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The map label for this gene is rnr [H]

Identifier: 134301465

GI number: 134301465

Start: 368040

End: 370337

Strand: Direct

Name: rnr [H]

Synonym: FTW_0374

Alternate gene names: 134301465

Gene position: 368040-370337 (Clockwise)

Preceding gene: 134301464

Following gene: 134301470

Centisome position: 19.39

GC content: 34.07

Gene sequence:

>2298_bases
GTGAGTAAGTACAGCATACATAATGATCCGAATAAGGATATTGAAGCGCAAAAATATGAAAATCCAATTCCAAGTAGGGA
AGTGATTTTAAATTATATAAGAGATGTAAAACTTCCTGTAAGCATTGAAAATATAGCAAATGCTTTAGAGATTTTTAAAA
AAAATCTTTTCGAAGGTCTTGTAAATCGTTTGGGTGCAATGGTTAGAGATGGTCAGCTAGAGAAGGATAGATCATATTAT
AATTTGCCGGAAATGGCGCCAATATATATCACATCTAAAGTTGCTGCAGATAGAGATTCTCGTTTAGAGCTATTTAGCCA
TACTCTAAATACAAAGGTAGGTATAGTATCTCATCAAGCAAAAATGGTAATGGTTGGTGATGAGGTAACTGCAAAAGTTC
TTGGGCTTAATAAGCGTGGTCGAATAGATGCTGAAATTAAAACCATAGTGACAAGAGCTCAGAAGACAGTCACGGGCTAT
TATTATAAGAGCTTTGATTGTGATTTTATTAAGCCGATAAGCAAAAGCATAATAAGTGACATAGTGCTATTACCACCAAA
GCAAAAAATAGAGCATAACTCTTTAATAGAAGCTGAGATTATTGTTTATCCTAGTATAAGTAGTGCAGCTGTTGCTAAAT
TTAAGCAAGAGGTCGAAGCAGTATCTCCAGTTAAAGAAGCGATGATGATGACAACACAGAAGTATGATTTAATTGAGCAG
TGGAGTAAAAAGGCTTTACGCTATTTAGATAATATTTCTGATGACGTGGTTGTTGGCAACAGGGTTGATCTACGTAATCA
ACACTTTGTAACAATTGATGGTGAAGATGCTAAGGATTTTGATGATGCAGTTTATGCACATAGGACTAAAAGTGGTAGTT
GGAAGTTATATATAGCAATTGCAGATGTCTCAAACTATGTTGAGAAAGATTCAGCTTTGGATTTAGACGCTAAGCGTCGT
TCTACTTCAGTGTATTTCCCTGGTTATGTGATACCAATGCTACCAGAGAAATTATCAAATGGTTTATGTTCATTAAGACC
AAACGAAGATAGATATTCCTTAGTCTGTGAGATGAATATTAGTAAAGAAGGTAAACTTTCTAGGTATAAGTTTTATTCTG
CTGTAATAAACTCAAAGGCACGCTTAACTTATACAGAAGTTGCTAAACTTTTAGAAAAGAAACAAAACACTATAGTTGAG
AATACTCCTGAGCTAGTACCTAATATATTTGATTTATACGAGTTGTATAAAGTACTTCACCAAGCTAGGCAAGAACGAGG
TGCTATAGACTTTGATACAGTTGAAACACAGATAATTCTTGATGAGCATAATCATATTGAATCAATTGTGCCAAGGCATC
GTAATGATGCACATAGGCTTATTGAAGAGTGTATGCTTGTTGCTAACGTTGCAGCAGCTAAGTTTACTATTAAGCATAAA
AAGACATCACCATTTAGAGTTCATAGTGAGCCTAAAGAAGATAGAATGGAAACTCTTAAGAAGTATCTTGCTAAGCATGG
TATACATCTTGCTCATGGTAAGAATGGTAAAGTGACTCCCAAAGCTTTAGCACAAATGCTAGATAGTATAAAAGATCGTC
CTGATTATGATGATATTCAGATGATGACTTTACGTAGTATGAATCAGGCCGTATATAGCATAAATAATGATGGACACTTT
GGACTAGCATATAGTGAATATACGCATTTTACCTCACCAATTCGTAGATATCCAGATTTAGTAGTACACAGAATAATAAA
ATCAATTATTGGTGAATATGAACATGGTGCTGCTGATTATAAACCTTCTGAATTGGCAAATATTTGTGAAAATGCCTCTG
ATCAAGAGCGAAATGCTGATGCAGCCTCTAAGCAAGTTGAGAATTGGTTGAAGTGCTACTTTATGCAAGACTACATTGGT
CATATACTTGAAGCTCAAATTAAGCATGTTAATGGTTTAGGTCTTTTTGCTGAACTAAAAGATATGTACATAGAAGGTCT
GATACATGTATCAGCTATTCCTGGTGATTACTATATTTATGATGAAGCCAAAGATATATTAATTGGTAAACGAACCCATA
AAGTCTATAAAGTTGGTCAAGATATTACAGTAAGAGTTGTTCGAGCAGATCTCGAAAGAATTCATATAGATTTTGAGCTG
TATGATCCACGTAAGCCATTTGCTGAGAATAGCTCAGATAAGCCATTTGCAAAAAAAACAAAAAAACTTAAAAAAGCTAA
AAAGAAGAAAGTAAGAAGTAGAAAAAAGAATAAAACAAAAGCAAAATTAGCACACTAA

Upstream 100 bases:

>100_bases
ACGGTCAGGATATATGATGTTGAGAAGTTTGTTGCTATAGCAGAGTTTGATAAAGGTAAGTTGATTAATAAAAAATTTTT
TGATCAGGATATATTGATAA

Downstream 100 bases:

>100_bases
ATTTAATTTAAAAAGTTTTTGATCTAAATAGTTTTCTTCGGTTGCTTAAAATCCCAAACTATTCTGAACTTTCTCAAGAC
GCATAAAATCATATAGGTAA

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 765; Mature: 764

Protein sequence:

>765_residues
MSKYSIHNDPNKDIEAQKYENPIPSREVILNYIRDVKLPVSIENIANALEIFKKNLFEGLVNRLGAMVRDGQLEKDRSYY
NLPEMAPIYITSKVAADRDSRLELFSHTLNTKVGIVSHQAKMVMVGDEVTAKVLGLNKRGRIDAEIKTIVTRAQKTVTGY
YYKSFDCDFIKPISKSIISDIVLLPPKQKIEHNSLIEAEIIVYPSISSAAVAKFKQEVEAVSPVKEAMMMTTQKYDLIEQ
WSKKALRYLDNISDDVVVGNRVDLRNQHFVTIDGEDAKDFDDAVYAHRTKSGSWKLYIAIADVSNYVEKDSALDLDAKRR
STSVYFPGYVIPMLPEKLSNGLCSLRPNEDRYSLVCEMNISKEGKLSRYKFYSAVINSKARLTYTEVAKLLEKKQNTIVE
NTPELVPNIFDLYELYKVLHQARQERGAIDFDTVETQIILDEHNHIESIVPRHRNDAHRLIEECMLVANVAAAKFTIKHK
KTSPFRVHSEPKEDRMETLKKYLAKHGIHLAHGKNGKVTPKALAQMLDSIKDRPDYDDIQMMTLRSMNQAVYSINNDGHF
GLAYSEYTHFTSPIRRYPDLVVHRIIKSIIGEYEHGAADYKPSELANICENASDQERNADAASKQVENWLKCYFMQDYIG
HILEAQIKHVNGLGLFAELKDMYIEGLIHVSAIPGDYYIYDEAKDILIGKRTHKVYKVGQDITVRVVRADLERIHIDFEL
YDPRKPFAENSSDKPFAKKTKKLKKAKKKKVRSRKKNKTKAKLAH

Sequences:

>Translated_765_residues
MSKYSIHNDPNKDIEAQKYENPIPSREVILNYIRDVKLPVSIENIANALEIFKKNLFEGLVNRLGAMVRDGQLEKDRSYY
NLPEMAPIYITSKVAADRDSRLELFSHTLNTKVGIVSHQAKMVMVGDEVTAKVLGLNKRGRIDAEIKTIVTRAQKTVTGY
YYKSFDCDFIKPISKSIISDIVLLPPKQKIEHNSLIEAEIIVYPSISSAAVAKFKQEVEAVSPVKEAMMMTTQKYDLIEQ
WSKKALRYLDNISDDVVVGNRVDLRNQHFVTIDGEDAKDFDDAVYAHRTKSGSWKLYIAIADVSNYVEKDSALDLDAKRR
STSVYFPGYVIPMLPEKLSNGLCSLRPNEDRYSLVCEMNISKEGKLSRYKFYSAVINSKARLTYTEVAKLLEKKQNTIVE
NTPELVPNIFDLYELYKVLHQARQERGAIDFDTVETQIILDEHNHIESIVPRHRNDAHRLIEECMLVANVAAAKFTIKHK
KTSPFRVHSEPKEDRMETLKKYLAKHGIHLAHGKNGKVTPKALAQMLDSIKDRPDYDDIQMMTLRSMNQAVYSINNDGHF
GLAYSEYTHFTSPIRRYPDLVVHRIIKSIIGEYEHGAADYKPSELANICENASDQERNADAASKQVENWLKCYFMQDYIG
HILEAQIKHVNGLGLFAELKDMYIEGLIHVSAIPGDYYIYDEAKDILIGKRTHKVYKVGQDITVRVVRADLERIHIDFEL
YDPRKPFAENSSDKPFAKKTKKLKKAKKKKVRSRKKNKTKAKLAH
>Mature_764_residues
SKYSIHNDPNKDIEAQKYENPIPSREVILNYIRDVKLPVSIENIANALEIFKKNLFEGLVNRLGAMVRDGQLEKDRSYYN
LPEMAPIYITSKVAADRDSRLELFSHTLNTKVGIVSHQAKMVMVGDEVTAKVLGLNKRGRIDAEIKTIVTRAQKTVTGYY
YKSFDCDFIKPISKSIISDIVLLPPKQKIEHNSLIEAEIIVYPSISSAAVAKFKQEVEAVSPVKEAMMMTTQKYDLIEQW
SKKALRYLDNISDDVVVGNRVDLRNQHFVTIDGEDAKDFDDAVYAHRTKSGSWKLYIAIADVSNYVEKDSALDLDAKRRS
TSVYFPGYVIPMLPEKLSNGLCSLRPNEDRYSLVCEMNISKEGKLSRYKFYSAVINSKARLTYTEVAKLLEKKQNTIVEN
TPELVPNIFDLYELYKVLHQARQERGAIDFDTVETQIILDEHNHIESIVPRHRNDAHRLIEECMLVANVAAAKFTIKHKK
TSPFRVHSEPKEDRMETLKKYLAKHGIHLAHGKNGKVTPKALAQMLDSIKDRPDYDDIQMMTLRSMNQAVYSINNDGHFG
LAYSEYTHFTSPIRRYPDLVVHRIIKSIIGEYEHGAADYKPSELANICENASDQERNADAASKQVENWLKCYFMQDYIGH
ILEAQIKHVNGLGLFAELKDMYIEGLIHVSAIPGDYYIYDEAKDILIGKRTHKVYKVGQDITVRVVRADLERIHIDFELY
DPRKPFAENSSDKPFAKKTKKLKKAKKKKVRSRKKNKTKAKLAH

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=510, Percent_Identity=29.0196078431373, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI190014625, Length=510, Percent_Identity=29.0196078431373, Blast_Score=173, Evalue=6e-43,
Organism=Homo sapiens, GI219521928, Length=408, Percent_Identity=28.4313725490196, Blast_Score=155, Evalue=2e-37,
Organism=Homo sapiens, GI19115966, Length=408, Percent_Identity=28.4313725490196, Blast_Score=155, Evalue=2e-37,
Organism=Homo sapiens, GI134288890, Length=399, Percent_Identity=29.3233082706767, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI156105695, Length=568, Percent_Identity=22.1830985915493, Blast_Score=98, Evalue=4e-20,
Organism=Homo sapiens, GI156105693, Length=414, Percent_Identity=24.6376811594203, Blast_Score=93, Evalue=1e-18,
Organism=Escherichia coli, GI87082383, Length=729, Percent_Identity=39.917695473251, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1787542, Length=471, Percent_Identity=30.5732484076433, Blast_Score=179, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI212645896, Length=375, Percent_Identity=30.6666666666667, Blast_Score=173, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17553506, Length=388, Percent_Identity=30.1546391752577, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324552, Length=448, Percent_Identity=29.6875, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24649634, Length=492, Percent_Identity=28.2520325203252, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24654592, Length=390, Percent_Identity=27.1794871794872, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI19922976, Length=390, Percent_Identity=27.1794871794872, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24654597, Length=390, Percent_Identity=27.1794871794872, Blast_Score=139, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 87602; Mature: 87470

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYSIHNDPNKDIEAQKYENPIPSREVILNYIRDVKLPVSIENIANALEIFKKNLFEGL
CCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
VNRLGAMVRDGQLEKDRSYYNLPEMAPIYITSKVAADRDSRLELFSHTLNTKVGIVSHQA
HHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECHHCCCCHHHHHHHHHHCCEEEEEECCC
KMVMVGDEVTAKVLGLNKRGRIDAEIKTIVTRAQKTVTGYYYKSFDCDFIKPISKSIISD
EEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHH
IVLLPPKQKIEHNSLIEAEIIVYPSISSAAVAKFKQEVEAVSPVKEAMMMTTQKYDLIEQ
EEECCCHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WSKKALRYLDNISDDVVVGNRVDLRNQHFVTIDGEDAKDFDDAVYAHRTKSGSWKLYIAI
HHHHHHHHHHCCCCCEEECCEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEE
ADVSNYVEKDSALDLDAKRRSTSVYFPGYVIPMLPEKLSNGLCSLRPNEDRYSLVCEMNI
ECHHHHHHCCCCCCCCHHHCCCEEECCCEEHHCCHHHHCCCCCCCCCCCCCEEEEEEECC
SKEGKLSRYKFYSAVINSKARLTYTEVAKLLEKKQNTIVENTPELVPNIFDLYELYKVLH
CCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QARQERGAIDFDTVETQIILDEHNHIESIVPRHRNDAHRLIEECMLVANVAAAKFTIKHK
HHHHHCCCCCCCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEC
KTSPFRVHSEPKEDRMETLKKYLAKHGIHLAHGKNGKVTPKALAQMLDSIKDRPDYDDIQ
CCCCEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHH
MMTLRSMNQAVYSINNDGHFGLAYSEYTHFTSPIRRYPDLVVHRIIKSIIGEYEHGAADY
HHHHHHHHHHHEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KPSELANICENASDQERNADAASKQVENWLKCYFMQDYIGHILEAQIKHVNGLGLFAELK
CHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DMYIEGLIHVSAIPGDYYIYDEAKDILIGKRTHKVYKVGQDITVRVVRADLERIHIDFEL
HHHHHHHEEEEECCCCEEEEECCCHHHCCCHHHHHHHCCCCCEEEHEEECHHHEEEEEEE
YDPRKPFAENSSDKPFAKKTKKLKKAKKKKVRSRKKNKTKAKLAH
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCC
>Mature Secondary Structure 
SKYSIHNDPNKDIEAQKYENPIPSREVILNYIRDVKLPVSIENIANALEIFKKNLFEGL
CCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
VNRLGAMVRDGQLEKDRSYYNLPEMAPIYITSKVAADRDSRLELFSHTLNTKVGIVSHQA
HHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECHHCCCCHHHHHHHHHHCCEEEEEECCC
KMVMVGDEVTAKVLGLNKRGRIDAEIKTIVTRAQKTVTGYYYKSFDCDFIKPISKSIISD
EEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHH
IVLLPPKQKIEHNSLIEAEIIVYPSISSAAVAKFKQEVEAVSPVKEAMMMTTQKYDLIEQ
EEECCCHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WSKKALRYLDNISDDVVVGNRVDLRNQHFVTIDGEDAKDFDDAVYAHRTKSGSWKLYIAI
HHHHHHHHHHCCCCCEEECCEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEE
ADVSNYVEKDSALDLDAKRRSTSVYFPGYVIPMLPEKLSNGLCSLRPNEDRYSLVCEMNI
ECHHHHHHCCCCCCCCHHHCCCEEECCCEEHHCCHHHHCCCCCCCCCCCCCEEEEEEECC
SKEGKLSRYKFYSAVINSKARLTYTEVAKLLEKKQNTIVENTPELVPNIFDLYELYKVLH
CCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QARQERGAIDFDTVETQIILDEHNHIESIVPRHRNDAHRLIEECMLVANVAAAKFTIKHK
HHHHHCCCCCCCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEC
KTSPFRVHSEPKEDRMETLKKYLAKHGIHLAHGKNGKVTPKALAQMLDSIKDRPDYDDIQ
CCCCEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHH
MMTLRSMNQAVYSINNDGHFGLAYSEYTHFTSPIRRYPDLVVHRIIKSIIGEYEHGAADY
HHHHHHHHHHHEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KPSELANICENASDQERNADAASKQVENWLKCYFMQDYIGHILEAQIKHVNGLGLFAELK
CHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DMYIEGLIHVSAIPGDYYIYDEAKDILIGKRTHKVYKVGQDITVRVVRADLERIHIDFEL
HHHHHHHEEEEECCCCEEEEECCCHHHCCCHHHHHHHCCCCCEEEHEEECHHHEEEEEEE
YDPRKPFAENSSDKPFAKKTKKLKKAKKKKVRSRKKNKTKAKLAH
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]