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The map label for this gene is cbh [H]

Identifier: 134301748

GI number: 134301748

Start: 691299

End: 692396

Strand: Reverse

Name: cbh [H]

Synonym: FTW_0710

Alternate gene names: 134301748

Gene position: 692396-691299 (Counterclockwise)

Preceding gene: 134301750

Following gene: 134301746

Centisome position: 36.47

GC content: 31.6

Gene sequence:

>1098_bases
ATGCTAATTTCACAGTCACTTGCATGCACTGCTCTGACATTAGTTAAAAATGGTCAAACCGTTTCTGGTAGAACTATGGA
GTGGGGATTTAATTGGAGCTGGCAACTCATTTATATACCCAAAGGAACAAAACACTATCTAAGTGCACCAAGTAATTTAA
ACTTAGCTAAAATTAGCTATGCCTCTAAATACTCAATAATTGCTACTGGGCTTGTCAATGCTAATCAAGAATTTTTAGTT
GATGGCCAGAATGATCAAGGTCTTAGTATTAGTGCAAACTATATGCCAGGATTTGCCGAATATCAAAAAGTAACCAATAC
AGATAAAAAATATGCCTCTATAAATCAAATTAGTATATTAATCTTAAGCGAGTATGCCAATGTAGAGCAAGTCAAACAAG
CTCTACAACAATACAAAGTCTGGTCAGATAAAAGTACTATGATTAATGGAGTTGCGCCACAATTACACTTTTTAATTACT
GATAGAAATGGTAAAGGGCTAGTTGTTGAATATATAAAAGGAGAAGTAAAATTATATGATGTCAATTCAAATGTCAAAGT
AATGACAAATGCTCCTACTTATGATTGGCATCTTATAAACTTGCGAAATTACTTAAATTTAAGTAATCAAACAACAACTA
GAGTGAAAATAAGTGATGCTATAGATCCTTCACAAAACAAAGATATCCAAGATATAAACTCACTTGGTCAGGGTAATGGC
TTTTTAGGCTTACCTGGAGACTATTCGCCACCATCAAGATTTATTAAAACGGCAATACTTGGATATTATGCTAATAATAA
AGGTGATAATAATGAAAATCTTGTCACTAAAGTTACCCATATCCTTAATAACGTTGATATAACTAAGGGAACAGTTACTG
AAAAGCTTGGAAATCAGACAATGTTTGATCATACTGCATTTACAGTAATAAAAGACCTTAACAATAATAAGCTTTATATT
AAAAGCTATAATTCCCCTAATAATGCTATGGAAATTGATTTAAATACATTAGATCAAAATAATTCTAAGCAGTTTGCTAT
CGATATAGACAAGTTACCTTATCCAAATAATAATATATCGGCTAATCTTATCACCTAG

Upstream 100 bases:

>100_bases
AAACTATATTAGTATAGAGATAGTTCATATTACTAATATTAAAGGATAGAAGCATGAAAACTATAATAAAAAAATTTTTG
TCTGTTGTCGCGCTTTATTG

Downstream 100 bases:

>100_bases
TTAAGATCTTTTTTTAGCTAAAAGTCTATCGTAAACTTGTTGAATCCCTTCAGCTTCATTTTGAATCTTATATTTAGTAG
TTACCAAATCATAACCATTT

Product: choloylglycine hydrolase family protein

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MLISQSLACTALTLVKNGQTVSGRTMEWGFNWSWQLIYIPKGTKHYLSAPSNLNLAKISYASKYSIIATGLVNANQEFLV
DGQNDQGLSISANYMPGFAEYQKVTNTDKKYASINQISILILSEYANVEQVKQALQQYKVWSDKSTMINGVAPQLHFLIT
DRNGKGLVVEYIKGEVKLYDVNSNVKVMTNAPTYDWHLINLRNYLNLSNQTTTRVKISDAIDPSQNKDIQDINSLGQGNG
FLGLPGDYSPPSRFIKTAILGYYANNKGDNNENLVTKVTHILNNVDITKGTVTEKLGNQTMFDHTAFTVIKDLNNNKLYI
KSYNSPNNAMEIDLNTLDQNNSKQFAIDIDKLPYPNNNISANLIT

Sequences:

>Translated_365_residues
MLISQSLACTALTLVKNGQTVSGRTMEWGFNWSWQLIYIPKGTKHYLSAPSNLNLAKISYASKYSIIATGLVNANQEFLV
DGQNDQGLSISANYMPGFAEYQKVTNTDKKYASINQISILILSEYANVEQVKQALQQYKVWSDKSTMINGVAPQLHFLIT
DRNGKGLVVEYIKGEVKLYDVNSNVKVMTNAPTYDWHLINLRNYLNLSNQTTTRVKISDAIDPSQNKDIQDINSLGQGNG
FLGLPGDYSPPSRFIKTAILGYYANNKGDNNENLVTKVTHILNNVDITKGTVTEKLGNQTMFDHTAFTVIKDLNNNKLYI
KSYNSPNNAMEIDLNTLDQNNSKQFAIDIDKLPYPNNNISANLIT
>Mature_365_residues
MLISQSLACTALTLVKNGQTVSGRTMEWGFNWSWQLIYIPKGTKHYLSAPSNLNLAKISYASKYSIIATGLVNANQEFLV
DGQNDQGLSISANYMPGFAEYQKVTNTDKKYASINQISILILSEYANVEQVKQALQQYKVWSDKSTMINGVAPQLHFLIT
DRNGKGLVVEYIKGEVKLYDVNSNVKVMTNAPTYDWHLINLRNYLNLSNQTTTRVKISDAIDPSQNKDIQDINSLGQGNG
FLGLPGDYSPPSRFIKTAILGYYANNKGDNNENLVTKVTHILNNVDITKGTVTEKLGNQTMFDHTAFTVIKDLNNNKLYI
KSYNSPNNAMEIDLNTLDQNNSKQFAIDIDKLPYPNNNISANLIT

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 40773; Mature: 40773

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLISQSLACTALTLVKNGQTVSGRTMEWGFNWSWQLIYIPKGTKHYLSAPSNLNLAKISY
CCCCCCHHHEEEEEEECCCEECCCEEEECCCEEEEEEEECCCCHHEECCCCCCCEEEEEC
ASKYSIIATGLVNANQEFLVDGQNDQGLSISANYMPGFAEYQKVTNTDKKYASINQISIL
CCCEEEEEEEEECCCCEEEEECCCCCCEEEEECCCCCHHHHHHHCCCCHHHEECCEEEEE
ILSEYANVEQVKQALQQYKVWSDKSTMINGVAPQLHFLITDRNGKGLVVEYIKGEVKLYD
EEECCCCHHHHHHHHHHHCCCCCCCCEECCCCCEEEEEEECCCCCEEEEEEECCEEEEEE
VNSNVKVMTNAPTYDWHLINLRNYLNLSNQTTTRVKISDAIDPSQNKDIQDINSLGQGNG
ECCCEEEEECCCCCEEEEEEEHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCC
FLGLPGDYSPPSRFIKTAILGYYANNKGDNNENLVTKVTHILNNVDITKGTVTEKLGNQT
EEECCCCCCCHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCE
MFDHTAFTVIKDLNNNKLYIKSYNSPNNAMEIDLNTLDQNNSKQFAIDIDKLPYPNNNIS
EEHHHEEEEEEECCCCEEEEEECCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCEE
ANLIT
EEEEC
>Mature Secondary Structure
MLISQSLACTALTLVKNGQTVSGRTMEWGFNWSWQLIYIPKGTKHYLSAPSNLNLAKISY
CCCCCCHHHEEEEEEECCCEECCCEEEECCCEEEEEEEECCCCHHEECCCCCCCEEEEEC
ASKYSIIATGLVNANQEFLVDGQNDQGLSISANYMPGFAEYQKVTNTDKKYASINQISIL
CCCEEEEEEEEECCCCEEEEECCCCCCEEEEECCCCCHHHHHHHCCCCHHHEECCEEEEE
ILSEYANVEQVKQALQQYKVWSDKSTMINGVAPQLHFLITDRNGKGLVVEYIKGEVKLYD
EEECCCCHHHHHHHHHHHCCCCCCCCEECCCCCEEEEEEECCCCCEEEEEEECCEEEEEE
VNSNVKVMTNAPTYDWHLINLRNYLNLSNQTTTRVKISDAIDPSQNKDIQDINSLGQGNG
ECCCEEEEECCCCCEEEEEEEHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCC
FLGLPGDYSPPSRFIKTAILGYYANNKGDNNENLVTKVTHILNNVDITKGTVTEKLGNQT
EEECCCCCCCHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCE
MFDHTAFTVIKDLNNNKLYIKSYNSPNNAMEIDLNTLDQNNSKQFAIDIDKLPYPNNNIS
EEHHHEEEEEEECCCCEEEEEECCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCEE
ANLIT
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]