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The map label for this gene is hemA

Identifier: 134301374

GI number: 134301374

Start: 266746

End: 267990

Strand: Direct

Name: hemA

Synonym: FTW_0258

Alternate gene names: 134301374

Gene position: 266746-267990 (Clockwise)

Preceding gene: 134301369

Following gene: 134301375

Centisome position: 14.05

GC content: 32.85

Gene sequence:

>1245_bases
ATGGCGTTAATATCTTTAGCAATTGATTATAAAAAGTCTCCGATAGAAGTTCGTAGTGAGTTTGCACTCTCTGGTTTAGA
TGTATCTATGCTATATAGATCAATACTTGCTATAGATAATGTTGTACATGCTGTAATCTTATCAACTTGTAATCGTACAG
AAGTATATCTTGAGATATCTGATCTAAGAGTAGTTGATGATATTTTAGTATGGTGGCAAGGCTATGTTAGAAACCCTAAT
TATAAAATAAAAGATTATTTTAAGCTAAGACAAGGTACAGAAGTAATTATGCACCTTATGAAATTGGCTTGTGGTTTAGA
ATCGATGGTTTTAGGTGAACCGCAAATATTAGGACAAGTAAAAGATTCTTATACTCTCAGTAAAAAAAATCATGCTATTG
GTAAAGAACTAGATAGGGTTTTTCAGAAGGTTTTTGCAACTGCTAAAAGAGTACGTAGTGAAACTAGAATTGGTCATTGC
CCAGTTTCAGTTGCATTCTCAGCAATTACTTTGGCTAAAAGGCAACTAGATAATATTTCTAGTAAGAATGTCCTTATTAT
TGGTGCTGGTCAAACAGGAGAGCTTTTGTTTCGTCATGTTACAGCACTTGCTCCTAAGCAGATAATGCTAGCAAACCGAA
CTATCGAGAAAGCACAGAAAATTACTTCTGCTTTTAGAAATGCTAGTGCTCATTACTTATCAGAGCTACCGCAATTGATC
AAAAAAGCTGATATTATAATTGCTGCAGTCAATGTTTTAGAATACATTGTCACATGCAAATATGTTGGCGATAAACCTAG
AGTTTTTATTGATATATCAATACCTCAAGCTTTAGACCCTAAATTAGGCGAGTTAGAGCAAAATGTTTATTATTGCGTTG
ATGATATTAACGCTGTTATTGAAGATAACAAAGATAAAAGAAAGTATGAAAGCTCTAAAGCACAGAAAATTATTGTAAAA
TCTCTTGAGGAATATCTTGAAAAAGAAAAGGCTATTATCTCAAATAGTGCGATTAAAGAGCTTTTCCAAAAAGCTGACGG
TTTAGTTGATTTATCGCTAGAGAAAAGCTTAGCTAAGATAAGAAATGGTAAAGATGCCGAAGAGATAATTAAAAGATTTG
CTTATGAAATTAAAAAGAAAGTTTTACACTATCCTGTTGTAGGAATGAAAGAGGCTTCCAAGCAGGGTAGAAGTGACTGT
CTTGTATGTATGAAACGTATGTTTGGTTTAAATGTGGAAAAATAA

Upstream 100 bases:

>100_bases
TATTAATCAGATTAGAATGTAATGTCTTAGTCTTTTGTGTTAAAATATGTTTTTGTTTTTCTAGGTTAATTTATTTTATT
ACATTTAATAATATTTGAAT

Downstream 100 bases:

>100_bases
ATGAAAGATTCTATTAAAGCAAAATTGCAAAGTTTGATAGAAAGGCATGAGGAAGTTAGTGCCTTATTAAGTGAGGCAGG
AATTATCTCTGATCAAAATA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MALISLAIDYKKSPIEVRSEFALSGLDVSMLYRSILAIDNVVHAVILSTCNRTEVYLEISDLRVVDDILVWWQGYVRNPN
YKIKDYFKLRQGTEVIMHLMKLACGLESMVLGEPQILGQVKDSYTLSKKNHAIGKELDRVFQKVFATAKRVRSETRIGHC
PVSVAFSAITLAKRQLDNISSKNVLIIGAGQTGELLFRHVTALAPKQIMLANRTIEKAQKITSAFRNASAHYLSELPQLI
KKADIIIAAVNVLEYIVTCKYVGDKPRVFIDISIPQALDPKLGELEQNVYYCVDDINAVIEDNKDKRKYESSKAQKIIVK
SLEEYLEKEKAIISNSAIKELFQKADGLVDLSLEKSLAKIRNGKDAEEIIKRFAYEIKKKVLHYPVVGMKEASKQGRSDC
LVCMKRMFGLNVEK

Sequences:

>Translated_414_residues
MALISLAIDYKKSPIEVRSEFALSGLDVSMLYRSILAIDNVVHAVILSTCNRTEVYLEISDLRVVDDILVWWQGYVRNPN
YKIKDYFKLRQGTEVIMHLMKLACGLESMVLGEPQILGQVKDSYTLSKKNHAIGKELDRVFQKVFATAKRVRSETRIGHC
PVSVAFSAITLAKRQLDNISSKNVLIIGAGQTGELLFRHVTALAPKQIMLANRTIEKAQKITSAFRNASAHYLSELPQLI
KKADIIIAAVNVLEYIVTCKYVGDKPRVFIDISIPQALDPKLGELEQNVYYCVDDINAVIEDNKDKRKYESSKAQKIIVK
SLEEYLEKEKAIISNSAIKELFQKADGLVDLSLEKSLAKIRNGKDAEEIIKRFAYEIKKKVLHYPVVGMKEASKQGRSDC
LVCMKRMFGLNVEK
>Mature_413_residues
ALISLAIDYKKSPIEVRSEFALSGLDVSMLYRSILAIDNVVHAVILSTCNRTEVYLEISDLRVVDDILVWWQGYVRNPNY
KIKDYFKLRQGTEVIMHLMKLACGLESMVLGEPQILGQVKDSYTLSKKNHAIGKELDRVFQKVFATAKRVRSETRIGHCP
VSVAFSAITLAKRQLDNISSKNVLIIGAGQTGELLFRHVTALAPKQIMLANRTIEKAQKITSAFRNASAHYLSELPQLIK
KADIIIAAVNVLEYIVTCKYVGDKPRVFIDISIPQALDPKLGELEQNVYYCVDDINAVIEDNKDKRKYESSKAQKIIVKS
LEEYLEKEKAIISNSAIKELFQKADGLVDLSLEKSLAKIRNGKDAEEIIKRFAYEIKKKVLHYPVVGMKEASKQGRSDCL
VCMKRMFGLNVEK

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=33.7320574162679, Blast_Score=244, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_FRAT1 (Q14JR2)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_666364.1
- ProteinModelPortal:   Q14JR2
- STRING:   Q14JR2
- GeneID:   4200370
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF0167
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q14JR2
- ProtClustDB:   PRK13940
- BioCyc:   FTUL393115:FTF0167-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46731; Mature: 46600

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 52-52 BINDING 110-110 BINDING 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALISLAIDYKKSPIEVRSEFALSGLDVSMLYRSILAIDNVVHAVILSTCNRTEVYLEIS
CCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEH
DLRVVDDILVWWQGYVRNPNYKIKDYFKLRQGTEVIMHLMKLACGLESMVLGEPQILGQV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHH
KDSYTLSKKNHAIGKELDRVFQKVFATAKRVRSETRIGHCPVSVAFSAITLAKRQLDNIS
HHCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
SKNVLIIGAGQTGELLFRHVTALAPKQIMLANRTIEKAQKITSAFRNASAHYLSELPQLI
CCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
KKADIIIAAVNVLEYIVTCKYVGDKPRVFIDISIPQALDPKLGELEQNVYYCVDDINAVI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHEEHHHHHHHHH
EDNKDKRKYESSKAQKIIVKSLEEYLEKEKAIISNSAIKELFQKADGLVDLSLEKSLAKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
RNGKDAEEIIKRFAYEIKKKVLHYPVVGMKEASKQGRSDCLVCMKRMFGLNVEK
HCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ALISLAIDYKKSPIEVRSEFALSGLDVSMLYRSILAIDNVVHAVILSTCNRTEVYLEIS
CEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEH
DLRVVDDILVWWQGYVRNPNYKIKDYFKLRQGTEVIMHLMKLACGLESMVLGEPQILGQV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHH
KDSYTLSKKNHAIGKELDRVFQKVFATAKRVRSETRIGHCPVSVAFSAITLAKRQLDNIS
HHCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
SKNVLIIGAGQTGELLFRHVTALAPKQIMLANRTIEKAQKITSAFRNASAHYLSELPQLI
CCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
KKADIIIAAVNVLEYIVTCKYVGDKPRVFIDISIPQALDPKLGELEQNVYYCVDDINAVI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHEEHHHHHHHHH
EDNKDKRKYESSKAQKIIVKSLEEYLEKEKAIISNSAIKELFQKADGLVDLSLEKSLAKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
RNGKDAEEIIKRFAYEIKKKVLHYPVVGMKEASKQGRSDCLVCMKRMFGLNVEK
HCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA