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The map label for this gene is proC [H]

Identifier: 134301459

GI number: 134301459

Start: 362316

End: 363140

Strand: Direct

Name: proC [H]

Synonym: FTW_0368

Alternate gene names: 134301459

Gene position: 362316-363140 (Clockwise)

Preceding gene: 134301453

Following gene: 134301460

Centisome position: 19.08

GC content: 31.64

Gene sequence:

>825_bases
ATGAAAATATGCTTTATCGGTGGTGGTAATATGGCGGCAGCAATGATTGCTGGTATGACCTCACATGGTTATAAAAGTCA
GGATATAATCGTTTTTGATAGAAATGAACATAAATGCTTAAACTTAATTAAAAAGTATAATATCAACACATCTACGTCAT
TACTAAATACAATTAAACTTGCTGATATTCTTATTTTAGCAATCAAGCCTCAAAATATGTTTGAGCTTATAAAAAATATC
AGAGATACAGTTACATCTACTCAAGTAATAGTTACAGTAGCTGCAGGTATCCAGACTAGTGCGTACGAGGAATTATTTAA
CAAAGAAATCTCTTTTGCTAGAACAATTCCAAATACACCTAGTAGCTTAGGTTACGGCGCTACGGGAATTTTCTTTAATA
AAGTTATTGCTGCTGATAAAAAAGATTTAGTTATAGATATTATGCAGACTATGGGAGTAGTAACTGTTGTTGAGGATGAG
AAAGAAATTGATATTATCGCAGCTATAGCTAGTTCTGGACCGGCATATTATTTTCAGTTTATGGAGCATATGGTTGAAGC
AGCAATCAAGCAAGGTTTAGATAAAAAACAAGCCGAAAAACTAGTTGTTCAAACATGCTTAGGGGCAGCACAGATGGCAT
TAAATACTAATGAAAATATGTCAGAGTTAAGAAAAAATGTAACTTCTAAAAAAGGTATAACTTATGAAGCATTAAATATT
TTTGAGCAATTTAATCTTGGTGGAATTGTAGATAAAGCAATTCAAGCAAATATAGCTAGAGCACAGCAATTAGCTATAGA
ATTTACTAAATTAATAGATAATTGA

Upstream 100 bases:

>100_bases
GAGCTTTATATATTTATTCGATCAAGATATATTAGCAATATTTGTTATAAATGTTATCCTTTAAATACATATAATTTTGA
AATATTGTTAGGTTAAGTTT

Downstream 100 bases:

>100_bases
TCGATTATAACTTGAAAGAGTTTTTATTAGCCTTATGTGTATTACAAAGAAGTTGAGATAGCTGAAAATATTTGTTTTAT
TTAAAGGCTTAAAGCTTTAT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MKICFIGGGNMAAAMIAGMTSHGYKSQDIIVFDRNEHKCLNLIKKYNINTSTSLLNTIKLADILILAIKPQNMFELIKNI
RDTVTSTQVIVTVAAGIQTSAYEELFNKEISFARTIPNTPSSLGYGATGIFFNKVIAADKKDLVIDIMQTMGVVTVVEDE
KEIDIIAAIASSGPAYYFQFMEHMVEAAIKQGLDKKQAEKLVVQTCLGAAQMALNTNENMSELRKNVTSKKGITYEALNI
FEQFNLGGIVDKAIQANIARAQQLAIEFTKLIDN

Sequences:

>Translated_274_residues
MKICFIGGGNMAAAMIAGMTSHGYKSQDIIVFDRNEHKCLNLIKKYNINTSTSLLNTIKLADILILAIKPQNMFELIKNI
RDTVTSTQVIVTVAAGIQTSAYEELFNKEISFARTIPNTPSSLGYGATGIFFNKVIAADKKDLVIDIMQTMGVVTVVEDE
KEIDIIAAIASSGPAYYFQFMEHMVEAAIKQGLDKKQAEKLVVQTCLGAAQMALNTNENMSELRKNVTSKKGITYEALNI
FEQFNLGGIVDKAIQANIARAQQLAIEFTKLIDN
>Mature_274_residues
MKICFIGGGNMAAAMIAGMTSHGYKSQDIIVFDRNEHKCLNLIKKYNINTSTSLLNTIKLADILILAIKPQNMFELIKNI
RDTVTSTQVIVTVAAGIQTSAYEELFNKEISFARTIPNTPSSLGYGATGIFFNKVIAADKKDLVIDIMQTMGVVTVVEDE
KEIDIIAAIASSGPAYYFQFMEHMVEAAIKQGLDKKQAEKLVVQTCLGAAQMALNTNENMSELRKNVTSKKGITYEALNI
FEQFNLGGIVDKAIQANIARAQQLAIEFTKLIDN

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=29.7397769516729, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=27.6119402985075, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=27.1375464684015, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=27.1375464684015, Blast_Score=115, Evalue=3e-26,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=28.6792452830189, Blast_Score=131, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=264, Percent_Identity=28.4090909090909, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=288, Percent_Identity=28.4722222222222, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320861, Length=190, Percent_Identity=23.1578947368421, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=27.7153558052434, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=27.536231884058, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=29.2397660818713, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 30099; Mature: 30099

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKICFIGGGNMAAAMIAGMTSHGYKSQDIIVFDRNEHKCLNLIKKYNINTSTSLLNTIKL
CEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHH
ADILILAIKPQNMFELIKNIRDTVTSTQVIVTVAAGIQTSAYEELFNKEISFARTIPNTP
HHEEEEEECCHHHHHHHHHHHHHHCCHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
SSLGYGATGIFFNKVIAADKKDLVIDIMQTMGVVTVVEDEKEIDIIAAIASSGPAYYFQF
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCHHHEEEECCCCCHHHHHH
MEHMVEAAIKQGLDKKQAEKLVVQTCLGAAQMALNTNENMSELRKNVTSKKGITYEALNI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHH
FEQFNLGGIVDKAIQANIARAQQLAIEFTKLIDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKICFIGGGNMAAAMIAGMTSHGYKSQDIIVFDRNEHKCLNLIKKYNINTSTSLLNTIKL
CEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHH
ADILILAIKPQNMFELIKNIRDTVTSTQVIVTVAAGIQTSAYEELFNKEISFARTIPNTP
HHEEEEEECCHHHHHHHHHHHHHHCCHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
SSLGYGATGIFFNKVIAADKKDLVIDIMQTMGVVTVVEDEKEIDIIAAIASSGPAYYFQF
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCHHHEEEECCCCCHHHHHH
MEHMVEAAIKQGLDKKQAEKLVVQTCLGAAQMALNTNENMSELRKNVTSKKGITYEALNI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHH
FEQFNLGGIVDKAIQANIARAQQLAIEFTKLIDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]