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The map label for this gene is ubiB [H]

Identifier: 134301781

GI number: 134301781

Start: 724039

End: 725697

Strand: Reverse

Name: ubiB [H]

Synonym: FTW_0749

Alternate gene names: 134301781

Gene position: 725697-724039 (Counterclockwise)

Preceding gene: 134301782

Following gene: 134301780

Centisome position: 38.23

GC content: 33.57

Gene sequence:

>1659_bases
ATGATTAAAAAATTTCTAAGGCTTATCTACATTTTTTATGTTATAAATAAGTACTGTCTACTCAATGAACCTATCAGAGC
GACAAAAATAAAAACTCTAAGAGCCTTATTATTGCTAAATCCATTTTACTACTCTCGAAGAGTACGCAGACTTGAGCATG
GTGTGCGTATTAGAGAGGCTTTAGAAAAACTTGGACCTATTTTTATCAAATTCGGTCAAGCATTATCAGTTAGAGCCGAT
TTACTACCGCCAGATGTAATAAAAGAAGTTTCAAAACTTCAAGATAACGTTCCGCTATTTGATAATAAAATAGCGGCTGA
ACAAATTGAAAAAGCTGCGAAAAAACCTATCAATGAGATTTTTAAAAGCTTTGAAAGTTCTCCATTAGCTTCGGCATCTG
TAGCTCAAGTGCATGCTGCTATATTGCAAAATGATGATAAAGTAGTAGTCAAAGTATTACGTCCAGGCATAGAGAAAATT
CTTAAACTTGATACCTCTTTGATGCTATTTTTTGCAACTTTACTTAGTAAACTTAAAGAAATAAGAAGATTTAAGCCCGT
AGAGATTGTCAAAGAGATAAACCAAAGCTTTTTTGATGAGCTTGATCTAGTCCGTGAAGCATCAAATGCTTCTCAAATTC
GCAGAAATTTTGAAGACTCTGCCATACATTATGTACCAAAAATTTATTGGGAATATACTAGTTCTACTGTGATGGTGATG
GAAAGAGTTGGTGGTGTAAGAGTTTCAGACATAGAAACCCTAGATGCTTTAGGAGTTGATCGTCGTCTATTAGCACAGCG
CGGTGTAGAAATTTTTTATTCACAAGTATTTGATGACTGTTTTTTTCATGCTGATATGCATCCTGGTAATATGTTTATTG
ATGTATCAAATCCTGCTGATCCTAAATATATTTCAATAGACTTTGGTATCGTTGGCACTCTTAACCGCGATGATCAAAGG
TATCTAGCTGGTAATTTTCTAGCATTTTTCAAAAGAGATTATCGCAAGGTTGCAGAGCTTCATATAGAATCTGGCTGGGT
TCCAAGCGATACGCGTGTTGATGTACTTGAATCAGCAATTAGAACAGTTTGTGAGCCAATCTTTGAAAAACCTATGAAAG
AGATATCACTAGGGTACACATTGATGCAACTTTTTGCAGTAGCTCGTCGTTTTAATATGAATATTCAACCTCAACTCACA
CTTCTACAAAAAACTCTTTTTCATGTAGAGGGACTTGGACAAAAACTTTGCCCTGAATTAAATATTTGGGAAACATCCCG
ACCAATCCTAGAAAAGTGGATGAAGGAGCAAATGGGACTAAGAGGTTTCTACCATCGTTCAATGGAAAATATGCCTAGAG
TTAGTGATAAACTACCAGAATTACCACGTATGGTTTTTGATATATTACAACAAACACAAATCAATCTAAAAAATACTACT
ACATCTACACAATTTAATAACTTAAAAGAACCTAAGAAAAAATATCGATTTGCATTAGGCTGTGGACTAGTTTTGACAAC
TATTGGAGTAATATATACTTTGAATAAAGATACAACTCCTTTAATTAAACTACAAAACTTTATTAGTAATTATAGTACTA
GTTTTATAATTGTTGGAGTTGCATGCTTGATTTACTATAGTTTTAAAAAGGAGAAATAA

Upstream 100 bases:

>100_bases
TCTCAAAATGAGATTAATATCTTTTATCGCCAAGTTCAAGAGCTAAAGCAAGCTACTGATAGAATAGAAGCGAAGCTAAA
ATTATTAGAAGGCTTAAACA

Downstream 100 bases:

>100_bases
ACATTATGTCAGATTGTATTTTTTGCAAGATTATCACAGGCGAAATTCCATCTAAAAAAGTGTATGAAGATGAAAATATT
TTTGCTTTTCATGATATCAA

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MIKKFLRLIYIFYVINKYCLLNEPIRATKIKTLRALLLLNPFYYSRRVRRLEHGVRIREALEKLGPIFIKFGQALSVRAD
LLPPDVIKEVSKLQDNVPLFDNKIAAEQIEKAAKKPINEIFKSFESSPLASASVAQVHAAILQNDDKVVVKVLRPGIEKI
LKLDTSLMLFFATLLSKLKEIRRFKPVEIVKEINQSFFDELDLVREASNASQIRRNFEDSAIHYVPKIYWEYTSSTVMVM
ERVGGVRVSDIETLDALGVDRRLLAQRGVEIFYSQVFDDCFFHADMHPGNMFIDVSNPADPKYISIDFGIVGTLNRDDQR
YLAGNFLAFFKRDYRKVAELHIESGWVPSDTRVDVLESAIRTVCEPIFEKPMKEISLGYTLMQLFAVARRFNMNIQPQLT
LLQKTLFHVEGLGQKLCPELNIWETSRPILEKWMKEQMGLRGFYHRSMENMPRVSDKLPELPRMVFDILQQTQINLKNTT
TSTQFNNLKEPKKKYRFALGCGLVLTTIGVIYTLNKDTTPLIKLQNFISNYSTSFIIVGVACLIYYSFKKEK

Sequences:

>Translated_552_residues
MIKKFLRLIYIFYVINKYCLLNEPIRATKIKTLRALLLLNPFYYSRRVRRLEHGVRIREALEKLGPIFIKFGQALSVRAD
LLPPDVIKEVSKLQDNVPLFDNKIAAEQIEKAAKKPINEIFKSFESSPLASASVAQVHAAILQNDDKVVVKVLRPGIEKI
LKLDTSLMLFFATLLSKLKEIRRFKPVEIVKEINQSFFDELDLVREASNASQIRRNFEDSAIHYVPKIYWEYTSSTVMVM
ERVGGVRVSDIETLDALGVDRRLLAQRGVEIFYSQVFDDCFFHADMHPGNMFIDVSNPADPKYISIDFGIVGTLNRDDQR
YLAGNFLAFFKRDYRKVAELHIESGWVPSDTRVDVLESAIRTVCEPIFEKPMKEISLGYTLMQLFAVARRFNMNIQPQLT
LLQKTLFHVEGLGQKLCPELNIWETSRPILEKWMKEQMGLRGFYHRSMENMPRVSDKLPELPRMVFDILQQTQINLKNTT
TSTQFNNLKEPKKKYRFALGCGLVLTTIGVIYTLNKDTTPLIKLQNFISNYSTSFIIVGVACLIYYSFKKEK
>Mature_552_residues
MIKKFLRLIYIFYVINKYCLLNEPIRATKIKTLRALLLLNPFYYSRRVRRLEHGVRIREALEKLGPIFIKFGQALSVRAD
LLPPDVIKEVSKLQDNVPLFDNKIAAEQIEKAAKKPINEIFKSFESSPLASASVAQVHAAILQNDDKVVVKVLRPGIEKI
LKLDTSLMLFFATLLSKLKEIRRFKPVEIVKEINQSFFDELDLVREASNASQIRRNFEDSAIHYVPKIYWEYTSSTVMVM
ERVGGVRVSDIETLDALGVDRRLLAQRGVEIFYSQVFDDCFFHADMHPGNMFIDVSNPADPKYISIDFGIVGTLNRDDQR
YLAGNFLAFFKRDYRKVAELHIESGWVPSDTRVDVLESAIRTVCEPIFEKPMKEISLGYTLMQLFAVARRFNMNIQPQLT
LLQKTLFHVEGLGQKLCPELNIWETSRPILEKWMKEQMGLRGFYHRSMENMPRVSDKLPELPRMVFDILQQTQINLKNTT
TSTQFNNLKEPKKKYRFALGCGLVLTTIGVIYTLNKDTTPLIKLQNFISNYSTSFIIVGVACLIYYSFKKEK

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=274, Percent_Identity=26.6423357664234, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI41393593, Length=269, Percent_Identity=25.6505576208178, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI217035081, Length=228, Percent_Identity=26.3157894736842, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI32261307, Length=332, Percent_Identity=25, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI2367309, Length=506, Percent_Identity=48.4189723320158, Blast_Score=490, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17559152, Length=282, Percent_Identity=25.886524822695, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32565180, Length=277, Percent_Identity=26.7148014440433, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323282, Length=249, Percent_Identity=29.3172690763052, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325148, Length=444, Percent_Identity=23.1981981981982, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=201, Percent_Identity=28.3582089552239, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI22024280, Length=289, Percent_Identity=31.1418685121107, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24662575, Length=229, Percent_Identity=27.9475982532751, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63771; Mature: 63771

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA