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The map label for this gene is groEL [H]

Identifier: 134301378

GI number: 134301378

Start: 271407

End: 273041

Strand: Reverse

Name: groEL [H]

Synonym: FTW_0264

Alternate gene names: 134301378

Gene position: 273041-271407 (Counterclockwise)

Preceding gene: 134301379

Following gene: 134301373

Centisome position: 14.38

GC content: 38.9

Gene sequence:

>1635_bases
ATGGCTGCAAAACAAGTTTTATTTTCAGATGAAGCTCGTGCAAAAATGCTAGATGGTGTTAACACACTAGCAAATGCTGT
AAAAGTTACTTTAGGTCCAAAAGGTCGTAATGTTGTTTTAGATAAATCATTTGGCGCGCCTACTATCACTAAAGATGGTG
TATCTGTTGCTAAAGAAATTGAACTAGAAGATAAGTTTGAGAATATGGGGGCTCAGATAGTTAAAGAAGTAGCTTCAAAG
ACAGCGGATGTTGCTGGTGATGGTACTACTACAGCGACTGTACTTGCTCAGGCATTATTGACAGAGGGTCTAAAAGCTGT
CGCTGCAGGTATGAATCCTATGGATCTAAAAAGAGGTATCGACAAAGCAACTGCTAGGTTAGTTGAAGAATTAAAAGCAC
TTTCTAAACCATGTTCAGATCCAAAATCAATTGAGCAAGTTGGTACTATCTCTGCTAACTCTGATGCTACTGTAGGTAAG
CTTATCGCTGACGCAATGGCAAAAGTTGGTAAAGAAGGTGTGATTACAGTTGAAGAAGGCAAAGGCTTTGAAGATGAGCT
TGATGTAGTTGAAGGTATGCAGTTTGATAGAGGTTATCTATCTCCGTATTTTGCAACAAATCAAGAGAATATGACTACTG
ATTTAGAGAATCCATATATTCTAATAGTTGATAAGAAAATCTCTAATATCCGCGATTTATTACCGATATTAGAAGGTGTT
TCTAAATCTGGTAGAGCGTTACTAATAATAGCTGAAGATGTAGAAAGTGAAGCTCTAGCTACTTTAGTTGTAAATAATAT
GCGTGGTGTAGTTAAAGTATGTGCTGTCAAAGCTCCTGGCTTTGGTGATAGAAGAAAAGCTATGCTAGAAGATATCGCTA
CTCTAACTGGAGCTACGTTTGTATCAGAAGACCTAAGCATGAAGTTAGAAGAAACTAACATGGAGCATTTAGGTACGGCT
AGTAGAGTACTAGTAACAAAAGATAATACAACAATTATTGATGGTGCTGGTGAAAAAGAAGCTATCGCTAAACGAATAAA
TGTAATCAAAGCTAATATTGCTGAAGCTAACTCTGATTATGATCGTGAGAAGCTGCAAGAAAGATTGGCTAAACTTTCTG
GTGGTGTCGCGGTGATAAAAGTTGGTGCTGTTACAGAAGCTGAGATGAAAGAGAAGAAAGATCGTGTCGATGATGCTTTA
CATGCTACTCGTGCGGCTGTAGAAGAAGGTATTGTTGCTGGTGGTGGCGTTGCTTTAATTAGAGCACAAAAAGCATTAGA
TGGCTTAACAGGTGAAAATGACGATCAAAACCATGGTATAGCGCTACTTAGAAAAGCAATAGAAGCTCCTCTAAGACAGA
TAGTATCAAATGCTGGCGGTGAGTCTTCTGTAGTTGTTAACCAAGTTAAAGCTAATCAAGGTAACTATGGTTATAATGCT
GCAAATGATACTTATGGTGATATGGTTGAGATGGGTATTTTAGATCCTACTAAAGTTACTCGTTCAGCTCTACAACATGC
TGCTTCAATTGCTGGACTTATGATCACTACAGAGGCGATGATCGGTGAGATCAAAGAAGCTGCTCCTGCTATGCCTATGG
GCGGTGGCATGGGCGGTATGCCTGGCATGATATAA

Upstream 100 bases:

>100_bases
AAAGTTGGTGATGAAACTCTTCTAATGATGAGAGAAGAAGATATCATGGGTATTATTGCATAATCAAAGAATATTACAAA
TTTTAAAGGAGAAATTAAAA

Downstream 100 bases:

>100_bases
TAGTCTTTATATTGTTATTAATCTAATAATACTTTTATATTATACTCAACTAGCTTATTTTCATTTAATTATTATTTCTT
CTATTACTTTAGCTCCGGAC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAAKQVLFSDEARAKMLDGVNTLANAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAKEIELEDKFENMGAQIVKEVASK
TADVAGDGTTTATVLAQALLTEGLKAVAAGMNPMDLKRGIDKATARLVEELKALSKPCSDPKSIEQVGTISANSDATVGK
LIADAMAKVGKEGVITVEEGKGFEDELDVVEGMQFDRGYLSPYFATNQENMTTDLENPYILIVDKKISNIRDLLPILEGV
SKSGRALLIIAEDVESEALATLVVNNMRGVVKVCAVKAPGFGDRRKAMLEDIATLTGATFVSEDLSMKLEETNMEHLGTA
SRVLVTKDNTTIIDGAGEKEAIAKRINVIKANIAEANSDYDREKLQERLAKLSGGVAVIKVGAVTEAEMKEKKDRVDDAL
HATRAAVEEGIVAGGGVALIRAQKALDGLTGENDDQNHGIALLRKAIEAPLRQIVSNAGGESSVVVNQVKANQGNYGYNA
ANDTYGDMVEMGILDPTKVTRSALQHAASIAGLMITTEAMIGEIKEAAPAMPMGGGMGGMPGMI

Sequences:

>Translated_544_residues
MAAKQVLFSDEARAKMLDGVNTLANAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAKEIELEDKFENMGAQIVKEVASK
TADVAGDGTTTATVLAQALLTEGLKAVAAGMNPMDLKRGIDKATARLVEELKALSKPCSDPKSIEQVGTISANSDATVGK
LIADAMAKVGKEGVITVEEGKGFEDELDVVEGMQFDRGYLSPYFATNQENMTTDLENPYILIVDKKISNIRDLLPILEGV
SKSGRALLIIAEDVESEALATLVVNNMRGVVKVCAVKAPGFGDRRKAMLEDIATLTGATFVSEDLSMKLEETNMEHLGTA
SRVLVTKDNTTIIDGAGEKEAIAKRINVIKANIAEANSDYDREKLQERLAKLSGGVAVIKVGAVTEAEMKEKKDRVDDAL
HATRAAVEEGIVAGGGVALIRAQKALDGLTGENDDQNHGIALLRKAIEAPLRQIVSNAGGESSVVVNQVKANQGNYGYNA
ANDTYGDMVEMGILDPTKVTRSALQHAASIAGLMITTEAMIGEIKEAAPAMPMGGGMGGMPGMI
>Mature_543_residues
AAKQVLFSDEARAKMLDGVNTLANAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAKEIELEDKFENMGAQIVKEVASKT
ADVAGDGTTTATVLAQALLTEGLKAVAAGMNPMDLKRGIDKATARLVEELKALSKPCSDPKSIEQVGTISANSDATVGKL
IADAMAKVGKEGVITVEEGKGFEDELDVVEGMQFDRGYLSPYFATNQENMTTDLENPYILIVDKKISNIRDLLPILEGVS
KSGRALLIIAEDVESEALATLVVNNMRGVVKVCAVKAPGFGDRRKAMLEDIATLTGATFVSEDLSMKLEETNMEHLGTAS
RVLVTKDNTTIIDGAGEKEAIAKRINVIKANIAEANSDYDREKLQERLAKLSGGVAVIKVGAVTEAEMKEKKDRVDDALH
ATRAAVEEGIVAGGGVALIRAQKALDGLTGENDDQNHGIALLRKAIEAPLRQIVSNAGGESSVVVNQVKANQGNYGYNAA
NDTYGDMVEMGILDPTKVTRSALQHAASIAGLMITTEAMIGEIKEAAPAMPMGGGMGGMPGMI

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=523, Percent_Identity=49.9043977055449, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI31542947, Length=523, Percent_Identity=49.9043977055449, Blast_Score=511, Evalue=1e-145,
Organism=Escherichia coli, GI1790586, Length=524, Percent_Identity=74.618320610687, Blast_Score=776, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=524, Percent_Identity=51.1450381679389, Blast_Score=518, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI193210679, Length=206, Percent_Identity=51.4563106796116, Blast_Score=203, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323288, Length=522, Percent_Identity=55.1724137931034, Blast_Score=560, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6322524, Length=161, Percent_Identity=29.8136645962733, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641193, Length=523, Percent_Identity=49.3307839388145, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24641191, Length=523, Percent_Identity=49.3307839388145, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550936, Length=523, Percent_Identity=49.3307839388145, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI45550132, Length=523, Percent_Identity=49.3307839388145, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI45550935, Length=523, Percent_Identity=49.3307839388145, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI17864606, Length=542, Percent_Identity=41.8819188191882, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24584129, Length=533, Percent_Identity=38.0863039399625, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI19921262, Length=533, Percent_Identity=38.0863039399625, Blast_Score=329, Evalue=3e-90,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57340; Mature: 57209

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKQVLFSDEARAKMLDGVNTLANAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAKEI
CCCCHHHHCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELEDKFENMGAQIVKEVASKTADVAGDGTTTATVLAQALLTEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKATARLVEELKALSKPCSDPKSIEQVGTISANSDATVGKLIADAMAKVGKEGVITVEEG
HHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECC
KGFEDELDVVEGMQFDRGYLSPYFATNQENMTTDLENPYILIVDKKISNIRDLLPILEGV
CCCHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCC
SKSGRALLIIAEDVESEALATLVVNNMRGVVKVCAVKAPGFGDRRKAMLEDIATLTGATF
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
VSEDLSMKLEETNMEHLGTASRVLVTKDNTTIIDGAGEKEAIAKRINVIKANIAEANSDY
HHHHHHHHHHHCCHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLSGGVAVIKVGAVTEAEMKEKKDRVDDALHATRAAVEEGIVAGGGVALI
CHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAQKALDGLTGENDDQNHGIALLRKAIEAPLRQIVSNAGGESSVVVNQVKANQGNYGYNA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ANDTYGDMVEMGILDPTKVTRSALQHAASIAGLMITTEAMIGEIKEAAPAMPMGGGMGGM
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PGMI
CCCC
>Mature Secondary Structure 
AAKQVLFSDEARAKMLDGVNTLANAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAKEI
CCCHHHHCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELEDKFENMGAQIVKEVASKTADVAGDGTTTATVLAQALLTEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKATARLVEELKALSKPCSDPKSIEQVGTISANSDATVGKLIADAMAKVGKEGVITVEEG
HHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECC
KGFEDELDVVEGMQFDRGYLSPYFATNQENMTTDLENPYILIVDKKISNIRDLLPILEGV
CCCHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCC
SKSGRALLIIAEDVESEALATLVVNNMRGVVKVCAVKAPGFGDRRKAMLEDIATLTGATF
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHH
VSEDLSMKLEETNMEHLGTASRVLVTKDNTTIIDGAGEKEAIAKRINVIKANIAEANSDY
HHHHHHHHHHHCCHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLSGGVAVIKVGAVTEAEMKEKKDRVDDALHATRAAVEEGIVAGGGVALI
CHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAQKALDGLTGENDDQNHGIALLRKAIEAPLRQIVSNAGGESSVVVNQVKANQGNYGYNA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
ANDTYGDMVEMGILDPTKVTRSALQHAASIAGLMITTEAMIGEIKEAAPAMPMGGGMGGM
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PGMI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA