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The map label for this gene is yclK [H]

Identifier: 134299752

GI number: 134299752

Start: 2090331

End: 2091812

Strand: Reverse

Name: yclK [H]

Synonym: Dred_1902

Alternate gene names: 134299752

Gene position: 2091812-2090331 (Counterclockwise)

Preceding gene: 134299753

Following gene: 134299751

Centisome position: 57.98

GC content: 39.88

Gene sequence:

>1482_bases
ATGATTGGTGGCAGTATAGTAAAAAAACTCTGGTTAGCAACATCTCTATTGGTTTTATTAGCAATGGGCGCCTCTACATT
GACACAAATGTGGTTGCTAAAGAGCACTTATTATGATCAACAAATTGAGCAATTATTAGAGGCTACCAGGAAATTGGCAG
TTAAAATACAAATAGACGAACCAATGGCAGTGGCACAGGAAATGGAGTATTTAGCAGATAATTTACAAGGGGCCACTGCA
TTCCTTGTTAACAGAGATGGGCAAATTATTTATAAAACACGTGGAGGCTGGAGCAGGGGACCCAAACACCAAATGGGCAT
GCATGGAAATGGTTATGGTATGTATGGTATATTAACTGGTCTAAACATGAAAGATATTCTTGCTGGTAAGGAGATTATTT
TTAAAGGTCATCATCCAATGTTTGGTGTGGATGTTATCACTGTGGCGGTTCCTGTAAAAAAAGAAGAAATCATTGGAGAA
GTGTTGGTTTTAAGCACACCACGTCAAGCCATTGATACGAACATTAAGGCTTTACAGAGTATGAGTGTATACAGTCTTCT
TTTTGGCCTAGTGTTAGCAACATTGTTTAGCTGGTTACTATCCCGTTCACTTTCAAGACCCTTGCTTAAAATGAAAGACG
TAGCTAATGCAATGTCCCGTGGGGATTATAGTAGGAGTATCAACATAAAGTCTAAAGATGAAATTGGCATGCTAGCGGAT
TCGCTGAACACCCTCTCCCATGATTTGGAGGAGAAAATTAATCAATTGAGGCGAATTGACGATACCCGAAGAGATTTTGT
TGCAGGAGTATCTCACGAACTTCGAACACCGCTAACCATTATACAAGGAAATGCAGAGGCTTTGCTAGATGGGGTAATTG
AAGACAAAGATAAACAAAGGGACTTTTTAATTAACATATATGAAGAGTCCTTACGGTTAAAACGGTTGTCTAACGAACTC
TTAGATATGAGAAAAATAGAGACTGGACAGGTTAACTTATATAAGGAAAAGGTGAATGCCTCAGAGATATTTTTCAATGT
AGTATCCAGAATGCAGCATCTTGCCAAGCAAAGGGGAATTATATTAAACCTTTCCGTGCCAGAACAACCAGTAATCCTTT
ATCTGGATACAGATCGCTTAGGCCAAGTTTTGATCAATTTAATTGACAATGCCCTTCGGTTCTCGCGATCAGAGGTTACC
ATTGAGCTAAAGGATTTCCCTGATAAAATTAAAGTACAAATCAGCGATAACGGCCCGGGTATCCCGGAAGCTGAAAGAAA
TTTGGTATGGGATAAATTTTATAAAGTAGATAAGTCCCGTTCTCGATCAGCTGGGGGGACAGGCCTAGGCCTGTCCATTG
TTAAGCAATTAATAGAACTTCACGGTGGGACGGTCTGCCTAACAAGCAGAGAAGGGGAAGGAACAACCTTTATATTTACC
ATTCCGAAAGAACAAGGTGGAAAATCCACAGGGCAAAACTAG

Upstream 100 bases:

>100_bases
ATACTCATATAAATCGCCTGAGGGATAAACTCAATATGGAAGGGACAAAGCAAGCCATTACAACGGTCTGGGGTGTGGGT
TATAAATTTGAGGTAACTAA

Downstream 100 bases:

>100_bases
AAAAGCTTTAGCCATTTTGCAACGTCATCAGGGTAACCCAAAACAGCAAAACGAAGGTTTCCGTTGCATGTATAAGGGTT
TGCTTGTTTGATACCTCCCA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MIGGSIVKKLWLATSLLVLLAMGASTLTQMWLLKSTYYDQQIEQLLEATRKLAVKIQIDEPMAVAQEMEYLADNLQGATA
FLVNRDGQIIYKTRGGWSRGPKHQMGMHGNGYGMYGILTGLNMKDILAGKEIIFKGHHPMFGVDVITVAVPVKKEEIIGE
VLVLSTPRQAIDTNIKALQSMSVYSLLFGLVLATLFSWLLSRSLSRPLLKMKDVANAMSRGDYSRSINIKSKDEIGMLAD
SLNTLSHDLEEKINQLRRIDDTRRDFVAGVSHELRTPLTIIQGNAEALLDGVIEDKDKQRDFLINIYEESLRLKRLSNEL
LDMRKIETGQVNLYKEKVNASEIFFNVVSRMQHLAKQRGIILNLSVPEQPVILYLDTDRLGQVLINLIDNALRFSRSEVT
IELKDFPDKIKVQISDNGPGIPEAERNLVWDKFYKVDKSRSRSAGGTGLGLSIVKQLIELHGGTVCLTSREGEGTTFIFT
IPKEQGGKSTGQN

Sequences:

>Translated_493_residues
MIGGSIVKKLWLATSLLVLLAMGASTLTQMWLLKSTYYDQQIEQLLEATRKLAVKIQIDEPMAVAQEMEYLADNLQGATA
FLVNRDGQIIYKTRGGWSRGPKHQMGMHGNGYGMYGILTGLNMKDILAGKEIIFKGHHPMFGVDVITVAVPVKKEEIIGE
VLVLSTPRQAIDTNIKALQSMSVYSLLFGLVLATLFSWLLSRSLSRPLLKMKDVANAMSRGDYSRSINIKSKDEIGMLAD
SLNTLSHDLEEKINQLRRIDDTRRDFVAGVSHELRTPLTIIQGNAEALLDGVIEDKDKQRDFLINIYEESLRLKRLSNEL
LDMRKIETGQVNLYKEKVNASEIFFNVVSRMQHLAKQRGIILNLSVPEQPVILYLDTDRLGQVLINLIDNALRFSRSEVT
IELKDFPDKIKVQISDNGPGIPEAERNLVWDKFYKVDKSRSRSAGGTGLGLSIVKQLIELHGGTVCLTSREGEGTTFIFT
IPKEQGGKSTGQN
>Mature_493_residues
MIGGSIVKKLWLATSLLVLLAMGASTLTQMWLLKSTYYDQQIEQLLEATRKLAVKIQIDEPMAVAQEMEYLADNLQGATA
FLVNRDGQIIYKTRGGWSRGPKHQMGMHGNGYGMYGILTGLNMKDILAGKEIIFKGHHPMFGVDVITVAVPVKKEEIIGE
VLVLSTPRQAIDTNIKALQSMSVYSLLFGLVLATLFSWLLSRSLSRPLLKMKDVANAMSRGDYSRSINIKSKDEIGMLAD
SLNTLSHDLEEKINQLRRIDDTRRDFVAGVSHELRTPLTIIQGNAEALLDGVIEDKDKQRDFLINIYEESLRLKRLSNEL
LDMRKIETGQVNLYKEKVNASEIFFNVVSRMQHLAKQRGIILNLSVPEQPVILYLDTDRLGQVLINLIDNALRFSRSEVT
IELKDFPDKIKVQISDNGPGIPEAERNLVWDKFYKVDKSRSRSAGGTGLGLSIVKQLIELHGGTVCLTSREGEGTTFIFT
IPKEQGGKSTGQN

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=286, Percent_Identity=28.6713286713287, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786600, Length=287, Percent_Identity=31.3588850174216, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=33.6134453781513, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789149, Length=340, Percent_Identity=28.5294117647059, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=28.158844765343, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=33.4763948497854, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786783, Length=274, Percent_Identity=32.1167883211679, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=31.6872427983539, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87081816, Length=338, Percent_Identity=28.9940828402367, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788713, Length=244, Percent_Identity=32.3770491803279, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788279, Length=306, Percent_Identity=25.8169934640523, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=27.8538812785388, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787894, Length=289, Percent_Identity=25.9515570934256, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789808, Length=320, Percent_Identity=25.3125, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790861, Length=331, Percent_Identity=25.6797583081571, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082128, Length=312, Percent_Identity=25, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788549, Length=251, Percent_Identity=25.4980079681275, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790300, Length=234, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=303, Percent_Identity=26.7326732673267, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=289, Percent_Identity=22.1453287197232, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789403, Length=279, Percent_Identity=26.8817204301075, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322044, Length=76, Percent_Identity=43.421052631579, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55106; Mature: 55106

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGGSIVKKLWLATSLLVLLAMGASTLTQMWLLKSTYYDQQIEQLLEATRKLAVKIQIDE
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECC
PMAVAQEMEYLADNLQGATAFLVNRDGQIIYKTRGGWSRGPKHQMGMHGNGYGMYGILTG
HHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCC
LNMKDILAGKEIIFKGHHPMFGVDVITVAVPVKKEEIIGEVLVLSTPRQAIDTNIKALQS
CCHHHHHCCCCEEEECCCCCCCEEEEEEEECCCHHHHHHHHEEECCCHHHHHHHHHHHHH
MSVYSLLFGLVLATLFSWLLSRSLSRPLLKMKDVANAMSRGDYSRSINIKSKDEIGMLAD
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
SLNTLSHDLEEKINQLRRIDDTRRDFVAGVSHELRTPLTIIQGNAEALLDGVIEDKDKQR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHCCCEEEEECCHHHHHHHHHCCCCCCC
DFLINIYEESLRLKRLSNELLDMRKIETGQVNLYKEKVNASEIFFNVVSRMQHLAKQRGI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHCCE
ILNLSVPEQPVILYLDTDRLGQVLINLIDNALRFSRSEVTIELKDFPDKIKVQISDNGPG
EEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCC
IPEAERNLVWDKFYKVDKSRSRSAGGTGLGLSIVKQLIELHGGTVCLTSREGEGTTFIFT
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEE
IPKEQGGKSTGQN
CCCCCCCCCCCCC
>Mature Secondary Structure
MIGGSIVKKLWLATSLLVLLAMGASTLTQMWLLKSTYYDQQIEQLLEATRKLAVKIQIDE
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECC
PMAVAQEMEYLADNLQGATAFLVNRDGQIIYKTRGGWSRGPKHQMGMHGNGYGMYGILTG
HHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCC
LNMKDILAGKEIIFKGHHPMFGVDVITVAVPVKKEEIIGEVLVLSTPRQAIDTNIKALQS
CCHHHHHCCCCEEEECCCCCCCEEEEEEEECCCHHHHHHHHEEECCCHHHHHHHHHHHHH
MSVYSLLFGLVLATLFSWLLSRSLSRPLLKMKDVANAMSRGDYSRSINIKSKDEIGMLAD
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
SLNTLSHDLEEKINQLRRIDDTRRDFVAGVSHELRTPLTIIQGNAEALLDGVIEDKDKQR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHCCCEEEEECCHHHHHHHHHCCCCCCC
DFLINIYEESLRLKRLSNELLDMRKIETGQVNLYKEKVNASEIFFNVVSRMQHLAKQRGI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHCCE
ILNLSVPEQPVILYLDTDRLGQVLINLIDNALRFSRSEVTIELKDFPDKIKVQISDNGPG
EEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCC
IPEAERNLVWDKFYKVDKSRSRSAGGTGLGLSIVKQLIELHGGTVCLTSREGEGTTFIFT
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEE
IPKEQGGKSTGQN
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]