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The map label for this gene is lepB [H]

Identifier: 134299895

GI number: 134299895

Start: 2247691

End: 2248248

Strand: Reverse

Name: lepB [H]

Synonym: Dred_2049

Alternate gene names: 134299895

Gene position: 2248248-2247691 (Counterclockwise)

Preceding gene: 134299896

Following gene: 134299894

Centisome position: 62.31

GC content: 37.28

Gene sequence:

>558_bases
ATGGAGCGGTTGGATCCACATAATGATGAACAAAAAGAAACCAAACCCAAAAAATCAGTTATTCGTGAGATGTTGGAATC
GGTTGTTATAGCAGTTTTGTTGGCTGCTGTTATTCGCCTATTTATTTTAGAACCATTTTTTATACCATCTGGTTCAATGG
AGCCCAATTTAATGATAGGGGACAGAATTATTGTCAGTAAGATCACCTATCATTTAAAAGAGCCCCAGAGGGGAGATATT
ATTGTCTTTAAGTTCCCCTTAGATCCCAGTCGAAATTTTGTGAAAAGATTGATTGCTAAAGGTGGAGAAACCGTAGAGAT
CAAGAATAGTGTTTTATATATAAACAATCAGCCCATTGAAGAGAACTATTTGCCAAAGGGACTTAAATTTAAGGATTTTG
GTCCTGAGATTGTTCCAGAGGGCCATTACTTTATGATGGGTGATAATCGGAATAACAGTGATGACAGTAGAGTTTGGGGC
TTCTTGGATAAGGAGCTAATCATTGGTAAAGCAGAAGTCATTTACTGGCCCCTGAACAGGATTAGTTTAGCTAAATAA

Upstream 100 bases:

>100_bases
CTGCGTGGCAAAAAAGCTCGTATTAAGGAGCTTAGCACTCGCTAAACTAGAGGGGACTGGCAACCAGTCCCTTTTTTGGC
TTTTGGGGAGGGTATGACTT

Downstream 100 bases:

>100_bases
TATTTTTTAGATTTAAGCTTTCGAAGAGGCTGTTTCCGGGTAAACTCTTACGGAAGCTTTTATTTTTATGGAGGTACCAA
AGTGGATATTCAGATTCAGT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MERLDPHNDEQKETKPKKSVIREMLESVVIAVLLAAVIRLFILEPFFIPSGSMEPNLMIGDRIIVSKITYHLKEPQRGDI
IVFKFPLDPSRNFVKRLIAKGGETVEIKNSVLYINNQPIEENYLPKGLKFKDFGPEIVPEGHYFMMGDNRNNSDDSRVWG
FLDKELIIGKAEVIYWPLNRISLAK

Sequences:

>Translated_185_residues
MERLDPHNDEQKETKPKKSVIREMLESVVIAVLLAAVIRLFILEPFFIPSGSMEPNLMIGDRIIVSKITYHLKEPQRGDI
IVFKFPLDPSRNFVKRLIAKGGETVEIKNSVLYINNQPIEENYLPKGLKFKDFGPEIVPEGHYFMMGDNRNNSDDSRVWG
FLDKELIIGKAEVIYWPLNRISLAK
>Mature_185_residues
MERLDPHNDEQKETKPKKSVIREMLESVVIAVLLAAVIRLFILEPFFIPSGSMEPNLMIGDRIIVSKITYHLKEPQRGDI
IVFKFPLDPSRNFVKRLIAKGGETVEIKNSVLYINNQPIEENYLPKGLKFKDFGPEIVPEGHYFMMGDNRNNSDDSRVWG
FLDKELIIGKAEVIYWPLNRISLAK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Homo sapiens, GI21450679, Length=134, Percent_Identity=29.1044776119403, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1788921, Length=106, Percent_Identity=40.5660377358491, Blast_Score=77, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24642241, Length=134, Percent_Identity=29.8507462686567, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 21312; Mature: 21312

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLDPHNDEQKETKPKKSVIREMLESVVIAVLLAAVIRLFILEPFFIPSGSMEPNLMIG
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEC
DRIIVSKITYHLKEPQRGDIIVFKFPLDPSRNFVKRLIAKGGETVEIKNSVLYINNQPIE
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCEEEEECCCCC
ENYLPKGLKFKDFGPEIVPEGHYFMMGDNRNNSDDSRVWGFLDKELIIGKAEVIYWPLNR
CCCCCCCCEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEECCCEEEEECCCH
ISLAK
HCCCC
>Mature Secondary Structure
MERLDPHNDEQKETKPKKSVIREMLESVVIAVLLAAVIRLFILEPFFIPSGSMEPNLMIG
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEC
DRIIVSKITYHLKEPQRGDIIVFKFPLDPSRNFVKRLIAKGGETVEIKNSVLYINNQPIE
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCEEEEECCCCC
ENYLPKGLKFKDFGPEIVPEGHYFMMGDNRNNSDDSRVWGFLDKELIIGKAEVIYWPLNR
CCCCCCCCEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEECCCEEEEECCCH
ISLAK
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7865790 [H]