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The map label for this gene is ymxG [H]

Identifier: 134299795

GI number: 134299795

Start: 2137102

End: 2138370

Strand: Reverse

Name: ymxG [H]

Synonym: Dred_1947

Alternate gene names: 134299795

Gene position: 2138370-2137102 (Counterclockwise)

Preceding gene: 134299796

Following gene: 134299794

Centisome position: 59.27

GC content: 40.66

Gene sequence:

>1269_bases
GTGTTTTATCAAAAAGAAGTACTACCAAATGGAGTAAGAATATTAACACAACAAGTATCCCATGTCCGCTCAGTGGCCAT
GGGGATTTGGGTGGATGTTGGTTCCCGGGATGAAAGTGATGAAACAGCTGGAATTTCTCACTATATTGAACATATGATGT
TTAAAGGAACAAAGCATCGAACACCCAAACAAATTGCTGAAGAATTGGATGCAGTGGGAGGGCAATTGAATGCCTTTACC
ACAAAAGAGTACACTTGTTACTATGCCAAGGTATTGGATGAACATTTTAATCTAGCAGTCGATGTTCTAACAGATATGTT
ATTTCACTCAAATATATCCGAACTGGACGTAGAGCGAGAAAAGAATGTTATCTTGGAAGAAATTAAAATGTATGAGGATG
CACCAGATGAACTGGTTCATGACATGTTTGCTAAGACCATATGGGCAGGACACCCACTGGGCAGACCTATCATTGGTACT
ACAGAAACTGTCAGCAGTTTTTCCTATCAGGATTTACGTTTATTTATGAAAGAGAACTATGCTCCCAATCGTATTGTGGT
CTCGGTATCAGGTAATATCACACACCAGCAGGTGATAAACAAACTTGCACCGTTATTTGGCAATATGAGCGGAAATCAAG
TGAGAAGGCAACTTGAAAAACCCACTCACAGCATTGAAGTAAATTGTCGGAGCAAAGAAACGGAACAAGTACATATGGTA
ATCGGGGCACCGGGGTTGCGTCTGGATGATGATAGTTTATATATTGCCCAGGTTATCAACACTGTTTTGGGCGGAGGTCT
TTCCTCTAGACTGTTTCAAGAAATAAGGGAACAGAGGGGGTTGGTTTACTCAGTATATTCGTACCATAGTTCCTACCATG
ACACGGGTATTTTCGGAGTTTATGCTGGCCTAAGCAAGCAGAATGTAAACAATGCCATGGAACTTATTTTTAAGGAAATA
AAAGATATTAAGCAGAATGGCATATCCCAAAAGGAATTGCAAAGGGCCAAGGATCAACTCAAAGGAAACCTTTTGCTTTC
ATTGGAAAGTGTTAATACACATATGAGCAGGTTGGGCAAGTCCGAGCTATATTTGGGTAAGGTCTACAGCCCTGAAGAAA
TTGTAGAAAAATTAAATCGTGTTACACTAGAAGATACCGTGAGGGTTGCTGAAGAATTGTTTCAGCCGGATAAATTCTCC
ATGGCCGCTATTGGTCCCTGGCAGGATTGCGGTGATTTGAAGAAGGTTCTGGAAACCCTAAAAGATTAA

Upstream 100 bases:

>100_bases
TACATTGATACTCCATAATTGTCTATAATCTTAAATATAAAAAGGGTTTTTTGTAAATCATGGAGAAGGTTCCATAATTG
CGCTTCCAGGGGGTGTTGTA

Downstream 100 bases:

>100_bases
AAACCCCCCCTCATAAGAGGGGGTTTTTAATCAAATTGGTTGAATGTAGATATTATGTCATATTTACCCAACCACTTCCA
TAGAATTTACTAGGGAGGTG

Product: peptidase M16 domain-containing protein

Products: NA

Alternate protein names: ORFP [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MFYQKEVLPNGVRILTQQVSHVRSVAMGIWVDVGSRDESDETAGISHYIEHMMFKGTKHRTPKQIAEELDAVGGQLNAFT
TKEYTCYYAKVLDEHFNLAVDVLTDMLFHSNISELDVEREKNVILEEIKMYEDAPDELVHDMFAKTIWAGHPLGRPIIGT
TETVSSFSYQDLRLFMKENYAPNRIVVSVSGNITHQQVINKLAPLFGNMSGNQVRRQLEKPTHSIEVNCRSKETEQVHMV
IGAPGLRLDDDSLYIAQVINTVLGGGLSSRLFQEIREQRGLVYSVYSYHSSYHDTGIFGVYAGLSKQNVNNAMELIFKEI
KDIKQNGISQKELQRAKDQLKGNLLLSLESVNTHMSRLGKSELYLGKVYSPEEIVEKLNRVTLEDTVRVAEELFQPDKFS
MAAIGPWQDCGDLKKVLETLKD

Sequences:

>Translated_422_residues
MFYQKEVLPNGVRILTQQVSHVRSVAMGIWVDVGSRDESDETAGISHYIEHMMFKGTKHRTPKQIAEELDAVGGQLNAFT
TKEYTCYYAKVLDEHFNLAVDVLTDMLFHSNISELDVEREKNVILEEIKMYEDAPDELVHDMFAKTIWAGHPLGRPIIGT
TETVSSFSYQDLRLFMKENYAPNRIVVSVSGNITHQQVINKLAPLFGNMSGNQVRRQLEKPTHSIEVNCRSKETEQVHMV
IGAPGLRLDDDSLYIAQVINTVLGGGLSSRLFQEIREQRGLVYSVYSYHSSYHDTGIFGVYAGLSKQNVNNAMELIFKEI
KDIKQNGISQKELQRAKDQLKGNLLLSLESVNTHMSRLGKSELYLGKVYSPEEIVEKLNRVTLEDTVRVAEELFQPDKFS
MAAIGPWQDCGDLKKVLETLKD
>Mature_422_residues
MFYQKEVLPNGVRILTQQVSHVRSVAMGIWVDVGSRDESDETAGISHYIEHMMFKGTKHRTPKQIAEELDAVGGQLNAFT
TKEYTCYYAKVLDEHFNLAVDVLTDMLFHSNISELDVEREKNVILEEIKMYEDAPDELVHDMFAKTIWAGHPLGRPIIGT
TETVSSFSYQDLRLFMKENYAPNRIVVSVSGNITHQQVINKLAPLFGNMSGNQVRRQLEKPTHSIEVNCRSKETEQVHMV
IGAPGLRLDDDSLYIAQVINTVLGGGLSSRLFQEIREQRGLVYSVYSYHSSYHDTGIFGVYAGLSKQNVNNAMELIFKEI
KDIKQNGISQKELQRAKDQLKGNLLLSLESVNTHMSRLGKSELYLGKVYSPEEIVEKLNRVTLEDTVRVAEELFQPDKFS
MAAIGPWQDCGDLKKVLETLKD

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=422, Percent_Identity=28.6729857819905, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI46593007, Length=426, Percent_Identity=24.8826291079812, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI24308013, Length=434, Percent_Identity=24.6543778801843, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI50592988, Length=408, Percent_Identity=21.3235294117647, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI155969707, Length=237, Percent_Identity=26.5822784810127, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1787770, Length=418, Percent_Identity=22.7272727272727, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI2367164, Length=349, Percent_Identity=24.3553008595989, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71999683, Length=412, Percent_Identity=26.2135922330097, Blast_Score=181, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17553678, Length=398, Percent_Identity=26.3819095477387, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17510601, Length=447, Percent_Identity=22.5950782997763, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323192, Length=415, Percent_Identity=32.289156626506, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6321813, Length=407, Percent_Identity=25.0614250614251, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6319426, Length=422, Percent_Identity=21.3270142180095, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357875, Length=422, Percent_Identity=26.303317535545, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24646943, Length=422, Percent_Identity=26.303317535545, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI19921772, Length=437, Percent_Identity=23.7986270022883, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47821; Mature: 47821

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYQKEVLPNGVRILTQQVSHVRSVAMGIWVDVGSRDESDETAGISHYIEHMMFKGTKHR
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHCCCCCC
TPKQIAEELDAVGGQLNAFTTKEYTCYYAKVLDEHFNLAVDVLTDMLFHSNISELDVERE
CHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KNVILEEIKMYEDAPDELVHDMFAKTIWAGHPLGRPIIGTTETVSSFSYQDLRLFMKENY
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCC
APNRIVVSVSGNITHQQVINKLAPLFGNMSGNQVRRQLEKPTHSIEVNCRSKETEQVHMV
CCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEEE
IGAPGLRLDDDSLYIAQVINTVLGGGLSSRLFQEIREQRGLVYSVYSYHSSYHDTGIFGV
EECCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCHHHH
YAGLSKQNVNNAMELIFKEIKDIKQNGISQKELQRAKDQLKGNLLLSLESVNTHMSRLGK
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCC
SELYLGKVYSPEEIVEKLNRVTLEDTVRVAEELFQPDKFSMAAIGPWQDCGDLKKVLETL
CCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHH
KD
CC
>Mature Secondary Structure
MFYQKEVLPNGVRILTQQVSHVRSVAMGIWVDVGSRDESDETAGISHYIEHMMFKGTKHR
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHCCCCCC
TPKQIAEELDAVGGQLNAFTTKEYTCYYAKVLDEHFNLAVDVLTDMLFHSNISELDVERE
CHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KNVILEEIKMYEDAPDELVHDMFAKTIWAGHPLGRPIIGTTETVSSFSYQDLRLFMKENY
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCC
APNRIVVSVSGNITHQQVINKLAPLFGNMSGNQVRRQLEKPTHSIEVNCRSKETEQVHMV
CCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEEE
IGAPGLRLDDDSLYIAQVINTVLGGGLSSRLFQEIREQRGLVYSVYSYHSSYHDTGIFGV
EECCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCHHHH
YAGLSKQNVNNAMELIFKEIKDIKQNGISQKELQRAKDQLKGNLLLSLESVNTHMSRLGK
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCC
SELYLGKVYSPEEIVEKLNRVTLEDTVRVAEELFQPDKFSMAAIGPWQDCGDLKKVLETL
CCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHH
KD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 8098035 [H]