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The map label for this gene is figD [H]

Identifier: 134301241

GI number: 134301241

Start: 109528

End: 110718

Strand: Reverse

Name: figD [H]

Synonym: FTW_0101

Alternate gene names: 134301241

Gene position: 110718-109528 (Counterclockwise)

Preceding gene: 134301242

Following gene: 134301240

Centisome position: 5.83

GC content: 33.92

Gene sequence:

>1191_bases
ATGCAGATTGATAATAAAAATTTAAAATATATCCCTTTACTTGTTCTTTTAACATGGTTTTTAGGTAATATGGGCGTACA
TTTCTTGCTGCCATTACTACCTTTACTATCAAACAACCTCGATGCATCTGTAAAACTAACTCAGTATGTAATAGCTTTCT
TCTTAGCTGGTAAGGCTCTAGGAATGATAGTCTATGGGCCACTATCTGAAATCTATGGTCGCCGTAAATTTATGCTTTTT
GGTCTAATATTATATATGTCAAGTAGTCTGTTATGTATGCTAACAACAGATATATACTGGTTAATCTTTTGGCGTTTTGT
TCAAGGACTCGGTGTAAGTGGTACTATACTTATGGGTAGGGTTATTATTAATGACTCATATCCAAATGATAAAGCTGCTA
ATATTTTTGGCTACTTGTTTGCCCTAGCTGCAGTAATTATTGCTTGTTTGCCTACTTTAGGAGGAATAATAGCCATATTC
AAAAATTGGCAACTAGCTTTTGCTACCATGATGATTTATAGCAGTTTAATATTTGTGATAATGCTAAAATTTTTACCAGA
AACACAGTCTGAGCAATTCCAAAAATCATTTTCTCTAATAGGGATTATTAAGGATTATTCTAATATCTTACGTAACCGCG
TATTTTTGGGTTATCTGATGTGTACAAGCCTAATGGTAGCTGGTGAATCAGCATTTAACACAAATGCTGCTTTCTTGATG
ATAAAAACTTACGGAGTCTCACCAAAAATTTTTGGCATGATGATGTCTAGCTTGTTAATAGCTCACCTACTTGGAGCCGC
CATATGTGGTCGCTATGTGGTCAAAAGAGGTATTTCAAAACTAACAGGAGTTGGTGCGCTAATATTAGTATTAGCAGCAA
TGTTCCTATCAGTAACATCTATACTTAAATTTGATGGTCCATACCTTACCATAACAGCGATGTTCATTTATTTCTTAGGA
ACAGGTTTTATCATGACAACAGCGGCAGTTGGCGTAGTATCACCATTTCCTAAAATGATTGGTACGGCCATGGCTTTTGC
ACTATCATTAGAATTTTTATTATCAGCATTAAGCAGTTTTATTACTAGTCACTTATCAATTTCTTCTTTATTTCCTATTA
CTGTACTTATAACTTTACTAAGTCTAGGCTCTTTTGCAATGTGGTTTTTCTGTATTAAAAGAGATAAATAA

Upstream 100 bases:

>100_bases
GTTCATCCATCTAAAGCCAAGTGTAATTCTAATCGACAAAAATCATCAATACCAAGTTCTCAGAGTTAGACAAACACATC
AATAATAATAGGTAATTAAA

Downstream 100 bases:

>100_bases
TATTTTTTACCAAATAGTATTGATTATCATTATCATTTAATTTAATATCTAAAAATTAATTTATATTCTTTGTTTCTTTC
TTAATATGCTAAATAAAATT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MQIDNKNLKYIPLLVLLTWFLGNMGVHFLLPLLPLLSNNLDASVKLTQYVIAFFLAGKALGMIVYGPLSEIYGRRKFMLF
GLILYMSSSLLCMLTTDIYWLIFWRFVQGLGVSGTILMGRVIINDSYPNDKAANIFGYLFALAAVIIACLPTLGGIIAIF
KNWQLAFATMMIYSSLIFVIMLKFLPETQSEQFQKSFSLIGIIKDYSNILRNRVFLGYLMCTSLMVAGESAFNTNAAFLM
IKTYGVSPKIFGMMMSSLLIAHLLGAAICGRYVVKRGISKLTGVGALILVLAAMFLSVTSILKFDGPYLTITAMFIYFLG
TGFIMTTAAVGVVSPFPKMIGTAMAFALSLEFLLSALSSFITSHLSISSLFPITVLITLLSLGSFAMWFFCIKRDK

Sequences:

>Translated_396_residues
MQIDNKNLKYIPLLVLLTWFLGNMGVHFLLPLLPLLSNNLDASVKLTQYVIAFFLAGKALGMIVYGPLSEIYGRRKFMLF
GLILYMSSSLLCMLTTDIYWLIFWRFVQGLGVSGTILMGRVIINDSYPNDKAANIFGYLFALAAVIIACLPTLGGIIAIF
KNWQLAFATMMIYSSLIFVIMLKFLPETQSEQFQKSFSLIGIIKDYSNILRNRVFLGYLMCTSLMVAGESAFNTNAAFLM
IKTYGVSPKIFGMMMSSLLIAHLLGAAICGRYVVKRGISKLTGVGALILVLAAMFLSVTSILKFDGPYLTITAMFIYFLG
TGFIMTTAAVGVVSPFPKMIGTAMAFALSLEFLLSALSSFITSHLSISSLFPITVLITLLSLGSFAMWFFCIKRDK
>Mature_396_residues
MQIDNKNLKYIPLLVLLTWFLGNMGVHFLLPLLPLLSNNLDASVKLTQYVIAFFLAGKALGMIVYGPLSEIYGRRKFMLF
GLILYMSSSLLCMLTTDIYWLIFWRFVQGLGVSGTILMGRVIINDSYPNDKAANIFGYLFALAAVIIACLPTLGGIIAIF
KNWQLAFATMMIYSSLIFVIMLKFLPETQSEQFQKSFSLIGIIKDYSNILRNRVFLGYLMCTSLMVAGESAFNTNAAFLM
IKTYGVSPKIFGMMMSSLLIAHLLGAAICGRYVVKRGISKLTGVGALILVLAAMFLSVTSILKFDGPYLTITAMFIYFLG
TGFIMTTAAVGVVSPFPKMIGTAMAFALSLEFLLSALSSFITSHLSISSLFPITVLITLLSLGSFAMWFFCIKRDK

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=356, Percent_Identity=25.2808988764045, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788509, Length=368, Percent_Identity=21.4673913043478, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082312, Length=355, Percent_Identity=22.8169014084507, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790146, Length=232, Percent_Identity=24.5689655172414, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790794, Length=207, Percent_Identity=22.7053140096618, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43742; Mature: 43742

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]