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The map label for this gene is gmk [H]

Identifier: 134301687

GI number: 134301687

Start: 620405

End: 620977

Strand: Direct

Name: gmk [H]

Synonym: FTW_0628

Alternate gene names: 134301687

Gene position: 620405-620977 (Clockwise)

Preceding gene: 134301686

Following gene: 134301688

Centisome position: 32.68

GC content: 34.55

Gene sequence:

>573_bases
ATGAATAACTATATTTTTATAGTTTCTGCACCATCTGGCGCGGGTAAAAGTTCTTTACTAAAAGCTTTTTTAGCAACTGA
CATAGGCAAGGATAACTACGCTGTAGCAATCTCCCACACTACTAGAGAGCCACGTGTTGGCGAGATCAATAGTAGAGAAT
ATTATTTTGTCACAGTAGCTGAATTTGAACAATTACTTAGTCAAGATGGCTTTATTGAATATGCTAAAGTTTTCAAAAAC
TATTATGGTACATCTAAAGCTGAGCTTGATAGATTGCTTGCATTAGGTAAGAATATTATCCTTGAGATTGACTGGCAAGG
TGCACAACAAACACGCGCTATTTATGGCGATAGGGCTAAGAGTATATTTATATTACCGCCTTCTTTAGATGAGTTAAGAA
AACGTCTAGAAAAAAGAAATACAGATTCTAAGGAGACTATAGATTATCGTATGGAGCAAGCACAATCAGAGATTTCACAT
GCTGATGAATATGATTATCTGCTGGTTAACGATGATTTTAGCCAGTCATTAGAACAATTATGTAAATATTTCGAACAAAA
TATCCAAAGTTAA

Upstream 100 bases:

>100_bases
TAATAAATTACAAATAATTAATTTTCAAACACATTATTCTATTTATAGTTTTAAAACTGTATAATTAGTCGAACTAGCTA
TTTGATTACGATTTCTACAA

Downstream 100 bases:

>100_bases
AGGCTAAGGAGAACATTTGGATGTTAAACAAAAAACTTATAAAAGATAAGATATCACAAGCTAGACAAGAATTACCTAGT
TTGAAAATTAAAGATACTGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MNNYIFIVSAPSGAGKSSLLKAFLATDIGKDNYAVAISHTTREPRVGEINSREYYFVTVAEFEQLLSQDGFIEYAKVFKN
YYGTSKAELDRLLALGKNIILEIDWQGAQQTRAIYGDRAKSIFILPPSLDELRKRLEKRNTDSKETIDYRMEQAQSEISH
ADEYDYLLVNDDFSQSLEQLCKYFEQNIQS

Sequences:

>Translated_190_residues
MNNYIFIVSAPSGAGKSSLLKAFLATDIGKDNYAVAISHTTREPRVGEINSREYYFVTVAEFEQLLSQDGFIEYAKVFKN
YYGTSKAELDRLLALGKNIILEIDWQGAQQTRAIYGDRAKSIFILPPSLDELRKRLEKRNTDSKETIDYRMEQAQSEISH
ADEYDYLLVNDDFSQSLEQLCKYFEQNIQS
>Mature_190_residues
MNNYIFIVSAPSGAGKSSLLKAFLATDIGKDNYAVAISHTTREPRVGEINSREYYFVTVAEFEQLLSQDGFIEYAKVFKN
YYGTSKAELDRLLALGKNIILEIDWQGAQQTRAIYGDRAKSIFILPPSLDELRKRLEKRNTDSKETIDYRMEQAQSEISH
ADEYDYLLVNDDFSQSLEQLCKYFEQNIQS

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=187, Percent_Identity=35.8288770053476, Blast_Score=123, Evalue=9e-29,
Organism=Homo sapiens, GI226874833, Length=187, Percent_Identity=35.8288770053476, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI4504221, Length=187, Percent_Identity=35.8288770053476, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI38570142, Length=181, Percent_Identity=28.7292817679558, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI14780902, Length=186, Percent_Identity=25.2688172043011, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI111154074, Length=168, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=176, Percent_Identity=53.9772727272727, Blast_Score=191, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193203132, Length=188, Percent_Identity=29.7872340425532, Blast_Score=105, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=188, Percent_Identity=29.7872340425532, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71984092, Length=148, Percent_Identity=26.3513513513513, Blast_Score=63, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=176, Percent_Identity=40.9090909090909, Blast_Score=151, Evalue=7e-38,
Organism=Drosophila melanogaster, GI21356141, Length=170, Percent_Identity=38.2352941176471, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24640542, Length=177, Percent_Identity=27.1186440677966, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116007136, Length=177, Percent_Identity=27.1186440677966, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45554481, Length=177, Percent_Identity=27.1186440677966, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI85724806, Length=177, Percent_Identity=27.1186440677966, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45554489, Length=177, Percent_Identity=27.1186440677966, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161077626, Length=177, Percent_Identity=27.1186440677966, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21824; Mature: 21824

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNYIFIVSAPSGAGKSSLLKAFLATDIGKDNYAVAISHTTREPRVGEINSREYYFVTVA
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEHH
EFEQLLSQDGFIEYAKVFKNYYGTSKAELDRLLALGKNIILEIDWQGAQQTRAIYGDRAK
HHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCC
SIFILPPSLDELRKRLEKRNTDSKETIDYRMEQAQSEISHADEYDYLLVNDDFSQSLEQL
EEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
CKYFEQNIQS
HHHHHHHCCC
>Mature Secondary Structure
MNNYIFIVSAPSGAGKSSLLKAFLATDIGKDNYAVAISHTTREPRVGEINSREYYFVTVA
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEHH
EFEQLLSQDGFIEYAKVFKNYYGTSKAELDRLLALGKNIILEIDWQGAQQTRAIYGDRAK
HHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCC
SIFILPPSLDELRKRLEKRNTDSKETIDYRMEQAQSEISHADEYDYLLVNDDFSQSLEQL
EEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
CKYFEQNIQS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA