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The map label for this gene is blh [H]

Identifier: 134301531

GI number: 134301531

Start: 451998

End: 452684

Strand: Direct

Name: blh [H]

Synonym: FTW_0460

Alternate gene names: 134301531

Gene position: 451998-452684 (Clockwise)

Preceding gene: 134301530

Following gene: 134301532

Centisome position: 23.81

GC content: 35.81

Gene sequence:

>687_bases
ATGATTTTCAGGCAATTAATCGATAGAGATACTTATACTTATACTTATATTCTAGCTTGTGAGCGGACTAGACAAGCAGT
GATAATAGATTCGGTAAGATTTAATGTTAATCAGTATCTAAAGTTACTCAAAGAACTAGATCTTAAACTGATCTACGCCA
TAGACACTCATGTCCATGCTGATCATGTCACTGCAGCAGGGATTTTAAGGAAAGAAACTGGTTGTGATATCGTTATCGGT
GGCGAAAGCAAAGCTGAATGTGCAACCAAAAAAGTCTTTGATGGCGATATCCTAGAGTTTGGTAACTATCAACTAAAAGC
TTTGTATACCCCAGGTCATACAGATGACTCATATTGTTTCATTACTGAGAATATGCTTTTCACAGGTGATACTCTATTAA
TAAGAGGATCCGGTAGAACTGACTTCCAAAATGGTGATTCATATGCAGCATATGATAGTATTATGAATAAGCTAATGACT
TTGCCGGGTAGTACTATTATTTATCCTGGTCATGACTATAATGGTATAACTAGTAGTAGTGTCGCTGAAGAGAGACAAAA
CAATCCAAGATTGAAGGTTAAGTCACCAGATGAATACGCTAAGTTAATGGCTGATTTAAAGTTACCACCGCCAAACTATA
TAGATATCGCAGTTCCAGCAAATTTAAAATGTGGTATAGAAGAATAA

Upstream 100 bases:

>100_bases
ATTATTATGATACTATTGCACATATGACAGGCAAAAAAATTTCCTTTACTAGATAAAGGAATGTTTTAAATAATGTGATG
TTTTGCATCTAAGGAGAATT

Downstream 100 bases:

>100_bases
AATGTTTTTGATAATTTTTGGCTTTATCTGTGGAATTGCATTAGGGTTGACAGGTGGGGGCGGCTCTATTTTGGCAGTTT
CTTTGCTTACTTATGGTGTT

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MIFRQLIDRDTYTYTYILACERTRQAVIIDSVRFNVNQYLKLLKELDLKLIYAIDTHVHADHVTAAGILRKETGCDIVIG
GESKAECATKKVFDGDILEFGNYQLKALYTPGHTDDSYCFITENMLFTGDTLLIRGSGRTDFQNGDSYAAYDSIMNKLMT
LPGSTIIYPGHDYNGITSSSVAEERQNNPRLKVKSPDEYAKLMADLKLPPPNYIDIAVPANLKCGIEE

Sequences:

>Translated_228_residues
MIFRQLIDRDTYTYTYILACERTRQAVIIDSVRFNVNQYLKLLKELDLKLIYAIDTHVHADHVTAAGILRKETGCDIVIG
GESKAECATKKVFDGDILEFGNYQLKALYTPGHTDDSYCFITENMLFTGDTLLIRGSGRTDFQNGDSYAAYDSIMNKLMT
LPGSTIIYPGHDYNGITSSSVAEERQNNPRLKVKSPDEYAKLMADLKLPPPNYIDIAVPANLKCGIEE
>Mature_228_residues
MIFRQLIDRDTYTYTYILACERTRQAVIIDSVRFNVNQYLKLLKELDLKLIYAIDTHVHADHVTAAGILRKETGCDIVIG
GESKAECATKKVFDGDILEFGNYQLKALYTPGHTDDSYCFITENMLFTGDTLLIRGSGRTDFQNGDSYAAYDSIMNKLMT
LPGSTIIYPGHDYNGITSSSVAEERQNNPRLKVKSPDEYAKLMADLKLPPPNYIDIAVPANLKCGIEE

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=230, Percent_Identity=46.0869565217391, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI94538320, Length=172, Percent_Identity=28.4883720930233, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI94538322, Length=172, Percent_Identity=28.4883720930233, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1787158, Length=206, Percent_Identity=31.0679611650485, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17538952, Length=227, Percent_Identity=44.4933920704846, Blast_Score=192, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17536925, Length=244, Percent_Identity=27.8688524590164, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324614, Length=175, Percent_Identity=33.7142857142857, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI221330176, Length=228, Percent_Identity=46.9298245614035, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24667703, Length=169, Percent_Identity=33.1360946745562, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24667711, Length=169, Percent_Identity=33.1360946745562, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21356335, Length=169, Percent_Identity=33.1360946745562, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 25594; Mature: 25594

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFRQLIDRDTYTYTYILACERTRQAVIIDSVRFNVNQYLKLLKELDLKLIYAIDTHVHA
CHHHHHHCCCCEEEEEEEEECCCCCEEEEEEEEECHHHHHHHHHHCCEEEEEEEECCCCC
DHVTAAGILRKETGCDIVIGGESKAECATKKVFDGDILEFGNYQLKALYTPGHTDDSYCF
CHHHHHHHEECCCCCEEEECCCCCHHHHHHHCCCCCEEECCCEEEEEEECCCCCCCCEEE
ITENMLFTGDTLLIRGSGRTDFQNGDSYAAYDSIMNKLMTLPGSTIIYPGHDYNGITSSS
EECCEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHH
VAEERQNNPRLKVKSPDEYAKLMADLKLPPPNYIDIAVPANLKCGIEE
HHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MIFRQLIDRDTYTYTYILACERTRQAVIIDSVRFNVNQYLKLLKELDLKLIYAIDTHVHA
CHHHHHHCCCCEEEEEEEEECCCCCEEEEEEEEECHHHHHHHHHHCCEEEEEEEECCCCC
DHVTAAGILRKETGCDIVIGGESKAECATKKVFDGDILEFGNYQLKALYTPGHTDDSYCF
CHHHHHHHEECCCCCEEEECCCCCHHHHHHHCCCCCEEECCCEEEEEEECCCCCCCCEEE
ITENMLFTGDTLLIRGSGRTDFQNGDSYAAYDSIMNKLMTLPGSTIIYPGHDYNGITSSS
EECCEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHH
VAEERQNNPRLKVKSPDEYAKLMADLKLPPPNYIDIAVPANLKCGIEE
HHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]