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The map label for this gene is fnr [H]

Identifier: 134298566

GI number: 134298566

Start: 752093

End: 752776

Strand: Reverse

Name: fnr [H]

Synonym: Dred_0698

Alternate gene names: 134298566

Gene position: 752776-752093 (Counterclockwise)

Preceding gene: 134298567

Following gene: 134298559

Centisome position: 20.86

GC content: 44.3

Gene sequence:

>684_bases
GTGAACACCATTGCAAAATATTTACAAAGGATACCGCTCTTTTTTGGCTTATCGGAGGAACAAATACGGGATCTATCCAG
CCTTTTATTGGAACGGAGTTACCAGAAGGGGCGTATTATTTTTATGGAAGGTGAACCCGGTGAAGCACTGTATGTCTTAA
AGTCAGGGCTCATTAAATTAACCAAAAGACTGGAAGACGGACGTGAGCACATTTTGCACTTCGTGAATCCCGGAGAAGTC
TTTGCGGAGGTGGTGCTTTTTGAAGGGGGCGATTACCCGGCCACTGCGGAAGTACAAGAAGACTGTATCGTAGGTGTTTT
ACGAAACCAGGATATCGAAAGGCTAATCAGCCAGAACCCAAACATGGCTGTCAGTATGCTAAGAATCATGTCCCGTCGCC
TGCGCACAGCCCAGGAAAAAGTTATGAATCTAGCCTTGCATGACACAGCCCGCCGTTTGTCCTTTACTCTGCTGAAAATG
TCCCAGGAACACGGTATTCAAAAAAATGACGGTATTTTAATCAATATAAACTTGACGAACCAAGAACTGGCAAGTTTAAC
CGGCAGTTCCCGGGAAACCATCAACCGAATGTTAAACAGTTTTAAAAGGGCCGGGGCCATTGATGTGGATCGACAACAAA
TTACGGTTTTAGACAGAAATAAATTAGAGGATTTACTACGCTAG

Upstream 100 bases:

>100_bases
TGACTTTAACCGTAAAACACACGGGCGAGACAGTCAATCGACGGTGCTTCAAACCTTTCGCAGAAGATCTTGCAAGTTAG
GTTAGTAGGGGGTGTAATAA

Downstream 100 bases:

>100_bases
AAGCACCGTACTTGCACGGTGCTTCTAATATGTACTACTGTTTTTAAGAATTGTAGGTTATTCCGTTAGAATGGAGTTAC
CAATTTCTCACGGTCTTCTA

Product: CRP/FNR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MNTIAKYLQRIPLFFGLSEEQIRDLSSLLLERSYQKGRIIFMEGEPGEALYVLKSGLIKLTKRLEDGREHILHFVNPGEV
FAEVVLFEGGDYPATAEVQEDCIVGVLRNQDIERLISQNPNMAVSMLRIMSRRLRTAQEKVMNLALHDTARRLSFTLLKM
SQEHGIQKNDGILININLTNQELASLTGSSRETINRMLNSFKRAGAIDVDRQQITVLDRNKLEDLLR

Sequences:

>Translated_227_residues
MNTIAKYLQRIPLFFGLSEEQIRDLSSLLLERSYQKGRIIFMEGEPGEALYVLKSGLIKLTKRLEDGREHILHFVNPGEV
FAEVVLFEGGDYPATAEVQEDCIVGVLRNQDIERLISQNPNMAVSMLRIMSRRLRTAQEKVMNLALHDTARRLSFTLLKM
SQEHGIQKNDGILININLTNQELASLTGSSRETINRMLNSFKRAGAIDVDRQQITVLDRNKLEDLLR
>Mature_227_residues
MNTIAKYLQRIPLFFGLSEEQIRDLSSLLLERSYQKGRIIFMEGEPGEALYVLKSGLIKLTKRLEDGREHILHFVNPGEV
FAEVVLFEGGDYPATAEVQEDCIVGVLRNQDIERLISQNPNMAVSMLRIMSRRLRTAQEKVMNLALHDTARRLSFTLLKM
SQEHGIQKNDGILININLTNQELASLTGSSRETINRMLNSFKRAGAIDVDRQQITVLDRNKLEDLLR

Specific function: It is involved in the activation of genes necessary for anaerobic respiration [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=185, Percent_Identity=31.3513513513514, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1787595, Length=219, Percent_Identity=25.1141552511416, Blast_Score=74, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 25910; Mature: 25910

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIAKYLQRIPLFFGLSEEQIRDLSSLLLERSYQKGRIIFMEGEPGEALYVLKSGLIKL
CCHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHH
TKRLEDGREHILHFVNPGEVFAEVVLFEGGDYPATAEVQEDCIVGVLRNQDIERLISQNP
HHHHHHHHHHHEECCCHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCC
NMAVSMLRIMSRRLRTAQEKVMNLALHDTARRLSFTLLKMSQEHGIQKNDGILININLTN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECH
QELASLTGSSRETINRMLNSFKRAGAIDVDRQQITVLDRNKLEDLLR
HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHEEEHHHHHHHHHHC
>Mature Secondary Structure
MNTIAKYLQRIPLFFGLSEEQIRDLSSLLLERSYQKGRIIFMEGEPGEALYVLKSGLIKL
CCHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHH
TKRLEDGREHILHFVNPGEVFAEVVLFEGGDYPATAEVQEDCIVGVLRNQDIERLISQNP
HHHHHHHHHHHEECCCHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCC
NMAVSMLRIMSRRLRTAQEKVMNLALHDTARRLSFTLLKMSQEHGIQKNDGILININLTN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECH
QELASLTGSSRETINRMLNSFKRAGAIDVDRQQITVLDRNKLEDLLR
HHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHEEEHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8846791; 9384377 [H]