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The map label for this gene is nuoL [H]

Identifier: 134301257

GI number: 134301257

Start: 125448

End: 127457

Strand: Direct

Name: nuoL [H]

Synonym: FTW_0117

Alternate gene names: 134301257

Gene position: 125448-127457 (Clockwise)

Preceding gene: 134301256

Following gene: 134301258

Centisome position: 6.61

GC content: 34.98

Gene sequence:

>2010_bases
ATGATAATAAACAATCAAGTAGCAGCTGTATTAATCGCAGTTATAGTTCTAGCACCTCTATTAGGTGCATTGATAGCTGG
GTTTGGTGGTAAATCGGTAAAAAATGCAGGTGTTAACTTTTTCACAATTTCTCTATGTGGTCTGTCTTTTGTCCTTAGTG
TGATTTTAGCTTATGGTGTTTTTAGTGGCGCTGAAGTCTATTCTGTTAGCTTTTATCAGTGGGCTCCTATTTCAAATATG
TTTGCCTTTGATGTTGGCTTTACTGTAAATAAGATAACTGTGTATATGATGTTGATAGTAACATTTGTATCAACACTAGT
TCATATTTACTCGATTGGGTATATGAAAGGCGAAGAAGGATATGCAAGGTTTTTTGCATATATTTCAGGTTTTACATTTG
CAATGCTTTGTTTGGTAATGGGAAATAATTTCTTACTATTATTCTTTGGTTGGGAAGGCGTAGGCTTATTTTCATACTTA
CTAATTGGTTTTTATTTCAATAGAGATAAGGCAAATGTTGCAAGTTTAAGAGCTTTTATTGTAAATAGAATTGGTGACTT
GGGCTTCTTGTTGGGAATTGGAGCAGTTATTTTATATACAAAATCGGTTGACTATACGACAGTTTTTGCAGCTTTACCCG
ATATTGATAATACTCAAACTATACACTTTCTAGGTATTAGTTTTAGTCCAGTTACGCTAATGTGTTCATTATTGTTTATA
GGAGCAATGGGTAAGTCAGCTCAGTTTCCTTTACATTCATGGTTAGAAGGATCAATGGAGGGTCCTACACCGATTTCAGC
ACTAATCCATGCAGCAACAATGGTTACAGCTGGGGTATTTATGGTTGCGAGACTTTCTCCAATGTTTGTATTGTCACCAG
CGGCCCTAAGCTTTGTATTAATTATTGGCGCTATAACATGCTTGTTTATGGGGTTGATTGCAATCGTTCAAACAGATATT
AAAAGAGTCATAGCATACTGTACGCTATCGCAATTAGGCTATATGATGGTAGCTCAAGGCGCTGGTGCGTTTTCAATAGG
TATGTTCCATTTGATGACACACGCAATGTTTAAGGCATTATTATTCTTGGCAGCTGGATCTGTTATTGTTGCGATGCATC
ATGAGCAAGATATTCGTAGAATGGGCGGTTTAAGGAAATATATGCCGGTTACATATTTGTGTATGTTAATAGGTGCTTGG
GCGCTTGCGGCTTTACCACCTTTCTCAGGATTTTTCTCAAAAGACTTGATTATTGAAGCAGCTCAAGCTACTACAGTATA
TGGACATGAGTTTGCTTACTATATGGTATTAGCGTGTGCGTTTGTTACATCGTTTTATATCTTTAGAATGTTTTTCTTGG
TATTCCATGGTAAAGAAAGAATGTCAGATGAAGAAAGATCACATCTTAAAGAATCTCCATTTAGTATATTAATACCTTTA
ATATTATTGGCTATACCTTCTGTATTTGTTGGGGAGTATTTCTTTAGTAGTATTTTGTCACAGGAGCATGGTTTATTCGG
TAATACTATAACCCCATTTATACAAGCTGGCCTTGGTTGGGAGTCGGTAACAGCACACTTAGCTAATGAGCCAGCTATAG
TAAGTTCAATGGCATTCATTAAACATTCTGTAACAACGCTACCATTCTGGTTAGCTTTTAGTGCTTTAGTATTGGCATAT
GTTTTATATGTGTGGCTACCAGCAATTCCAAGACTATTTGCAAATGCAAAATCAGGATTTGGAATAATCTATCATATTTT
AGTTAAGAAGTATTTTATTGATGCTTTGTATGATGTGATATTTGTTAATATCTTCTTGGCAATTAGTAATTTCTTGTGGA
AAGTTGTTGATATCTTCATTATCGATAAAACAGTTGTAAATGGTACATCTAATCTGATATATCATACTGGCGATAGTTTT
AGAAAGATCCAAAGAGGATATTTGTTTGACTATGCATTTGTGATGATGGTTGGTGTATTATTGTTTATGATTTTGCTAAT
TTCTGTTTAG

Upstream 100 bases:

>100_bases
TGAGACAGCAATTGGTTTAGCAATTGTTGTGGCAATATTTAGAAAACGCAAAACTATTGATTTAAGTAAACTTAATACAC
TAAGAGGTTAAGAGTAAACT

Downstream 100 bases:

>100_bases
GCAAGTTAGAGGATAAATTTGTATTATGAATTTAGGTAATTACTTATTAAGTTTAATAATCTGGCTCCCAATAGTTGGTG
GTTTTGTTGTTTTGGCGACA

Product: NADH dehydrogenase I, L subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MIINNQVAAVLIAVIVLAPLLGALIAGFGGKSVKNAGVNFFTISLCGLSFVLSVILAYGVFSGAEVYSVSFYQWAPISNM
FAFDVGFTVNKITVYMMLIVTFVSTLVHIYSIGYMKGEEGYARFFAYISGFTFAMLCLVMGNNFLLLFFGWEGVGLFSYL
LIGFYFNRDKANVASLRAFIVNRIGDLGFLLGIGAVILYTKSVDYTTVFAALPDIDNTQTIHFLGISFSPVTLMCSLLFI
GAMGKSAQFPLHSWLEGSMEGPTPISALIHAATMVTAGVFMVARLSPMFVLSPAALSFVLIIGAITCLFMGLIAIVQTDI
KRVIAYCTLSQLGYMMVAQGAGAFSIGMFHLMTHAMFKALLFLAAGSVIVAMHHEQDIRRMGGLRKYMPVTYLCMLIGAW
ALAALPPFSGFFSKDLIIEAAQATTVYGHEFAYYMVLACAFVTSFYIFRMFFLVFHGKERMSDEERSHLKESPFSILIPL
ILLAIPSVFVGEYFFSSILSQEHGLFGNTITPFIQAGLGWESVTAHLANEPAIVSSMAFIKHSVTTLPFWLAFSALVLAY
VLYVWLPAIPRLFANAKSGFGIIYHILVKKYFIDALYDVIFVNIFLAISNFLWKVVDIFIIDKTVVNGTSNLIYHTGDSF
RKIQRGYLFDYAFVMMVGVLLFMILLISV

Sequences:

>Translated_669_residues
MIINNQVAAVLIAVIVLAPLLGALIAGFGGKSVKNAGVNFFTISLCGLSFVLSVILAYGVFSGAEVYSVSFYQWAPISNM
FAFDVGFTVNKITVYMMLIVTFVSTLVHIYSIGYMKGEEGYARFFAYISGFTFAMLCLVMGNNFLLLFFGWEGVGLFSYL
LIGFYFNRDKANVASLRAFIVNRIGDLGFLLGIGAVILYTKSVDYTTVFAALPDIDNTQTIHFLGISFSPVTLMCSLLFI
GAMGKSAQFPLHSWLEGSMEGPTPISALIHAATMVTAGVFMVARLSPMFVLSPAALSFVLIIGAITCLFMGLIAIVQTDI
KRVIAYCTLSQLGYMMVAQGAGAFSIGMFHLMTHAMFKALLFLAAGSVIVAMHHEQDIRRMGGLRKYMPVTYLCMLIGAW
ALAALPPFSGFFSKDLIIEAAQATTVYGHEFAYYMVLACAFVTSFYIFRMFFLVFHGKERMSDEERSHLKESPFSILIPL
ILLAIPSVFVGEYFFSSILSQEHGLFGNTITPFIQAGLGWESVTAHLANEPAIVSSMAFIKHSVTTLPFWLAFSALVLAY
VLYVWLPAIPRLFANAKSGFGIIYHILVKKYFIDALYDVIFVNIFLAISNFLWKVVDIFIIDKTVVNGTSNLIYHTGDSF
RKIQRGYLFDYAFVMMVGVLLFMILLISV
>Mature_669_residues
MIINNQVAAVLIAVIVLAPLLGALIAGFGGKSVKNAGVNFFTISLCGLSFVLSVILAYGVFSGAEVYSVSFYQWAPISNM
FAFDVGFTVNKITVYMMLIVTFVSTLVHIYSIGYMKGEEGYARFFAYISGFTFAMLCLVMGNNFLLLFFGWEGVGLFSYL
LIGFYFNRDKANVASLRAFIVNRIGDLGFLLGIGAVILYTKSVDYTTVFAALPDIDNTQTIHFLGISFSPVTLMCSLLFI
GAMGKSAQFPLHSWLEGSMEGPTPISALIHAATMVTAGVFMVARLSPMFVLSPAALSFVLIIGAITCLFMGLIAIVQTDI
KRVIAYCTLSQLGYMMVAQGAGAFSIGMFHLMTHAMFKALLFLAAGSVIVAMHHEQDIRRMGGLRKYMPVTYLCMLIGAW
ALAALPPFSGFFSKDLIIEAAQATTVYGHEFAYYMVLACAFVTSFYIFRMFFLVFHGKERMSDEERSHLKESPFSILIPL
ILLAIPSVFVGEYFFSSILSQEHGLFGNTITPFIQAGLGWESVTAHLANEPAIVSSMAFIKHSVTTLPFWLAFSALVLAY
VLYVWLPAIPRLFANAKSGFGIIYHILVKKYFIDALYDVIFVNIFLAISNFLWKVVDIFIIDKTVVNGTSNLIYHTGDSF
RKIQRGYLFDYAFVMMVGVLLFMILLISV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=423, Percent_Identity=38.5342789598109, Blast_Score=285, Evalue=1e-76,
Organism=Escherichia coli, GI1788614, Length=663, Percent_Identity=38.0090497737557, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI1788829, Length=499, Percent_Identity=30.060120240481, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788827, Length=477, Percent_Identity=26.8343815513627, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788831, Length=377, Percent_Identity=27.3209549071618, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI2367154, Length=215, Percent_Identity=31.1627906976744, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1788613, Length=407, Percent_Identity=24.0786240786241, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 73842; Mature: 73842

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIINNQVAAVLIAVIVLAPLLGALIAGFGGKSVKNAGVNFFTISLCGLSFVLSVILAYGV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEHHHHHHHHHHHHHHHHHHC
FSGAEVYSVSFYQWAPISNMFAFDVGFTVNKITVYMMLIVTFVSTLVHIYSIGYMKGEEG
CCCCCEEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
YARFFAYISGFTFAMLCLVMGNNFLLLFFGWEGVGLFSYLLIGFYFNRDKANVASLRAFI
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VNRIGDLGFLLGIGAVILYTKSVDYTTVFAALPDIDNTQTIHFLGISFSPVTLMCSLLFI
HHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
GAMGKSAQFPLHSWLEGSMEGPTPISALIHAATMVTAGVFMVARLSPMFVLSPAALSFVL
HCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEECHHHHHHHH
IIGAITCLFMGLIAIVQTDIKRVIAYCTLSQLGYMMVAQGAGAFSIGMFHLMTHAMFKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LFLAAGSVIVAMHHEQDIRRMGGLRKYMPVTYLCMLIGAWALAALPPFSGFFSKDLIIEA
HHHHCCCCEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AQATTVYGHEFAYYMVLACAFVTSFYIFRMFFLVFHGKERMSDEERSHLKESPFSILIPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHCCHHHHHHH
ILLAIPSVFVGEYFFSSILSQEHGLFGNTITPFIQAGLGWESVTAHLANEPAIVSSMAFI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHH
KHSVTTLPFWLAFSALVLAYVLYVWLPAIPRLFANAKSGFGIIYHILVKKYFIDALYDVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FVNIFLAISNFLWKVVDIFIIDKTVVNGTSNLIYHTGDSFRKIQRGYLFDYAFVMMVGVL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
LFMILLISV
HHHHHHHCC
>Mature Secondary Structure
MIINNQVAAVLIAVIVLAPLLGALIAGFGGKSVKNAGVNFFTISLCGLSFVLSVILAYGV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEHHHHHHHHHHHHHHHHHHC
FSGAEVYSVSFYQWAPISNMFAFDVGFTVNKITVYMMLIVTFVSTLVHIYSIGYMKGEEG
CCCCCEEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
YARFFAYISGFTFAMLCLVMGNNFLLLFFGWEGVGLFSYLLIGFYFNRDKANVASLRAFI
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VNRIGDLGFLLGIGAVILYTKSVDYTTVFAALPDIDNTQTIHFLGISFSPVTLMCSLLFI
HHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
GAMGKSAQFPLHSWLEGSMEGPTPISALIHAATMVTAGVFMVARLSPMFVLSPAALSFVL
HCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEECHHHHHHHH
IIGAITCLFMGLIAIVQTDIKRVIAYCTLSQLGYMMVAQGAGAFSIGMFHLMTHAMFKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LFLAAGSVIVAMHHEQDIRRMGGLRKYMPVTYLCMLIGAWALAALPPFSGFFSKDLIIEA
HHHHCCCCEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AQATTVYGHEFAYYMVLACAFVTSFYIFRMFFLVFHGKERMSDEERSHLKESPFSILIPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHCCHHHHHHH
ILLAIPSVFVGEYFFSSILSQEHGLFGNTITPFIQAGLGWESVTAHLANEPAIVSSMAFI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHH
KHSVTTLPFWLAFSALVLAYVLYVWLPAIPRLFANAKSGFGIIYHILVKKYFIDALYDVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FVNIFLAISNFLWKVVDIFIIDKTVVNGTSNLIYHTGDSFRKIQRGYLFDYAFVMMVGVL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
LFMILLISV
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]