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The map label for this gene is thrC [H]

Identifier: 134299238

GI number: 134299238

Start: 1482890

End: 1484389

Strand: Reverse

Name: thrC [H]

Synonym: Dred_1379

Alternate gene names: 134299238

Gene position: 1484389-1482890 (Counterclockwise)

Preceding gene: 134299244

Following gene: 134299236

Centisome position: 41.14

GC content: 41.6

Gene sequence:

>1500_bases
ATGAGATACGAAAGCACACGAGGTCACTCTCCTGTTGTTTCATCCGCTGAAGCAATAACAAAAGGTATAGCCCCTGACGG
GGGATTATATGTACCAACTGAGAAGGTATCAATAGATCTAAGTAAAATTGAAGCCCTAAGTTCTTTATCCTATCCTGAAA
GGGCTACCTTCGTATTAAAACATTTTCTGACAGACTTTAGTGACGACGAATTAATTCAGTGTGTTGATGCAGCCTATGGC
AATAGTAATTTTTCCTCACCGGATGTTGCCCCTGTTAAACCACTTACTGACAACACAGCGATTTTGGAACTCTGGCACGG
TCCCACCTGTGCCTTTAAAGACATGGCCTTGCAAATTCTGCCCCAATTTTTAGTGAGATCCCTTACAAAGACCGGTGAAG
CATCTGAAATTGTTATACTTGTAGCCACCTCCGGGGACACAGGTAAAGCAGCTTTGGAAGGTTTTGCAAATGTTCCTGGT
ACAAGCATTATAGTATTTTTCCCACAACAAGGAGTTAGTGAAGTACAAAGGCTGCAGATGCTAACTCAGGAAGGTAAAAA
TGTGTATGTAGTTGGGGTTAAGGGTAATTTTGATGATGCCCAAACCGGGGTTAAGAAGGTATTTAGCGACCAGGAATTTG
CAGCTTTACTGGCTAACAAGGGTTTCCGTTTATCTTCGGCCAACTCCATAAACTGGGGTCGTCTGGTCCCTCAGATTGTT
TACTACTTCTCCGCCTATGCGGATATTGTAAAAAATGGTACTGTTAAAAATGGTGAGTCCATCAACTTTGTGGTGCCTAC
AGGAAACTTTGGCAACATCCTGGCAGGCTATTATGCTAAAAGTATGGGCCTACCAGTAAATCGCTTGATTTGTGCATCAA
ATACCAATAACGTACTAACAGATTTTATCCGAACAGGTACCTATAACCGCAAACGAGAATTTTTCAAAACCAACTCACCT
TCTATGGATATTTTAATCTCCAGTAATCTGGAACGACTGCTGTACGAATTAACCGGCAAACAGTCTGATAAAATCAATGA
ATGGATGACGCAATTGAAGAGTACCGGCATCTATAGGGTTGACTCTGATTTGCTGGACCTAATCCAACAACATTTCTGGT
CTGACTATGCCACCGATGAAGAAACATTAGACACCATTCACAAAGTTTGGTTAGACCATAATTATTTAATGGACACCCAT
ACAGCAGTTGCCATGAATGTTCTAGAAAAATATCGAGCTGCCACAGGGGATAATACCTATTCTGTGGTGGCTTCCACGGC
TAGCCCTTTTAAGTTTAACGGTAGCGTAACAAAGGCTATTCTTGGTGAAAAAGCAGTGTCTGGCAAAAGTGAGTTTGCAT
TATTGAATGACTTAGCTTCCTTTACCAACTGGTCCATACCTGTAGGTCTACGGAATTTGGATAAGCGCCCGGTCCTACAC
CAAAGGTTGACCAACAAGGATGAAATCGGTAACTCTGTTAAAAATATTTTAATTGGTTAA

Upstream 100 bases:

>100_bases
ACCTTAACGTAACTTTTCCAATACCCGTCTTTACTTGACCGGAATTTTATTGTTTAATGTATGTTATAGTTAGTCATGTA
TCCTAGTAGGAGGCAAATGT

Downstream 100 bases:

>100_bases
CATAAATTCCCCGGTTCTGCCGGGGAATTTATCTGTATTAGCCCTCTTTGTTATAGGGTGGCTTTAGGCAGTACAAAAAA
ATAGACCCGGCAAATATTTT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MRYESTRGHSPVVSSAEAITKGIAPDGGLYVPTEKVSIDLSKIEALSSLSYPERATFVLKHFLTDFSDDELIQCVDAAYG
NSNFSSPDVAPVKPLTDNTAILELWHGPTCAFKDMALQILPQFLVRSLTKTGEASEIVILVATSGDTGKAALEGFANVPG
TSIIVFFPQQGVSEVQRLQMLTQEGKNVYVVGVKGNFDDAQTGVKKVFSDQEFAALLANKGFRLSSANSINWGRLVPQIV
YYFSAYADIVKNGTVKNGESINFVVPTGNFGNILAGYYAKSMGLPVNRLICASNTNNVLTDFIRTGTYNRKREFFKTNSP
SMDILISSNLERLLYELTGKQSDKINEWMTQLKSTGIYRVDSDLLDLIQQHFWSDYATDEETLDTIHKVWLDHNYLMDTH
TAVAMNVLEKYRAATGDNTYSVVASTASPFKFNGSVTKAILGEKAVSGKSEFALLNDLASFTNWSIPVGLRNLDKRPVLH
QRLTNKDEIGNSVKNILIG

Sequences:

>Translated_499_residues
MRYESTRGHSPVVSSAEAITKGIAPDGGLYVPTEKVSIDLSKIEALSSLSYPERATFVLKHFLTDFSDDELIQCVDAAYG
NSNFSSPDVAPVKPLTDNTAILELWHGPTCAFKDMALQILPQFLVRSLTKTGEASEIVILVATSGDTGKAALEGFANVPG
TSIIVFFPQQGVSEVQRLQMLTQEGKNVYVVGVKGNFDDAQTGVKKVFSDQEFAALLANKGFRLSSANSINWGRLVPQIV
YYFSAYADIVKNGTVKNGESINFVVPTGNFGNILAGYYAKSMGLPVNRLICASNTNNVLTDFIRTGTYNRKREFFKTNSP
SMDILISSNLERLLYELTGKQSDKINEWMTQLKSTGIYRVDSDLLDLIQQHFWSDYATDEETLDTIHKVWLDHNYLMDTH
TAVAMNVLEKYRAATGDNTYSVVASTASPFKFNGSVTKAILGEKAVSGKSEFALLNDLASFTNWSIPVGLRNLDKRPVLH
QRLTNKDEIGNSVKNILIG
>Mature_499_residues
MRYESTRGHSPVVSSAEAITKGIAPDGGLYVPTEKVSIDLSKIEALSSLSYPERATFVLKHFLTDFSDDELIQCVDAAYG
NSNFSSPDVAPVKPLTDNTAILELWHGPTCAFKDMALQILPQFLVRSLTKTGEASEIVILVATSGDTGKAALEGFANVPG
TSIIVFFPQQGVSEVQRLQMLTQEGKNVYVVGVKGNFDDAQTGVKKVFSDQEFAALLANKGFRLSSANSINWGRLVPQIV
YYFSAYADIVKNGTVKNGESINFVVPTGNFGNILAGYYAKSMGLPVNRLICASNTNNVLTDFIRTGTYNRKREFFKTNSP
SMDILISSNLERLLYELTGKQSDKINEWMTQLKSTGIYRVDSDLLDLIQQHFWSDYATDEETLDTIHKVWLDHNYLMDTH
TAVAMNVLEKYRAATGDNTYSVVASTASPFKFNGSVTKAILGEKAVSGKSEFALLNDLASFTNWSIPVGLRNLDKRPVLH
QRLTNKDEIGNSVKNILIG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=435, Percent_Identity=40.2298850574713, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI149193323, Length=443, Percent_Identity=33.8600451467269, Blast_Score=234, Evalue=2e-61,
Organism=Escherichia coli, GI1786185, Length=481, Percent_Identity=30.7692307692308, Blast_Score=189, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319901, Length=468, Percent_Identity=37.3931623931624, Blast_Score=290, Evalue=5e-79,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 54917; Mature: 54917

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYESTRGHSPVVSSAEAITKGIAPDGGLYVPTEKVSIDLSKIEALSSLSYPERATFVLK
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCHHEEEEHHHHHHHHHCCCCHHHHHHHH
HFLTDFSDDELIQCVDAAYGNSNFSSPDVAPVKPLTDNTAILELWHGPTCAFKDMALQIL
HHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
PQFLVRSLTKTGEASEIVILVATSGDTGKAALEGFANVPGTSIIVFFPQQGVSEVQRLQM
HHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHH
LTQEGKNVYVVGVKGNFDDAQTGVKKVFSDQEFAALLANKGFRLSSANSINWGRLVPQIV
HHHCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHCCCCEECCCCCCCHHHHHHHHH
YYFSAYADIVKNGTVKNGESINFVVPTGNFGNILAGYYAKSMGLPVNRLICASNTNNVLT
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHEEEECCCCHHHH
DFIRTGTYNRKREFFKTNSPSMDILISSNLERLLYELTGKQSDKINEWMTQLKSTGIYRV
HHHHHCCCHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEE
DSDLLDLIQQHFWSDYATDEETLDTIHKVWLDHNYLMDTHTAVAMNVLEKYRAATGDNTY
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCE
SVVASTASPFKFNGSVTKAILGEKAVSGKSEFALLNDLASFTNWSIPVGLRNLDKRPVLH
EEEEECCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
QRLTNKDEIGNSVKNILIG
HHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRYESTRGHSPVVSSAEAITKGIAPDGGLYVPTEKVSIDLSKIEALSSLSYPERATFVLK
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCHHEEEEHHHHHHHHHCCCCHHHHHHHH
HFLTDFSDDELIQCVDAAYGNSNFSSPDVAPVKPLTDNTAILELWHGPTCAFKDMALQIL
HHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
PQFLVRSLTKTGEASEIVILVATSGDTGKAALEGFANVPGTSIIVFFPQQGVSEVQRLQM
HHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHH
LTQEGKNVYVVGVKGNFDDAQTGVKKVFSDQEFAALLANKGFRLSSANSINWGRLVPQIV
HHHCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHCCCCEECCCCCCCHHHHHHHHH
YYFSAYADIVKNGTVKNGESINFVVPTGNFGNILAGYYAKSMGLPVNRLICASNTNNVLT
HHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHEEEECCCCHHHH
DFIRTGTYNRKREFFKTNSPSMDILISSNLERLLYELTGKQSDKINEWMTQLKSTGIYRV
HHHHHCCCHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEE
DSDLLDLIQQHFWSDYATDEETLDTIHKVWLDHNYLMDTHTAVAMNVLEKYRAATGDNTY
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCE
SVVASTASPFKFNGSVTKAILGEKAVSGKSEFALLNDLASFTNWSIPVGLRNLDKRPVLH
EEEEECCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
QRLTNKDEIGNSVKNILIG
HHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]