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The map label for this gene is adhB [H]

Identifier: 134300509

GI number: 134300509

Start: 2895831

End: 2896946

Strand: Reverse

Name: adhB [H]

Synonym: Dred_2674

Alternate gene names: 134300509

Gene position: 2896946-2895831 (Counterclockwise)

Preceding gene: 134300510

Following gene: 134300507

Centisome position: 80.29

GC content: 49.55

Gene sequence:

>1116_bases
ATGCAATTCAATTTTTACTGTCCCACCAAGTTATTCTTTGGCCAGGGCTGCCTAGAACAAAACAGCAGTGAACTGGCGGC
CTTAGGTAAGAGAGCCTTGATTGTCACCGGAGGTAGTTCTTCTAAAAAGAATGGTTCCCTGGAGGACATGACTACTGCCC
TACATAAAGAAGGAATTGAATATCAAATATTTAATGAGGTAGAACAAAACCCCAGCCTTGCCACCGTATTACGAGGGGGG
CAGCGGGCTAAGGAAATGGGAGCTGATTTCATCGTTGGTATCGGCGGGGGCAGTCCCCTGGATGCTGCCAAAGCCATAGC
TGTCATGGCGATTAACGAGATAAGCCAGCAGGATTTAATGGCCAAGAAATGGACCAATGAACCTCTGCCAACGGTAGCAG
TTCCCACCACTGCCGGTACCGGCAGTGAGGTAACTCCCTATGCCGTATTGACGGTGGATTGGGCAGAAACCAAGATGTCC
ATTGCCGGGGAGAAGCTGTTTCCAACCCTAGCCTTCCTTGATGGCAGATATATGCTGAACCTACCATGGAGTATCACTGC
CAATACTGCGGTGGATGCCCTGTCCCATAGTATCGAGGGGTATATCAGCAACCGTGCCACAGTTTATTCCGACCTGTTGG
CCCTGGAAAGCATCCGTATCCTTGGCCAGTTGTTGAGAACTATAAACCCTGATAGTATTTCCCTGGCTGAGAGGGAAGAA
TTGCTCTACGCCTCCACGTTGGCAGGCATCGTCATTGCTCAAACTGGCACAAGTGTAGTTCATGCCCTGGGCTATCCATT
AACCTATTATAAGGATCTGCCCCACGGCTTGGCCAACGGTGTGACCACGAAAGCCGCTCTGGAGTTTATGGCTCAGGATG
CCCCCGACAGGGTGAAACAGGTAATAAAAGCAATGGGCTGTCATGACCTTGCAGAAGTAGGAAACTTGTTCAATAAAGTG
TTGCCGGCTGTAGATATTAAGCTAACCGCCGAAGAACAGGCAAGGTTTGTGGAAAAAACCCTGCAGGCCAAAAACCTGAC
CAACTGTCCCAGAAGGCCTGAGGAGAAGGATATTTATGAAATGCTGAGGAGAAGCAACCTGGTGGAACTTGTGTAG

Upstream 100 bases:

>100_bases
TTGGCTTGATAAATCATGTTATGAGTTGAAAAATTTAAGGAAATAGGTGATAAAATAGGGAACAAGTACTGATTACTTTA
CTGATACAGGAGGGTATCCT

Downstream 100 bases:

>100_bases
ATAAATAATCTCCTGCAGCCCATGAATGACTTAGCTAAAATCTATTGAGTAATATTAAATATCCCCCTCTATACATATCT
TTTACTATGTATAGAGGGGG

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase II; ADH II [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MQFNFYCPTKLFFGQGCLEQNSSELAALGKRALIVTGGSSSKKNGSLEDMTTALHKEGIEYQIFNEVEQNPSLATVLRGG
QRAKEMGADFIVGIGGGSPLDAAKAIAVMAINEISQQDLMAKKWTNEPLPTVAVPTTAGTGSEVTPYAVLTVDWAETKMS
IAGEKLFPTLAFLDGRYMLNLPWSITANTAVDALSHSIEGYISNRATVYSDLLALESIRILGQLLRTINPDSISLAEREE
LLYASTLAGIVIAQTGTSVVHALGYPLTYYKDLPHGLANGVTTKAALEFMAQDAPDRVKQVIKAMGCHDLAEVGNLFNKV
LPAVDIKLTAEEQARFVEKTLQAKNLTNCPRRPEEKDIYEMLRRSNLVELV

Sequences:

>Translated_371_residues
MQFNFYCPTKLFFGQGCLEQNSSELAALGKRALIVTGGSSSKKNGSLEDMTTALHKEGIEYQIFNEVEQNPSLATVLRGG
QRAKEMGADFIVGIGGGSPLDAAKAIAVMAINEISQQDLMAKKWTNEPLPTVAVPTTAGTGSEVTPYAVLTVDWAETKMS
IAGEKLFPTLAFLDGRYMLNLPWSITANTAVDALSHSIEGYISNRATVYSDLLALESIRILGQLLRTINPDSISLAEREE
LLYASTLAGIVIAQTGTSVVHALGYPLTYYKDLPHGLANGVTTKAALEFMAQDAPDRVKQVIKAMGCHDLAEVGNLFNKV
LPAVDIKLTAEEQARFVEKTLQAKNLTNCPRRPEEKDIYEMLRRSNLVELV
>Mature_371_residues
MQFNFYCPTKLFFGQGCLEQNSSELAALGKRALIVTGGSSSKKNGSLEDMTTALHKEGIEYQIFNEVEQNPSLATVLRGG
QRAKEMGADFIVGIGGGSPLDAAKAIAVMAINEISQQDLMAKKWTNEPLPTVAVPTTAGTGSEVTPYAVLTVDWAETKMS
IAGEKLFPTLAFLDGRYMLNLPWSITANTAVDALSHSIEGYISNRATVYSDLLALESIRILGQLLRTINPDSISLAEREE
LLYASTLAGIVIAQTGTSVVHALGYPLTYYKDLPHGLANGVTTKAALEFMAQDAPDRVKQVIKAMGCHDLAEVGNLFNKV
LPAVDIKLTAEEQARFVEKTLQAKNLTNCPRRPEEKDIYEMLRRSNLVELV

Specific function: This Enzyme Has Three Activities: Adh, Acdh, And Pfl- Deactivase. In Aerobic Conditions Adhe Acts As A Hydrogen Peroxide Scavenger. Pfl Deactivase Catalyzes The Quenching Of The Pyruvate- Formate-Lyase Catalyst In An Iron, NAD, And CoA Dependent Reactio

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=339, Percent_Identity=26.5486725663717, Blast_Score=101, Evalue=9e-22,
Organism=Escherichia coli, GI1787493, Length=304, Percent_Identity=33.5526315789474, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI48994951, Length=304, Percent_Identity=33.2236842105263, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789163, Length=300, Percent_Identity=31.6666666666667, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI87082107, Length=303, Percent_Identity=31.3531353135314, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789386, Length=286, Percent_Identity=29.020979020979, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=334, Percent_Identity=27.8443113772455, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321181, Length=282, Percent_Identity=34.3971631205674, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24657991, Length=416, Percent_Identity=24.5192307692308, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40302; Mature: 40302

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFNFYCPTKLFFGQGCLEQNSSELAALGKRALIVTGGSSSKKNGSLEDMTTALHKEGIE
CCCEEECCHHHHHCCCHHHCCCHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCC
YQIFNEVEQNPSLATVLRGGQRAKEMGADFIVGIGGGSPLDAAKAIAVMAINEISQQDLM
EEEHHHHHCCCCHHHHHHCCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
AKKWTNEPLPTVAVPTTAGTGSEVTPYAVLTVDWAETKMSIAGEKLFPTLAFLDGRYMLN
HHHCCCCCCCEEEECCCCCCCCCCCCEEEEEEEHHHHHHHHCCHHHHHHHHHCCCCEEEE
LPWSITANTAVDALSHSIEGYISNRATVYSDLLALESIRILGQLLRTINPDSISLAEREE
CCCEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LLYASTLAGIVIAQTGTSVVHALGYPLTYYKDLPHGLANGVTTKAALEFMAQDAPDRVKQ
HHHHHHHHHEEEECCCHHHHHHHCCCHHHHHHCCHHHHCCCHHHHHHHHHHCCCHHHHHH
VIKAMGCHDLAEVGNLFNKVLPAVDIKLTAEEQARFVEKTLQAKNLTNCPRRPEEKDIYE
HHHHHCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
MLRRSNLVELV
HHHHCCCHHCC
>Mature Secondary Structure
MQFNFYCPTKLFFGQGCLEQNSSELAALGKRALIVTGGSSSKKNGSLEDMTTALHKEGIE
CCCEEECCHHHHHCCCHHHCCCHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCC
YQIFNEVEQNPSLATVLRGGQRAKEMGADFIVGIGGGSPLDAAKAIAVMAINEISQQDLM
EEEHHHHHCCCCHHHHHHCCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
AKKWTNEPLPTVAVPTTAGTGSEVTPYAVLTVDWAETKMSIAGEKLFPTLAFLDGRYMLN
HHHCCCCCCCEEEECCCCCCCCCCCCEEEEEEEHHHHHHHHCCHHHHHHHHHCCCCEEEE
LPWSITANTAVDALSHSIEGYISNRATVYSDLLALESIRILGQLLRTINPDSISLAEREE
CCCEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LLYASTLAGIVIAQTGTSVVHALGYPLTYYKDLPHGLANGVTTKAALEFMAQDAPDRVKQ
HHHHHHHHHEEEECCCHHHHHHHCCCHHHHHHCCHHHHCCCHHHHHHHHHHCCCHHHHHH
VIKAMGCHDLAEVGNLFNKVLPAVDIKLTAEEQARFVEKTLQAKNLTNCPRRPEEKDIYE
HHHHHCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
MLRRSNLVELV
HHHHCCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3584063; 2308827; 2935393 [H]