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The map label for this gene is hbd [H]

Identifier: 134299741

GI number: 134299741

Start: 2077903

End: 2078802

Strand: Reverse

Name: hbd [H]

Synonym: Dred_1890

Alternate gene names: 134299741

Gene position: 2078802-2077903 (Counterclockwise)

Preceding gene: 134299742

Following gene: 134299740

Centisome position: 57.61

GC content: 42.0

Gene sequence:

>900_bases
ATGCTCACCTATGGATATAAGTTTAAAAAAGGGGAGATTATTGTGGCCATTAAAAAGATGGGGGTATTGGGTGCTGGCAC
CATGGGAGCGGGGATTGCCCAAGTAGGTGCTCAGTCAGGGTTACAGGTTGTACTGGTAGATATTGAACAAAAATATGTAG
ATAAGGCACTGGCAGGTATGATGAAGAATTGGGAAAAGAGTGTGACCAAGGGGAAAATCACTGATCAGGATAAGGCCAGT
TACCTTCAAAACATAAAATTAAGCACCAATAATAATGATTTCAAAGATTGTGACCTAGTGATTGAAGTGGTAGTTGAAAA
CCTAGACGTAAAGAAAAAGGTTTTCAAGGAATTAAATGAAATATGTGCACCCAACACAGTTATTGCTTCGAATACTTCAG
GCTTTAGTATTACCGAAATCGGGGCAGCCAGTGGTAGACCGGATAGGGTTGTGGGAATGCACTTTTTTAACCCGGTACCC
GTTATGAAACTGGTGGAGTTAATTCCCGGCGTTGAAACTAGCCAGGAAACAGTAGAATTAGCTATAGAAGCATGTAAAAT
AATTGGTAAAACTGCTATAAAGGCCAATGAAGCACCAGGTTTTATCGTAAACCGCATATTAGTTCCTTACCTAAATGACG
CTGCCCACACTTACCAGGAAGGTGTGGCTTCTGTGGAGGAAATTGACGAAGCCATGAAACTAGGTGCCAACATGCCTATA
GGACCGCTGGCCTTGTGTGATTTGATAGGTATTGATGTACTATTAATGGTAATTGAGTATTTCTACAAGGAATTCGGCGA
TCCTAAGTTCCGTCCCTCTCAGGCCCTTAAACAAAAGGTCCGAGCAGGACATCTTGGTGTCAAGACCGGCAGGGGATTTT
ACGATTATTCTAAAAGTTAG

Upstream 100 bases:

>100_bases
GGATTTAATTCAGAATATTCAATCAGATGCGTTTTAGTATTTTTATAAGAACTGTTATAGATGTTTCGGTGAAATAGCTT
GATACATTTGCAAATTAATT

Downstream 100 bases:

>100_bases
AATTAATCCCAAAAGAGAACGTAGGAATGTACAGTATTTGTAATTGGCTGATTAACTTGTAATTTGAATATACTATTTTA
AGGGCTCTTACCTGCGGGGA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLTYGYKFKKGEIIVAIKKMGVLGAGTMGAGIAQVGAQSGLQVVLVDIEQKYVDKALAGMMKNWEKSVTKGKITDQDKAS
YLQNIKLSTNNNDFKDCDLVIEVVVENLDVKKKVFKELNEICAPNTVIASNTSGFSITEIGAASGRPDRVVGMHFFNPVP
VMKLVELIPGVETSQETVELAIEACKIIGKTAIKANEAPGFIVNRILVPYLNDAAHTYQEGVASVEEIDEAMKLGANMPI
GPLALCDLIGIDVLLMVIEYFYKEFGDPKFRPSQALKQKVRAGHLGVKTGRGFYDYSKS

Sequences:

>Translated_299_residues
MLTYGYKFKKGEIIVAIKKMGVLGAGTMGAGIAQVGAQSGLQVVLVDIEQKYVDKALAGMMKNWEKSVTKGKITDQDKAS
YLQNIKLSTNNNDFKDCDLVIEVVVENLDVKKKVFKELNEICAPNTVIASNTSGFSITEIGAASGRPDRVVGMHFFNPVP
VMKLVELIPGVETSQETVELAIEACKIIGKTAIKANEAPGFIVNRILVPYLNDAAHTYQEGVASVEEIDEAMKLGANMPI
GPLALCDLIGIDVLLMVIEYFYKEFGDPKFRPSQALKQKVRAGHLGVKTGRGFYDYSKS
>Mature_299_residues
MLTYGYKFKKGEIIVAIKKMGVLGAGTMGAGIAQVGAQSGLQVVLVDIEQKYVDKALAGMMKNWEKSVTKGKITDQDKAS
YLQNIKLSTNNNDFKDCDLVIEVVVENLDVKKKVFKELNEICAPNTVIASNTSGFSITEIGAASGRPDRVVGMHFFNPVP
VMKLVELIPGVETSQETVELAIEACKIIGKTAIKANEAPGFIVNRILVPYLNDAAHTYQEGVASVEEIDEAMKLGANMPI
GPLALCDLIGIDVLLMVIEYFYKEFGDPKFRPSQALKQKVRAGHLGVKTGRGFYDYSKS

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=290, Percent_Identity=43.7931034482759, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=41.3680781758958, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI20127408, Length=285, Percent_Identity=36.140350877193, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI68989263, Length=295, Percent_Identity=31.1864406779661, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI261878539, Length=295, Percent_Identity=31.1864406779661, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI115430219, Length=233, Percent_Identity=29.6137339055794, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1787661, Length=285, Percent_Identity=41.7543859649123, Blast_Score=228, Evalue=3e-61,
Organism=Escherichia coli, GI1788682, Length=262, Percent_Identity=35.8778625954198, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1790281, Length=265, Percent_Identity=35.0943396226415, Blast_Score=148, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=43.0555555555556, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=39.5833333333333, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=37.9790940766551, Blast_Score=196, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI25144276, Length=292, Percent_Identity=36.986301369863, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17508951, Length=292, Percent_Identity=36.986301369863, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17508953, Length=292, Percent_Identity=36.986301369863, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17558304, Length=292, Percent_Identity=35.2739726027397, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=31.9148936170213, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=29.6428571428571, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI115533614, Length=204, Percent_Identity=28.4313725490196, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193203623, Length=204, Percent_Identity=28.4313725490196, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=37.2340425531915, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=37.2340425531915, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=37.2340425531915, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI45549573, Length=239, Percent_Identity=30.5439330543933, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129993, Length=255, Percent_Identity=26.2745098039216, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32557; Mature: 32557

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYGYKFKKGEIIVAIKKMGVLGAGTMGAGIAQVGAQSGLQVVLVDIEQKYVDKALAGM
CCCCCCEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHH
MKNWEKSVTKGKITDQDKASYLQNIKLSTNNNDFKDCDLVIEVVVENLDVKKKVFKELNE
HHHHHHHHHCCCCCCHHHHHHHHHCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
ICAPNTVIASNTSGFSITEIGAASGRPDRVVGMHFFNPVPVMKLVELIPGVETSQETVEL
HHCCCCEEECCCCCCEEEECCCCCCCCCEEEEEHHCCCCCHHHHHHHHCCCCCHHHHHHH
AIEACKIIGKTAIKANEAPGFIVNRILVPYLNDAAHTYQEGVASVEEIDEAMKLGANMPI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GPLALCDLIGIDVLLMVIEYFYKEFGDPKFRPSQALKQKVRAGHLGVKTGRGFYDYSKS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLTYGYKFKKGEIIVAIKKMGVLGAGTMGAGIAQVGAQSGLQVVLVDIEQKYVDKALAGM
CCCCCCEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHH
MKNWEKSVTKGKITDQDKASYLQNIKLSTNNNDFKDCDLVIEVVVENLDVKKKVFKELNE
HHHHHHHHHCCCCCCHHHHHHHHHCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
ICAPNTVIASNTSGFSITEIGAASGRPDRVVGMHFFNPVPVMKLVELIPGVETSQETVEL
HHCCCCEEECCCCCCEEEECCCCCCCCCEEEEEHHCCCCCHHHHHHHHCCCCCHHHHHHH
AIEACKIIGKTAIKANEAPGFIVNRILVPYLNDAAHTYQEGVASVEEIDEAMKLGANMPI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GPLALCDLIGIDVLLMVIEYFYKEFGDPKFRPSQALKQKVRAGHLGVKTGRGFYDYSKS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA