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The map label for this gene is bioA [H]

Identifier: 134301849

GI number: 134301849

Start: 810267

End: 811553

Strand: Direct

Name: bioA [H]

Synonym: FTW_0832

Alternate gene names: 134301849

Gene position: 810267-811553 (Clockwise)

Preceding gene: 134301845

Following gene: 134301855

Centisome position: 42.68

GC content: 31.31

Gene sequence:

>1287_bases
ATGTATAGCTCAAACATATGGCATCCATGCACACAAATGAAAGACTTTGAAAAATCTCCACCTTTGAATGTTTATAGAAC
GGAAGGGCGATATATCTACACTAAAGATAATAGAAAGCTTTTTGATGCTACTTCAAGTTGGTGGTGTAAATCTCTTGGAC
ATAGACATCCATACATAATAGATAAGCTTAAAAAACAACTAGATAAATATGAGCATACGATATTTGCAAATACTACAAAT
GATGAAATAGATAGGTTTAGTCAAAGAATTTGTAATTTGACAGGTATGGATAAAACTTTATACGCAAGTGATGGATCTTG
TGCTGTAGAGATAGCTCTAAAGATGACAATACACCTTAGAAGCTTTCAAAATCAAACTAAAAAAATTAAGTTTGTATGCC
TTGAAAACTCATATCATGGTGAGACTTTAGCAACTATGAGTGTCAGTGATTGTGGTTTATATTCTGATCCATATAAACCA
TTATTATTTGATAGTTTTAAGCTAAAAAATATTCCCTATGTTACTGGCAAAAATGATCCGCTATGGGCAAATGCTGAAAG
GTATTGGAATAAATCGCAACAATATCTTGAGCAACACAAAGAATTTATTAATGCTTTAATAGTAGAGCCAATCTGCCAAG
GTGCTGGGGGTATGTTGATTTATAGCAAAGATTATTTAAATATACTTTGTAAGTGGTGTAAGGAAAATGATATTTATATT
ATTTTTGATGAGATAATGACTGGACTAGGGCGATTGGGTAAACTTTTTGCTTATGAATATCTAGATATCACGCCTGATTT
TTTGTGTGTATCAAAGGGGCTAACCTCTGGGATTATACCTTTTAGTATTGTTTTGACAAAAAATCAATATTATGAGATGT
TTTATGATGATCAGTTAACTAAAGCCTTTTTACATTCACATACTCATAGTGGTAATGTTTTAGGAGCTGTGGTAGCAAAT
GCAGTATTAGATATATTTGAAGAAGAAAATATACTTACTAATGTTAAAGATCTCGAAAAACAATTTAGTGAATCTTTTCT
TGAGCTACAAGAGCAATTACCTATTATAAAAAACGTTAGAGGTATTGGAGCAGTTATCGCAGCAGATTTAAATATTGATA
AAAAAAGAGCTGGCTTAGATGTCTATCGAGAAGCTATAAAATTAGGCGCATTATTAAGACCACTAGGAAATACTATCTAC
TGGCTACCACCATTCAATAGTACTTATCAAGAGATTGATTTATTAAAGCAAATCACAAAACAGTCAATTATAAATGCTTT
TAAATAG

Upstream 100 bases:

>100_bases
GTAATGTCATTTTTTATAAAAAAGTTTTTTAAAGTTGTAAAGTATTTTATATCTTGTGTACAATTTATGTCAACTTAATA
TTTTACAAAAGGTTTACAAT

Downstream 100 bases:

>100_bases
ACATATTAATCTAAGAGTAAGATAGAGATCTTTGTTATATATTTACTTGATTTTTAGTCATTTCTTATTAATTCTGTTTT
CTAATCAGATATATTCAATA

Product: aminotransferase class III

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MYSSNIWHPCTQMKDFEKSPPLNVYRTEGRYIYTKDNRKLFDATSSWWCKSLGHRHPYIIDKLKKQLDKYEHTIFANTTN
DEIDRFSQRICNLTGMDKTLYASDGSCAVEIALKMTIHLRSFQNQTKKIKFVCLENSYHGETLATMSVSDCGLYSDPYKP
LLFDSFKLKNIPYVTGKNDPLWANAERYWNKSQQYLEQHKEFINALIVEPICQGAGGMLIYSKDYLNILCKWCKENDIYI
IFDEIMTGLGRLGKLFAYEYLDITPDFLCVSKGLTSGIIPFSIVLTKNQYYEMFYDDQLTKAFLHSHTHSGNVLGAVVAN
AVLDIFEEENILTNVKDLEKQFSESFLELQEQLPIIKNVRGIGAVIAADLNIDKKRAGLDVYREAIKLGALLRPLGNTIY
WLPPFNSTYQEIDLLKQITKQSIINAFK

Sequences:

>Translated_428_residues
MYSSNIWHPCTQMKDFEKSPPLNVYRTEGRYIYTKDNRKLFDATSSWWCKSLGHRHPYIIDKLKKQLDKYEHTIFANTTN
DEIDRFSQRICNLTGMDKTLYASDGSCAVEIALKMTIHLRSFQNQTKKIKFVCLENSYHGETLATMSVSDCGLYSDPYKP
LLFDSFKLKNIPYVTGKNDPLWANAERYWNKSQQYLEQHKEFINALIVEPICQGAGGMLIYSKDYLNILCKWCKENDIYI
IFDEIMTGLGRLGKLFAYEYLDITPDFLCVSKGLTSGIIPFSIVLTKNQYYEMFYDDQLTKAFLHSHTHSGNVLGAVVAN
AVLDIFEEENILTNVKDLEKQFSESFLELQEQLPIIKNVRGIGAVIAADLNIDKKRAGLDVYREAIKLGALLRPLGNTIY
WLPPFNSTYQEIDLLKQITKQSIINAFK
>Mature_428_residues
MYSSNIWHPCTQMKDFEKSPPLNVYRTEGRYIYTKDNRKLFDATSSWWCKSLGHRHPYIIDKLKKQLDKYEHTIFANTTN
DEIDRFSQRICNLTGMDKTLYASDGSCAVEIALKMTIHLRSFQNQTKKIKFVCLENSYHGETLATMSVSDCGLYSDPYKP
LLFDSFKLKNIPYVTGKNDPLWANAERYWNKSQQYLEQHKEFINALIVEPICQGAGGMLIYSKDYLNILCKWCKENDIYI
IFDEIMTGLGRLGKLFAYEYLDITPDFLCVSKGLTSGIIPFSIVLTKNQYYEMFYDDQLTKAFLHSHTHSGNVLGAVVAN
AVLDIFEEENILTNVKDLEKQFSESFLELQEQLPIIKNVRGIGAVIAADLNIDKKRAGLDVYREAIKLGALLRPLGNTIY
WLPPFNSTYQEIDLLKQITKQSIINAFK

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=436, Percent_Identity=27.2935779816514, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=24.3181818181818, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI284507298, Length=328, Percent_Identity=27.4390243902439, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI37574042, Length=380, Percent_Identity=23.9473684210526, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI226442709, Length=342, Percent_Identity=24.5614035087719, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI24119277, Length=374, Percent_Identity=22.7272727272727, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI226442705, Length=382, Percent_Identity=23.0366492146597, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786991, Length=426, Percent_Identity=31.6901408450704, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI1788044, Length=393, Percent_Identity=28.2442748091603, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789759, Length=379, Percent_Identity=26.3852242744063, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI145693181, Length=394, Percent_Identity=23.6040609137056, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1789016, Length=355, Percent_Identity=27.6056338028169, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787560, Length=406, Percent_Identity=25.8620689655172, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786349, Length=350, Percent_Identity=24.5714285714286, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=424, Percent_Identity=26.6509433962264, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=437, Percent_Identity=25.629290617849, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71992977, Length=386, Percent_Identity=25.3886010362694, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=305, Percent_Identity=28.1967213114754, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=458, Percent_Identity=29.9126637554585, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324432, Length=406, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=25.5421686746988, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21357415, Length=429, Percent_Identity=27.039627039627, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI161085790, Length=438, Percent_Identity=24.6575342465753, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI28574759, Length=421, Percent_Identity=25.8907363420428, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI21356575, Length=373, Percent_Identity=23.5924932975871, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281366494, Length=391, Percent_Identity=24.8081841432225, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667139, Length=391, Percent_Identity=24.8081841432225, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667143, Length=391, Percent_Identity=24.8081841432225, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49345; Mature: 49345

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSSNIWHPCTQMKDFEKSPPLNVYRTEGRYIYTKDNRKLFDATSSWWCKSLGHRHPYII
CCCCCCCCCHHHHHCCCCCCCCCEEEECCEEEEECCCCEEECCCHHHHHHHHCCCCCHHH
DKLKKQLDKYEHTIFANTTNDEIDRFSQRICNLTGMDKTLYASDGSCAVEIALKMTIHLR
HHHHHHHHHHHCEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEHHHHHH
SFQNQTKKIKFVCLENSYHGETLATMSVSDCGLYSDPYKPLLFDSFKLKNIPYVTGKNDP
HHHCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHCCCEECCCCCEEECCCCC
LWANAERYWNKSQQYLEQHKEFINALIVEPICQGAGGMLIYSKDYLNILCKWCKENDIYI
CCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCEEE
IFDEIMTGLGRLGKLFAYEYLDITPDFLCVSKGLTSGIIPFSIVLTKNQYYEMFYDDQLT
EHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEEECCCCEEHHHHHHHH
KAFLHSHTHSGNVLGAVVANAVLDIFEEENILTNVKDLEKQFSESFLELQEQLPIIKNVR
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
GIGAVIAADLNIDKKRAGLDVYREAIKLGALLRPLGNTIYWLPPFNSTYQEIDLLKQITK
CCCEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
QSIINAFK
HHHHHHCC
>Mature Secondary Structure
MYSSNIWHPCTQMKDFEKSPPLNVYRTEGRYIYTKDNRKLFDATSSWWCKSLGHRHPYII
CCCCCCCCCHHHHHCCCCCCCCCEEEECCEEEEECCCCEEECCCHHHHHHHHCCCCCHHH
DKLKKQLDKYEHTIFANTTNDEIDRFSQRICNLTGMDKTLYASDGSCAVEIALKMTIHLR
HHHHHHHHHHHCEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEHHHHHH
SFQNQTKKIKFVCLENSYHGETLATMSVSDCGLYSDPYKPLLFDSFKLKNIPYVTGKNDP
HHHCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHCCCEECCCCCEEECCCCC
LWANAERYWNKSQQYLEQHKEFINALIVEPICQGAGGMLIYSKDYLNILCKWCKENDIYI
CCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCEEE
IFDEIMTGLGRLGKLFAYEYLDITPDFLCVSKGLTSGIIPFSIVLTKNQYYEMFYDDQLT
EHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEEECCCCEEHHHHHHHH
KAFLHSHTHSGNVLGAVVANAVLDIFEEENILTNVKDLEKQFSESFLELQEQLPIIKNVR
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
GIGAVIAADLNIDKKRAGLDVYREAIKLGALLRPLGNTIYWLPPFNSTYQEIDLLKQITK
CCCEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
QSIINAFK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]