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The map label for this gene is gppA [H]

Identifier: 134301523

GI number: 134301523

Start: 441278

End: 442204

Strand: Reverse

Name: gppA [H]

Synonym: FTW_0449

Alternate gene names: 134301523

Gene position: 442204-441278 (Counterclockwise)

Preceding gene: 134301526

Following gene: 134301522

Centisome position: 23.29

GC content: 34.63

Gene sequence:

>927_bases
ATGTCAAAGATAGTAGCAACAGTAGATTTAGGTTCAAATAGTTTTCATATGCTTATAAGCGAAATCAAGCCTGATGGTGA
GGTTGTTACATTGTCTAAGCAGAAGCATAAAGTGCAACTAAGGGCTGGTCTTAATAATAATCTGACAATTAGTAAGGATG
CTCAAGAAAGAGCCATCGAATGTCTGGAGTTTTTTGCACAGGAAATCCAAAAATATAAAGTTGAGTATGTCCGTGCTGTA
GGCACATACACTCTTAGGAAAGCAAAAAATAATATAAAAGGTTTTAAAAAGAAGCTAGATAAAGCTCTTGGTACTAAGAT
TAAAATTATTTCCGGATTGGAGGAAGCAAGGCTTGTCTATGTTGGAGCTAGAGACAATCATGATATCAAGCAAAAAACAT
TAGTCATAGATATCGGTGGAGGCTCAACAGAATTTGTAATTGGTAGAGGCAATAAAATATTAATTGCGCGTAGTTTAGAT
ATGGGTTGTGTCGGAATGCAGAAGGATTTTTTTGCAAATGAAAAGCTTGATTTTGCTAATTTTCATGCAGCAGCGGCTAA
AGCTAGAGAGATAATTGCCCCAATCTTATATAGATATAAAAGAATAGGCTGGAGTACTGTGCTTGGTTCTTCTGGGACCA
TTATTTCAGTTACAAATATTTGTCAAAAACTCACGGGTAATTCTGTTATTACTAAAGATTTTTTAAATGATTTAATTACT
ATGATGATGGACAAACGTGAAGTTGAGCATATTTGTTTTGAAGGTCTTAGAGAAGATCGTGAGAGTGTCCTTGCTGGTGG
GGTTGTTATTTTGTATGCGATATTTGATTGTCTTGGAATTTCTGAGATGAGATTATCAAATGGTGCTGTACGTGAAGGTA
TGCTCTATGAGCTTGTTAAAAGTAAGTATAAGATTATTATTAATTAG

Upstream 100 bases:

>100_bases
AGTTATTATAAACAAAAAAACTTCTTAGACAAATTTTTTTAGCTATTTTACAGATATTTTTTTATAATGGGGGTAGTTAA
GGAATAAGCTTTTGTTTTAT

Downstream 100 bases:

>100_bases
AAAATCATGGACTAGGTATAAGGTTTATGTTAATAGTTTCGCAACTGGCTTTGCCAGTTATTGCGACATACTTTTTTCAT
AGCAGAAAAAGTATGCAAAA

Product: exopolyphosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSKIVATVDLGSNSFHMLISEIKPDGEVVTLSKQKHKVQLRAGLNNNLTISKDAQERAIECLEFFAQEIQKYKVEYVRAV
GTYTLRKAKNNIKGFKKKLDKALGTKIKIISGLEEARLVYVGARDNHDIKQKTLVIDIGGGSTEFVIGRGNKILIARSLD
MGCVGMQKDFFANEKLDFANFHAAAAKAREIIAPILYRYKRIGWSTVLGSSGTIISVTNICQKLTGNSVITKDFLNDLIT
MMMDKREVEHICFEGLREDRESVLAGGVVILYAIFDCLGISEMRLSNGAVREGMLYELVKSKYKIIIN

Sequences:

>Translated_308_residues
MSKIVATVDLGSNSFHMLISEIKPDGEVVTLSKQKHKVQLRAGLNNNLTISKDAQERAIECLEFFAQEIQKYKVEYVRAV
GTYTLRKAKNNIKGFKKKLDKALGTKIKIISGLEEARLVYVGARDNHDIKQKTLVIDIGGGSTEFVIGRGNKILIARSLD
MGCVGMQKDFFANEKLDFANFHAAAAKAREIIAPILYRYKRIGWSTVLGSSGTIISVTNICQKLTGNSVITKDFLNDLIT
MMMDKREVEHICFEGLREDRESVLAGGVVILYAIFDCLGISEMRLSNGAVREGMLYELVKSKYKIIIN
>Mature_307_residues
SKIVATVDLGSNSFHMLISEIKPDGEVVTLSKQKHKVQLRAGLNNNLTISKDAQERAIECLEFFAQEIQKYKVEYVRAVG
TYTLRKAKNNIKGFKKKLDKALGTKIKIISGLEEARLVYVGARDNHDIKQKTLVIDIGGGSTEFVIGRGNKILIARSLDM
GCVGMQKDFFANEKLDFANFHAAAAKAREIIAPILYRYKRIGWSTVLGSSGTIISVTNICQKLTGNSVITKDFLNDLITM
MMDKREVEHICFEGLREDRESVLAGGVVILYAIFDCLGISEMRLSNGAVREGMLYELVKSKYKIIIN

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=294, Percent_Identity=37.7551020408163, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI48994966, Length=295, Percent_Identity=38.9830508474576, Blast_Score=194, Evalue=9e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 34349; Mature: 34217

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIVATVDLGSNSFHMLISEIKPDGEVVTLSKQKHKVQLRAGLNNNLTISKDAQERAIE
CCCEEEEEECCCCCHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEECCCHHHHHHH
CLEFFAQEIQKYKVEYVRAVGTYTLRKAKNNIKGFKKKLDKALGTKIKIISGLEEARLVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEE
VGARDNHDIKQKTLVIDIGGGSTEFVIGRGNKILIARSLDMGCVGMQKDFFANEKLDFAN
EECCCCCCCCEEEEEEEECCCCEEEEEECCCEEEEEECCCCCCCCCCHHHCCCCCCCHHH
FHAAAAKAREIIAPILYRYKRIGWSTVLGSSGTIISVTNICQKLTGNSVITKDFLNDLIT
HHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHH
MMMDKREVEHICFEGLREDRESVLAGGVVILYAIFDCLGISEMRLSNGAVREGMLYELVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHH
SKYKIIIN
CCEEEEEC
>Mature Secondary Structure 
SKIVATVDLGSNSFHMLISEIKPDGEVVTLSKQKHKVQLRAGLNNNLTISKDAQERAIE
CCEEEEEECCCCCHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEECCCHHHHHHH
CLEFFAQEIQKYKVEYVRAVGTYTLRKAKNNIKGFKKKLDKALGTKIKIISGLEEARLVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEE
VGARDNHDIKQKTLVIDIGGGSTEFVIGRGNKILIARSLDMGCVGMQKDFFANEKLDFAN
EECCCCCCCCEEEEEEEECCCCEEEEEECCCEEEEEECCCCCCCCCCHHHCCCCCCCHHH
FHAAAAKAREIIAPILYRYKRIGWSTVLGSSGTIISVTNICQKLTGNSVITKDFLNDLIT
HHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHH
MMMDKREVEHICFEGLREDRESVLAGGVVILYAIFDCLGISEMRLSNGAVREGMLYELVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHH
SKYKIIIN
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA