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The map label for this gene is lldD [H]

Identifier: 134302004

GI number: 134302004

Start: 977380

End: 978522

Strand: Reverse

Name: lldD [H]

Synonym: FTW_1032

Alternate gene names: 134302004

Gene position: 978522-977380 (Counterclockwise)

Preceding gene: 134302006

Following gene: 134302003

Centisome position: 51.54

GC content: 32.46

Gene sequence:

>1143_bases
ATGAAAATAAATAATATTTATGATATTACAGATATGCATAAAGCAGCTAAAAAGAGATTGCCAAGAGTTTTTTTAGACTA
TATTGATAGCCGCTCATATCAGCAACAAACAGTCTATGAGAATGAGCAAGCGTTTAGAAAAATTAGAATAAATCAAAGCG
CATTTAAAGATTGTAGTCAGAGAAACCAAACTATAGAGATATTTGGTTTCAAATCTAGTGTTCCATTTGCAATAGCACCA
ACAGGCTTAGCTGGGATGTTTTGGCCGAAAGGTGAAATAGCATTAGCCTTAGCTGCTGAAAAATTAGATATTGCATATAC
AATGAGTACTATGGCTATTTGTTCTTTAGAAACGGTAGCAAAAGAAGCTAATAATCATTTTTGGTTTCAACTCTATCTTA
TGAAAGATAGAGGATTTACTAAGTCGTTACTTGAAAGAGCAAAGGCTTGTGGTTGTCAGACAATTTTTGTTAATGCTGAT
TTACCAGTAAGTGGTATTAGATATAGTGATATGCGTAATGGTTTATCAATTCCTCCTAAATTTGGAATTAGGGATATAAT
TAATATTGCAGCTAAACAAAGTTGGGTTTGGGGATATTTATTAAGTAAATACAAACAGTTTGGTAATTTAAGTGGTCATA
TTCCAACTGGTGCTAAAGGGATGAAAAGTGTTACAGATTTTATGGACTCACAATTTGATCAAAGTGTCACTTGGAAGGAT
ATAGAGTGGTTAAGAAATATTTGGGATGGTAATTTGATAATAAAAGGTCTTTTAAATACACAAGGTGCTGAAAATGCAGT
AAAGGTTGGTGCTGATGGTATTGTTGTATCTAATCATAGAGGAAGACAACTTGATGGTGTGTTACCAACTATAGAAGCTT
TGCCAGCAATAGCTGATAAAGTAAAAGGTGATATAAAAATAATTTTAGACAGTGGTATTAGATCGGGTCAAGATATCATA
AAAGCTTTAGCCTTAGGTGCGGATTTTACTTTGGTTGGTAGACCATTTCTATATGGATTGTCAGCATTCGGTCAAAAAGG
TGTAGAAAAAGTTTATGACATACTCAAAAAAGAGATAGATAATACTATGGCATTAGCAGGAATTTCAGATTTAAATAATA
TTTCAACTAATGTTGTAGTTTAG

Upstream 100 bases:

>100_bases
TGGCATTTTTATTAGACATTATAACATTTCTACAAATATCTTTTTCTACAAATATCTTTCGGATTAACTATATATGGCTT
GCAAATATAGGAAAATTGCT

Downstream 100 bases:

>100_bases
TAAATTAGACAGGTAAATTATTATGCAAATAATAACTGTAAGTGAGTATTTAAGAACAAAATTAAGTGAGTTAGGAATAA
AAGATATAATAGGTGTTGCT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKINNIYDITDMHKAAKKRLPRVFLDYIDSRSYQQQTVYENEQAFRKIRINQSAFKDCSQRNQTIEIFGFKSSVPFAIAP
TGLAGMFWPKGEIALALAAEKLDIAYTMSTMAICSLETVAKEANNHFWFQLYLMKDRGFTKSLLERAKACGCQTIFVNAD
LPVSGIRYSDMRNGLSIPPKFGIRDIINIAAKQSWVWGYLLSKYKQFGNLSGHIPTGAKGMKSVTDFMDSQFDQSVTWKD
IEWLRNIWDGNLIIKGLLNTQGAENAVKVGADGIVVSNHRGRQLDGVLPTIEALPAIADKVKGDIKIILDSGIRSGQDII
KALALGADFTLVGRPFLYGLSAFGQKGVEKVYDILKKEIDNTMALAGISDLNNISTNVVV

Sequences:

>Translated_380_residues
MKINNIYDITDMHKAAKKRLPRVFLDYIDSRSYQQQTVYENEQAFRKIRINQSAFKDCSQRNQTIEIFGFKSSVPFAIAP
TGLAGMFWPKGEIALALAAEKLDIAYTMSTMAICSLETVAKEANNHFWFQLYLMKDRGFTKSLLERAKACGCQTIFVNAD
LPVSGIRYSDMRNGLSIPPKFGIRDIINIAAKQSWVWGYLLSKYKQFGNLSGHIPTGAKGMKSVTDFMDSQFDQSVTWKD
IEWLRNIWDGNLIIKGLLNTQGAENAVKVGADGIVVSNHRGRQLDGVLPTIEALPAIADKVKGDIKIILDSGIRSGQDII
KALALGADFTLVGRPFLYGLSAFGQKGVEKVYDILKKEIDNTMALAGISDLNNISTNVVV
>Mature_380_residues
MKINNIYDITDMHKAAKKRLPRVFLDYIDSRSYQQQTVYENEQAFRKIRINQSAFKDCSQRNQTIEIFGFKSSVPFAIAP
TGLAGMFWPKGEIALALAAEKLDIAYTMSTMAICSLETVAKEANNHFWFQLYLMKDRGFTKSLLERAKACGCQTIFVNAD
LPVSGIRYSDMRNGLSIPPKFGIRDIINIAAKQSWVWGYLLSKYKQFGNLSGHIPTGAKGMKSVTDFMDSQFDQSVTWKD
IEWLRNIWDGNLIIKGLLNTQGAENAVKVGADGIVVSNHRGRQLDGVLPTIEALPAIADKVKGDIKIILDSGIRSGQDII
KALALGADFTLVGRPFLYGLSAFGQKGVEKVYDILKKEIDNTMALAGISDLNNISTNVVV

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=372, Percent_Identity=34.1397849462366, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI54234014, Length=372, Percent_Identity=35.2150537634409, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI7705393, Length=372, Percent_Identity=35.2150537634409, Blast_Score=226, Evalue=4e-59,
Organism=Escherichia coli, GI1790033, Length=374, Percent_Identity=41.1764705882353, Blast_Score=317, Evalue=9e-88,
Organism=Caenorhabditis elegans, GI193208036, Length=377, Percent_Identity=31.5649867374005, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI32566217, Length=288, Percent_Identity=29.8611111111111, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323587, Length=388, Percent_Identity=29.3814432989691, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI78707188, Length=373, Percent_Identity=36.7292225201072, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI281363140, Length=373, Percent_Identity=36.7292225201072, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI78707190, Length=373, Percent_Identity=36.7292225201072, Blast_Score=235, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42223; Mature: 42223

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINNIYDITDMHKAAKKRLPRVFLDYIDSRSYQQQTVYENEQAFRKIRINQSAFKDCSQ
CCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RNQTIEIFGFKSSVPFAIAPTGLAGMFWPKGEIALALAAEKLDIAYTMSTMAICSLETVA
CCCEEEEEEECCCCCEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
KEANNHFWFQLYLMKDRGFTKSLLERAKACGCQTIFVNADLPVSGIRYSDMRNGLSIPPK
HHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHCCCCCCCCC
FGIRDIINIAAKQSWVWGYLLSKYKQFGNLSGHIPTGAKGMKSVTDFMDSQFDQSVTWKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
IEWLRNIWDGNLIIKGLLNTQGAENAVKVGADGIVVSNHRGRQLDGVLPTIEALPAIADK
HHHHHHHCCCCEEEEEECCCCCCCCCEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
VKGDIKIILDSGIRSGQDIIKALALGADFTLVGRPFLYGLSAFGQKGVEKVYDILKKEID
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHC
NTMALAGISDLNNISTNVVV
CCEEECCCHHHCCCCCCCCC
>Mature Secondary Structure
MKINNIYDITDMHKAAKKRLPRVFLDYIDSRSYQQQTVYENEQAFRKIRINQSAFKDCSQ
CCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RNQTIEIFGFKSSVPFAIAPTGLAGMFWPKGEIALALAAEKLDIAYTMSTMAICSLETVA
CCCEEEEEEECCCCCEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
KEANNHFWFQLYLMKDRGFTKSLLERAKACGCQTIFVNADLPVSGIRYSDMRNGLSIPPK
HHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHCCCCCCCCC
FGIRDIINIAAKQSWVWGYLLSKYKQFGNLSGHIPTGAKGMKSVTDFMDSQFDQSVTWKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
IEWLRNIWDGNLIIKGLLNTQGAENAVKVGADGIVVSNHRGRQLDGVLPTIEALPAIADK
HHHHHHHCCCCEEEEEECCCCCCCCCEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
VKGDIKIILDSGIRSGQDIIKALALGADFTLVGRPFLYGLSAFGQKGVEKVYDILKKEID
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHC
NTMALAGISDLNNISTNVVV
CCEEECCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA