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The map label for this gene is fadE [H]

Identifier: 134301487

GI number: 134301487

Start: 394891

End: 397131

Strand: Reverse

Name: fadE [H]

Synonym: FTW_0402

Alternate gene names: 134301487

Gene position: 397131-394891 (Counterclockwise)

Preceding gene: 134301488

Following gene: 134301486

Centisome position: 20.92

GC content: 37.66

Gene sequence:

>2241_bases
ATGTTCAATAAAATTTATAAAATAGCCAAAAAAGCCACGCCGGCAATTTCGCAAACAGAACAAACAGCTCTTAATGCTGG
CAATAACTGGTTTGAACAAGATATATTCCAAGGTAAACCTGACTTTAATAAACTGCATAGTTTGAAAAAGTTTGAACTAA
CAGCTGAAGAAAAGTCTTTTTTAGCAAATGAAACAACCGAGCTATGTAAACTAATTGATGATTGGAAGATTAATTATCAA
GAAAAAGATTTAAGTGTCGAAGCTTGGGATTTTATCCGTAACAAAGGCTTTTTAGGGCTAGTAATCGGTAAAGAGTACGG
TGGTAAAGGTTTCTCAGCAGCAGCGCACTCAGAAATAGTGATGAAATTAGCAACCAAGAGTGTCACTGCAGCAATTACTG
TGATGGTACCTAACTCACTTGGACCAGGAGAGCTTCTAGTTCATTATGGTACAGATGAGCAAAAAGATCACTATCTACCA
AGATTAGCCTCTGGCCAAGAGATACCATGTTTTGCTTTAACAGGACCAACAGCTGGGTCTGATGCGACTTCATTACCTGA
CTATGGTGTTGTCTGCCATGAAGAGTTCAATGGTAAAAAAACTCTAGGGATAAAACTAAAAAATATTAATAAACGCTATA
TCACATTAGCTCCTATAGCCACCCTAGTTGGTCTAGCTTTTCAACTACAAGATCCTGATAATCTACTCGGTGATACAGGT
AAAGAAGGCATAACATGCGCACTGCTACCATATAACCATAAAGGCTTAGAAATCGGCAAACGTGGCTTTCCACTAGGGCA
AACATTTATGAATGGCTATATCAAAGCGAAAGATGTATTTATCCCAATTGATTGGATAATTGGCGGACAAAAAATGGCTG
GCGAAGGTTGGCGGATGCTAGTTGAGTGTCTATCTATAGGTAGAGCTATTTCACTACCAGCGTGTGGTACAGCTAACACA
CTAATGTCAGCTGTAATGACCGCAGCATATGCAAGTGTGCGTGAACAATTCAAAGTTCCAATCGCACAATTTGAAGGAGT
CCAAGAAAAACTAGCTCAAACTGCAGGACTTGCATATATTGCTAATGCTACTCGTCAATTCACGGTTGCTGCTGTTGATA
GTGGTCTGCGACCATCTGTATCATCTGCGATTGCAAAATATCACCTAACCGAGATGGGGCGTACAACTATCAACAATGCT
ATGGATATCCATGGTGGTCGAGCAATCATTATGGGACCAAATAACTATCTAGCTATTCCATATATGGCGACACCGATTGG
TATAACTGTTGAGGGTGCCAATATCATGACACGAAATCTAATGATCTTTGGTCAAGGTGCGATGAAGTGCCATCCATATA
TTCGTAACGAGATAGAAAGCCTAATGAATGATGATGAAGAACAATTTACAACTAATTTCAAAAGTCATTTTAAATATATG
GCTTTGAATGGCTCGCGTACTCTTTGGTATGGTTTAAGTGGTGGTTTCACTGCTCCTAGCTACCCTTCTAAATTTAAACG
TTACTATCGCTATATCTCACATATGAGTACTGCTTATTCGTATGTGAATGATATTTCAATAACAGTTTTAGGTGCTGGTC
TAAAACGTAAAGAAAGATTATCTGCCCGTTTGGGAGATATAATGAGTTATCTGTATATGGCTGTAGCTGTATTGAAATAC
TATAAGGACACAGGCGAACCTCAAAGTGATGATATCTATGTTGATTGGAGTATTCAGCACTGTCTGTACCAAGCTCAACA
AGCGATGTTAGACTTATTTAGAAATTTCCCAAATAGAATATTTGCTACCAAGATGAAGCTTTTTGTTTTTCCTTATGGTA
AAAAATTCAGAAGACCATCTGACAAGCTTGAAGCACAAATCTGTAATTCATTAGTCAGTAATAGTGATACTAGACAATGG
ATGAAAGATAAATGCTACATACCTAATGACGATAATGATCCTATTGGTAGAGTTGAAAATGCTTATCTTGCATCATTGAC
TACTCAACCTATCAAGAAAAAAATTATTGATGCTATAAAAACTGCTAAGCTACCAAAAGCAAGCTGGCAAAACTCTATAG
ACATAGCCCTAGAGAATAAAATAATCACACAACAAGAGGCAAATATTGCTCATGAGATGCTTACAAAGGTCAATAATATA
ATCCAAACTGATGAGTTTGATGATTATGCTCTAGGGCCTAAAAATGCTCATCTAGAATGGCAAAAAGATACCGACAAGTA
G

Upstream 100 bases:

>100_bases
AATACCGTTGGAAAAATAGATGTAAATGCATTACAAAAAGAATATGCTGAAAAGTATGAATAACAGATAATTAAACAGCT
TGCTGCTTAAGGAGCTAAAG

Downstream 100 bases:

>100_bases
TTTACTAATGTCATTCCGCCTAAATAACGGAATCTAAAAAACGATGGATATATTAACATCGGGAGGACAAATATGACAGA
GTTAGAGAAAAAGTTTGAAG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 746; Mature: 746

Protein sequence:

>746_residues
MFNKIYKIAKKATPAISQTEQTALNAGNNWFEQDIFQGKPDFNKLHSLKKFELTAEEKSFLANETTELCKLIDDWKINYQ
EKDLSVEAWDFIRNKGFLGLVIGKEYGGKGFSAAAHSEIVMKLATKSVTAAITVMVPNSLGPGELLVHYGTDEQKDHYLP
RLASGQEIPCFALTGPTAGSDATSLPDYGVVCHEEFNGKKTLGIKLKNINKRYITLAPIATLVGLAFQLQDPDNLLGDTG
KEGITCALLPYNHKGLEIGKRGFPLGQTFMNGYIKAKDVFIPIDWIIGGQKMAGEGWRMLVECLSIGRAISLPACGTANT
LMSAVMTAAYASVREQFKVPIAQFEGVQEKLAQTAGLAYIANATRQFTVAAVDSGLRPSVSSAIAKYHLTEMGRTTINNA
MDIHGGRAIIMGPNNYLAIPYMATPIGITVEGANIMTRNLMIFGQGAMKCHPYIRNEIESLMNDDEEQFTTNFKSHFKYM
ALNGSRTLWYGLSGGFTAPSYPSKFKRYYRYISHMSTAYSYVNDISITVLGAGLKRKERLSARLGDIMSYLYMAVAVLKY
YKDTGEPQSDDIYVDWSIQHCLYQAQQAMLDLFRNFPNRIFATKMKLFVFPYGKKFRRPSDKLEAQICNSLVSNSDTRQW
MKDKCYIPNDDNDPIGRVENAYLASLTTQPIKKKIIDAIKTAKLPKASWQNSIDIALENKIITQQEANIAHEMLTKVNNI
IQTDEFDDYALGPKNAHLEWQKDTDK

Sequences:

>Translated_746_residues
MFNKIYKIAKKATPAISQTEQTALNAGNNWFEQDIFQGKPDFNKLHSLKKFELTAEEKSFLANETTELCKLIDDWKINYQ
EKDLSVEAWDFIRNKGFLGLVIGKEYGGKGFSAAAHSEIVMKLATKSVTAAITVMVPNSLGPGELLVHYGTDEQKDHYLP
RLASGQEIPCFALTGPTAGSDATSLPDYGVVCHEEFNGKKTLGIKLKNINKRYITLAPIATLVGLAFQLQDPDNLLGDTG
KEGITCALLPYNHKGLEIGKRGFPLGQTFMNGYIKAKDVFIPIDWIIGGQKMAGEGWRMLVECLSIGRAISLPACGTANT
LMSAVMTAAYASVREQFKVPIAQFEGVQEKLAQTAGLAYIANATRQFTVAAVDSGLRPSVSSAIAKYHLTEMGRTTINNA
MDIHGGRAIIMGPNNYLAIPYMATPIGITVEGANIMTRNLMIFGQGAMKCHPYIRNEIESLMNDDEEQFTTNFKSHFKYM
ALNGSRTLWYGLSGGFTAPSYPSKFKRYYRYISHMSTAYSYVNDISITVLGAGLKRKERLSARLGDIMSYLYMAVAVLKY
YKDTGEPQSDDIYVDWSIQHCLYQAQQAMLDLFRNFPNRIFATKMKLFVFPYGKKFRRPSDKLEAQICNSLVSNSDTRQW
MKDKCYIPNDDNDPIGRVENAYLASLTTQPIKKKIIDAIKTAKLPKASWQNSIDIALENKIITQQEANIAHEMLTKVNNI
IQTDEFDDYALGPKNAHLEWQKDTDK
>Mature_746_residues
MFNKIYKIAKKATPAISQTEQTALNAGNNWFEQDIFQGKPDFNKLHSLKKFELTAEEKSFLANETTELCKLIDDWKINYQ
EKDLSVEAWDFIRNKGFLGLVIGKEYGGKGFSAAAHSEIVMKLATKSVTAAITVMVPNSLGPGELLVHYGTDEQKDHYLP
RLASGQEIPCFALTGPTAGSDATSLPDYGVVCHEEFNGKKTLGIKLKNINKRYITLAPIATLVGLAFQLQDPDNLLGDTG
KEGITCALLPYNHKGLEIGKRGFPLGQTFMNGYIKAKDVFIPIDWIIGGQKMAGEGWRMLVECLSIGRAISLPACGTANT
LMSAVMTAAYASVREQFKVPIAQFEGVQEKLAQTAGLAYIANATRQFTVAAVDSGLRPSVSSAIAKYHLTEMGRTTINNA
MDIHGGRAIIMGPNNYLAIPYMATPIGITVEGANIMTRNLMIFGQGAMKCHPYIRNEIESLMNDDEEQFTTNFKSHFKYM
ALNGSRTLWYGLSGGFTAPSYPSKFKRYYRYISHMSTAYSYVNDISITVLGAGLKRKERLSARLGDIMSYLYMAVAVLKY
YKDTGEPQSDDIYVDWSIQHCLYQAQQAMLDLFRNFPNRIFATKMKLFVFPYGKKFRRPSDKLEAQICNSLVSNSDTRQW
MKDKCYIPNDDNDPIGRVENAYLASLTTQPIKKKIIDAIKTAKLPKASWQNSIDIALENKIITQQEANIAHEMLTKVNNI
IQTDEFDDYALGPKNAHLEWQKDTDK

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=503, Percent_Identity=26.0437375745527, Blast_Score=109, Evalue=1e-23,
Organism=Homo sapiens, GI4557235, Length=417, Percent_Identity=23.7410071942446, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI76496475, Length=378, Percent_Identity=24.6031746031746, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI7656849, Length=349, Percent_Identity=24.6418338108883, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI4557233, Length=317, Percent_Identity=27.7602523659306, Blast_Score=80, Evalue=9e-15,
Organism=Homo sapiens, GI226958414, Length=284, Percent_Identity=28.169014084507, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI4501859, Length=316, Percent_Identity=26.8987341772152, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI226958412, Length=269, Percent_Identity=28.2527881040892, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI87081702, Length=736, Percent_Identity=47.0108695652174, Blast_Score=697, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17508101, Length=369, Percent_Identity=27.6422764227642, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71985184, Length=385, Percent_Identity=23.8961038961039, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17506239, Length=318, Percent_Identity=27.6729559748428, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71985192, Length=368, Percent_Identity=23.9130434782609, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17534899, Length=326, Percent_Identity=26.9938650306748, Blast_Score=73, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=339, Percent_Identity=27.7286135693215, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17570075, Length=365, Percent_Identity=26.5753424657534, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281363737, Length=326, Percent_Identity=27.3006134969325, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356377, Length=268, Percent_Identity=27.6119402985075, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24666513, Length=337, Percent_Identity=28.7833827893175, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: 1.3.99.3

Molecular weight: Translated: 83281; Mature: 83281

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKIYKIAKKATPAISQTEQTALNAGNNWFEQDIFQGKPDFNKLHSLKKFELTAEEKSF
CCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCCHHEEECHHHHHH
LANETTELCKLIDDWKINYQEKDLSVEAWDFIRNKGFLGLVIGKEYGGKGFSAAAHSEIV
HHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHH
MKLATKSVTAAITVMVPNSLGPGELLVHYGTDEQKDHYLPRLASGQEIPCFALTGPTAGS
HHHHHHCEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCC
DATSLPDYGVVCHEEFNGKKTLGIKLKNINKRYITLAPIATLVGLAFQLQDPDNLLGDTG
CCCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEEHHHHHHHHHHEEEECCCHHHHCCCC
KEGITCALLPYNHKGLEIGKRGFPLGQTFMNGYIKAKDVFIPIDWIIGGQKMAGEGWRML
CCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCEEEEEEEEEEEEEEECCCCCCCHHHHHH
VECLSIGRAISLPACGTANTLMSAVMTAAYASVREQFKVPIAQFEGVQEKLAQTAGLAYI
HHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCEE
ANATRQFTVAAVDSGLRPSVSSAIAKYHLTEMGRTTINNAMDIHGGRAIIMGPNNYLAIP
ECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCHHHHCCCEEECCCEEEEECCCCEEEEE
YMATPIGITVEGANIMTRNLMIFGQGAMKCHPYIRNEIESLMNDDEEQFTTNFKSHFKYM
EEECCEEEEEECCCEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCEEEE
ALNGSRTLWYGLSGGFTAPSYPSKFKRYYRYISHMSTAYSYVNDISITVLGAGLKRKERL
EECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
SARLGDIMSYLYMAVAVLKYYKDTGEPQSDDIYVDWSIQHCLYQAQQAMLDLFRNFPNRI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCHHH
FATKMKLFVFPYGKKFRRPSDKLEAQICNSLVSNSDTRQWMKDKCYIPNDDNDPIGRVEN
HHEEEEEEEEECCHHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCHHCC
AYLASLTTQPIKKKIIDAIKTAKLPKASWQNSIDIALENKIITQQEANIAHEMLTKVNNI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEECHHHHHHHHHHHHHHHHH
IQTDEFDDYALGPKNAHLEWQKDTDK
HCCCCCCCCCCCCCCCCEEECCCCCC
>Mature Secondary Structure
MFNKIYKIAKKATPAISQTEQTALNAGNNWFEQDIFQGKPDFNKLHSLKKFELTAEEKSF
CCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCCHHEEECHHHHHH
LANETTELCKLIDDWKINYQEKDLSVEAWDFIRNKGFLGLVIGKEYGGKGFSAAAHSEIV
HHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHH
MKLATKSVTAAITVMVPNSLGPGELLVHYGTDEQKDHYLPRLASGQEIPCFALTGPTAGS
HHHHHHCEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCC
DATSLPDYGVVCHEEFNGKKTLGIKLKNINKRYITLAPIATLVGLAFQLQDPDNLLGDTG
CCCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEEHHHHHHHHHHEEEECCCHHHHCCCC
KEGITCALLPYNHKGLEIGKRGFPLGQTFMNGYIKAKDVFIPIDWIIGGQKMAGEGWRML
CCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCEEEEEEEEEEEEEEECCCCCCCHHHHHH
VECLSIGRAISLPACGTANTLMSAVMTAAYASVREQFKVPIAQFEGVQEKLAQTAGLAYI
HHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCCEE
ANATRQFTVAAVDSGLRPSVSSAIAKYHLTEMGRTTINNAMDIHGGRAIIMGPNNYLAIP
ECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCHHHHCCCEEECCCEEEEECCCCEEEEE
YMATPIGITVEGANIMTRNLMIFGQGAMKCHPYIRNEIESLMNDDEEQFTTNFKSHFKYM
EEECCEEEEEECCCEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCEEEE
ALNGSRTLWYGLSGGFTAPSYPSKFKRYYRYISHMSTAYSYVNDISITVLGAGLKRKERL
EECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
SARLGDIMSYLYMAVAVLKYYKDTGEPQSDDIYVDWSIQHCLYQAQQAMLDLFRNFPNRI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCHHH
FATKMKLFVFPYGKKFRRPSDKLEAQICNSLVSNSDTRQWMKDKCYIPNDDNDPIGRVEN
HHEEEEEEEEECCHHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCHHCC
AYLASLTTQPIKKKIIDAIKTAKLPKASWQNSIDIALENKIITQQEANIAHEMLTKVNNI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEECHHHHHHHHHHHHHHHHH
IQTDEFDDYALGPKNAHLEWQKDTDK
HCCCCCCCCCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]