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The map label for this gene is tyrP [H]

Identifier: 134301813

GI number: 134301813

Start: 765231

End: 766442

Strand: Reverse

Name: tyrP [H]

Synonym: FTW_0789

Alternate gene names: 134301813

Gene position: 766442-765231 (Counterclockwise)

Preceding gene: 134301814

Following gene: 134301812

Centisome position: 40.37

GC content: 31.27

Gene sequence:

>1212_bases
ATGAATAGTAATAGTAAAATAAAAATTTTAGGATCTATAATGATTATTGTCGGTACCATGATTGGCGGCGGCATATTAGC
TTTACCAATAATTACTGCTAAACTTGGCTTTGTTATAGGCTCCATTCTCATATTCGTAGTTTGGAGTATAATGACTTACA
CTGCTGTGGTTATATCAGATATCTCTTGCTCGATGCCTTATGGTAGTAGTTTCAAAACTATAGCAGAAAAGTATCTTGGT
AAGTCAGGTGGAGTTGTTGCAAGTATTGCTTTTTTGATATTAATGTATTTCATAAGTACTGCATATATCTCTGCAGCTGC
ATCTTCATTATCGACAACATTCCCAAGTCTTGATGAAAAACTATCATCTTTAATTTTTGTGATTATCTTTGGTAGCATCG
TAGTCTTAGGGACTAGATTTGTAGATTACGCTAATAGATTTTTTATAATACTTAAGATCTTAGTGTTAGTAATTTTATGT
GTGGTTTTTAACAGATATATTGATATTCCAAATCTTTTTGTAGCACCTGTTGACCTTGGAATATCACTAGTAATAGCTAT
ACCTGTTTTTACAACATCTTTTACCTCGCATATTATTGTACCAGCTTTATCTGACTATCTTGGTAAAAATTCTAAAGATA
TGAAGCGTATTGTTATAATAGGCAGTATTATTCCATTAATACTATATTTAGTATGGGTCGTAACTATACTAGGTGTACTA
CCACTACATGGTCCAGTAAGCTTTATGGATTCAATTTTTAATCATATCCCTGTAGATAAGGCTAATATAGGCGATATCCT
AAAAACGCTAGGTACTAAAGTAAGAACTCCAACAACAGATGCTGTATTACATATTTTTACTTATGTGGCGATTATGACAT
CATTCTTAAGCGTGAACTTATCGCTATTTCATTTTAATTTAGACACATATAAATTATACAAAACTAAAAAAGTTATAGGT
TACTCAATAGCAGCAGTACTAACCTTTGCTATACCTCTAATAATAAACCAAATGGATCCAGATATTTTTATTTACGCAAT
GACTTGTGTTGGTTTATCAATCGCCATTTTATTGATGATTATGCCGGCGCTTATGGCATTTAAGATAAATAACCTTGGTG
AAAATTTCAATTATAAGATATCCACGTATAAAAGTTTATGGCTAATTTCACTAGTTTCTGGTGTAATAGTTATATTATGT
GTTGTTGCTTAA

Upstream 100 bases:

>100_bases
GAGATAAAAACCTAAAACAGTTAGAACAAGATTATAAAGAAATATTAGCGCTAGATTTGAATGGCAATTATTTTTAAATG
AAACACTATAAAGTAGAGAG

Downstream 100 bases:

>100_bases
AACTTAAGTATGACTAATTTAGAGCATATCAATAATTTTCTTGACAACTTACTTTATCTTAAAAACTATTCTCAAGAAAC
TATTAATAACTATCAAAGGG

Product: aromatic amino acid transporter family protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNSNSKIKILGSIMIIVGTMIGGGILALPIITAKLGFVIGSILIFVVWSIMTYTAVVISDISCSMPYGSSFKTIAEKYLG
KSGGVVASIAFLILMYFISTAYISAAASSLSTTFPSLDEKLSSLIFVIIFGSIVVLGTRFVDYANRFFIILKILVLVILC
VVFNRYIDIPNLFVAPVDLGISLVIAIPVFTTSFTSHIIVPALSDYLGKNSKDMKRIVIIGSIIPLILYLVWVVTILGVL
PLHGPVSFMDSIFNHIPVDKANIGDILKTLGTKVRTPTTDAVLHIFTYVAIMTSFLSVNLSLFHFNLDTYKLYKTKKVIG
YSIAAVLTFAIPLIINQMDPDIFIYAMTCVGLSIAILLMIMPALMAFKINNLGENFNYKISTYKSLWLISLVSGVIVILC
VVA

Sequences:

>Translated_403_residues
MNSNSKIKILGSIMIIVGTMIGGGILALPIITAKLGFVIGSILIFVVWSIMTYTAVVISDISCSMPYGSSFKTIAEKYLG
KSGGVVASIAFLILMYFISTAYISAAASSLSTTFPSLDEKLSSLIFVIIFGSIVVLGTRFVDYANRFFIILKILVLVILC
VVFNRYIDIPNLFVAPVDLGISLVIAIPVFTTSFTSHIIVPALSDYLGKNSKDMKRIVIIGSIIPLILYLVWVVTILGVL
PLHGPVSFMDSIFNHIPVDKANIGDILKTLGTKVRTPTTDAVLHIFTYVAIMTSFLSVNLSLFHFNLDTYKLYKTKKVIG
YSIAAVLTFAIPLIINQMDPDIFIYAMTCVGLSIAILLMIMPALMAFKINNLGENFNYKISTYKSLWLISLVSGVIVILC
VVA
>Mature_403_residues
MNSNSKIKILGSIMIIVGTMIGGGILALPIITAKLGFVIGSILIFVVWSIMTYTAVVISDISCSMPYGSSFKTIAEKYLG
KSGGVVASIAFLILMYFISTAYISAAASSLSTTFPSLDEKLSSLIFVIIFGSIVVLGTRFVDYANRFFIILKILVLVILC
VVFNRYIDIPNLFVAPVDLGISLVIAIPVFTTSFTSHIIVPALSDYLGKNSKDMKRIVIIGSIIPLILYLVWVVTILGVL
PLHGPVSFMDSIFNHIPVDKANIGDILKTLGTKVRTPTTDAVLHIFTYVAIMTSFLSVNLSLFHFNLDTYKLYKTKKVIG
YSIAAVLTFAIPLIINQMDPDIFIYAMTCVGLSIAILLMIMPALMAFKINNLGENFNYKISTYKSLWLISLVSGVIVILC
VVA

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=398, Percent_Identity=31.6582914572864, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1790145, Length=410, Percent_Identity=27.0731707317073, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789552, Length=349, Percent_Identity=26.647564469914, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43966; Mature: 43966

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSNSKIKILGSIMIIVGTMIGGGILALPIITAKLGFVIGSILIFVVWSIMTYTAVVISD
CCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISCSMPYGSSFKTIAEKYLGKSGGVVASIAFLILMYFISTAYISAAASSLSTTFPSLDEK
CCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LSSLIFVIIFGSIVVLGTRFVDYANRFFIILKILVLVILCVVFNRYIDIPNLFVAPVDLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHH
ISLVIAIPVFTTSFTSHIIVPALSDYLGKNSKDMKRIVIIGSIIPLILYLVWVVTILGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLHGPVSFMDSIFNHIPVDKANIGDILKTLGTKVRTPTTDAVLHIFTYVAIMTSFLSVNL
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SLFHFNLDTYKLYKTKKVIGYSIAAVLTFAIPLIINQMDPDIFIYAMTCVGLSIAILLMI
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
MPALMAFKINNLGENFNYKISTYKSLWLISLVSGVIVILCVVA
HHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSNSKIKILGSIMIIVGTMIGGGILALPIITAKLGFVIGSILIFVVWSIMTYTAVVISD
CCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISCSMPYGSSFKTIAEKYLGKSGGVVASIAFLILMYFISTAYISAAASSLSTTFPSLDEK
CCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LSSLIFVIIFGSIVVLGTRFVDYANRFFIILKILVLVILCVVFNRYIDIPNLFVAPVDLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHH
ISLVIAIPVFTTSFTSHIIVPALSDYLGKNSKDMKRIVIIGSIIPLILYLVWVVTILGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLHGPVSFMDSIFNHIPVDKANIGDILKTLGTKVRTPTTDAVLHIFTYVAIMTSFLSVNL
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SLFHFNLDTYKLYKTKKVIGYSIAAVLTFAIPLIINQMDPDIFIYAMTCVGLSIAILLMI
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
MPALMAFKINNLGENFNYKISTYKSLWLISLVSGVIVILCVVA
HHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]