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The map label for this gene is hrcA

Identifier: 134300338

GI number: 134300338

Start: 2719572

End: 2720615

Strand: Reverse

Name: hrcA

Synonym: Dred_2499

Alternate gene names: 134300338

Gene position: 2720615-2719572 (Counterclockwise)

Preceding gene: 134300339

Following gene: 134300337

Centisome position: 75.4

GC content: 42.53

Gene sequence:

>1044_bases
GTGAAAATGGATGAACGTAAACAGCAGATTCTGTTGGCCATCATAAAAGACTATATTAATACAGCAGAGCCAGTAGGATC
ACGAACCATTTCTCGTAAATATAAATTGGGTGTTAGTCCGGCTACCATTCGTAACGAGATGTCAGATTTAGAAGAGATGG
GTTATATTGAACAGCCCCATACCTCCGCCGGGCGTATACCATCTAATCTTGGCTATCGCTACTATGTGGATTGCTTGATG
CAACGAGAGCAATTAAGTGAAGAAGAAGAAGTGACCATTCGGCGTGGTTATGAAAATAAGGTACGAGAAGTGGGTGAAGT
CCTAAATCGCACCGGCAGAATGATGGCTCAACTTACTCATTATACAGCCCTTGTTCAGATGCCGAGCTTTCGTAGAAGTG
CCTACAAGCATGTGCAAATGGTGCTTATGGGACCATCCCAGGCCATATTAATTGTGGTCATGGATACAGGTGCTGTTCAT
CACCAGATGATGACTGTCCCTGAAAGCATTACACAGCAGGATTTGGACCAAATCTCCAGTGTGTTGAATGCTAAGCTTCA
GGGCAGGACCATGGACAACATTCGACTTACTTTGATCAAAGAAATTTATTTTGAACTTTCCAAACACCGTAGCATTCTGG
ATTTAGCCCTTGAATTGATGCAGGATAGGGTCATTTCGGTTGCAGAGGATAAAATTTATCTTGAAGGGGTATTTAATATC
CTGAATCAACCAGAATTTCATAATGTTGAAAGAGTGAAAATACTCCTTTCCTTATTGGAACAGGAAGATACCTTAAAGGA
TATTCTTGATTTTACCAGGGATAGACAGGGGATTACCATCAAAATCGGCAATGAAAATTTGCGACAAGAAATTCAGGATT
GCAGCATGGTAACTGCTACTTACCAGGTAGGTGATAAAATCTTAGGAACCATCGGGGTTCTGGGACCCACCCGCATGGAT
TATGCAAGGGTGGTAACCGTGATCGATTGTATGTCTCGCAATCTTTCTCGAACACTGGACCGAATTCTGAAGGGGCAGGT
TTAG

Upstream 100 bases:

>100_bases
TGACAAATAATTTTCCTTTTGCTAAATTTTAAGTTAGATTAGCACTCATCGACTGAGAGTGCTAACACCCTTTAAGGGTG
GAATAGGAGGGTGGGCCGAC

Downstream 100 bases:

>100_bases
TTGAGTAAGGAGGAACTGTTTCCGTGAGTCTTAAACAACAGGCAAGTCAAGGTGCCGAAGTGAATGAAAAATTAGCTGCT
CTGATGACTAATTCCAATGC

Product: heat-inducible transcription repressor HrcA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKMDERKQQILLAIIKDYINTAEPVGSRTISRKYKLGVSPATIRNEMSDLEEMGYIEQPHTSAGRIPSNLGYRYYVDCLM
QREQLSEEEEVTIRRGYENKVREVGEVLNRTGRMMAQLTHYTALVQMPSFRRSAYKHVQMVLMGPSQAILIVVMDTGAVH
HQMMTVPESITQQDLDQISSVLNAKLQGRTMDNIRLTLIKEIYFELSKHRSILDLALELMQDRVISVAEDKIYLEGVFNI
LNQPEFHNVERVKILLSLLEQEDTLKDILDFTRDRQGITIKIGNENLRQEIQDCSMVTATYQVGDKILGTIGVLGPTRMD
YARVVTVIDCMSRNLSRTLDRILKGQV

Sequences:

>Translated_347_residues
MKMDERKQQILLAIIKDYINTAEPVGSRTISRKYKLGVSPATIRNEMSDLEEMGYIEQPHTSAGRIPSNLGYRYYVDCLM
QREQLSEEEEVTIRRGYENKVREVGEVLNRTGRMMAQLTHYTALVQMPSFRRSAYKHVQMVLMGPSQAILIVVMDTGAVH
HQMMTVPESITQQDLDQISSVLNAKLQGRTMDNIRLTLIKEIYFELSKHRSILDLALELMQDRVISVAEDKIYLEGVFNI
LNQPEFHNVERVKILLSLLEQEDTLKDILDFTRDRQGITIKIGNENLRQEIQDCSMVTATYQVGDKILGTIGVLGPTRMD
YARVVTVIDCMSRNLSRTLDRILKGQV
>Mature_347_residues
MKMDERKQQILLAIIKDYINTAEPVGSRTISRKYKLGVSPATIRNEMSDLEEMGYIEQPHTSAGRIPSNLGYRYYVDCLM
QREQLSEEEEVTIRRGYENKVREVGEVLNRTGRMMAQLTHYTALVQMPSFRRSAYKHVQMVLMGPSQAILIVVMDTGAVH
HQMMTVPESITQQDLDQISSVLNAKLQGRTMDNIRLTLIKEIYFELSKHRSILDLALELMQDRVISVAEDKIYLEGVFNI
LNQPEFHNVERVKILLSLLEQEDTLKDILDFTRDRQGITIKIGNENLRQEIQDCSMVTATYQVGDKILGTIGVLGPTRMD
YARVVTVIDCMSRNLSRTLDRILKGQV

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_DESRM (A4J7F6)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113834.1
- STRING:   A4J7F6
- GeneID:   4957818
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2499
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   CLSK928793
- BioCyc:   DRED349161:DRED_2499-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 39800; Mature: 39800

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMDERKQQILLAIIKDYINTAEPVGSRTISRKYKLGVSPATIRNEMSDLEEMGYIEQPH
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
TSAGRIPSNLGYRYYVDCLMQREQLSEEEEVTIRRGYENKVREVGEVLNRTGRMMAQLTH
CCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
YTALVQMPSFRRSAYKHVQMVLMGPSQAILIVVMDTGAVHHQMMTVPESITQQDLDQISS
HHHHHHCCHHHHHHHHHHHHEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
VLNAKLQGRTMDNIRLTLIKEIYFELSKHRSILDLALELMQDRVISVAEDKIYLEGVFNI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNQPEFHNVERVKILLSLLEQEDTLKDILDFTRDRQGITIKIGNENLRQEIQDCSMVTAT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHH
YQVGDKILGTIGVLGPTRMDYARVVTVIDCMSRNLSRTLDRILKGQV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKMDERKQQILLAIIKDYINTAEPVGSRTISRKYKLGVSPATIRNEMSDLEEMGYIEQPH
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
TSAGRIPSNLGYRYYVDCLMQREQLSEEEEVTIRRGYENKVREVGEVLNRTGRMMAQLTH
CCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
YTALVQMPSFRRSAYKHVQMVLMGPSQAILIVVMDTGAVHHQMMTVPESITQQDLDQISS
HHHHHHCCHHHHHHHHHHHHEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
VLNAKLQGRTMDNIRLTLIKEIYFELSKHRSILDLALELMQDRVISVAEDKIYLEGVFNI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNQPEFHNVERVKILLSLLEQEDTLKDILDFTRDRQGITIKIGNENLRQEIQDCSMVTAT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHH
YQVGDKILGTIGVLGPTRMDYARVVTVIDCMSRNLSRTLDRILKGQV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA