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The map label for this gene is hemF [H]

Identifier: 134301962

GI number: 134301962

Start: 932938

End: 933864

Strand: Direct

Name: hemF [H]

Synonym: FTW_0975

Alternate gene names: 134301962

Gene position: 932938-933864 (Clockwise)

Preceding gene: 134301961

Following gene: 134301963

Centisome position: 49.14

GC content: 34.3

Gene sequence:

>927_bases
ATGCAAGAAAAAATTTCAAAATTTGAAGATTTTCTAACACAACTTCAACAAAATATTACCACAGCTCTAGAGCAGCATGA
AACAAATGCTGCAAAATTTATTTCTGACAAATGGCAAAAACCAGATACTCCCGATCAAAAACTTAAAGGCTATGGTAACT
CTATGATCATAGAAGGTGGCGAAATATTTGAAAAAGGTGTAGTAGCTTTTTCTAGAGTCCACGGTAGTGAGCTACCACCA
TCTGCTACAGCAAAAAGACAAGAATTAGCTGGTAAATCTTTTATAGCTACAGGGCTTTCATTAGTTATCCACCCCCGCAA
TCCTTTTGTGCCAACATCTCATGCTAATTTTAGAATTTTTATTGCTGGTGCTGATACTGATAATCCAATATGGTGGTTTG
GTGGAGGTTTTGATCTAACACCATACTATCCTTTTGAGGAGGATGCGATTCACTGGCATCAAACAGCAAAAAATATTTGT
GACAAGCATGATAAAACCTATTATCCAAAATTCAAAAAATGGTGTGATGAGTATTTTTATCTCAAACATCGTGATGAGTG
TCGTGGGGTTGGTGGTTTATTTTTTGATGATTTAAATGATAAATCTTTTGATGAATGCTTTAATTTTGTAACTGACTGTG
CAAATTCTTATTTAGATGCTTATATTCCAATAGTAGCACAAAGAAAAAATATTGAATATTCACAAAAGCATAAAGATTTT
CAACTTTATCGTCGTGGTAGATATGTTGAATTTAACTTAGTGTTTGATAGAGGTACGATATTTGGCTTACAAAGTGGTGG
GCGAACTGAGTCGATACTCTCATCAATGCCACCAATGGCAACTTGGAAATATAATTGGCAACCTGAACTAGGTTCTGAAG
AAGAAAAAGTTTACCAATATATAAAACCTCGCGATTGGATTAAATAA

Upstream 100 bases:

>100_bases
TTTTACAAGCAATTTTATTTCCCTACTGCTAAAATATCATTTATTAATTTCAGCTTCTATTTGTTTAAAATAGAATTTAA
AATCGAAGGTTTAGTATCAC

Downstream 100 bases:

>100_bases
TAGGTATTACAACAAAAATCAATTATGAGAAAAATATTCACTATCGGCATTTTAACCCTCATAGCTATAACACCAATCTT
TGCCAAAGATTCATATAATA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MQEKISKFEDFLTQLQQNITTALEQHETNAAKFISDKWQKPDTPDQKLKGYGNSMIIEGGEIFEKGVVAFSRVHGSELPP
SATAKRQELAGKSFIATGLSLVIHPRNPFVPTSHANFRIFIAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNIC
DKHDKTYYPKFKKWCDEYFYLKHRDECRGVGGLFFDDLNDKSFDECFNFVTDCANSYLDAYIPIVAQRKNIEYSQKHKDF
QLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPELGSEEEKVYQYIKPRDWIK

Sequences:

>Translated_308_residues
MQEKISKFEDFLTQLQQNITTALEQHETNAAKFISDKWQKPDTPDQKLKGYGNSMIIEGGEIFEKGVVAFSRVHGSELPP
SATAKRQELAGKSFIATGLSLVIHPRNPFVPTSHANFRIFIAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNIC
DKHDKTYYPKFKKWCDEYFYLKHRDECRGVGGLFFDDLNDKSFDECFNFVTDCANSYLDAYIPIVAQRKNIEYSQKHKDF
QLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPELGSEEEKVYQYIKPRDWIK
>Mature_308_residues
MQEKISKFEDFLTQLQQNITTALEQHETNAAKFISDKWQKPDTPDQKLKGYGNSMIIEGGEIFEKGVVAFSRVHGSELPP
SATAKRQELAGKSFIATGLSLVIHPRNPFVPTSHANFRIFIAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNIC
DKHDKTYYPKFKKWCDEYFYLKHRDECRGVGGLFFDDLNDKSFDECFNFVTDCANSYLDAYIPIVAQRKNIEYSQKHKDF
QLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPELGSEEEKVYQYIKPRDWIK

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=314, Percent_Identity=43.312101910828, Blast_Score=259, Evalue=3e-69,
Organism=Escherichia coli, GI1788777, Length=307, Percent_Identity=55.3745928338762, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6320249, Length=321, Percent_Identity=43.9252336448598, Blast_Score=268, Evalue=6e-73,
Organism=Drosophila melanogaster, GI17864388, Length=310, Percent_Identity=47.0967741935484, Blast_Score=295, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 35833; Mature: 35833

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKISKFEDFLTQLQQNITTALEQHETNAAKFISDKWQKPDTPDQKLKGYGNSMIIEGG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECH
EIFEKGVVAFSRVHGSELPPSATAKRQELAGKSFIATGLSLVIHPRNPFVPTSHANFRIF
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCEEEE
IAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNICDKHDKTYYPKFKKWCDEYFY
EEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LKHRDECRGVGGLFFDDLNDKSFDECFNFVTDCANSYLDAYIPIVAQRKNIEYSQKHKDF
HCCCHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
QLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPELGSEEEKVYQY
HHHHCCCEEEEEEEEECCEEEEECCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHH
IKPRDWIK
HCCCCCCC
>Mature Secondary Structure
MQEKISKFEDFLTQLQQNITTALEQHETNAAKFISDKWQKPDTPDQKLKGYGNSMIIEGG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECH
EIFEKGVVAFSRVHGSELPPSATAKRQELAGKSFIATGLSLVIHPRNPFVPTSHANFRIF
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHCCEEEEEECCCCCCCCCCCCEEEE
IAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNICDKHDKTYYPKFKKWCDEYFY
EEECCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LKHRDECRGVGGLFFDDLNDKSFDECFNFVTDCANSYLDAYIPIVAQRKNIEYSQKHKDF
HCCCHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
QLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPELGSEEEKVYQY
HHHHCCCEEEEEEEEECCEEEEECCCCCHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHH
IKPRDWIK
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA