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The map label for this gene is ggt [H]

Identifier: 134302163

GI number: 134302163

Start: 1158038

End: 1159843

Strand: Reverse

Name: ggt [H]

Synonym: FTW_1228

Alternate gene names: 134302163

Gene position: 1159843-1158038 (Counterclockwise)

Preceding gene: 134302164

Following gene: 134302161

Centisome position: 61.09

GC content: 35.22

Gene sequence:

>1806_bases
ATGCGTCGTTTTTTGTTATCTTATACTTATTCTGTTTTTAAAAATACACTGAGGTTATTAGTGAAAAAATTATTTGTAAA
CTTAATGTCATTGTTAATACTGCTACCAAGTTTAACTCTAATTGCTGCACCAGTCCCGACAGGTTATGGTTTTATTCCTA
TCCAAGAAGAGATGCAAATTGCTCAACCTGTTACTGCAACACATGGTATGGTTTCTTCTCAAGAAGCTCTGGCAAGTAAA
GTAGGCTTAGATATCCTAAAGCAAGGTGGTAATGCTGTAGATGCAGCTGTAGCTGTTGGTTTTGCTTTAGCTGTCACGCT
ACCAAGAGCTGGTAATCTCGCTGGTGGTGGATTTATGATTATACATCTACAAGATGGCAATAAGAATATAGCTATAAACT
ATCGTGAAAAAGCTCCAGCAAAAGCATCTCGTGATATGTTTCTAAATGATAAAGGTGATATTGATTATGCTAAAGTTTCT
GGTTCATATAGCGCATCTGGTGTTCCTGGTACTGTTGCAGGCTTAATCGATGCACAACAAAAATATGGCAAATTAAAACT
ATCACAAGTTATTGAACCTGCTATCAAACTTGCTGAAGATGGTATTCCTGTAAGCTATGATCTTCACCAGTCACTTGTAA
CTGCAAAACCGTGGCTACAAAAATCTCCAGATGCGATGAAAATCTTTTATAAAAAAGATGGATCAGCCTATGAGGTAGGA
GAAATCCTAAAACAGCCTGAACTTGCTAATAGTTTAAAGCTAATTGCAAAACAAGGCAAAAAAGCTTTCTATGAAGGAGA
AATAGCTCATAAGATAGCCGATAGTATGGCTAAAAATGGTGGTTTAATAACATTGCAAGATTTGAAAAATTATAATATTG
AGGAGATGAAGCCAGTTAAGGGAACTTATAGAGGTTATACTATATATTCTATGCTGCCGCCAAGTTCTGGTGGTGTGATT
CTAATAGAATTATTAAATATTCTGGAGAATTTTCCATTGTCTGACTATGGTAACAATAGTGCTAAGACTATTAATCTTAT
GAGTAATGCGATGAGCTATGCTTATAATGATAGGAATTCTGACTTAGGAGATCCAGATTTTGTCAAAATGGATTTAGCTA
AGTTTTTATCTAAGAAGTATGCAAAACAGATTGCTCAAAAGATAACTACAGATAAGCATATCCCTAGTAAAGATATTAGT
ACTATAGATCCGGATGATCATGAAAAATTACAAACTACACATTTTAGTATTATTGATAAAGATGGTAATATGGTATCAAA
TACTTATACCTTAAATTATTCTTATGGAAGTGGTATTGTAGTACCAGGAACGGGAATTTTTTTAAATAACGAAATGGATG
ATTTCGCTGCTAAAGTTGGCGAGGCAAATGTCTTTGGTTTGGTTCAAGGTGAAGCAAATACTGTCGCACCGAATAAACGA
CCATTAAGTTCAATGACTCCAACGATAGTATTAGATAAGGATGGTAAACCATTTTTAGCTACAGGTTCTCCTGGAGGAAG
TCGTATTATTACAACAACGTTACAAGTGATTCTAAATATCATTGATTTTAATATGAATCTTCAAGCAGCAGTTAATAATC
CTCGTATACATAGTCAATTATGGCCAGAAGAGATTGGTGTAGAGCAGGGTATATCTGTAGATACAATTAATCTACTTAAG
AAGATGGGTAACACTGTCACACCTTATGCTGCTATGGGAGCTGCTGAATCTGTAATGTCAGATGGACAATATGTCTATGG
AGCTGCAGATCCACGCAGAGCTAGCGCATTAGCTATAGGTTATTAA

Upstream 100 bases:

>100_bases
GCTTAAAAGCAGTCTTTCAAGTGTAAACCAGGTTGCTGAAGTTTAATTAAATCTTATGATGTAATTTTTAAATATTTTTT
GGTTTATTTTTGTTTCTTTA

Downstream 100 bases:

>100_bases
ACACTTTAATAGATTTTATTTGTTGATATAACATTTAAATATAATTGGCCAAACGACAGTATATACTTTTTTACTGTCTC
CCCATGATTCTCTGAATTTA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MRRFLLSYTYSVFKNTLRLLVKKLFVNLMSLLILLPSLTLIAAPVPTGYGFIPIQEEMQIAQPVTATHGMVSSQEALASK
VGLDILKQGGNAVDAAVAVGFALAVTLPRAGNLAGGGFMIIHLQDGNKNIAINYREKAPAKASRDMFLNDKGDIDYAKVS
GSYSASGVPGTVAGLIDAQQKYGKLKLSQVIEPAIKLAEDGIPVSYDLHQSLVTAKPWLQKSPDAMKIFYKKDGSAYEVG
EILKQPELANSLKLIAKQGKKAFYEGEIAHKIADSMAKNGGLITLQDLKNYNIEEMKPVKGTYRGYTIYSMLPPSSGGVI
LIELLNILENFPLSDYGNNSAKTINLMSNAMSYAYNDRNSDLGDPDFVKMDLAKFLSKKYAKQIAQKITTDKHIPSKDIS
TIDPDDHEKLQTTHFSIIDKDGNMVSNTYTLNYSYGSGIVVPGTGIFLNNEMDDFAAKVGEANVFGLVQGEANTVAPNKR
PLSSMTPTIVLDKDGKPFLATGSPGGSRIITTTLQVILNIIDFNMNLQAAVNNPRIHSQLWPEEIGVEQGISVDTINLLK
KMGNTVTPYAAMGAAESVMSDGQYVYGAADPRRASALAIGY

Sequences:

>Translated_601_residues
MRRFLLSYTYSVFKNTLRLLVKKLFVNLMSLLILLPSLTLIAAPVPTGYGFIPIQEEMQIAQPVTATHGMVSSQEALASK
VGLDILKQGGNAVDAAVAVGFALAVTLPRAGNLAGGGFMIIHLQDGNKNIAINYREKAPAKASRDMFLNDKGDIDYAKVS
GSYSASGVPGTVAGLIDAQQKYGKLKLSQVIEPAIKLAEDGIPVSYDLHQSLVTAKPWLQKSPDAMKIFYKKDGSAYEVG
EILKQPELANSLKLIAKQGKKAFYEGEIAHKIADSMAKNGGLITLQDLKNYNIEEMKPVKGTYRGYTIYSMLPPSSGGVI
LIELLNILENFPLSDYGNNSAKTINLMSNAMSYAYNDRNSDLGDPDFVKMDLAKFLSKKYAKQIAQKITTDKHIPSKDIS
TIDPDDHEKLQTTHFSIIDKDGNMVSNTYTLNYSYGSGIVVPGTGIFLNNEMDDFAAKVGEANVFGLVQGEANTVAPNKR
PLSSMTPTIVLDKDGKPFLATGSPGGSRIITTTLQVILNIIDFNMNLQAAVNNPRIHSQLWPEEIGVEQGISVDTINLLK
KMGNTVTPYAAMGAAESVMSDGQYVYGAADPRRASALAIGY
>Mature_601_residues
MRRFLLSYTYSVFKNTLRLLVKKLFVNLMSLLILLPSLTLIAAPVPTGYGFIPIQEEMQIAQPVTATHGMVSSQEALASK
VGLDILKQGGNAVDAAVAVGFALAVTLPRAGNLAGGGFMIIHLQDGNKNIAINYREKAPAKASRDMFLNDKGDIDYAKVS
GSYSASGVPGTVAGLIDAQQKYGKLKLSQVIEPAIKLAEDGIPVSYDLHQSLVTAKPWLQKSPDAMKIFYKKDGSAYEVG
EILKQPELANSLKLIAKQGKKAFYEGEIAHKIADSMAKNGGLITLQDLKNYNIEEMKPVKGTYRGYTIYSMLPPSSGGVI
LIELLNILENFPLSDYGNNSAKTINLMSNAMSYAYNDRNSDLGDPDFVKMDLAKFLSKKYAKQIAQKITTDKHIPSKDIS
TIDPDDHEKLQTTHFSIIDKDGNMVSNTYTLNYSYGSGIVVPGTGIFLNNEMDDFAAKVGEANVFGLVQGEANTVAPNKR
PLSSMTPTIVLDKDGKPFLATGSPGGSRIITTTLQVILNIIDFNMNLQAAVNNPRIHSQLWPEEIGVEQGISVDTINLLK
KMGNTVTPYAAMGAAESVMSDGQYVYGAADPRRASALAIGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=498, Percent_Identity=32.7309236947791, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI73915090, Length=498, Percent_Identity=32.7309236947791, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI73915096, Length=498, Percent_Identity=32.7309236947791, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI73915094, Length=498, Percent_Identity=32.7309236947791, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI113429324, Length=484, Percent_Identity=30.7851239669421, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI113429326, Length=488, Percent_Identity=30.1229508196721, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI109148539, Length=550, Percent_Identity=30, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI153266885, Length=548, Percent_Identity=28.2846715328467, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI153266901, Length=549, Percent_Identity=28.2331511839709, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI153266907, Length=549, Percent_Identity=27.1402550091075, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI30581157, Length=186, Percent_Identity=36.0215053763441, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI30581155, Length=186, Percent_Identity=36.0215053763441, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI218505805, Length=177, Percent_Identity=35.0282485875706, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI310124095, Length=179, Percent_Identity=32.4022346368715, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1789856, Length=547, Percent_Identity=52.4680073126143, Blast_Score=543, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI212646519, Length=545, Percent_Identity=33.394495412844, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI72000294, Length=545, Percent_Identity=33.394495412844, Blast_Score=261, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17542894, Length=603, Percent_Identity=31.8407960199005, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17506189, Length=555, Percent_Identity=32.0720720720721, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI193208247, Length=562, Percent_Identity=31.3167259786477, Blast_Score=219, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI193208245, Length=562, Percent_Identity=31.3167259786477, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17564448, Length=435, Percent_Identity=27.1264367816092, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI72001497, Length=226, Percent_Identity=28.3185840707965, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI72001495, Length=226, Percent_Identity=28.3185840707965, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323330, Length=574, Percent_Identity=30.4878048780488, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI18859893, Length=511, Percent_Identity=32.6810176125245, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI161077496, Length=505, Percent_Identity=31.4851485148515, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI161077878, Length=542, Percent_Identity=30.4428044280443, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI161077880, Length=542, Percent_Identity=30.4428044280443, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24642670, Length=542, Percent_Identity=30.4428044280443, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24642666, Length=542, Percent_Identity=30.4428044280443, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI45551474, Length=542, Percent_Identity=30.4428044280443, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI18859741, Length=520, Percent_Identity=26.7307692307692, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 65058; Mature: 65058

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRFLLSYTYSVFKNTLRLLVKKLFVNLMSLLILLPSLTLIAAPVPTGYGFIPIQEEMQI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECCCCCCCEEECHHHHHH
AQPVTATHGMVSSQEALASKVGLDILKQGGNAVDAAVAVGFALAVTLPRAGNLAGGGFMI
HCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCCEEE
IHLQDGNKNIAINYREKAPAKASRDMFLNDKGDIDYAKVSGSYSASGVPGTVAGLIDAQQ
EEEECCCCEEEEEECCCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
KYGKLKLSQVIEPAIKLAEDGIPVSYDLHQSLVTAKPWLQKSPDAMKIFYKKDGSAYEVG
HHCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCHHCCCCCCEEEEEECCCCEEHHH
EILKQPELANSLKLIAKQGKKAFYEGEIAHKIADSMAKNGGLITLQDLKNYNIEEMKPVK
HHHCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCCCC
GTYRGYTIYSMLPPSSGGVILIELLNILENFPLSDYGNNSAKTINLMSNAMSYAYNDRNS
CCCCCEEEEEECCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCC
DLGDPDFVKMDLAKFLSKKYAKQIAQKITTDKHIPSKDISTIDPDDHEKLQTTHFSIIDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHEEEEEEEEEC
DGNMVSNTYTLNYSYGSGIVVPGTGIFLNNEMDDFAAKVGEANVFGLVQGEANTVAPNKR
CCCEEEEEEEEEEECCCCEEECCCEEEECCCHHHHHHHCCCCCEEEEEECCCCCCCCCCC
PLSSMTPTIVLDKDGKPFLATGSPGGSRIITTTLQVILNIIDFNMNLQAAVNNPRIHSQL
CCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHC
WPEEIGVEQGISVDTINLLKKMGNTVTPYAAMGAAESVMSDGQYVYGAADPRRASALAIG
CHHHHCHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEC
Y
C
>Mature Secondary Structure
MRRFLLSYTYSVFKNTLRLLVKKLFVNLMSLLILLPSLTLIAAPVPTGYGFIPIQEEMQI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECCCCCCCEEECHHHHHH
AQPVTATHGMVSSQEALASKVGLDILKQGGNAVDAAVAVGFALAVTLPRAGNLAGGGFMI
HCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCCEEE
IHLQDGNKNIAINYREKAPAKASRDMFLNDKGDIDYAKVSGSYSASGVPGTVAGLIDAQQ
EEEECCCCEEEEEECCCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
KYGKLKLSQVIEPAIKLAEDGIPVSYDLHQSLVTAKPWLQKSPDAMKIFYKKDGSAYEVG
HHCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCHHCCCCCCEEEEEECCCCEEHHH
EILKQPELANSLKLIAKQGKKAFYEGEIAHKIADSMAKNGGLITLQDLKNYNIEEMKPVK
HHHCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCCCC
GTYRGYTIYSMLPPSSGGVILIELLNILENFPLSDYGNNSAKTINLMSNAMSYAYNDRNS
CCCCCEEEEEECCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCC
DLGDPDFVKMDLAKFLSKKYAKQIAQKITTDKHIPSKDISTIDPDDHEKLQTTHFSIIDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHEEEEEEEEEC
DGNMVSNTYTLNYSYGSGIVVPGTGIFLNNEMDDFAAKVGEANVFGLVQGEANTVAPNKR
CCCEEEEEEEEEEECCCCEEECCCEEEECCCHHHHHHHCCCCCEEEEEECCCCCCCCCCC
PLSSMTPTIVLDKDGKPFLATGSPGGSRIITTTLQVILNIIDFNMNLQAAVNNPRIHSQL
CCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHC
WPEEIGVEQGISVDTINLLKKMGNTVTPYAAMGAAESVMSDGQYVYGAADPRRASALAIG
CHHHHCHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]