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The map label for this gene is icd [H]

Identifier: 134301490

GI number: 134301490

Start: 399469

End: 401685

Strand: Direct

Name: icd [H]

Synonym: FTW_0405

Alternate gene names: 134301490

Gene position: 399469-401685 (Clockwise)

Preceding gene: 134301489

Following gene: 134301491

Centisome position: 21.04

GC content: 35.54

Gene sequence:

>2217_bases
ATGCATAAAATATTTTATACATTTACAGATGAAGCACCAGCATTGGCAACAGGATCATTTTTACCAATAGTTGAGAGCTT
TACTAAAGTTGCAGATATAGAGTTAGAAACGAAAGATATTTCTCTATCAGCGCGGATATTGGCTAACTTTAATGATTACC
TTACTGCAGAGCAAAAGTGTTCTGATGATTTAGCGATACTTGGAGAGCTTGCAAAAACTCCAGATGCTAATATTATAAAA
CTTCCAAATATTAGTGCATCAATTCCTCAGCTTACAGCAGCTATTAAAGAACTTCAGTCAAAGGGTTATAAAATACCTGA
TTATCCATATGAGCCAAAAGATGATAAAGAGCAAGAAATTAAAGCACGCTATGCAAAAGTTTTAGGGAGTGCCGTAAACC
CTGTTTTAAGAGAAGGTAACTCTGATCGTAGAGTTGCTGATGCTGTTAAGAAGTACGCCGAGAAACATCCACATTCTATG
GGTGAATGGACAAAAGACTCTAAATCTCATGTGGCAAGTATGAGTGCTGATGACTTTTATGCTAATGAGAAATCTTATAT
TGTACCAAAAGCAACTAAGGTTAAAATAGTCCATATAGATACAAAAGGCACTCAAACTGTGCTTAAAGATAATCTTGCGC
TAGAAGAAAAAGAAATTATTGATGCTACTAAGATATCTATAAAAGCTTTAAGAGAATTCTACAAAAATGAAATAGCTAAG
GCTAAAAAAGAAGGTACGCTATTATCCCTCCACCTAAAAGCTACGATGATGAAAGTTTCTGATCCAATATTGTTTGGTCA
TGCGGTAGAGATCTTTTTCGAAGATATTTTCAAAAAGTATGCTAAAGAGTTTAAAGAGTTAGGTGTAAATCCTCGTAATG
GTTGGGGTGATGCAGTAGAGAAAATCAAGCAACTTCCACAAGAACTTCAAGATAAAATTAATGCCGATATTGAAAAAGTA
TTTGCAAAGCAGCCTGATATTGCGATGGTTAATTCTAACAAGGGTATTACAAACCTAAATGTTCCGAGTGATGTAATTAT
TGATGCTTCTATGCCTGCGGCTATTCGTTCATCTGGTAAGATGTGGAACAAAGATGGCAAACTTCAAGATATGAAAGCGA
TGATTCCTGATAGATGTTATGCTGGAGTGTATGCGGCAACTATCGATTTCTGTAAAGAAAATGGCGCTTTTGATGTGGCT
ACTATGGGTGATGTTTCTAACGTTGGTCTGATGGCGAAAAAAGCAGAAGAGTATGGTTCTCATGATAAGACATTTGAAAT
CCAAGCTGATGGTAAAGTTGAAGTTATTGATGCTGAAGGTAATGTAATATTTGAGCATCAAGTCGAAAAAGGCGATATTT
GGCGTGCTTGTCAAACTAAAGATATCGCAGTTAAAGACTGGGTTAAACTAGTTGTTAATAGAGCTAAAATTACTCAAAAT
CCTGCGATTTTTTGGTTGGATTCAAAAAGAGCTCATGATAGAAACCTAATTGCTAAAGTGAATGAGTATTTAACTCATCA
TGATACTACTGGCTTAGATATTCAAATATTATCTCCAGTAGAAGCTACGAAATACTCTCTAAAAAGAATGAAAGAGGGTA
AAAATACAATTTCTGTGACAGGTAACGTTTTAAGAGATTACTTGACAGATTTATTTCCTATTTTAGAGCTTGGTACTTCT
GCTAAGATGCTTTCTATAGTTCCGCTATTAGCTGGAGGTGGATTATTTGAAACTGGGGCTGGTGGTTCTGCGCCTAAACA
CGTTGAGCAACTTATTGAGGAAAATCACCTAAGATGGGATTCTTTAGGTGAGTTTTTGGCTTTAGGAGCATCATTAGAAG
ACTTGGCTATCAAAACTAGAGATGCTAAAATCAAGGTTTTAGCTGAGACATTATCACAGGCAAACAAAGATTTCTTGGAT
AATGATAAATCGCCGCGTCGTAAAGTTGGTGAGCTTGATACTCGAGGAAGTCATTTCTATTTGGCTTACTATTGGGTTAA
GGCTCTAGCTGAGCAAACAGGTAATGCTGAATTAAAAGCTAAATTTGAGCCAATTTATATTGAACTAAAAGCTAATAAGG
ATAAAATTGTCAAAGAGCTTAATGATGCTCAAGGCAAAAAAGTTGATGTTGGTGGCTACTATCATATGGATAGAGTAAAA
TTAGATGCAGTGATGAGGCCGAGTAAAACTTTTAATACAATTTTGGCGCAAATATAA

Upstream 100 bases:

>100_bases
AGTAGTTGCAAGGTCTGATGAGAAAATACAACAGATATTAAATACCTACTAGTTTTATGTTAGTATTTGAACAGTGAAAT
TCTATCTACAGGAGATTTTT

Downstream 100 bases:

>100_bases
GGAAAGAGAGACAATGGCTGAAATTAAAAATGATGAATATATAGAAATTAGTTTAATTAAAATTTTAGTTGGATTATTTA
GTAATATAAAGACATTTCTT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH-II; IDP-2; NADP+-specific ICDH 2; Oxalosuccinate decarboxylase 2 [H]

Number of amino acids: Translated: 738; Mature: 738

Protein sequence:

>738_residues
MHKIFYTFTDEAPALATGSFLPIVESFTKVADIELETKDISLSARILANFNDYLTAEQKCSDDLAILGELAKTPDANIIK
LPNISASIPQLTAAIKELQSKGYKIPDYPYEPKDDKEQEIKARYAKVLGSAVNPVLREGNSDRRVADAVKKYAEKHPHSM
GEWTKDSKSHVASMSADDFYANEKSYIVPKATKVKIVHIDTKGTQTVLKDNLALEEKEIIDATKISIKALREFYKNEIAK
AKKEGTLLSLHLKATMMKVSDPILFGHAVEIFFEDIFKKYAKEFKELGVNPRNGWGDAVEKIKQLPQELQDKINADIEKV
FAKQPDIAMVNSNKGITNLNVPSDVIIDASMPAAIRSSGKMWNKDGKLQDMKAMIPDRCYAGVYAATIDFCKENGAFDVA
TMGDVSNVGLMAKKAEEYGSHDKTFEIQADGKVEVIDAEGNVIFEHQVEKGDIWRACQTKDIAVKDWVKLVVNRAKITQN
PAIFWLDSKRAHDRNLIAKVNEYLTHHDTTGLDIQILSPVEATKYSLKRMKEGKNTISVTGNVLRDYLTDLFPILELGTS
AKMLSIVPLLAGGGLFETGAGGSAPKHVEQLIEENHLRWDSLGEFLALGASLEDLAIKTRDAKIKVLAETLSQANKDFLD
NDKSPRRKVGELDTRGSHFYLAYYWVKALAEQTGNAELKAKFEPIYIELKANKDKIVKELNDAQGKKVDVGGYYHMDRVK
LDAVMRPSKTFNTILAQI

Sequences:

>Translated_738_residues
MHKIFYTFTDEAPALATGSFLPIVESFTKVADIELETKDISLSARILANFNDYLTAEQKCSDDLAILGELAKTPDANIIK
LPNISASIPQLTAAIKELQSKGYKIPDYPYEPKDDKEQEIKARYAKVLGSAVNPVLREGNSDRRVADAVKKYAEKHPHSM
GEWTKDSKSHVASMSADDFYANEKSYIVPKATKVKIVHIDTKGTQTVLKDNLALEEKEIIDATKISIKALREFYKNEIAK
AKKEGTLLSLHLKATMMKVSDPILFGHAVEIFFEDIFKKYAKEFKELGVNPRNGWGDAVEKIKQLPQELQDKINADIEKV
FAKQPDIAMVNSNKGITNLNVPSDVIIDASMPAAIRSSGKMWNKDGKLQDMKAMIPDRCYAGVYAATIDFCKENGAFDVA
TMGDVSNVGLMAKKAEEYGSHDKTFEIQADGKVEVIDAEGNVIFEHQVEKGDIWRACQTKDIAVKDWVKLVVNRAKITQN
PAIFWLDSKRAHDRNLIAKVNEYLTHHDTTGLDIQILSPVEATKYSLKRMKEGKNTISVTGNVLRDYLTDLFPILELGTS
AKMLSIVPLLAGGGLFETGAGGSAPKHVEQLIEENHLRWDSLGEFLALGASLEDLAIKTRDAKIKVLAETLSQANKDFLD
NDKSPRRKVGELDTRGSHFYLAYYWVKALAEQTGNAELKAKFEPIYIELKANKDKIVKELNDAQGKKVDVGGYYHMDRVK
LDAVMRPSKTFNTILAQI
>Mature_738_residues
MHKIFYTFTDEAPALATGSFLPIVESFTKVADIELETKDISLSARILANFNDYLTAEQKCSDDLAILGELAKTPDANIIK
LPNISASIPQLTAAIKELQSKGYKIPDYPYEPKDDKEQEIKARYAKVLGSAVNPVLREGNSDRRVADAVKKYAEKHPHSM
GEWTKDSKSHVASMSADDFYANEKSYIVPKATKVKIVHIDTKGTQTVLKDNLALEEKEIIDATKISIKALREFYKNEIAK
AKKEGTLLSLHLKATMMKVSDPILFGHAVEIFFEDIFKKYAKEFKELGVNPRNGWGDAVEKIKQLPQELQDKINADIEKV
FAKQPDIAMVNSNKGITNLNVPSDVIIDASMPAAIRSSGKMWNKDGKLQDMKAMIPDRCYAGVYAATIDFCKENGAFDVA
TMGDVSNVGLMAKKAEEYGSHDKTFEIQADGKVEVIDAEGNVIFEHQVEKGDIWRACQTKDIAVKDWVKLVVNRAKITQN
PAIFWLDSKRAHDRNLIAKVNEYLTHHDTTGLDIQILSPVEATKYSLKRMKEGKNTISVTGNVLRDYLTDLFPILELGTS
AKMLSIVPLLAGGGLFETGAGGSAPKHVEQLIEENHLRWDSLGEFLALGASLEDLAIKTRDAKIKVLAETLSQANKDFLD
NDKSPRRKVGELDTRGSHFYLAYYWVKALAEQTGNAELKAKFEPIYIELKANKDKIVKELNDAQGKKVDVGGYYHMDRVK
LDAVMRPSKTFNTILAQI

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 82254; Mature: 82254

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKIFYTFTDEAPALATGSFLPIVESFTKVADIELETKDISLSARILANFNDYLTAEQKC
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEECCCCEEEHHHHHCCHHHHCCHHHC
SDDLAILGELAKTPDANIIKLPNISASIPQLTAAIKELQSKGYKIPDYPYEPKDDKEQEI
CCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
KARYAKVLGSAVNPVLREGNSDRRVADAVKKYAEKHPHSMGEWTKDSKSHVASMSADDFY
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHC
ANEKSYIVPKATKVKIVHIDTKGTQTVLKDNLALEEKEIIDATKISIKALREFYKNEIAK
CCCCCEECCCCCEEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AKKEGTLLSLHLKATMMKVSDPILFGHAVEIFFEDIFKKYAKEFKELGVNPRNGWGDAVE
HHHCCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
KIKQLPQELQDKINADIEKVFAKQPDIAMVNSNKGITNLNVPSDVIIDASMPAAIRSSGK
HHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCCCCEECCCCCCEEEECCCCHHHHCCCC
MWNKDGKLQDMKAMIPDRCYAGVYAATIDFCKENGAFDVATMGDVSNVGLMAKKAEEYGS
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCC
HDKTFEIQADGKVEVIDAEGNVIFEHQVEKGDIWRACQTKDIAVKDWVKLVVNRAKITQN
CCCEEEEEECCEEEEEECCCCEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCC
PAIFWLDSKRAHDRNLIAKVNEYLTHHDTTGLDIQILSPVEATKYSLKRMKEGKNTISVT
CEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEC
GNVLRDYLTDLFPILELGTSAKMLSIVPLLAGGGLFETGAGGSAPKHVEQLIEENHLRWD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHCCCCHH
SLGEFLALGASLEDLAIKTRDAKIKVLAETLSQANKDFLDNDKSPRRKVGELDTRGSHFY
HHHHHHHHCCCHHHHEEECCCCHHHHHHHHHHHHCHHHHCCCCCHHHHHCCCCCCCCEEE
LAYYWVKALAEQTGNAELKAKFEPIYIELKANKDKIVKELNDAQGKKVDVGGYYHMDRVK
HHHHHHHHHHHCCCCCEEEEEECEEEEEEECCHHHHHHHHHHCCCCEEECCCEEEECCEE
LDAVMRPSKTFNTILAQI
EHHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MHKIFYTFTDEAPALATGSFLPIVESFTKVADIELETKDISLSARILANFNDYLTAEQKC
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEECCCCEEEHHHHHCCHHHHCCHHHC
SDDLAILGELAKTPDANIIKLPNISASIPQLTAAIKELQSKGYKIPDYPYEPKDDKEQEI
CCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
KARYAKVLGSAVNPVLREGNSDRRVADAVKKYAEKHPHSMGEWTKDSKSHVASMSADDFY
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHC
ANEKSYIVPKATKVKIVHIDTKGTQTVLKDNLALEEKEIIDATKISIKALREFYKNEIAK
CCCCCEECCCCCEEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AKKEGTLLSLHLKATMMKVSDPILFGHAVEIFFEDIFKKYAKEFKELGVNPRNGWGDAVE
HHHCCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
KIKQLPQELQDKINADIEKVFAKQPDIAMVNSNKGITNLNVPSDVIIDASMPAAIRSSGK
HHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCCCCEECCCCCCEEEECCCCHHHHCCCC
MWNKDGKLQDMKAMIPDRCYAGVYAATIDFCKENGAFDVATMGDVSNVGLMAKKAEEYGS
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCC
HDKTFEIQADGKVEVIDAEGNVIFEHQVEKGDIWRACQTKDIAVKDWVKLVVNRAKITQN
CCCEEEEEECCEEEEEECCCCEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCC
PAIFWLDSKRAHDRNLIAKVNEYLTHHDTTGLDIQILSPVEATKYSLKRMKEGKNTISVT
CEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEC
GNVLRDYLTDLFPILELGTSAKMLSIVPLLAGGGLFETGAGGSAPKHVEQLIEENHLRWD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHCCCCHH
SLGEFLALGASLEDLAIKTRDAKIKVLAETLSQANKDFLDNDKSPRRKVGELDTRGSHFY
HHHHHHHHCCCHHHHEEECCCCHHHHHHHHHHHHCHHHHCCCCCHHHHHCCCCCCCCEEE
LAYYWVKALAEQTGNAELKAKFEPIYIELKANKDKIVKELNDAQGKKVDVGGYYHMDRVK
HHHHHHHHHHHCCCCCEEEEEECEEEEEEECCHHHHHHHHHHCCCCEEECCCEEEECCEE
LDAVMRPSKTFNTILAQI
EHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226630; 1295895 [H]