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The map label for this gene is coaBC [H]

Identifier: 134302135

GI number: 134302135

Start: 1118586

End: 1119761

Strand: Reverse

Name: coaBC [H]

Synonym: FTW_1186

Alternate gene names: 134302135

Gene position: 1119761-1118586 (Counterclockwise)

Preceding gene: 134302136

Following gene: 134302130

Centisome position: 58.98

GC content: 29.25

Gene sequence:

>1176_bases
ATGAGTAATAAGATTTTATTTGGGATCACTGGCAGTGTATCAGCTTTTAAAACTATAAATTTGATAAGACTTTTTATTAA
AAGTGGTGTTGAATGTAGAGCTATAGTTACTAAAGGTGCACAGCAGTTTATAAAGCCTGAACTTTTAGTAGCTTTAGGCT
GTGATGTTTATACTGATGAAAAACTAGATATGTTATCTTATCAGCAAAGTATGGCACATATAAATTTATCACGTTGGGCT
GATAAGATATTTATAGTTCCTGCTTCAGCAAATACTATTGCAAAATTAGCTTATGGTTTAGCAGATGATTTATTAAGTCA
AACAATATTAGCTAATGATGATAATTCTAAGGTATATATAGCTCCTGCTATGAATGTAAATATGTGGCAAAACCAACTTA
CTCAAGATAATATTAATAAACTTCAAACTCTAGGATTTAATTTGATATTACCTGATAAAGGTCTTCAAGCTTGTGGAGAT
ATTGGTAGTGGTAGATTACATGAGCCGGAAGTCTTGTTTGATTTATTGAGTGTTTCTCAAGATTTCAAAGCTAAAAAAGT
AGTGATAACAGTAGGAGCAACTGTAGAAGATATTGATGGTGTTAGATATTTATCAAATTATAGCTCTGGTAAAATGGGCT
TTGCTTTGGTAAGAGAGTTACTTGCAAGAGGAGCGAGTGTTGTAGTATTAAAAGCAAAAACTACAATAAGCTTTGATATT
AAACATCCTAATTTAGAAATTATTAATACCAAAAGTGCTGATGATATGAACCAAGCAATGCTTGAAAAAGCTAAAGATAG
TGATATTTTTATAGGCTGTGCTGCAGTTGCTGATTATAAGATCAAAAATAAATTTACTAATAAAATTAAAAAAACTGATG
ATACATTAACTTTAGAGTTTATAAAAAATCCTGATGTTTTAGCTAATTGTAAAAAAACATACCCAAATATCTTTGCTATA
GGTTTTGCAGCAGAATCACAAAATATAGTAGATTATGCTCAGGCTAAACTTGTCAAAAAGAATCTAAATATGGTAGTTGC
AAATTCAACTGAAGTATTTGGTAATGATAACTCAAGTGTAACAATATTATCTAAGCATCAAACTAAACAATATAACAATA
AATCAAAGTCAGAAATAGCTAAGTTAATATTAGATTTTGCTAAGGAAATAATATGA

Upstream 100 bases:

>100_bases
GAATGTGAATATCTTAGCTGTAGTAGTTGCTATTATGGTCTTACTAATAATCATGTTTTATAAAAGAGAGAAGATATTAA
ATAAATAGAGATTAATATTT

Downstream 100 bases:

>100_bases
GTATTAGAGAAGTTTGTATAGCTGGTAAATGTAATAAGCTGATAACTTTAAAAAATGATAATATTGAATTGATACTTTTG
GATCAAGGAGCAACTGTTTT

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSNKILFGITGSVSAFKTINLIRLFIKSGVECRAIVTKGAQQFIKPELLVALGCDVYTDEKLDMLSYQQSMAHINLSRWA
DKIFIVPASANTIAKLAYGLADDLLSQTILANDDNSKVYIAPAMNVNMWQNQLTQDNINKLQTLGFNLILPDKGLQACGD
IGSGRLHEPEVLFDLLSVSQDFKAKKVVITVGATVEDIDGVRYLSNYSSGKMGFALVRELLARGASVVVLKAKTTISFDI
KHPNLEIINTKSADDMNQAMLEKAKDSDIFIGCAAVADYKIKNKFTNKIKKTDDTLTLEFIKNPDVLANCKKTYPNIFAI
GFAAESQNIVDYAQAKLVKKNLNMVVANSTEVFGNDNSSVTILSKHQTKQYNNKSKSEIAKLILDFAKEII

Sequences:

>Translated_391_residues
MSNKILFGITGSVSAFKTINLIRLFIKSGVECRAIVTKGAQQFIKPELLVALGCDVYTDEKLDMLSYQQSMAHINLSRWA
DKIFIVPASANTIAKLAYGLADDLLSQTILANDDNSKVYIAPAMNVNMWQNQLTQDNINKLQTLGFNLILPDKGLQACGD
IGSGRLHEPEVLFDLLSVSQDFKAKKVVITVGATVEDIDGVRYLSNYSSGKMGFALVRELLARGASVVVLKAKTTISFDI
KHPNLEIINTKSADDMNQAMLEKAKDSDIFIGCAAVADYKIKNKFTNKIKKTDDTLTLEFIKNPDVLANCKKTYPNIFAI
GFAAESQNIVDYAQAKLVKKNLNMVVANSTEVFGNDNSSVTILSKHQTKQYNNKSKSEIAKLILDFAKEII
>Mature_390_residues
SNKILFGITGSVSAFKTINLIRLFIKSGVECRAIVTKGAQQFIKPELLVALGCDVYTDEKLDMLSYQQSMAHINLSRWAD
KIFIVPASANTIAKLAYGLADDLLSQTILANDDNSKVYIAPAMNVNMWQNQLTQDNINKLQTLGFNLILPDKGLQACGDI
GSGRLHEPEVLFDLLSVSQDFKAKKVVITVGATVEDIDGVRYLSNYSSGKMGFALVRELLARGASVVVLKAKTTISFDIK
HPNLEIINTKSADDMNQAMLEKAKDSDIFIGCAAVADYKIKNKFTNKIKKTDDTLTLEFIKNPDVLANCKKTYPNIFAIG
FAAESQNIVDYAQAKLVKKNLNMVVANSTEVFGNDNSSVTILSKHQTKQYNNKSKSEIAKLILDFAKEII

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=179, Percent_Identity=33.5195530726257, Blast_Score=99, Evalue=9e-21,
Organism=Escherichia coli, GI87082301, Length=396, Percent_Identity=36.3636363636364, Blast_Score=244, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI17560194, Length=171, Percent_Identity=34.5029239766082, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322762, Length=179, Percent_Identity=32.9608938547486, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=29.5698924731183, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43080; Mature: 42949

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKILFGITGSVSAFKTINLIRLFIKSGVECRAIVTKGAQQFIKPELLVALGCDVYTDE
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCEEEEECCCCCCCC
KLDMLSYQQSMAHINLSRWADKIFIVPASANTIAKLAYGLADDLLSQTILANDDNSKVYI
CHHHHHHHHHHHHEEHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEE
APAMNVNMWQNQLTQDNINKLQTLGFNLILPDKGLQACGDIGSGRLHEPEVLFDLLSVSQ
EECCCCHHHHHHCCHHHHHHHHHCCCEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHCCC
DFKAKKVVITVGATVEDIDGVRYLSNYSSGKMGFALVRELLARGASVVVLKAKTTISFDI
CCCCEEEEEEECCCHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEEEE
KHPNLEIINTKSADDMNQAMLEKAKDSDIFIGCAAVADYKIKNKFTNKIKKTDDTLTLEF
ECCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEHHHCHHHHHHHHHHHHCCCCEEEEEE
IKNPDVLANCKKTYPNIFAIGFAAESQNIVDYAQAKLVKKNLNMVVANSTEVFGNDNSSV
ECCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCEEEECCCCCEE
TILSKHQTKQYNNKSKSEIAKLILDFAKEII
EEEECCCHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNKILFGITGSVSAFKTINLIRLFIKSGVECRAIVTKGAQQFIKPELLVALGCDVYTDE
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCEEEEECCCCCCCC
KLDMLSYQQSMAHINLSRWADKIFIVPASANTIAKLAYGLADDLLSQTILANDDNSKVYI
CHHHHHHHHHHHHEEHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEE
APAMNVNMWQNQLTQDNINKLQTLGFNLILPDKGLQACGDIGSGRLHEPEVLFDLLSVSQ
EECCCCHHHHHHCCHHHHHHHHHCCCEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHCCC
DFKAKKVVITVGATVEDIDGVRYLSNYSSGKMGFALVRELLARGASVVVLKAKTTISFDI
CCCCEEEEEEECCCHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEEEE
KHPNLEIINTKSADDMNQAMLEKAKDSDIFIGCAAVADYKIKNKFTNKIKKTDDTLTLEF
ECCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEHHHCHHHHHHHHHHHHCCCCEEEEEE
IKNPDVLANCKKTYPNIFAIGFAAESQNIVDYAQAKLVKKNLNMVVANSTEVFGNDNSSV
ECCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCEEEECCCCCEE
TILSKHQTKQYNNKSKSEIAKLILDFAKEII
EEEECCCHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]