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The map label for this gene is tyrP [H]

Identifier: 134301806

GI number: 134301806

Start: 757609

End: 758805

Strand: Direct

Name: tyrP [H]

Synonym: FTW_0781

Alternate gene names: 134301806

Gene position: 757609-758805 (Clockwise)

Preceding gene: 134301804

Following gene: 134301807

Centisome position: 39.91

GC content: 32.83

Gene sequence:

>1197_bases
ATGAAACGAGTCTCAAAAGTTAAGCAAATTGGCGCTATAGCAATTATAGCTGGAACAGCTATTGGCGCAGGTATGCTTGG
GATTCCTTTTGCAGTAGCAGCAGTCGGGTTTAATTATGCAGTTGCGGCTTTATTTCTTGTTTGGATAATTATGTATGCAA
CTGCTTTATTGATTATCGAGGCGAATATTTCTCAGCCTTTAGGTACAGATATGGATTCTATTACACATAATATATTAGGC
AAGCCTGGTAGAGTATTGAATTTGTTATTTTATCTATTATTATTATATTCGTTACTTACGGCTTATATTTTTATGGGCGG
GCAACTTTTTCAAACATACATACTTTGTTGGTTAAATCTAGAGAATGCTAGCTTAGCAAAGTTACTATTCTGTTTGATAT
TTGGTTTTTTTATATATAAAGGTATCAAAGTAGTATTTAGTGTTAATGAATTATTTTTAAGTTTAAAAGTATTAGCTTTT
ATTTTATTTATTGCATTTGTTGCACCACAAATTAGCACTTCTTTACTAGAAAATAAAGTTTTAGGAGTAGAGTATGTTTG
GTTTGCTATTCCAATACTTGTCACATCATTTGGTTTTCATATTGTTATCCCAGCAATTAGGAACTACTTTGAGAATGATA
TTGTCTTCAAAAGAACAGTCGCTATTGGAGCACTAGCACCATTGCTTGTTTATTTGGTATGGGTTGTAGCTACGCTTGGA
ACTGTAAGTCTATATGGAAACAATGGCTTCATAGCGTTGAGTAAAGCAGGAGAGACTTTAGCCGAAGCGTACCAAGGTTT
AGGACAGAATGGTCCATTAGTTTTTATAAGACTTTTTGAGAACTTTGCAATTATTACATCTTTTTTGGGAGTTGCTTTAG
CTTTATTCTCTTTTAACAGAGATCTTTATGGTTTAGATATCAGGAAAAAATTACTGACTTTGGTGATAACATTATTACCA
CCGCTTATATTTGCGATATATTTTGTCAATAGTTTTATAGCTGCTCTAGGCTATGCTAGTATCTTTGTTTCAGTGTTACT
GATAGTGCAGCCTGCGATGATGGTTTGGGCTATAAGAACTAAACAGGGTAAAAATGATATTCTTAGTAAACTATATTTAT
CTTTGATATTATTTAGCGGTCTTGGTATTATTGCGTTGCAATTATTAGTAGCCTTTGGTAGATTACCTCATATATAA

Upstream 100 bases:

>100_bases
TTGACTTAATTTCCTATGTAATTAGAATAAGTGATTGGTTGATGTTTATTTACATTAAATTATTAAAATTGGTATAATTT
AGTGTTTTTAAGGTTAAATA

Downstream 100 bases:

>100_bases
TTTCATTAACTTTCAAATCCTTGATTATTTTCTATGAAGAAACCTAATTTTGATATTAATAAAAAATCTTTTCCTAATGA
TGATTTAGTAGGCGATGAGT

Product: putative tryptophan/tyrosine permease family protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKRVSKVKQIGAIAIIAGTAIGAGMLGIPFAVAAVGFNYAVAALFLVWIIMYATALLIIEANISQPLGTDMDSITHNILG
KPGRVLNLLFYLLLLYSLLTAYIFMGGQLFQTYILCWLNLENASLAKLLFCLIFGFFIYKGIKVVFSVNELFLSLKVLAF
ILFIAFVAPQISTSLLENKVLGVEYVWFAIPILVTSFGFHIVIPAIRNYFENDIVFKRTVAIGALAPLLVYLVWVVATLG
TVSLYGNNGFIALSKAGETLAEAYQGLGQNGPLVFIRLFENFAIITSFLGVALALFSFNRDLYGLDIRKKLLTLVITLLP
PLIFAIYFVNSFIAALGYASIFVSVLLIVQPAMMVWAIRTKQGKNDILSKLYLSLILFSGLGIIALQLLVAFGRLPHI

Sequences:

>Translated_398_residues
MKRVSKVKQIGAIAIIAGTAIGAGMLGIPFAVAAVGFNYAVAALFLVWIIMYATALLIIEANISQPLGTDMDSITHNILG
KPGRVLNLLFYLLLLYSLLTAYIFMGGQLFQTYILCWLNLENASLAKLLFCLIFGFFIYKGIKVVFSVNELFLSLKVLAF
ILFIAFVAPQISTSLLENKVLGVEYVWFAIPILVTSFGFHIVIPAIRNYFENDIVFKRTVAIGALAPLLVYLVWVVATLG
TVSLYGNNGFIALSKAGETLAEAYQGLGQNGPLVFIRLFENFAIITSFLGVALALFSFNRDLYGLDIRKKLLTLVITLLP
PLIFAIYFVNSFIAALGYASIFVSVLLIVQPAMMVWAIRTKQGKNDILSKLYLSLILFSGLGIIALQLLVAFGRLPHI
>Mature_398_residues
MKRVSKVKQIGAIAIIAGTAIGAGMLGIPFAVAAVGFNYAVAALFLVWIIMYATALLIIEANISQPLGTDMDSITHNILG
KPGRVLNLLFYLLLLYSLLTAYIFMGGQLFQTYILCWLNLENASLAKLLFCLIFGFFIYKGIKVVFSVNELFLSLKVLAF
ILFIAFVAPQISTSLLENKVLGVEYVWFAIPILVTSFGFHIVIPAIRNYFENDIVFKRTVAIGALAPLLVYLVWVVATLG
TVSLYGNNGFIALSKAGETLAEAYQGLGQNGPLVFIRLFENFAIITSFLGVALALFSFNRDLYGLDIRKKLLTLVITLLP
PLIFAIYFVNSFIAALGYASIFVSVLLIVQPAMMVWAIRTKQGKNDILSKLYLSLILFSGLGIIALQLLVAFGRLPHI

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=402, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1789552, Length=387, Percent_Identity=29.7157622739018, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1790145, Length=361, Percent_Identity=27.4238227146814, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43692; Mature: 43692

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVSKVKQIGAIAIIAGTAIGAGMLGIPFAVAAVGFNYAVAALFLVWIIMYATALLIIE
CCHHHHHHHHHHHHEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ANISQPLGTDMDSITHNILGKPGRVLNLLFYLLLLYSLLTAYIFMGGQLFQTYILCWLNL
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
ENASLAKLLFCLIFGFFIYKGIKVVFSVNELFLSLKVLAFILFIAFVAPQISTSLLENKV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LGVEYVWFAIPILVTSFGFHIVIPAIRNYFENDIVFKRTVAIGALAPLLVYLVWVVATLG
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TVSLYGNNGFIALSKAGETLAEAYQGLGQNGPLVFIRLFENFAIITSFLGVALALFSFNR
HEEEECCCCEEEEECCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCC
DLYGLDIRKKLLTLVITLLPPLIFAIYFVNSFIAALGYASIFVSVLLIVQPAMMVWAIRT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KQGKNDILSKLYLSLILFSGLGIIALQLLVAFGRLPHI
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKRVSKVKQIGAIAIIAGTAIGAGMLGIPFAVAAVGFNYAVAALFLVWIIMYATALLIIE
CCHHHHHHHHHHHHEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ANISQPLGTDMDSITHNILGKPGRVLNLLFYLLLLYSLLTAYIFMGGQLFQTYILCWLNL
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
ENASLAKLLFCLIFGFFIYKGIKVVFSVNELFLSLKVLAFILFIAFVAPQISTSLLENKV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LGVEYVWFAIPILVTSFGFHIVIPAIRNYFENDIVFKRTVAIGALAPLLVYLVWVVATLG
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TVSLYGNNGFIALSKAGETLAEAYQGLGQNGPLVFIRLFENFAIITSFLGVALALFSFNR
HEEEECCCCEEEEECCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCC
DLYGLDIRKKLLTLVITLLPPLIFAIYFVNSFIAALGYASIFVSVLLIVQPAMMVWAIRT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KQGKNDILSKLYLSLILFSGLGIIALQLLVAFGRLPHI
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]