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The map label for this gene is bioF [H]

Identifier: 134301886

GI number: 134301886

Start: 851965

End: 853206

Strand: Direct

Name: bioF [H]

Synonym: FTW_0885

Alternate gene names: 134301886

Gene position: 851965-853206 (Clockwise)

Preceding gene: 134301882

Following gene: 134301887

Centisome position: 44.88

GC content: 29.63

Gene sequence:

>1242_bases
ATGCAAATTACAGAAAACTGGTTTATAAAAAGAGTTAATCGAGCTGAGAAATTTTTAGATTTAAGTTATAGTTGTGCTCG
TAATACTTTCAAAAAATCTGAAAGAAAAAATATTTTATTAACAGATAACAAAACTTACTTAGAGTTTGTTTCATGCTCTT
ATCTAGGTTTACATAATGACAAACAAATAATTGATGCGGTTAAGAAAAGTAAAGCTCTTAAAGCACAAGGTTTTTTGTTT
TCAAGTTCAAGAACAAGGGTAATATCGCAAAATGAGAAAGATGCTCTTGATAAACTAAAGGAAGTTTTTGCACCATATTC
GCCAGTATTATTTCAAAATTTACATACAGCACACCTTGGAATTATACCTTTATTACTCTCTGGCATATTCCCTAAAATAG
ATCAAGGTAAGCCAATACATTGTATAATTGATAAATATGCTCATCAGTCACTTAAGATTTTAGTAGGAATCATAAAGCAG
TTTTGTGAGGTCGAATTTATAGATAATACAGATATTGATAAACTCTCTGCTAGATTAAAGCAAATTCACCAAGGCAATAA
AATACCATTTATAATGATGGACAGCGTAGGTTCTATGGGAAAAATTTATCCTGTTAAAGAAATTGTAGATTTGGTTAATA
CATATAATGGATATGTTTACTTTGATGATGCACATGGAATGTCAATAATTGGTAAGAATGGTAGTGGATATGTGTTAAAA
GAGCTTGACTATAGACTAAATGATAGAGTATTCATAGCAACTTCATTAACTAAAGCCTTCGGTGGGCAAGGAGGTGTTAT
ACTAATGTCTTATCAAGAGCAAATAGACTTTATTTTACAATATTGTACTACGTACACATTTTCAGGTCCTTTATCAATAC
CTAGCTTAGAAGTAATTAGTAAAAGTTGTGAAATTCATTTATCATCACAAATTGATTTACTCCAGCAGAAACTACACAAT
AACTTAAAATACTTTGACCAAGAAATTAGTAATATTAAATATAACCAACTACGCAATAGTTTTGTACCATTCAGAATTAT
ATACATCGGTAATGAAGACGATGCCATAAAATATTACAAACAATTAAAGGCAGCAGGCATACTTGTGACCTGTGCTATAT
ATCCTGTTGTAGAAAAATCTAATGCTATATTAAGAATTACTTTCTCGGCAAGTCATAAAAATAGTGATATAAAGTTGCTA
GTAAGTAATTTAAAGAATATCTTAACTGACTATAATGCATGA

Upstream 100 bases:

>100_bases
ATAAAATAAAAATATTTTAAATCTGCTATAAAATTTATTTCAAAATGAAATTGCTTAATGCAGAATTACTGATAAGTAAA
AAATAGTTAAATACAATATT

Downstream 100 bases:

>100_bases
TAATTTAGACAAATTACTAGTTCACTAATATTTAAGGATATTTAGCGGTAATACTTTTCATGTATGTAAAAATATAGATC
CTAAATATTCCAAACCCTTT

Product: hypothetical protein

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MQITENWFIKRVNRAEKFLDLSYSCARNTFKKSERKNILLTDNKTYLEFVSCSYLGLHNDKQIIDAVKKSKALKAQGFLF
SSSRTRVISQNEKDALDKLKEVFAPYSPVLFQNLHTAHLGIIPLLLSGIFPKIDQGKPIHCIIDKYAHQSLKILVGIIKQ
FCEVEFIDNTDIDKLSARLKQIHQGNKIPFIMMDSVGSMGKIYPVKEIVDLVNTYNGYVYFDDAHGMSIIGKNGSGYVLK
ELDYRLNDRVFIATSLTKAFGGQGGVILMSYQEQIDFILQYCTTYTFSGPLSIPSLEVISKSCEIHLSSQIDLLQQKLHN
NLKYFDQEISNIKYNQLRNSFVPFRIIYIGNEDDAIKYYKQLKAAGILVTCAIYPVVEKSNAILRITFSASHKNSDIKLL
VSNLKNILTDYNA

Sequences:

>Translated_413_residues
MQITENWFIKRVNRAEKFLDLSYSCARNTFKKSERKNILLTDNKTYLEFVSCSYLGLHNDKQIIDAVKKSKALKAQGFLF
SSSRTRVISQNEKDALDKLKEVFAPYSPVLFQNLHTAHLGIIPLLLSGIFPKIDQGKPIHCIIDKYAHQSLKILVGIIKQ
FCEVEFIDNTDIDKLSARLKQIHQGNKIPFIMMDSVGSMGKIYPVKEIVDLVNTYNGYVYFDDAHGMSIIGKNGSGYVLK
ELDYRLNDRVFIATSLTKAFGGQGGVILMSYQEQIDFILQYCTTYTFSGPLSIPSLEVISKSCEIHLSSQIDLLQQKLHN
NLKYFDQEISNIKYNQLRNSFVPFRIIYIGNEDDAIKYYKQLKAAGILVTCAIYPVVEKSNAILRITFSASHKNSDIKLL
VSNLKNILTDYNA
>Mature_413_residues
MQITENWFIKRVNRAEKFLDLSYSCARNTFKKSERKNILLTDNKTYLEFVSCSYLGLHNDKQIIDAVKKSKALKAQGFLF
SSSRTRVISQNEKDALDKLKEVFAPYSPVLFQNLHTAHLGIIPLLLSGIFPKIDQGKPIHCIIDKYAHQSLKILVGIIKQ
FCEVEFIDNTDIDKLSARLKQIHQGNKIPFIMMDSVGSMGKIYPVKEIVDLVNTYNGYVYFDDAHGMSIIGKNGSGYVLK
ELDYRLNDRVFIATSLTKAFGGQGGVILMSYQEQIDFILQYCTTYTFSGPLSIPSLEVISKSCEIHLSSQIDLLQQKLHN
NLKYFDQEISNIKYNQLRNSFVPFRIIYIGNEDDAIKYYKQLKAAGILVTCAIYPVVEKSNAILRITFSASHKNSDIKLL
VSNLKNILTDYNA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=368, Percent_Identity=24.7282608695652, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI7657118, Length=360, Percent_Identity=24.7222222222222, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI83977444, Length=365, Percent_Identity=24.3835616438356, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI83977440, Length=365, Percent_Identity=24.3835616438356, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI83977442, Length=365, Percent_Identity=24.3835616438356, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790046, Length=413, Percent_Identity=26.8765133171913, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786993, Length=369, Percent_Identity=24.1192411924119, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71994529, Length=396, Percent_Identity=25.2525252525253, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560912, Length=267, Percent_Identity=25.4681647940075, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560914, Length=267, Percent_Identity=25.4681647940075, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24662918, Length=360, Percent_Identity=26.6666666666667, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 46996; Mature: 46996

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQITENWFIKRVNRAEKFLDLSYSCARNTFKKSERKNILLTDNKTYLEFVSCSYLGLHND
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEECCCCC
KQIIDAVKKSKALKAQGFLFSSSRTRVISQNEKDALDKLKEVFAPYSPVLFQNLHTAHLG
HHHHHHHHHHHHHHHCCEEEECCCCEEECCCCHHHHHHHHHHHCCCCHHHHHCCHHHHHH
IIPLLLSGIFPKIDQGKPIHCIIDKYAHQSLKILVGIIKQFCEVEFIDNTDIDKLSARLK
HHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHH
QIHQGNKIPFIMMDSVGSMGKIYPVKEIVDLVNTYNGYVYFDDAHGMSIIGKNGSGYVLK
HHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCEEEE
ELDYRLNDRVFIATSLTKAFGGQGGVILMSYQEQIDFILQYCTTYTFSGPLSIPSLEVIS
ECCCCCCCCEEEEEEHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KSCEIHLSSQIDLLQQKLHNNLKYFDQEISNIKYNQLRNSFVPFRIIYIGNEDDAIKYYK
HCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHH
QLKAAGILVTCAIYPVVEKSNAILRITFSASHKNSDIKLLVSNLKNILTDYNA
HHHHCCEEEEEEEEHEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQITENWFIKRVNRAEKFLDLSYSCARNTFKKSERKNILLTDNKTYLEFVSCSYLGLHND
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEECCCCC
KQIIDAVKKSKALKAQGFLFSSSRTRVISQNEKDALDKLKEVFAPYSPVLFQNLHTAHLG
HHHHHHHHHHHHHHHCCEEEECCCCEEECCCCHHHHHHHHHHHCCCCHHHHHCCHHHHHH
IIPLLLSGIFPKIDQGKPIHCIIDKYAHQSLKILVGIIKQFCEVEFIDNTDIDKLSARLK
HHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHH
QIHQGNKIPFIMMDSVGSMGKIYPVKEIVDLVNTYNGYVYFDDAHGMSIIGKNGSGYVLK
HHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCEEEE
ELDYRLNDRVFIATSLTKAFGGQGGVILMSYQEQIDFILQYCTTYTFSGPLSIPSLEVIS
ECCCCCCCCEEEEEEHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KSCEIHLSSQIDLLQQKLHNNLKYFDQEISNIKYNQLRNSFVPFRIIYIGNEDDAIKYYK
HCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHH
QLKAAGILVTCAIYPVVEKSNAILRITFSASHKNSDIKLLVSNLKNILTDYNA
HHHHCCEEEEEEEEHEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA