACTATTTCATCGTCCAGATATTGGTAC
TAAAGAGCTTATCAATAAGCGTATCAAACACATGAATTTGTTGCGTGGTGATAAATATCAGGAGCTTAAATAA

Upstream 100 bases:

>100_bases
ATCAATTTGACAAGATGCAAGAATTAGCTAAAAAACATACTAATACAAAACTATATCAAATTGGTAAAATCACAAATTCA
GGAAAGGTAGAAATTATCTA

Downstream 100 bases:

>100_bases
ATAATGTCTAAGCTAAATCTTGTTATATTAGGCTCTACGCGTGGGACTAATATGCAAGCTATAATAGATGCAATAGCAAA
TAAGCAGCTAAATGCTCAGG

Product: fusion protein PurC/PurD

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 770; Mature: 770

Protein sequence:

>770_residues
MLDKQIIANNIKNVLKSTNLDIKNKYIGKVRDMYFTDDKSILISTDRQSAFDRSLGFIPFKGQILAQSSVWWFKETAHIV
KNHFIDSPDPNVVIARKAKVLPIEFVVRGYITGSTSTSLWTHYKNGSRDYCGNILPEGLKKNQKLPQNILTPTTKEQDHD
RPISAEDIVKEGWLTQQQWDFASQKALELFEFGQKKALEHGLILADTKYEFGIDEQTGEIILIDEIHTPDSSRFWLKDSY
ATRFENGEEPENIDKEFFRLWFAKNCDPYNDEVLPQAPQELVVELSQKYIALFEMITGQKFEVPRDLENINQRIVKNVTD
YLNMEKPVNILLVGSGSREHAIAEAVKRSSIANKLFCISTAINPAIDKITQGYQIADICNCDEVLEYAKSQSIDIAIIGP
EAPLEAGLADALKTAAIGVVGPTKKLAQLETSKGFTRDLIRDYDIGANPFFRKFNSMDGVEETLKKYQNQFVIKADGLCG
GKGVLVWGDHLHSLDEAIRHCQSLVDAGKEFVIEEKLVGQEFSLISFTDGKNFIHMPAVQDHKRAHEGDKGPNTGGMGTY
SDANHSLPFLSAADIERAKQINEKVVRALADKFGEPYQGILYGGFMATKDDTKVIEYNARFGDPEAMNLLTLLETDFVEI
AQAITQGKLDTVKAKFKNQASVCKYLVPLGYPNQSVKNFEIDISQCPDNVELFLGAVDYKDGKLIGTGSRAIAVLGLGDT
IAEAEQKAENAVKNIYGKLFHRPDIGTKELINKRIKHMNLLRGDKYQELK

Sequences:

>Translated_770_residues
MLDKQIIANNIKNVLKSTNLDIKNKYIGKVRDMYFTDDKSILISTDRQSAFDRSLGFIPFKGQILAQSSVWWFKETAHIV
KNHFIDSPDPNVVIARKAKVLPIEFVVRGYITGSTSTSLWTHYKNGSRDYCGNILPEGLKKNQKLPQNILTPTTKEQDHD
RPISAEDIVKEGWLTQQQWDFASQKALELFEFGQKKALEHGLILADTKYEFGIDEQTGEIILIDEIHTPDSSRFWLKDSY
ATRFENGEEPENIDKEFFRLWFAKNCDPYNDEVLPQAPQELVVELSQKYIALFEMITGQKFEVPRDLENINQRIVKNVTD
YLNMEKPVNILLVGSGSREHAIAEAVKRSSIANKLFCISTAINPAIDKITQGYQIADICNCDEVLEYAKSQSIDIAIIGP
EAPLEAGLADALKTAAIGVVGPTKKLAQLETSKGFTRDLIRDYDIGANPFFRKFNSMDGVEETLKKYQNQFVIKADGLCG
GKGVLVWGDHLHSLDEAIRHCQSLVDAGKEFVIEEKLVGQEFSLISFTDGKNFIHMPAVQDHKRAHEGDKGPNTGGMGTY
SDANHSLPFLSAADIERAKQINEKVVRALADKFGEPYQGILYGGFMATKDDTKVIEYNARFGDPEAMNLLTLLETDFVEI
AQAITQGKLDTVKAKFKNQASVCKYLVPLGYPNQSVKNFEIDISQCPDNVELFLGAVDYKDGKLIGTGSRAIAVLGLGDT
IAEAEQKAENAVKNIYGKLFHRPDIGTKELINKRIKHMNLLRGDKYQELK
>Mature_770_residues
MLDKQIIANNIKNVLKSTNLDIKNKYIGKVRDMYFTDDKSILISTDRQSAFDRSLGFIPFKGQILAQSSVWWFKETAHIV
KNHFIDSPDPNVVIARKAKVLPIEFVVRGYITGSTSTSLWTHYKNGSRDYCGNILPEGLKKNQKLPQNILTPTTKEQDHD
RPISAEDIVKEGWLTQQQWDFASQKALELFEFGQKKALEHGLILADTKYEFGIDEQTGEIILIDEIHTPDSSRFWLKDSY
ATRFENGEEPENIDKEFFRLWFAKNCDPYNDEVLPQAPQELVVELSQKYIALFEMITGQKFEVPRDLENINQRIVKNVTD
YLNMEKPVNILLVGSGSREHAIAEAVKRSSIANKLFCISTAINPAIDKITQGYQIADICNCDEVLEYAKSQSIDIAIIGP
EAPLEAGLADALKTAAIGVVGPTKKLAQLETSKGFTRDLIRDYDIGANPFFRKFNSMDGVEETLKKYQNQFVIKADGLCG
GKGVLVWGDHLHSLDEAIRHCQSLVDAGKEFVIEEKLVGQEFSLISFTDGKNFIHMPAVQDHKRAHEGDKGPNTGGMGTY
SDANHSLPFLSAADIERAKQINEKVVRALADKFGEPYQGILYGGFMATKDDTKVIEYNARFGDPEAMNLLTLLETDFVEI
AQAITQGKLDTVKAKFKNQASVCKYLVPLGYPNQSVKNFEIDISQCPDNVELFLGAVDYKDGKLIGTGSRAIAVLGLGDT
IAEAEQKAENAVKNIYGKLFHRPDIGTKELINKRIKHMNLLRGDKYQELK

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=436, Percent_Identity=32.7981651376147, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI209869995, Length=436, Percent_Identity=32.7981651376147, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI209869993, Length=436, Percent_Identity=32.7981651376147, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI28416899, Length=438, Percent_Identity=32.8767123287671, Blast_Score=214, Evalue=2e-55,
Organism=Escherichia coli, GI1790438, Length=438, Percent_Identity=33.1050228310502, Blast_Score=221, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17567511, Length=432, Percent_Identity=35.1851851851852, Blast_Score=206, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6321203, Length=467, Percent_Identity=28.9079229122056, Blast_Score=200, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6319326, Length=304, Percent_Identity=37.828947368421, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24582400, Length=427, Percent_Identity=31.8501170960187, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI62471619, Length=427, Percent_Identity=31.8501170960187, Blast_Score=185, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 86383; Mature: 86383

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50975 ATP_GRASP ; PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2 ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKQIIANNIKNVLKSTNLDIKNKYIGKVRDMYFTDDKSILISTDRQSAFDRSLGFIPF
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEECCCEEEEECCCHHHHHHCCCCCCC
KGQILAQSSVWWFKETAHIVKNHFIDSPDPNVVIARKAKVLPIEFVVRGYITGSTSTSLW
CCEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCEECCHHHEEEEEEECCCCCCCE
THYKNGSRDYCGNILPEGLKKNQKLPQNILTPTTKEQDHDRPISAEDIVKEGWLTQQQWD
EECCCCCHHHHCCCCCHHHHHCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHC
FASQKALELFEFGQKKALEHGLILADTKYEFGIDEQTGEIILIDEIHTPDSSRFWLKDSY
HHHHHHHHHHHHHHHHHHHCCEEEEECCEECCCCCCCCCEEEEEECCCCCCCCEEEECCH
ATRFENGEEPENIDKEFFRLWFAKNCDPYNDEVLPQAPQELVVELSQKYIALFEMITGQK
HHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
FEVPRDLENINQRIVKNVTDYLNMEKPVNILLVGSGSREHAIAEAVKRSSIANKLFCIST
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEH
AINPAIDKITQGYQIADICNCDEVLEYAKSQSIDIAIIGPEAPLEAGLADALKTAAIGVV
HCCHHHHHHHCCCEEHHHCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHEECC
GPTKKLAQLETSKGFTRDLIRDYDIGANPFFRKFNSMDGVEETLKKYQNQFVIKADGLCG
CCHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHCCEEEEECCCCC
GKGVLVWGDHLHSLDEAIRHCQSLVDAGKEFVIEEKLVGQEFSLISFTDGKNFIHMPAVQ
CCEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCEEECCCCH
DHKRAHEGDKGPNTGGMGTYSDANHSLPFLSAADIERAKQINEKVVRALADKFGEPYQGI
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
LYGGFMATKDDTKVIEYNARFGDPEAMNLLTLLETDFVEIAQAITQGKLDTVKAKFKNQA
EEECEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHH
SVCKYLVPLGYPNQSVKNFEIDISQCPDNVELFLGAVDYKDGKLIGTGSRAIAVLGLGDT
HHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEEEEECCCCEEEECCCCEEEEEECCHH
IAEAEQKAENAVKNIYGKLFHRPDIGTKELINKRIKHMNLLRGDKYQELK
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLDKQIIANNIKNVLKSTNLDIKNKYIGKVRDMYFTDDKSILISTDRQSAFDRSLGFIPF
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEECCCEEEEECCCHHHHHHCCCCCCC
KGQILAQSSVWWFKETAHIVKNHFIDSPDPNVVIARKAKVLPIEFVVRGYITGSTSTSLW
CCEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCEECCHHHEEEEEEECCCCCCCE
THYKNGSRDYCGNILPEGLKKNQKLPQNILTPTTKEQDHDRPISAEDIVKEGWLTQQQWD
EECCCCCHHHHCCCCCHHHHHCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHC
FASQKALELFEFGQKKALEHGLILADTKYEFGIDEQTGEIILIDEIHTPDSSRFWLKDSY
HHHHHHHHHHHHHHHHHHHCCEEEEECCEECCCCCCCCCEEEEEECCCCCCCCEEEECCH
ATRFENGEEPENIDKEFFRLWFAKNCDPYNDEVLPQAPQELVVELSQKYIALFEMITGQK
HHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
FEVPRDLENINQRIVKNVTDYLNMEKPVNILLVGSGSREHAIAEAVKRSSIANKLFCIST
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEH
AINPAIDKITQGYQIADICNCDEVLEYAKSQSIDIAIIGPEAPLEAGLADALKTAAIGVV
HCCHHHHHHHCCCEEHHHCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHEECC
GPTKKLAQLETSKGFTRDLIRDYDIGANPFFRKFNSMDGVEETLKKYQNQFVIKADGLCG
CCHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHCCEEEEECCCCC
GKGVLVWGDHLHSLDEAIRHCQSLVDAGKEFVIEEKLVGQEFSLISFTDGKNFIHMPAVQ
CCEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCEEECCCCH
DHKRAHEGDKGPNTGGMGTYSDANHSLPFLSAADIERAKQINEKVVRALADKFGEPYQGI
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
LYGGFMATKDDTKVIEYNARFGDPEAMNLLTLLETDFVEIAQAITQGKLDTVKAKFKNQA
EEECEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHH
SVCKYLVPLGYPNQSVKNFEIDISQCPDNVELFLGAVDYKDGKLIGTGSRAIAVLGLGDT
HHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEEEEECCCCEEEECCCCEEEEEECCHH
IAEAEQKAENAVKNIYGKLFHRPDIGTKELINKRIKHMNLLRGDKYQELK
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA