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The map label for this gene is serA [H]

Identifier: 134301751

GI number: 134301751

Start: 696030

End: 697265

Strand: Reverse

Name: serA [H]

Synonym: FTW_0716

Alternate gene names: 134301751

Gene position: 697265-696030 (Counterclockwise)

Preceding gene: 134301752

Following gene: 134301750

Centisome position: 36.73

GC content: 33.9

Gene sequence:

>1236_bases
ATGAGCCAGCTATCTCTTAATAAAAAGAAAATCCCAATTCTTCTCTTAGAAGGTATACACTCAAATGCAGTTGAATCATT
CAAAGCTGCAGGATACGAAAATATCGAATTACTAAACACTGCGCTTGAAGGACAAGAACTAATAGATAAACTTAAAGATT
TTAAAATTGTCGGCTTACGCTCTCGTACACAACTTACAAAAGAAGTCCTAGAGCAATCTGATCACCTTATAGCTATTGGT
TGCTTTTGTATTGGTACTAATCAAGTAGATCTTAAAACTGCACAAAGCTTAGGTATACCTGTTTTTAATGCCCCATTTTC
AAATACTCGTAGTGTTGCTGAGCTTGTCTTAGCAGAAGCTATTTTACTGATACGTAATGTAATTGACAAAAATGCTAAAG
CTCACAGAGGTGAATGGCTTAAGTCAGCTGATAATGCTAATGAAGTAAGAGGTAAAACCTTAGGAATTGTTGGTTATGGT
CATATCGGTATGCAGCTTGGAGTTCTAGCAGAAAATATCGGTTTAAATGTGATATTTTATGATATCGAAGAGAAACTACC
TTTAGGTAATGCTTGTCAAGTTGATAGTTTAGCAACGCTATTACAACAATCTGATGTAGTTTCTCTACATGTACCACAGC
TGCCAACTACTGCAAATATGATATCAACCAAAGAATTCGCTCTTATGAAGCAAAATGCAGTGCTTATCAATGCTTCAAGA
GGTAATGTAATAGATATTGATGCTTTGGTTGATGCACTAACAAGCTCCAAGCTTAAAGGTGCGGCAATTGATGTTTTCCC
TAAAGAGCCATCATCAAAAGGTGAAATTTTTGAAAGTCCTTTAACAGGCCTTGATAATGTTTTTCTAACACTACACATAG
GTGGCAGTACTATAGAGGCACAAGAAAATATTGCTACAGAAGTAAGTGCAAAATTAATCAAATATTCAGACAATGGTTCA
ACATTAAATGCAGTAAACTTTCCTGAATTATCCTTACCTAGTCATAGAGAAACTCATCGAATCTTACATATTCATCAGAA
TATCCCAGGTATTATTAATGAGCTAAATAGAATTTTGGCGTCTAAAAATATCAATGTTGAAGGTCAATATTTAAGAACAT
TAGAAAATATTGGTTATGTTGTTATGGATATTAAATCAAGCTCAGATGAGGCTAAAGAACTTATTGATGAATTCAAAAAA
GTTAAAGCTACCATAAAAGCCCGTTATTTAGTATAA

Upstream 100 bases:

>100_bases
CAAACTCCATCTTTGATTATAAATACGAAGATTTTGAATTTGAGAACTATAACCATCACCCTGCCATCAAAGCAAAAATA
TCTGTATAAGGATGCCCAAA

Downstream 100 bases:

>100_bases
ATGTCTATAAGCAAATCTCTTGTTTTAAATGAAATAAAAAAATTCTCGCCTTCTCATATTATTATTGGTTATAGTGGTGG
CGTTGACTCAAGTGTTTTAC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSQLSLNKKKIPILLLEGIHSNAVESFKAAGYENIELLNTALEGQELIDKLKDFKIVGLRSRTQLTKEVLEQSDHLIAIG
CFCIGTNQVDLKTAQSLGIPVFNAPFSNTRSVAELVLAEAILLIRNVIDKNAKAHRGEWLKSADNANEVRGKTLGIVGYG
HIGMQLGVLAENIGLNVIFYDIEEKLPLGNACQVDSLATLLQQSDVVSLHVPQLPTTANMISTKEFALMKQNAVLINASR
GNVIDIDALVDALTSSKLKGAAIDVFPKEPSSKGEIFESPLTGLDNVFLTLHIGGSTIEAQENIATEVSAKLIKYSDNGS
TLNAVNFPELSLPSHRETHRILHIHQNIPGIINELNRILASKNINVEGQYLRTLENIGYVVMDIKSSSDEAKELIDEFKK
VKATIKARYLV

Sequences:

>Translated_411_residues
MSQLSLNKKKIPILLLEGIHSNAVESFKAAGYENIELLNTALEGQELIDKLKDFKIVGLRSRTQLTKEVLEQSDHLIAIG
CFCIGTNQVDLKTAQSLGIPVFNAPFSNTRSVAELVLAEAILLIRNVIDKNAKAHRGEWLKSADNANEVRGKTLGIVGYG
HIGMQLGVLAENIGLNVIFYDIEEKLPLGNACQVDSLATLLQQSDVVSLHVPQLPTTANMISTKEFALMKQNAVLINASR
GNVIDIDALVDALTSSKLKGAAIDVFPKEPSSKGEIFESPLTGLDNVFLTLHIGGSTIEAQENIATEVSAKLIKYSDNGS
TLNAVNFPELSLPSHRETHRILHIHQNIPGIINELNRILASKNINVEGQYLRTLENIGYVVMDIKSSSDEAKELIDEFKK
VKATIKARYLV
>Mature_410_residues
SQLSLNKKKIPILLLEGIHSNAVESFKAAGYENIELLNTALEGQELIDKLKDFKIVGLRSRTQLTKEVLEQSDHLIAIGC
FCIGTNQVDLKTAQSLGIPVFNAPFSNTRSVAELVLAEAILLIRNVIDKNAKAHRGEWLKSADNANEVRGKTLGIVGYGH
IGMQLGVLAENIGLNVIFYDIEEKLPLGNACQVDSLATLLQQSDVVSLHVPQLPTTANMISTKEFALMKQNAVLINASRG
NVIDIDALVDALTSSKLKGAAIDVFPKEPSSKGEIFESPLTGLDNVFLTLHIGGSTIEAQENIATEVSAKLIKYSDNGST
LNAVNFPELSLPSHRETHRILHIHQNIPGIINELNRILASKNINVEGQYLRTLENIGYVVMDIKSSSDEAKELIDEFKKV
KATIKARYLV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=304, Percent_Identity=31.25, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4557497, Length=309, Percent_Identity=31.0679611650485, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI61743967, Length=309, Percent_Identity=31.0679611650485, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI145580578, Length=282, Percent_Identity=31.9148936170213, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4557499, Length=282, Percent_Identity=31.9148936170213, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI145580575, Length=282, Percent_Identity=31.9148936170213, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI6912396, Length=238, Percent_Identity=27.3109243697479, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1789279, Length=410, Percent_Identity=59.0243902439024, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI87082289, Length=279, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1787645, Length=239, Percent_Identity=27.1966527196653, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788660, Length=281, Percent_Identity=26.3345195729537, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=321, Percent_Identity=31.1526479750779, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=291, Percent_Identity=28.8659793814433, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322116, Length=411, Percent_Identity=47.6885644768856, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6320925, Length=411, Percent_Identity=47.6885644768856, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324964, Length=315, Percent_Identity=28.8888888888889, Blast_Score=103, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=236, Percent_Identity=27.1186440677966, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=202, Percent_Identity=29.2079207920792, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921140, Length=330, Percent_Identity=30, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24646446, Length=265, Percent_Identity=32.8301886792453, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24646448, Length=265, Percent_Identity=32.8301886792453, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24646452, Length=265, Percent_Identity=32.8301886792453, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24646450, Length=265, Percent_Identity=32.8301886792453, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=32.8301886792453, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574286, Length=281, Percent_Identity=28.8256227758007, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585514, Length=286, Percent_Identity=26.5734265734266, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574282, Length=286, Percent_Identity=26.5734265734266, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574284, Length=286, Percent_Identity=26.5734265734266, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45552429, Length=286, Percent_Identity=26.5734265734266, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45551003, Length=286, Percent_Identity=26.5734265734266, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28571528, Length=250, Percent_Identity=28.4, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585516, Length=287, Percent_Identity=23.6933797909408, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44919; Mature: 44788

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLSLNKKKIPILLLEGIHSNAVESFKAAGYENIELLNTALEGQELIDKLKDFKIVGLR
CCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHCCEEEECC
SRTQLTKEVLEQSDHLIAIGCFCIGTNQVDLKTAQSLGIPVFNAPFSNTRSVAELVLAEA
HHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
ILLIRNVIDKNAKAHRGEWLKSADNANEVRGKTLGIVGYGHIGMQLGVLAENIGLNVIFY
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEEECHHHHHHHHHHHCCCCEEEEE
DIEEKLPLGNACQVDSLATLLQQSDVVSLHVPQLPTTANMISTKEFALMKQNAVLINASR
ECCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHEECCEEEEECCC
GNVIDIDALVDALTSSKLKGAAIDVFPKEPSSKGEIFESPLTGLDNVFLTLHIGGSTIEA
CCEEEHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHCCCCCCCCEEEEEEECCCEEEH
QENIATEVSAKLIKYSDNGSTLNAVNFPELSLPSHRETHRILHIHQNIPGIINELNRILA
HHHHHHHHHHEEEEECCCCCEEEECCCCCCCCCCCCCCHHEEEEECCCCHHHHHHHHHHH
SKNINVEGQYLRTLENIGYVVMDIKSSSDEAKELIDEFKKVKATIKARYLV
HCCCCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
SQLSLNKKKIPILLLEGIHSNAVESFKAAGYENIELLNTALEGQELIDKLKDFKIVGLR
CCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHCCEEEECC
SRTQLTKEVLEQSDHLIAIGCFCIGTNQVDLKTAQSLGIPVFNAPFSNTRSVAELVLAEA
HHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
ILLIRNVIDKNAKAHRGEWLKSADNANEVRGKTLGIVGYGHIGMQLGVLAENIGLNVIFY
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEEECHHHHHHHHHHHCCCCEEEEE
DIEEKLPLGNACQVDSLATLLQQSDVVSLHVPQLPTTANMISTKEFALMKQNAVLINASR
ECCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHEECCEEEEECCC
GNVIDIDALVDALTSSKLKGAAIDVFPKEPSSKGEIFESPLTGLDNVFLTLHIGGSTIEA
CCEEEHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHCCCCCCCCEEEEEEECCCEEEH
QENIATEVSAKLIKYSDNGSTLNAVNFPELSLPSHRETHRILHIHQNIPGIINELNRILA
HHHHHHHHHHEEEEECCCCCEEEECCCCCCCCCCCCCCHHEEEEECCCCHHHHHHHHHHH
SKNINVEGQYLRTLENIGYVVMDIKSSSDEAKELIDEFKKVKATIKARYLV
HCCCCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]