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The map label for this gene is mdmC [H]

Identifier: 134301183

GI number: 134301183

Start: 18694

End: 19350

Strand: Reverse

Name: mdmC [H]

Synonym: FTW_0021

Alternate gene names: 134301183

Gene position: 19350-18694 (Counterclockwise)

Preceding gene: 134301184

Following gene: 134301180

Centisome position: 1.02

GC content: 33.18

Gene sequence:

>657_bases
ATGTCTATCAAATCATTATTTAAGAGTTCAAGTCTTGACGATTATATCGATACTAATTCAGTTAAGTTAGATGTTATTGC
ACAGCAACTTTTTAATAAAGCAAAAAATGATGAACTAAGTCATATGCTTAGCTCACCTAACCAGTTACAGTTACTTAGCC
TTTTGCTAAAAATCATTAATGTTAAAAGGGTTTTAGAAATAGGAGTTTTTCGTGGTTTTTCTACTTTAGTAATGGCACAA
GCTTTAGCTGATGATGCTACTATTGAAGCCTGTGATATTGGCTATGAGTATCTTAAGCCATATGAGCATTTTTGGCAGCA
GGCAAAAGTTGAACATAAGATTAACCTAAATATTGCACCAGCTCTTGAGACACTTGATAGATTTTTACAGCAACAGCTAA
AATTTGATTTTGTTTATATCGATGCTGATAAGCCAAACTACATAAATTATTATGAAAAAGCTTTAGCTCTAATGGATTCT
GGTGGGCTTATTGCTATAGATAATGTGCTTTGGTCAGGTCGGGTTGCTGATAAATCAAATAACGAGGTAAACACGCTTGT
AATAAGACAGCTAAATAACTTAATTCATGATGATAAGCGCGTAGACGCTTGTATAATACCGATTGGAGATGGTATAAATT
TACTTAGAAAGCGTTAG

Upstream 100 bases:

>100_bases
TTTCTATAACTAAAATTAAATAGTTTCTAGCAAGATTTTATTTTAGATTTTGCTCTATCTAGTTCATAACAAAGCAATTT
AGAATATTTAAGGTGTTCCT

Downstream 100 bases:

>100_bases
CTTATTTAGTAAGATGAATATGTGCTAGAGCTTGCTTAGAAGTTTCTAAAGCTATGTGAGTATTTTGTGCTTTTGCTAAG
ACAACTCCCATACGGCGTTT

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MSIKSLFKSSSLDDYIDTNSVKLDVIAQQLFNKAKNDELSHMLSSPNQLQLLSLLLKIINVKRVLEIGVFRGFSTLVMAQ
ALADDATIEACDIGYEYLKPYEHFWQQAKVEHKINLNIAPALETLDRFLQQQLKFDFVYIDADKPNYINYYEKALALMDS
GGLIAIDNVLWSGRVADKSNNEVNTLVIRQLNNLIHDDKRVDACIIPIGDGINLLRKR

Sequences:

>Translated_218_residues
MSIKSLFKSSSLDDYIDTNSVKLDVIAQQLFNKAKNDELSHMLSSPNQLQLLSLLLKIINVKRVLEIGVFRGFSTLVMAQ
ALADDATIEACDIGYEYLKPYEHFWQQAKVEHKINLNIAPALETLDRFLQQQLKFDFVYIDADKPNYINYYEKALALMDS
GGLIAIDNVLWSGRVADKSNNEVNTLVIRQLNNLIHDDKRVDACIIPIGDGINLLRKR
>Mature_217_residues
SIKSLFKSSSLDDYIDTNSVKLDVIAQQLFNKAKNDELSHMLSSPNQLQLLSLLLKIINVKRVLEIGVFRGFSTLVMAQA
LADDATIEACDIGYEYLKPYEHFWQQAKVEHKINLNIAPALETLDRFLQQQLKFDFVYIDADKPNYINYYEKALALMDSG
GLIAIDNVLWSGRVADKSNNEVNTLVIRQLNNLIHDDKRVDACIIPIGDGINLLRKR

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=170, Percent_Identity=39.4117647058824, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17565612, Length=188, Percent_Identity=35.6382978723404, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI72001127, Length=188, Percent_Identity=34.5744680851064, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25148771, Length=191, Percent_Identity=33.5078534031414, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI72001028, Length=186, Percent_Identity=32.7956989247312, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71991493, Length=237, Percent_Identity=27.8481012658228, Blast_Score=73, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24788; Mature: 24657

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKSLFKSSSLDDYIDTNSVKLDVIAQQLFNKAKNDELSHMLSSPNQLQLLSLLLKIIN
CCHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHH
VKRVLEIGVFRGFSTLVMAQALADDATIEACDIGYEYLKPYEHFWQQAKVEHKINLNIAP
HHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEECCEEHH
ALETLDRFLQQQLKFDFVYIDADKPNYINYYEKALALMDSGGLIAIDNVLWSGRVADKSN
HHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECEEECCCCCCCCC
NEVNTLVIRQLNNLIHDDKRVDACIIPIGDGINLLRKR
CCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHCC
>Mature Secondary Structure 
SIKSLFKSSSLDDYIDTNSVKLDVIAQQLFNKAKNDELSHMLSSPNQLQLLSLLLKIIN
CHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHH
VKRVLEIGVFRGFSTLVMAQALADDATIEACDIGYEYLKPYEHFWQQAKVEHKINLNIAP
HHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEECCEEHH
ALETLDRFLQQQLKFDFVYIDADKPNYINYYEKALALMDSGGLIAIDNVLWSGRVADKSN
HHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECEEECCCCCCCCC
NEVNTLVIRQLNNLIHDDKRVDACIIPIGDGINLLRKR
CCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]