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The map label for this gene is yvrH [H]

Identifier: 134299699

GI number: 134299699

Start: 2024564

End: 2025268

Strand: Reverse

Name: yvrH [H]

Synonym: Dred_1845

Alternate gene names: 134299699

Gene position: 2025268-2024564 (Counterclockwise)

Preceding gene: 134299700

Following gene: 134299698

Centisome position: 56.13

GC content: 38.01

Gene sequence:

>705_bases
ATGCTTAAAAAGATTCTGATCGTGGAAGATGACCTAGGCATTAGGGAACTTCTAAGACTTTACCTGAGTAAGCATGGCTA
CCAAGTTGTTATGGCCCAGGACGGTATAAGAGCATTAGAAATATACGAGCTTGAGCAGCCAGATTTAATTTTATTGGATA
TACTCTTGCCAGGTGTAGATGGTTATTCTGTTTGTCAGGAATTAAGAAAGTATTCAAATGTACCTATAATATTTATCAGT
TGTAAAAAAGATTCTAAAGACATCATTGAAGGCTTAGAGTTGGGTGCAGATGATTTTATCACTAAACCCTTTGACCCAGA
CGTTCTAATGGCTAGGGTGCAGGCCAGTCTCAGGCGCGCACCCATCTTCCGTAGGATAGCATCATCTCGCAAAATAGTGA
ATCGTCAGGTCATAAAATATGGTAATTTAGAAATTGATATGGCAAATTTTGAGGTTCGGCTAGACGGCAATCTAGTAACC
CTCTCTGCTAAGGAACTCCAACTACTTATCTTTCTGGTCCAACACCCGAACCAAATATTCTCCACTGAACAGCTTTACTT
AAAAGTATGGGGATTAGATAGTATCGGTGACAATAGGACGGTAATGGTTCATATTAGTAATATTCGTAAAAAAATAGAGT
CTAATCCTTCTCAGCCAGAACGAATTTTAAATATACGTGGTATTGGCTATAAATTTATTGGTTAA

Upstream 100 bases:

>100_bases
AAGATATTTATAAAAAGCCCTTCTTTATAAAGGAGATTAAATATAAATGTAAAATAAAGTAACTAGTCACATGTTGTAGA
ATTTTTTGGAGGCCTTTCAA

Downstream 100 bases:

>100_bases
CATTTTATATTTCCAGTTAATTAACAAAACAGGGGGGTATTTCAGTTGATTAGTAACAACTTATTTGAGCTGCAAAAAAT
TCTTAGCAATAATGGTCTTC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MLKKILIVEDDLGIRELLRLYLSKHGYQVVMAQDGIRALEIYELEQPDLILLDILLPGVDGYSVCQELRKYSNVPIIFIS
CKKDSKDIIEGLELGADDFITKPFDPDVLMARVQASLRRAPIFRRIASSRKIVNRQVIKYGNLEIDMANFEVRLDGNLVT
LSAKELQLLIFLVQHPNQIFSTEQLYLKVWGLDSIGDNRTVMVHISNIRKKIESNPSQPERILNIRGIGYKFIG

Sequences:

>Translated_234_residues
MLKKILIVEDDLGIRELLRLYLSKHGYQVVMAQDGIRALEIYELEQPDLILLDILLPGVDGYSVCQELRKYSNVPIIFIS
CKKDSKDIIEGLELGADDFITKPFDPDVLMARVQASLRRAPIFRRIASSRKIVNRQVIKYGNLEIDMANFEVRLDGNLVT
LSAKELQLLIFLVQHPNQIFSTEQLYLKVWGLDSIGDNRTVMVHISNIRKKIESNPSQPERILNIRGIGYKFIG
>Mature_234_residues
MLKKILIVEDDLGIRELLRLYLSKHGYQVVMAQDGIRALEIYELEQPDLILLDILLPGVDGYSVCQELRKYSNVPIIFIS
CKKDSKDIIEGLELGADDFITKPFDPDVLMARVQASLRRAPIFRRIASSRKIVNRQVIKYGNLEIDMANFEVRLDGNLVT
LSAKELQLLIFLVQHPNQIFSTEQLYLKVWGLDSIGDNRTVMVHISNIRKKIESNPSQPERILNIRGIGYKFIG

Specific function: Member of the two-component regulatory system YvrG/YvrH that positively regulates 7 transcriptional units (wprA, wapA- yxxG, dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX- rsiX), and negatively regulates the lytABC operon [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=236, Percent_Identity=36.0169491525424, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=35.9307359307359, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=35.3711790393013, Blast_Score=144, Evalue=3e-36,
Organism=Escherichia coli, GI1786911, Length=232, Percent_Identity=31.4655172413793, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=35.9307359307359, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI145693140, Length=239, Percent_Identity=34.7280334728033, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI87082012, Length=231, Percent_Identity=32.034632034632, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=31.140350877193, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=29.6137339055794, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=32.3144104803493, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=30, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=29.5652173913043, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787229, Length=217, Percent_Identity=31.7972350230415, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1790552, Length=232, Percent_Identity=31.8965517241379, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1788550, Length=118, Percent_Identity=32.2033898305085, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=37.2549019607843, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790299, Length=114, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=30.7017543859649, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=33.0188679245283, Blast_Score=61, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=108, Percent_Identity=34.2592592592593, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26781; Mature: 26781

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKILIVEDDLGIRELLRLYLSKHGYQVVMAQDGIRALEIYELEQPDLILLDILLPGVD
CCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCEEEEEEECCCCC
GYSVCQELRKYSNVPIIFISCKKDSKDIIEGLELGADDFITKPFDPDVLMARVQASLRRA
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
PIFRRIASSRKIVNRQVIKYGNLEIDMANFEVRLDGNLVTLSAKELQLLIFLVQHPNQIF
HHHHHHHHHHHHHHHHHHEECCEEEEEEEEEEEECCCEEEEEHHHHEEEEEEECCCCHHC
STEQLYLKVWGLDSIGDNRTVMVHISNIRKKIESNPSQPERILNIRGIGYKFIG
CCCEEEEEEECCCCCCCCCEEEEEEHHHHHHHHCCCCCHHHEEEEECCCEEECC
>Mature Secondary Structure
MLKKILIVEDDLGIRELLRLYLSKHGYQVVMAQDGIRALEIYELEQPDLILLDILLPGVD
CCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCEEEEEEECCCCC
GYSVCQELRKYSNVPIIFISCKKDSKDIIEGLELGADDFITKPFDPDVLMARVQASLRRA
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
PIFRRIASSRKIVNRQVIKYGNLEIDMANFEVRLDGNLVTLSAKELQLLIFLVQHPNQIF
HHHHHHHHHHHHHHHHHHEECCEEEEEEEEEEEECCCEEEEEHHHHEEEEEEECCCCHHC
STEQLYLKVWGLDSIGDNRTVMVHISNIRKKIESNPSQPERILNIRGIGYKFIG
CCCEEEEEEECCCCCCCCCEEEEEEHHHHHHHHCCCCCHHHEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]