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The map label for this gene is grxD [H]

Identifier: 134301281

GI number: 134301281

Start: 154597

End: 154926

Strand: Reverse

Name: grxD [H]

Synonym: FTW_0143

Alternate gene names: 134301281

Gene position: 154926-154597 (Counterclockwise)

Preceding gene: 134301283

Following gene: 134301270

Centisome position: 8.16

GC content: 35.15

Gene sequence:

>330_bases
ATGTACACTCCAGAAGAACAAAAAGTAGTTGAACGAATTGAAAAGCAATTAAAAGAAAATGATATTATTTTATACATGAA
AGGTTCACCAAATCTTCCACAGTGCGGTTTTTCTGCGCATGCAGCAACGGCAATTAGATCATGTGGTAAGCCATTTGCTT
TTGTAAATATTCTTGAGAACCCTGATATAAGAGCTATCTTACCAAAATATGCTGACTGGCCAACATTCCCTCAACTTTGG
GTAAAAGGCGAACTAATAGGCGGCTGCGATATAATTATGGAAATGAATGAATCTGGCGAACTAAAAAAATTAATTGACTC
TGTAAAATAA

Upstream 100 bases:

>100_bases
TAGTATCTTCTTACTATACCCATATAGTATAATATGCTATCATCTTTTAGGTGAAATTTCTAAACTTACTTGTTTAATTA
AAATAAAAAAGGAAGCAAAA

Downstream 100 bases:

>100_bases
TTAAACACAAATATCTTTATTTACTATCTATTTTTGTCCAAGCATCTGTACCATACTTACCAGTTGGTTTATAAGCTTCA
CTATTACACAAGCTAGATTC

Product: glutaredoxin-like protein

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin [H]

Number of amino acids: Translated: 109; Mature: 109

Protein sequence:

>109_residues
MYTPEEQKVVERIEKQLKENDIILYMKGSPNLPQCGFSAHAATAIRSCGKPFAFVNILENPDIRAILPKYADWPTFPQLW
VKGELIGGCDIIMEMNESGELKKLIDSVK

Sequences:

>Translated_109_residues
MYTPEEQKVVERIEKQLKENDIILYMKGSPNLPQCGFSAHAATAIRSCGKPFAFVNILENPDIRAILPKYADWPTFPQLW
VKGELIGGCDIIMEMNESGELKKLIDSVK
>Mature_109_residues
MYTPEEQKVVERIEKQLKENDIILYMKGSPNLPQCGFSAHAATAIRSCGKPFAFVNILENPDIRAILPKYADWPTFPQLW
VKGELIGGCDIIMEMNESGELKKLIDSVK

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters [H]

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI42516576, Length=99, Percent_Identity=38.3838383838384, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI95113651, Length=98, Percent_Identity=40.8163265306122, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1787943, Length=97, Percent_Identity=65.979381443299, Blast_Score=150, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17556042, Length=99, Percent_Identity=35.3535353535354, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71988153, Length=84, Percent_Identity=35.7142857142857, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71988159, Length=90, Percent_Identity=34.4444444444444, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325198, Length=100, Percent_Identity=40, Blast_Score=91, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321022, Length=83, Percent_Identity=44.578313253012, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320303, Length=87, Percent_Identity=41.3793103448276, Blast_Score=83, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24642023, Length=89, Percent_Identity=38.2022471910112, Blast_Score=92, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19921242, Length=99, Percent_Identity=38.3838383838384, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 12311; Mature: 12311

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTPEEQKVVERIEKQLKENDIILYMKGSPNLPQCGFSAHAATAIRSCGKPFAFVNILEN
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCC
PDIRAILPKYADWPTFPQLWVKGELIGGCDIIMEMNESGELKKLIDSVK
CCCEEECCCCCCCCCCCHHEECCCCCCCEEEEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MYTPEEQKVVERIEKQLKENDIILYMKGSPNLPQCGFSAHAATAIRSCGKPFAFVNILEN
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCC
PDIRAILPKYADWPTFPQLWVKGELIGGCDIIMEMNESGELKKLIDSVK
CCCEEECCCCCCCCCCCHHEECCCCCCCEEEEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]