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The map label for this gene is tlpB [H]

Identifier: 134299549

GI number: 134299549

Start: 1851438

End: 1853234

Strand: Reverse

Name: tlpB [H]

Synonym: Dred_1693

Alternate gene names: 134299549

Gene position: 1853234-1851438 (Counterclockwise)

Preceding gene: 134299573

Following gene: 134299547

Centisome position: 51.36

GC content: 41.07

Gene sequence:

>1797_bases
ATGGCCAATTGTTGGGATTATCTAAATTGTCCAGAAGATAGAAAATTAGCTTGTCCTGCCTTCACACAGAGCCAGGGCAT
AAATTGTTGGAAAGTCCCGGGAACCCTTTGCACCGGTGAGGTTCAAGGAACAGTGGCAGAAAAAATCCCTTTCTGCAGAA
AATGTGATTTTTTTGAAGCTAAGATTTCCAATAATGCATTTCCCATTAAAAGAAAACTTTTTACTGGCTTTGGGCTACTT
ATTACTTTACTGCTACTTGTAGGGGGCTTGTCCTACAACAATATGCACAAAATAATGACAAACTACGATCAATTAATTGA
TCAACGAGTTCTTGTTATCAATCAGACCAATGAATCCCTGATTCTTCTGCAAAAATCAGCCCTAGATCTAAGAAACTATC
TGATAACCGGGGATATGGACTATTTGGAACAACACAACAGCAAAATGTCTGAAACCAATGCTTCTTTAGCCAAGCTTCGA
TCCATTCTGAAAACCCAAAAGGGTAAAGAATTCTATAATCAATATAATCGGCAGGTTTCAATCTATAAGGCCTATGCAGG
AAACTTAATTAATATTCGTCAAGCCACTTCTCAGGATCAAATTATCAATGGAGACGCAAAGGAATTTAACACCTTAAAAA
GTATCCAAATGCAGACCTTAGCGGATAAAGGAACCATCGGCAATACGGTAACTGCTGGGCAAAATTTAATAGCATATGTT
AATAGCTTAGTAACAATCGAACATAACCGTGTTAAGGAAGCAGTCAAAGACTTAATTACTCTTATTACCGTGATTATTAT
ATTTTCCCTATTGAGCAGCCTCATTGTTGCTTATTATGCATCAAACATCATCGCTAAACCCATTGTTCTTTTGGAACAAA
GTGTAGCTAAAATTGCCGAGGGAGATCTGACCGGAGAAGAAATTAACATCAAAAACCGCGATGAAGTGGGCAAGCTGGGT
ACAGCCTTCAACCAAATGTCCATCGCCCTGAAGGATCTGGTGCTCCATATATCAGAAAAGGCTGGAACAGTTTCTGCAGC
CAGCCAAGAATTAACCTCTAGCACCCAACAGTGTTCAGCATCAGCTAACGAAGCTGCTACTACCTTGACAGAACTGGCAG
CAACTGTAGAAAAAGTAACTCAAAACACTGCAATGGTACATACAGCCTCCGAGATGGCAAATCAATCTGCGGATCACGGC
CATCAGGAACTCAATCAAATTGAACATCAAATGCAATCCATCAAAGATTCTACCGAAAAAGTAGCCGGGGTTATTAATGA
ACTAAATCACACCTCCGGTCGCATTACACAGATTGTAGAAATGATCACTCAAATTGCCGAACAAACAAACCTTTTGGCAT
TAAACGCTGCCATTGAAGCAGCCCGGGCCGGTGAGCAGGGACGAGGTTTTGCAGTGGTGGCTGAGGAGGTTAGGAAGTTA
GCTGAGGAAAGTGCCACCGCAGCCAAAGAGATTAAGGATTTAATTTTTTCCATACAGACCGAGTCCAGTAATGCTGTCAA
TACCATGGCTACGGAAATGGATGAAGTTGATAAAGGAACCAAAATTGTCAAGCAAGTTGCCAGTTCATTCCAAAAAATAC
TTTCCTCCATTCAAGAATTAAATAGCCAAATACAAGACGTTGCGTCATCCACCCATCAAATTTCTTCCGGTGTGCAAAAC
ATTGCCGGTTCGGCCGAAGAGCAAACAGCCATTATGGAAGAACTGGCCGCTTCCAGTGAAACCCTTTCAAATATGGCCGA
GGAATTAAGAGAAACAGCTGCCCGTTTTAAAGTATAG

Upstream 100 bases:

>100_bases
AATCTTTATATGGACTGCGCATGGATATGTTGATAGAATATAAATAATATGGTTGAAAATATTGGCAATTTTTAACTTAT
TATCGGGGAGGAACATTAAA

Downstream 100 bases:

>100_bases
GTGTTAAAGAAAACTTGGCTTACGCCATACCCTATAGGGCACGAGAGCCTTTAGGCGACGGCGTAAGCCTTAGTTGCCCT
TATGAAATCGGAAAGTTTTA

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MANCWDYLNCPEDRKLACPAFTQSQGINCWKVPGTLCTGEVQGTVAEKIPFCRKCDFFEAKISNNAFPIKRKLFTGFGLL
ITLLLLVGGLSYNNMHKIMTNYDQLIDQRVLVINQTNESLILLQKSALDLRNYLITGDMDYLEQHNSKMSETNASLAKLR
SILKTQKGKEFYNQYNRQVSIYKAYAGNLINIRQATSQDQIINGDAKEFNTLKSIQMQTLADKGTIGNTVTAGQNLIAYV
NSLVTIEHNRVKEAVKDLITLITVIIIFSLLSSLIVAYYASNIIAKPIVLLEQSVAKIAEGDLTGEEINIKNRDEVGKLG
TAFNQMSIALKDLVLHISEKAGTVSAASQELTSSTQQCSASANEAATTLTELAATVEKVTQNTAMVHTASEMANQSADHG
HQELNQIEHQMQSIKDSTEKVAGVINELNHTSGRITQIVEMITQIAEQTNLLALNAAIEAARAGEQGRGFAVVAEEVRKL
AEESATAAKEIKDLIFSIQTESSNAVNTMATEMDEVDKGTKIVKQVASSFQKILSSIQELNSQIQDVASSTHQISSGVQN
IAGSAEEQTAIMEELAASSETLSNMAEELRETAARFKV

Sequences:

>Translated_598_residues
MANCWDYLNCPEDRKLACPAFTQSQGINCWKVPGTLCTGEVQGTVAEKIPFCRKCDFFEAKISNNAFPIKRKLFTGFGLL
ITLLLLVGGLSYNNMHKIMTNYDQLIDQRVLVINQTNESLILLQKSALDLRNYLITGDMDYLEQHNSKMSETNASLAKLR
SILKTQKGKEFYNQYNRQVSIYKAYAGNLINIRQATSQDQIINGDAKEFNTLKSIQMQTLADKGTIGNTVTAGQNLIAYV
NSLVTIEHNRVKEAVKDLITLITVIIIFSLLSSLIVAYYASNIIAKPIVLLEQSVAKIAEGDLTGEEINIKNRDEVGKLG
TAFNQMSIALKDLVLHISEKAGTVSAASQELTSSTQQCSASANEAATTLTELAATVEKVTQNTAMVHTASEMANQSADHG
HQELNQIEHQMQSIKDSTEKVAGVINELNHTSGRITQIVEMITQIAEQTNLLALNAAIEAARAGEQGRGFAVVAEEVRKL
AEESATAAKEIKDLIFSIQTESSNAVNTMATEMDEVDKGTKIVKQVASSFQKILSSIQELNSQIQDVASSTHQISSGVQN
IAGSAEEQTAIMEELAASSETLSNMAEELRETAARFKV
>Mature_597_residues
ANCWDYLNCPEDRKLACPAFTQSQGINCWKVPGTLCTGEVQGTVAEKIPFCRKCDFFEAKISNNAFPIKRKLFTGFGLLI
TLLLLVGGLSYNNMHKIMTNYDQLIDQRVLVINQTNESLILLQKSALDLRNYLITGDMDYLEQHNSKMSETNASLAKLRS
ILKTQKGKEFYNQYNRQVSIYKAYAGNLINIRQATSQDQIINGDAKEFNTLKSIQMQTLADKGTIGNTVTAGQNLIAYVN
SLVTIEHNRVKEAVKDLITLITVIIIFSLLSSLIVAYYASNIIAKPIVLLEQSVAKIAEGDLTGEEINIKNRDEVGKLGT
AFNQMSIALKDLVLHISEKAGTVSAASQELTSSTQQCSASANEAATTLTELAATVEKVTQNTAMVHTASEMANQSADHGH
QELNQIEHQMQSIKDSTEKVAGVINELNHTSGRITQIVEMITQIAEQTNLLALNAAIEAARAGEQGRGFAVVAEEVRKLA
EESATAAKEIKDLIFSIQTESSNAVNTMATEMDEVDKGTKIVKQVASSFQKILSSIQELNSQIQDVASSTHQISSGVQNI
AGSAEEQTAIMEELAASSETLSNMAEELRETAARFKV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=358, Percent_Identity=32.6815642458101, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1788195, Length=307, Percent_Identity=32.2475570032573, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1787690, Length=370, Percent_Identity=30.8108108108108, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI2367378, Length=509, Percent_Identity=28.6836935166994, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789453, Length=353, Percent_Identity=27.4787535410765, Blast_Score=115, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 65389; Mature: 65258

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANCWDYLNCPEDRKLACPAFTQSQGINCWKVPGTLCTGEVQGTVAEKIPFCRKCDFFEA
CCCCCCCCCCCCCCCEECCCCCCCCCCEEEECCCCEECCCCCCHHHHHCCHHHCCCCHHH
KISNNAFPIKRKLFTGFGLLITLLLLVGGLSYNNMHKIMTNYDQLIDQRVLVINQTNESL
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCE
ILLQKSALDLRNYLITGDMDYLEQHNSKMSETNASLAKLRSILKTQKGKEFYNQYNRQVS
EEEEHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEE
IYKAYAGNLINIRQATSQDQIINGDAKEFNTLKSIQMQTLADKGTIGNTVTAGQNLIAYV
EEEHHCCCEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHH
NSLVTIEHNRVKEAVKDLITLITVIIIFSLLSSLIVAYYASNIIAKPIVLLEQSVAKIAE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GDLTGEEINIKNRDEVGKLGTAFNQMSIALKDLVLHISEKAGTVSAASQELTSSTQQCSA
CCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
SANEAATTLTELAATVEKVTQNTAMVHTASEMANQSADHGHQELNQIEHQMQSIKDSTEK
CHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VAGVINELNHTSGRITQIVEMITQIAEQTNLLALNAAIEAARAGEQGRGFAVVAEEVRKL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AEESATAAKEIKDLIFSIQTESSNAVNTMATEMDEVDKGTKIVKQVASSFQKILSSIQEL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSQIQDVASSTHQISSGVQNIAGSAEEQTAIMEELAASSETLSNMAEELRETAARFKV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ANCWDYLNCPEDRKLACPAFTQSQGINCWKVPGTLCTGEVQGTVAEKIPFCRKCDFFEA
CCCCCCCCCCCCCCEECCCCCCCCCCEEEECCCCEECCCCCCHHHHHCCHHHCCCCHHH
KISNNAFPIKRKLFTGFGLLITLLLLVGGLSYNNMHKIMTNYDQLIDQRVLVINQTNESL
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCE
ILLQKSALDLRNYLITGDMDYLEQHNSKMSETNASLAKLRSILKTQKGKEFYNQYNRQVS
EEEEHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEE
IYKAYAGNLINIRQATSQDQIINGDAKEFNTLKSIQMQTLADKGTIGNTVTAGQNLIAYV
EEEHHCCCEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHH
NSLVTIEHNRVKEAVKDLITLITVIIIFSLLSSLIVAYYASNIIAKPIVLLEQSVAKIAE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GDLTGEEINIKNRDEVGKLGTAFNQMSIALKDLVLHISEKAGTVSAASQELTSSTQQCSA
CCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
SANEAATTLTELAATVEKVTQNTAMVHTASEMANQSADHGHQELNQIEHQMQSIKDSTEK
CHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
VAGVINELNHTSGRITQIVEMITQIAEQTNLLALNAAIEAARAGEQGRGFAVVAEEVRKL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AEESATAAKEIKDLIFSIQTESSNAVNTMATEMDEVDKGTKIVKQVASSFQKILSSIQEL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSQIQDVASSTHQISSGVQNIAGSAEEQTAIMEELAASSETLSNMAEELRETAARFKV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]