BacMap

Definition	Desulfotomaculum reducens MI-1 chromosome, complete genome.
Accession	NC_009253
Length	3,608,104

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The map label for this gene is ppiB [H]

Identifier: 134299595

GI number: 134299595

Start: 1902936

End: 1903370

Strand: Reverse

Name: ppiB [H]

Synonym: Dred_1741

Alternate gene names: 134299595

Gene position: 1903370-1902936 (Counterclockwise)

Preceding gene: 134299596

Following gene: 134299573

Centisome position: 52.75

GC content: 45.29

Gene sequence:

>435_bases
TTGAAAAAAGGAAGTATTGAACTGGAAAATGGGGGCAAAATTATCATCGAATTCTTCGATGAAGCTGCACCTGGAACTGT
CGCTAACTTTGAGAAATTAGCAAATGAAGGTTTCTACAACGGCCTAAACTTTCACCGTGTAATTCCTGGCTTTGTGGCCC
AAGGTGGCTGCCCCTACGGTACCGGCACTGGTGGTCCTGGTTACACCATTAAGTGTGAAACCAAAGGTAATCCCCATAAA
CACCAAAAGGGTGCCTTATCTATGGCCCATGCCGGCAAAGACACCGGCGGCAGCCAGTTCTTCATCTGCTATGATGCTTT
CCCCCATTTAGATGGTGTACATACCGTTTTTGGTCAGGTAGTTGAGGGTCAGGAATACGTGGATCAAATTAAACCTGGCG
ATAAGATGAAAGAAGTTAAAGTTTGGGAAGAATAG

Upstream 100 bases:

>100_bases
TTTAATCAATAAAAAAATAGGATATTTTTTTATGTCATAATTTGCCTGCACCTGCACTCTGTAGTAGAATAATGAGAGTT
ACAACAAAGGAGGGTCTCTT

Downstream 100 bases:

>100_bases
GTTTTAACTAAAAAGCAGCCCGTACCACGTTAAGTGATACGGGTTGCTTTTTGCTTTAGGACCTTTATTATATTTTTAGA
AATTCTCCGGGCTGCAGGAT

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MKKGSIELENGGKIIIEFFDEAAPGTVANFEKLANEGFYNGLNFHRVIPGFVAQGGCPYGTGTGGPGYTIKCETKGNPHK
HQKGALSMAHAGKDTGGSQFFICYDAFPHLDGVHTVFGQVVEGQEYVDQIKPGDKMKEVKVWEE

Sequences:

>Translated_144_residues
MKKGSIELENGGKIIIEFFDEAAPGTVANFEKLANEGFYNGLNFHRVIPGFVAQGGCPYGTGTGGPGYTIKCETKGNPHK
HQKGALSMAHAGKDTGGSQFFICYDAFPHLDGVHTVFGQVVEGQEYVDQIKPGDKMKEVKVWEE
>Mature_144_residues
MKKGSIELENGGKIIIEFFDEAAPGTVANFEKLANEGFYNGLNFHRVIPGFVAQGGCPYGTGTGGPGYTIKCETKGNPHK
HQKGALSMAHAGKDTGGSQFFICYDAFPHLDGVHTVFGQVVEGQEYVDQIKPGDKMKEVKVWEE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=143, Percent_Identity=41.2587412587413, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI19557636, Length=123, Percent_Identity=44.7154471544715, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI24308049, Length=122, Percent_Identity=44.2622950819672, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI64276486, Length=113, Percent_Identity=40.7079646017699, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI10863927, Length=133, Percent_Identity=43.609022556391, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI4826932, Length=129, Percent_Identity=42.6356589147287, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI42560244, Length=141, Percent_Identity=41.1347517730496, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI4758950, Length=128, Percent_Identity=45.3125, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI6631100, Length=140, Percent_Identity=40, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI4505991, Length=127, Percent_Identity=44.0944881889764, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI5031987, Length=126, Percent_Identity=42.8571428571429, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI256017253, Length=124, Percent_Identity=44.3548387096774, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI221139811, Length=124, Percent_Identity=44.3548387096774, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI256017251, Length=124, Percent_Identity=44.3548387096774, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI310127646, Length=134, Percent_Identity=41.044776119403, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI310114371, Length=134, Percent_Identity=41.044776119403, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI310119221, Length=134, Percent_Identity=41.044776119403, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI178057341, Length=127, Percent_Identity=43.3070866141732, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI303305009, Length=137, Percent_Identity=39.4160583941606, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI45439316, Length=127, Percent_Identity=40.9448818897638, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI150418007, Length=127, Percent_Identity=42.5196850393701, Blast_Score=76, Evalue=9e-15,
Organism=Homo sapiens, GI5174637, Length=127, Percent_Identity=40.9448818897638, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI169164185, Length=127, Percent_Identity=41.7322834645669, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI169163623, Length=127, Percent_Identity=41.7322834645669, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI209417936, Length=126, Percent_Identity=42.0634920634921, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI30102944, Length=126, Percent_Identity=42.0634920634921, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI219842199, Length=126, Percent_Identity=42.0634920634921, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI310129267, Length=133, Percent_Identity=39.8496240601504, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI310120620, Length=133, Percent_Identity=39.8496240601504, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI20911035, Length=130, Percent_Identity=37.6923076923077, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI169163387, Length=127, Percent_Identity=41.7322834645669, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI310110104, Length=133, Percent_Identity=39.8496240601504, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI27735045, Length=134, Percent_Identity=34.3283582089552, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI22547215, Length=126, Percent_Identity=42.8571428571429, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI22547212, Length=126, Percent_Identity=42.8571428571429, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI7657473, Length=126, Percent_Identity=42.8571428571429, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI169214050, Length=150, Percent_Identity=36, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI239751853, Length=150, Percent_Identity=36, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI113428306, Length=150, Percent_Identity=36, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI5454154, Length=131, Percent_Identity=35.8778625954198, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI310132444, Length=126, Percent_Identity=38.0952380952381, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI310113152, Length=126, Percent_Identity=38.0952380952381, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI310114540, Length=123, Percent_Identity=40.650406504065, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI310127745, Length=123, Percent_Identity=40.650406504065, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI310119290, Length=123, Percent_Identity=40.650406504065, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1789763, Length=128, Percent_Identity=39.84375, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1786736, Length=132, Percent_Identity=39.3939393939394, Blast_Score=71, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=119, Percent_Identity=46.218487394958, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17551284, Length=141, Percent_Identity=42.5531914893617, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17551282, Length=141, Percent_Identity=42.5531914893617, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17506307, Length=139, Percent_Identity=45.3237410071942, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=126, Percent_Identity=44.4444444444444, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17552780, Length=130, Percent_Identity=45.3846153846154, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=123, Percent_Identity=43.9024390243902, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17532641, Length=127, Percent_Identity=39.3700787401575, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17559074, Length=133, Percent_Identity=41.3533834586466, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565860, Length=140, Percent_Identity=41.4285714285714, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997782, Length=123, Percent_Identity=41.4634146341463, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17566266, Length=133, Percent_Identity=40.6015037593985, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17552782, Length=136, Percent_Identity=38.2352941176471, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=124, Percent_Identity=37.0967741935484, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=124, Percent_Identity=37.0967741935484, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17552784, Length=143, Percent_Identity=37.0629370629371, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI32563659, Length=130, Percent_Identity=34.6153846153846, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=132, Percent_Identity=39.3939393939394, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321848, Length=133, Percent_Identity=45.1127819548872, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320359, Length=126, Percent_Identity=42.8571428571429, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323562, Length=126, Percent_Identity=43.6507936507937, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320510, Length=147, Percent_Identity=39.4557823129252, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323246, Length=135, Percent_Identity=41.4814814814815, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322492, Length=164, Percent_Identity=35.3658536585366, Blast_Score=64, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17986117, Length=141, Percent_Identity=41.1347517730496, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19922376, Length=134, Percent_Identity=41.7910447761194, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24650807, Length=134, Percent_Identity=43.2835820895522, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI20130249, Length=130, Percent_Identity=46.1538461538462, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45549139, Length=127, Percent_Identity=44.8818897637795, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357249, Length=112, Percent_Identity=39.2857142857143, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664125, Length=129, Percent_Identity=43.4108527131783, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21357783, Length=129, Percent_Identity=43.4108527131783, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17647301, Length=128, Percent_Identity=40.625, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24652460, Length=123, Percent_Identity=37.3983739837398, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19922912, Length=143, Percent_Identity=42.6573426573427, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136360, Length=129, Percent_Identity=39.5348837209302, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24586038, Length=132, Percent_Identity=37.1212121212121, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355677, Length=130, Percent_Identity=34.6153846153846, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15597; Mature: 15597

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGSIELENGGKIIIEFFDEAAPGTVANFEKLANEGFYNGLNFHRVIPGFVAQGGCPYG
CCCCCEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHCCHHHHCCCCCCC
TGTGGPGYTIKCETKGNPHKHQKGALSMAHAGKDTGGSQFFICYDAFPHLDGVHTVFGQV
CCCCCCCEEEEEECCCCCCCCCCCCEEHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHH
VEGQEYVDQIKPGDKMKEVKVWEE
HCCHHHHHHCCCCCCCCCEECCCC
>Mature Secondary Structure
MKKGSIELENGGKIIIEFFDEAAPGTVANFEKLANEGFYNGLNFHRVIPGFVAQGGCPYG
CCCCCEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHCCHHHHCCCCCCC
TGTGGPGYTIKCETKGNPHKHQKGALSMAHAGKDTGGSQFFICYDAFPHLDGVHTVFGQV
CCCCCCCEEEEEECCCCCCCCCCCCEEHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHH
VEGQEYVDQIKPGDKMKEVKVWEE
HCCHHHHHHCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934829; 8022278; 9384377; 8755892 [H]