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The map label for this gene is fucA [C]

Identifier: 134302031

GI number: 134302031

Start: 1006231

End: 1006929

Strand: Direct

Name: fucA [C]

Synonym: FTW_1063

Alternate gene names: 134302031

Gene position: 1006231-1006929 (Clockwise)

Preceding gene: 134302030

Following gene: 134302032

Centisome position: 53.0

GC content: 30.19

Gene sequence:

>699_bases
ATGTCTACAGAAAAAAATCTCAGAAAGAAATTAGCAGTTTGTCATCATGTAATACATTATTATGGTTGGGATGATCTATT
AGCTACACATATATCAGCAAGGCTCCCTAATGGAAATGTAATTATTACACCACATAATGTTACCTTCGATAAAGTTACCA
AAAAAAATATTGTTACCATAACACCTAATGGAGAAATAGTTTCAGATAATGGTTATAAAGTAATGCCTCAAGCTGCCAAT
ATCCATTTAGAAACATATAATGCTAGAAAAGATATTAATGCTATTATCCATACGCATAGTAAATATGCTGTAATACTCTC
CTCATTAGAATGCGGTATGCAATTTACTAATCAACAATCATTAAGATTTTATGATGATGTATCTTATCACCACTATGATG
GACTAGCTTTAGATAATGAAGGTAAGGCAATCGCAGCTAGTCTGGGTGAAAAAAATAGCATGATGATATTAGATAATCAT
GGAATTATCACAACTGCAGAATCAATTGAAAAAGCAATTTATAAGCACTATTATTTTGAAAAAGCTATTGAGATTGAAGT
AAAAACTCTAGCTACAGGTCAAAAAATTAGACAAATTCCTCAAGAGATATCTAAAAAGACTGCAGAGCAGTTTGCTAGGA
TAAATACTTGTCATTTGGAGTTTGAAGTATTTAAAACACTAACAAAAAAATATAGATAA

Upstream 100 bases:

>100_bases
TAAAAAATAATCTTTAGATATATGATAATTTAAAGCTAGATTAAATTTATAACTAGGTGATAAAATTTAAAATATATAAG
TCTTAAGGAATTATTGAAAT

Downstream 100 bases:

>100_bases
TTGATTTTATTTAAATGAAAAATATTGAAGATTTAAAACTTAGGCTAAGACATAATAAAAAAGTTTATGTCGGTTACCCT
ACCGCTACAGATTTTGATTA

Product: aldolase and adducin class II family protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MSTEKNLRKKLAVCHHVIHYYGWDDLLATHISARLPNGNVIITPHNVTFDKVTKKNIVTITPNGEIVSDNGYKVMPQAAN
IHLETYNARKDINAIIHTHSKYAVILSSLECGMQFTNQQSLRFYDDVSYHHYDGLALDNEGKAIAASLGEKNSMMILDNH
GIITTAESIEKAIYKHYYFEKAIEIEVKTLATGQKIRQIPQEISKKTAEQFARINTCHLEFEVFKTLTKKYR

Sequences:

>Translated_232_residues
MSTEKNLRKKLAVCHHVIHYYGWDDLLATHISARLPNGNVIITPHNVTFDKVTKKNIVTITPNGEIVSDNGYKVMPQAAN
IHLETYNARKDINAIIHTHSKYAVILSSLECGMQFTNQQSLRFYDDVSYHHYDGLALDNEGKAIAASLGEKNSMMILDNH
GIITTAESIEKAIYKHYYFEKAIEIEVKTLATGQKIRQIPQEISKKTAEQFARINTCHLEFEVFKTLTKKYR
>Mature_231_residues
STEKNLRKKLAVCHHVIHYYGWDDLLATHISARLPNGNVIITPHNVTFDKVTKKNIVTITPNGEIVSDNGYKVMPQAANI
HLETYNARKDINAIIHTHSKYAVILSSLECGMQFTNQQSLRFYDDVSYHHYDGLALDNEGKAIAASLGEKNSMMILDNHG
IITTAESIEKAIYKHYYFEKAIEIEVKTLATGQKIRQIPQEISKKTAEQFARINTCHLEFEVFKTLTKKYR

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826321, Length=195, Percent_Identity=32.3076923076923, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI29826319, Length=195, Percent_Identity=32.3076923076923, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI29826325, Length=195, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI29826323, Length=195, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI9943848, Length=194, Percent_Identity=31.4432989690722, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI9951927, Length=194, Percent_Identity=31.4432989690722, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI62912453, Length=194, Percent_Identity=31.4432989690722, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI89276787, Length=203, Percent_Identity=25.1231527093596, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI297307160, Length=203, Percent_Identity=25.1231527093596, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI9257190, Length=203, Percent_Identity=25.1231527093596, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI297307158, Length=203, Percent_Identity=25.1231527093596, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI9257192, Length=203, Percent_Identity=25.1231527093596, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI115533216, Length=193, Percent_Identity=27.4611398963731, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115533218, Length=197, Percent_Identity=27.4111675126904, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71989560, Length=215, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71989550, Length=215, Percent_Identity=25.5813953488372, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71989555, Length=215, Percent_Identity=25.5813953488372, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71989544, Length=215, Percent_Identity=25.5813953488372, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989541, Length=215, Percent_Identity=25.5813953488372, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363755, Length=215, Percent_Identity=27.4418604651163, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281363751, Length=215, Percent_Identity=27.4418604651163, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24655690, Length=215, Percent_Identity=27.4418604651163, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281363761, Length=215, Percent_Identity=27.4418604651163, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281363759, Length=215, Percent_Identity=27.4418604651163, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281363753, Length=215, Percent_Identity=27.4418604651163, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24655685, Length=215, Percent_Identity=27.4418604651163, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281363763, Length=215, Percent_Identity=27.4418604651163, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281363757, Length=215, Percent_Identity=27.4418604651163, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136738, Length=215, Percent_Identity=27.4418604651163, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 26467; Mature: 26335

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEKNLRKKLAVCHHVIHYYGWDDLLATHISARLPNGNVIITPHNVTFDKVTKKNIVTI
CCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEECCCCCHHCCCCCCEEEE
TPNGEIVSDNGYKVMPQAANIHLETYNARKDINAIIHTHSKYAVILSSLECGMQFTNQQS
CCCCCEECCCCCEEEECCCEEEEEEECCHHHHHHHEECCCHHEEHHHHHHHCHHCCCCCC
LRFYDDVSYHHYDGLALDNEGKAIAASLGEKNSMMILDNHGIITTAESIEKAIYKHYYFE
EEEEECCCEEECCCEEECCCCCEEEEECCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHH
KAIEIEVKTLATGQKIRQIPQEISKKTAEQFARINTCHLEFEVFKTLTKKYR
HEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHCC
>Mature Secondary Structure 
STEKNLRKKLAVCHHVIHYYGWDDLLATHISARLPNGNVIITPHNVTFDKVTKKNIVTI
CCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEECCCCCHHCCCCCCEEEE
TPNGEIVSDNGYKVMPQAANIHLETYNARKDINAIIHTHSKYAVILSSLECGMQFTNQQS
CCCCCEECCCCCEEEECCCEEEEEEECCHHHHHHHEECCCHHEEHHHHHHHCHHCCCCCC
LRFYDDVSYHHYDGLALDNEGKAIAASLGEKNSMMILDNHGIITTAESIEKAIYKHYYFE
EEEEECCCEEECCCEEECCCCCEEEEECCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHH
KAIEIEVKTLATGQKIRQIPQEISKKTAEQFARINTCHLEFEVFKTLTKKYR
HEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]