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The map label for this gene is clcA [H]

Identifier: 134301176

GI number: 134301176

Start: 6084

End: 7502

Strand: Direct

Name: clcA [H]

Synonym: FTW_0010

Alternate gene names: 134301176

Gene position: 6084-7502 (Clockwise)

Preceding gene: 134301175

Following gene: 134301177

Centisome position: 0.32

GC content: 35.94

Gene sequence:

>1419_bases
TTGCAAACTACCCTTATATCCATAATGAGTAATAAGGTATTAGATACATATTATAAAAACAATCGACATATTTGGGTGCT
AGTACTATCTGGTGCTGTTATAGGCACAATGATTGGTCTTCTAGCAACAGCATTTCAGCTACTCCTAGACTTTATTTTTA
AAATTAAGCTGGCTCTTTTTTCTTTCAGTGGTGGTAATCTTTTTATCGAAATCGCTATGTCAATATCATTAAGTATTGTG
ATGGTATTAATTTCGATTTTTATTGTTAAAAAATTTGCGAAAGAGGCTGGTGGTAGCGGTATCCAAGAGGTTGAGGGTGC
TTTAAAAGGCTGCCGCAAAATACGTAAAAGAGTTATGCCCGTGAAGTTTATAAGTGGACTTTTTTCGTTAGGCTCAGGTT
TAAGTTTAGGTAAAGAGGGACCATCAATTCATATGGCTGCTGCATTAGCGCAGTTTTTTGTTGATAAATTTAAACTTACT
ACAAAATATGCTAATGCGGTTATCTCTGCTGGGGCTGGAGCTGGACTAGCAGCTGCTTTTAATACCCCACTTTCTGGGAT
TATCTTTGTTATTGAAGAGATGAATAGAAAGTTTAGATTTAGTGTTTCGGCAATAAAGTGTGTGCTAGTAGCATGTATCA
TGAGTACAGTTATCTCTAGAGCTATTATGGGTAATCCTCCAGCAATACGCGTAGAAACTTTCAGCTCAGTACCACAAAAT
ACTCTTTGGTTATTTATGGTATTAGGGATTATATTTGGTTATTTTGGTTTACTATTTAACAAATCCTTAATCAAAGTGGC
AAACTTTTTCTCAGAAGGCTCCAAGAAGAGGTATTGGACTTTAGTTATAATTGTTTGCATAATTTTTGGTATTGGTGTTG
TTCTATCTCCAAATGCTGTTGGCGGTGGCTATATTGTCATAGCAAATACTCTTGATTATAACTTATCAATCAAGATGCTT
TTAGTGCTTTTTGTACTTCGTTTTGCTGGAGTTATTTTCTCATATGGCACCGGCGTTACTGGTGGGATATTCGCACCAAT
GATTGCGCTTGGTACTGTTTTTGGACTAGCTTATGGTTTATCAGTGGCGCAACTCTTCCCTCAGTATAATATTGAACCTG
GAGTTTTTGCAGTTGCTGGAATGAGTGCACTATTTACAGCAACTGTAGGTGCACCATTAACGGGTATTGTACTAGTAATG
GAGATGACTTGGAATTTCCATCTTTTACTTCCTTTGATGATAACTTGCTTTAGTGCATCTATGCTGACCTATATTCATCA
TCAAAAACCAATATATGATACCCTATTAAGACGTACTATTTCTAACGAAAGAAAACAACAAGCAAAGGAAAAAAATGAGC
GCAATCAAAAGCCAACTCCAAATACTTCAGGACAAACTATCTCAAAAGAAGAAATATAA

Upstream 100 bases:

>100_bases
GCAAACTCAATAACAAAAAATATCACCTAAGCAATATTTCTCGAACTTTGGTTAACTTTTTCTTTTTAAAAACTTTCAAA
AATGTATAATTTGTGTTAGT

Downstream 100 bases:

>100_bases
TCACGCAATTTCTCTAATGCACTGGGACTTAGAAACACAAGCCCCTAAAAACTCAATCAACACAACATCTGAAGTTATTG
GGTTTTTCAGTGAAAAAATC

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MQTTLISIMSNKVLDTYYKNNRHIWVLVLSGAVIGTMIGLLATAFQLLLDFIFKIKLALFSFSGGNLFIEIAMSISLSIV
MVLISIFIVKKFAKEAGGSGIQEVEGALKGCRKIRKRVMPVKFISGLFSLGSGLSLGKEGPSIHMAAALAQFFVDKFKLT
TKYANAVISAGAGAGLAAAFNTPLSGIIFVIEEMNRKFRFSVSAIKCVLVACIMSTVISRAIMGNPPAIRVETFSSVPQN
TLWLFMVLGIIFGYFGLLFNKSLIKVANFFSEGSKKRYWTLVIIVCIIFGIGVVLSPNAVGGGYIVIANTLDYNLSIKML
LVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLAYGLSVAQLFPQYNIEPGVFAVAGMSALFTATVGAPLTGIVLVM
EMTWNFHLLLPLMITCFSASMLTYIHHQKPIYDTLLRRTISNERKQQAKEKNERNQKPTPNTSGQTISKEEI

Sequences:

>Translated_472_residues
MQTTLISIMSNKVLDTYYKNNRHIWVLVLSGAVIGTMIGLLATAFQLLLDFIFKIKLALFSFSGGNLFIEIAMSISLSIV
MVLISIFIVKKFAKEAGGSGIQEVEGALKGCRKIRKRVMPVKFISGLFSLGSGLSLGKEGPSIHMAAALAQFFVDKFKLT
TKYANAVISAGAGAGLAAAFNTPLSGIIFVIEEMNRKFRFSVSAIKCVLVACIMSTVISRAIMGNPPAIRVETFSSVPQN
TLWLFMVLGIIFGYFGLLFNKSLIKVANFFSEGSKKRYWTLVIIVCIIFGIGVVLSPNAVGGGYIVIANTLDYNLSIKML
LVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLAYGLSVAQLFPQYNIEPGVFAVAGMSALFTATVGAPLTGIVLVM
EMTWNFHLLLPLMITCFSASMLTYIHHQKPIYDTLLRRTISNERKQQAKEKNERNQKPTPNTSGQTISKEEI
>Mature_472_residues
MQTTLISIMSNKVLDTYYKNNRHIWVLVLSGAVIGTMIGLLATAFQLLLDFIFKIKLALFSFSGGNLFIEIAMSISLSIV
MVLISIFIVKKFAKEAGGSGIQEVEGALKGCRKIRKRVMPVKFISGLFSLGSGLSLGKEGPSIHMAAALAQFFVDKFKLT
TKYANAVISAGAGAGLAAAFNTPLSGIIFVIEEMNRKFRFSVSAIKCVLVACIMSTVISRAIMGNPPAIRVETFSSVPQN
TLWLFMVLGIIFGYFGLLFNKSLIKVANFFSEGSKKRYWTLVIIVCIIFGIGVVLSPNAVGGGYIVIANTLDYNLSIKML
LVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLAYGLSVAQLFPQYNIEPGVFAVAGMSALFTATVGAPLTGIVLVM
EMTWNFHLLLPLMITCFSASMLTYIHHQKPIYDTLLRRTISNERKQQAKEKNERNQKPTPNTSGQTISKEEI

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770838, Length=437, Percent_Identity=24.0274599542334, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI55770840, Length=437, Percent_Identity=24.0274599542334, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4557473, Length=427, Percent_Identity=24.1217798594848, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI189217923, Length=427, Percent_Identity=23.8875878220141, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI189217921, Length=427, Percent_Identity=23.8875878220141, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI153252026, Length=423, Percent_Identity=23.6406619385343, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786350, Length=437, Percent_Identity=40.2745995423341, Blast_Score=284, Evalue=8e-78,
Organism=Escherichia coli, GI87081943, Length=349, Percent_Identity=26.3610315186246, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532615, Length=406, Percent_Identity=25.8620689655172, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71985148, Length=434, Percent_Identity=25.8064516129032, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71985141, Length=434, Percent_Identity=25.8064516129032, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71996455, Length=427, Percent_Identity=23.8875878220141, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71996452, Length=427, Percent_Identity=23.8875878220141, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71980828, Length=428, Percent_Identity=23.8317757009346, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980824, Length=428, Percent_Identity=23.8317757009346, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71980820, Length=433, Percent_Identity=23.5565819861432, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559050, Length=480, Percent_Identity=25.8333333333333, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322500, Length=388, Percent_Identity=27.5773195876289, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24665008, Length=414, Percent_Identity=25.1207729468599, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45551566, Length=400, Percent_Identity=25, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 51358; Mature: 51358

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTTLISIMSNKVLDTYYKNNRHIWVLVLSGAVIGTMIGLLATAFQLLLDFIFKIKLALF
CCCHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFSGGNLFIEIAMSISLSIVMVLISIFIVKKFAKEAGGSGIQEVEGALKGCRKIRKRVMP
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCH
VKFISGLFSLGSGLSLGKEGPSIHMAAALAQFFVDKFKLTTKYANAVISAGAGAGLAAAF
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
NTPLSGIIFVIEEMNRKFRFSVSAIKCVLVACIMSTVISRAIMGNPPAIRVETFSSVPQN
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCH
TLWLFMVLGIIFGYFGLLFNKSLIKVANFFSEGSKKRYWTLVIIVCIIFGIGVVLSPNAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECCCCC
GGGYIVIANTLDYNLSIKMLLVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLAYGL
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SVAQLFPQYNIEPGVFAVAGMSALFTATVGAPLTGIVLVMEMTWNFHLLLPLMITCFSAS
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MLTYIHHQKPIYDTLLRRTISNERKQQAKEKNERNQKPTPNTSGQTISKEEI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQTTLISIMSNKVLDTYYKNNRHIWVLVLSGAVIGTMIGLLATAFQLLLDFIFKIKLALF
CCCHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFSGGNLFIEIAMSISLSIVMVLISIFIVKKFAKEAGGSGIQEVEGALKGCRKIRKRVMP
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCH
VKFISGLFSLGSGLSLGKEGPSIHMAAALAQFFVDKFKLTTKYANAVISAGAGAGLAAAF
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
NTPLSGIIFVIEEMNRKFRFSVSAIKCVLVACIMSTVISRAIMGNPPAIRVETFSSVPQN
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCH
TLWLFMVLGIIFGYFGLLFNKSLIKVANFFSEGSKKRYWTLVIIVCIIFGIGVVLSPNAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECCCCC
GGGYIVIANTLDYNLSIKMLLVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLAYGL
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SVAQLFPQYNIEPGVFAVAGMSALFTATVGAPLTGIVLVMEMTWNFHLLLPLMITCFSAS
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MLTYIHHQKPIYDTLLRRTISNERKQQAKEKNERNQKPTPNTSGQTISKEEI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA