Click here to switch to the map view.

The map label for this gene is malS [H]

Identifier: 134302192

GI number: 134302192

Start: 1193904

End: 1195718

Strand: Reverse

Name: malS [H]

Synonym: FTW_1262

Alternate gene names: 134302192

Gene position: 1195718-1193904 (Counterclockwise)

Preceding gene: 134302196

Following gene: 134302191

Centisome position: 62.98

GC content: 35.54

Gene sequence:

>1815_bases
ATGGAAAGACGTGAAAAAAGAATAAGAAAATTAAGAAATAAAAGCGGTAAAGTTTTTGCAATAGAAACTAACCTTACAGG
TAGACAACTATTAAACAATAGGGTTTTGAATAAGGATGTTGCTTTTAGCCAAGAAGAAAGAGTTGCTTTTGATCTTATCG
GCTACCTACCAGAAAAAGTTGAAAGTCTCGAAGAGCAAGCTATCAGAGTAAGAAGACAGCTTGATTTGAAACCTAATTCT
CTTGAAAAATATGTATTTTTAAATAGGCTTCATGACTTAAACACTACGCTATTTTATCACTTTGTGCGTGAGAATTTAGA
AGAAATAATGCCAATTATATATACACCAACTGTGGGCGAAGCTGTCCAAAAATATAGTAGCTCATTTAGAAAGCAAAGTG
GTTTATTTATCTCTATAAGTCATAAAAAGCATATTGCTAGAATACTAGAGCGATATGAGTATAACAGTATTGACTTAGTG
CTTGTTACCGATGGTGAAGCAGTGCTTGGAATTGGTGACCAAGGGATTGGTGGTATGAATATCAGTATCGGTAAGATTAT
GGTTTATGTTGCTGCAAGTGGTATAGATCCAGCTAGAGTTTTGCCGGTACAGCTTGATATGGGTACAAATAATGATGCTT
TACTTAATGCTCCTGGTTATCTAGGTGTACGCTTGCCAAGAGTCTCTGGTGAAACCTATGATGAGTTTATTGAAGAATTT
GTTACCCAGGTTAAAGCTAGATTTCCAAATGTGTTTTTGCATTGGGAAGATTTAGGTCGTGATAATGCGACACGTATTTT
AGAAAAATACAAAGATAAGTTATGTACATTTAATGATGATATTGAGGGTACGGGCATTGTTGCAACAGCTAACTGTATAG
CTGGTGTGAAAACGGCAAGCACTATAAGAATAAACGCTGGTGAGATAACTGTTGAAGAGGCATTAAGTGGTATATGTGAT
ATCAAAGTAGTTATTTTTGGTGCTGGTAGTGCTGGTTGCGGTATCGCTAGACAGCTTGCTGATGTGATCGCTGATCGAGC
GGGGGTATCTATTGAGAAAGCCAGAAGTAGTATCTATCTAGTAGACAGATATGGTTTAGTTTGTGATAGATTAAGAGCAA
AAAGAATTACACCAGAGCAGAAATTATTTGTCAAAACTAGTGAAGAGATTGATAAATGGAAGGTTGAGGATTTTAACTAT
ATTACACTTGAAGAAACAGTTAAAAATACAAAATGTGATATTTTAATTGGGACATCTGGTCAACCAGGATCATTTACTAA
AGAAATTATAAAAACTATGGCAAAAAATAATAACTATCCTATTATTATGCCACTATCTAATCCTACATCTCTTTGTGAAG
CATTACCTGAAGACATTATTAAGTGGACAAATGGTAAGGCTCTAATTGCTGCAGGTAGTCCATTTCCAGATGTGACATAT
AATGGTCGTGATTACCGTATTTCTCAGGGGAATAACGCCTTTATATTCCCAGGTTTAGGTTTAGGCTCAGTAGCTGTGCA
TGCACGAGTTCTTACAAAAGGGATGATTAGAGCTGCTTGTTATAGATTAAGTGAGTTATCACCGATGGTAATAAATGAGG
ATATTACTCAGCCATTGTTAGCTAGGATAACAGATTTAGTTGATGTTACAAAAGAAATTACTAAAGCAGTAGCTAAACAA
GCAATTCTAGAGGGTGTTCATGGTGTTGATATAGATCTAGAAGATTTAACAGAAACTGAGCTTGATGAAGAGATTGAGAG
ACTAATTAACCTATCATCATGGACACCGACGTATGCACCATATATGCCAATTTAA

Upstream 100 bases:

>100_bases
GTATTCATTTTTTGTTGAAAAAAAGCAACTACTGATAGATACTTATTTGTTAGATGTTTTTGTTATCGTGTAATGTAAAA
TTTTATAAGTGGTTTGAGTC

Downstream 100 bases:

>100_bases
GTTGTTTTGTATTTTTGTTTCGGAAATAACTTTATATTAATTTTATAAGCGTTTTTATCTTTTCTTAAGGTATGAAATTT
ATTGAAACTAAGCGCGACTT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 3 [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MERREKRIRKLRNKSGKVFAIETNLTGRQLLNNRVLNKDVAFSQEERVAFDLIGYLPEKVESLEEQAIRVRRQLDLKPNS
LEKYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGEAVQKYSSSFRKQSGLFISISHKKHIARILERYEYNSIDLV
LVTDGEAVLGIGDQGIGGMNISIGKIMVYVAASGIDPARVLPVQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEF
VTQVKARFPNVFLHWEDLGRDNATRILEKYKDKLCTFNDDIEGTGIVATANCIAGVKTASTIRINAGEITVEEALSGICD
IKVVIFGAGSAGCGIARQLADVIADRAGVSIEKARSSIYLVDRYGLVCDRLRAKRITPEQKLFVKTSEEIDKWKVEDFNY
ITLEETVKNTKCDILIGTSGQPGSFTKEIIKTMAKNNNYPIIMPLSNPTSLCEALPEDIIKWTNGKALIAAGSPFPDVTY
NGRDYRISQGNNAFIFPGLGLGSVAVHARVLTKGMIRAACYRLSELSPMVINEDITQPLLARITDLVDVTKEITKAVAKQ
AILEGVHGVDIDLEDLTETELDEEIERLINLSSWTPTYAPYMPI

Sequences:

>Translated_604_residues
MERREKRIRKLRNKSGKVFAIETNLTGRQLLNNRVLNKDVAFSQEERVAFDLIGYLPEKVESLEEQAIRVRRQLDLKPNS
LEKYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGEAVQKYSSSFRKQSGLFISISHKKHIARILERYEYNSIDLV
LVTDGEAVLGIGDQGIGGMNISIGKIMVYVAASGIDPARVLPVQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEF
VTQVKARFPNVFLHWEDLGRDNATRILEKYKDKLCTFNDDIEGTGIVATANCIAGVKTASTIRINAGEITVEEALSGICD
IKVVIFGAGSAGCGIARQLADVIADRAGVSIEKARSSIYLVDRYGLVCDRLRAKRITPEQKLFVKTSEEIDKWKVEDFNY
ITLEETVKNTKCDILIGTSGQPGSFTKEIIKTMAKNNNYPIIMPLSNPTSLCEALPEDIIKWTNGKALIAAGSPFPDVTY
NGRDYRISQGNNAFIFPGLGLGSVAVHARVLTKGMIRAACYRLSELSPMVINEDITQPLLARITDLVDVTKEITKAVAKQ
AILEGVHGVDIDLEDLTETELDEEIERLINLSSWTPTYAPYMPI
>Mature_604_residues
MERREKRIRKLRNKSGKVFAIETNLTGRQLLNNRVLNKDVAFSQEERVAFDLIGYLPEKVESLEEQAIRVRRQLDLKPNS
LEKYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGEAVQKYSSSFRKQSGLFISISHKKHIARILERYEYNSIDLV
LVTDGEAVLGIGDQGIGGMNISIGKIMVYVAASGIDPARVLPVQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEF
VTQVKARFPNVFLHWEDLGRDNATRILEKYKDKLCTFNDDIEGTGIVATANCIAGVKTASTIRINAGEITVEEALSGICD
IKVVIFGAGSAGCGIARQLADVIADRAGVSIEKARSSIYLVDRYGLVCDRLRAKRITPEQKLFVKTSEEIDKWKVEDFNY
ITLEETVKNTKCDILIGTSGQPGSFTKEIIKTMAKNNNYPIIMPLSNPTSLCEALPEDIIKWTNGKALIAAGSPFPDVTY
NGRDYRISQGNNAFIFPGLGLGSVAVHARVLTKGMIRAACYRLSELSPMVINEDITQPLLARITDLVDVTKEITKAVAKQ
AILEGVHGVDIDLEDLTETELDEEIERLINLSSWTPTYAPYMPI

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=546, Percent_Identity=38.4615384615385, Blast_Score=345, Evalue=7e-95,
Organism=Homo sapiens, GI62420882, Length=539, Percent_Identity=35.8070500927644, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI62420880, Length=539, Percent_Identity=35.8070500927644, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI239049447, Length=539, Percent_Identity=35.8070500927644, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI4505145, Length=536, Percent_Identity=36.5671641791045, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI270265879, Length=474, Percent_Identity=39.0295358649789, Blast_Score=322, Evalue=7e-88,
Organism=Escherichia coli, GI87081919, Length=553, Percent_Identity=43.7613019891501, Blast_Score=441, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17537199, Length=570, Percent_Identity=36.6666666666667, Blast_Score=314, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6322823, Length=594, Percent_Identity=40.2356902356902, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24646388, Length=549, Percent_Identity=36.6120218579235, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24646386, Length=549, Percent_Identity=36.6120218579235, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI78707232, Length=545, Percent_Identity=35.4128440366973, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI281363505, Length=558, Percent_Identity=34.9462365591398, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI78707236, Length=558, Percent_Identity=34.9462365591398, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI281362674, Length=535, Percent_Identity=36.8224299065421, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI281362672, Length=534, Percent_Identity=37.0786516853933, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI21356279, Length=535, Percent_Identity=36.8224299065421, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI281363503, Length=547, Percent_Identity=35.1005484460695, Blast_Score=333, Evalue=3e-91,
Organism=Drosophila melanogaster, GI78707242, Length=570, Percent_Identity=33.5087719298246, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI78707238, Length=570, Percent_Identity=33.5087719298246, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI78707240, Length=536, Percent_Identity=34.1417910447761, Blast_Score=281, Evalue=6e-76,
Organism=Drosophila melanogaster, GI19922384, Length=491, Percent_Identity=28.3095723014257, Blast_Score=208, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 67377; Mature: 67377

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERREKRIRKLRNKSGKVFAIETNLTGRQLLNNRVLNKDVAFSQEERVAFDLIGYLPEKV
CCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCHHCCCCCCCCCHHHHHHHHHHHCHHHH
ESLEEQAIRVRRQLDLKPNSLEKYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHH
AVQKYSSSFRKQSGLFISISHKKHIARILERYEYNSIDLVLVTDGEAVLGIGDQGIGGMN
HHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCE
ISIGKIMVYVAASGIDPARVLPVQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEF
EEHHHEEEEEEECCCCCCEEEEEEEECCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHH
VTQVKARFPNVFLHWEDLGRDNATRILEKYKDKLCTFNDDIEGTGIVATANCIAGVKTAS
HHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHCCCCCC
TIRINAGEITVEEALSGICDIKVVIFGAGSAGCGIARQLADVIADRAGVSIEKARSSIYL
EEEEECCCEEHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCCEEE
VDRYGLVCDRLRAKRITPEQKLFVKTSEEIDKWKVEDFNYITLEETVKNTKCDILIGTSG
EEHHHHHHHHHHHHCCCCCHHEEEECCHHHCCEECCCCCEEEHHHHCCCCEEEEEEECCC
QPGSFTKEIIKTMAKNNNYPIIMPLSNPTSLCEALPEDIIKWTNGKALIAAGSPFPDVTY
CCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
NGRDYRISQGNNAFIFPGLGLGSVAVHARVLTKGMIRAACYRLSELSPMVINEDITQPLL
CCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHH
ARITDLVDVTKEITKAVAKQAILEGVHGVDIDLEDLTETELDEEIERLINLSSWTPTYAP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
YMPI
CCCC
>Mature Secondary Structure
MERREKRIRKLRNKSGKVFAIETNLTGRQLLNNRVLNKDVAFSQEERVAFDLIGYLPEKV
CCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCHHCCCCCCCCCHHHHHHHHHHHCHHHH
ESLEEQAIRVRRQLDLKPNSLEKYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHH
AVQKYSSSFRKQSGLFISISHKKHIARILERYEYNSIDLVLVTDGEAVLGIGDQGIGGMN
HHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCE
ISIGKIMVYVAASGIDPARVLPVQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEF
EEHHHEEEEEEECCCCCCEEEEEEEECCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHH
VTQVKARFPNVFLHWEDLGRDNATRILEKYKDKLCTFNDDIEGTGIVATANCIAGVKTAS
HHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHCCCCCC
TIRINAGEITVEEALSGICDIKVVIFGAGSAGCGIARQLADVIADRAGVSIEKARSSIYL
EEEEECCCEEHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCCEEE
VDRYGLVCDRLRAKRITPEQKLFVKTSEEIDKWKVEDFNYITLEETVKNTKCDILIGTSG
EEHHHHHHHHHHHHCCCCCHHEEEECCHHHCCEECCCCCEEEHHHHCCCCEEEEEEECCC
QPGSFTKEIIKTMAKNNNYPIIMPLSNPTSLCEALPEDIIKWTNGKALIAAGSPFPDVTY
CCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
NGRDYRISQGNNAFIFPGLGLGSVAVHARVLTKGMIRAACYRLSELSPMVINEDITQPLL
CCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHH
ARITDLVDVTKEITKAVAKQAILEGVHGVDIDLEDLTETELDEEIERLINLSSWTPTYAP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
YMPI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]