Click here to switch to the map view.

The map label for this gene is dtpA [H]

Identifier: 134298492

GI number: 134298492

Start: 669271

End: 670758

Strand: Reverse

Name: dtpA [H]

Synonym: Dred_0623

Alternate gene names: 134298492

Gene position: 670758-669271 (Counterclockwise)

Preceding gene: 134298495

Following gene: 134298491

Centisome position: 18.59

GC content: 43.41

Gene sequence:

>1488_bases
ATGTCAACAAATTCCAGTTCTCTAAAACAACCACGTCCCTTTTACATGATCTTTTTCTTAGAGATGTGGGAACGCTTTGG
TTTTTACGGACTTCAGGCTGTATTGGCAACCTTTTTTGTTAAATCCTTGGGTATGAGTGACGCAGAATCCTTTACCATTT
TTGGTGCTTTCAGCGCTATGGTGTATGGTTTTGTAGCTATCGGTGGTTTTATTGGCGACAAAGTTTTGGGTACCAAACGC
ACTATTGTACTGGGTGCTTTTACCATGATGATTGGTTATATTTTAATTGGTATGGCAACCCTAGATAAGAGCCTTGTTTA
TATTGCTTTGGCCTTTGTAGCTGTTGGTAACGGTTTGTTCAAGGCAAACCCCTCCAGTTTACTGTCAAAGCTCTATGAAA
AAGATGACCCACGATTGGATGGCGCCTTTACCCTGTATTACATGTCTGTAAACATAGGATCTTTCATTTCCATGATCTTG
GTTCCTATTTTGGGCGGCAAGTTTGGTTTAAGTGTTGGTTTCTATGTCTGTGCCGCAGGATTAATGCTTTCTCTTGCTAG
TTTCATCTTCTTCCGCCAGTTAGTTGAGGGAATTGATTCACCTGCGGGCCTGGCACCCATCCATTACCGCAATTTTTCCC
TGGTATTACTGGGTGAAGCAGTTCTCATTGGGTTCTCTACCTATATGCTACAAAACCTAACTGTGGCTCACTGGCTTTTA
TTACTGGTTGGTATCGGCGTAATATCCATCTTTTTTAAAGAGATATTTAAGAGTCAGGGTATTGAACGTAGCAAAATGAT
TGCCGCTGTAATTTTGATGGTTCAAGCAGTTGTCTTCTTTACTCTGTACCAGCAAATGCCCACCTCCTTAAATTTCTTTG
CCATTAAAAACGTAGAACACTCAATTTTAGGGATTGCTGTTAGCAACCCAGAAACCTTCCAGGCCCTGAATCCCTTCTGG
ATTGTGGTAGCCAGCCCACTTTTCGCTTATCTGTATGCTTACTTCGGTAAGCAGGGGCGCGATTTGTCTATGCCTGGTAA
ATTTGCTTTGGGTATGGTATTATGCGCAATCAGTTTTTTAATCCTACCTCTGGGTACTAAATTTGCGAACTCCCAGGGTA
TCGTTTCCGTTTGGTGGTTGGTGGCCAGCTATGGCTTCCAAAGTGTAGGAGAACTATTAATTAGCGGCTTAGGCTTATCA
ATGGTGGCCAAGTTGGTTCCCCAACGTATGGTAGGCTTTGTAATGGGTGCTTGGTTCCTTACCACCGCAGCCTCCGGTGT
TATTGGCGGCTGGGTTGCAACGCTAACTGCAGCACCCAAAGGTGTAACTGATCCTCTACAAACCCTGCCCATATATTCCA
AGGTGTTCCTGCAAATTGGTGAGGTTACCGCTGTGGTGGCTGTGATTATGATTATAACCGTACCCATTCTCCGTCGTATG
ATTGAGGGTAACTCACAGCAAAATAAAAAGGAACAACAAGCTGCCTAA

Upstream 100 bases:

>100_bases
AAAAAATAGTAAAATAATCTTTGTTCAGCTAACTGTGCAACTTATTATACATTTTTAGACAGCTAGCCAACGTACGTATA
TAGGAAAAAGGAGGAAATTT

Downstream 100 bases:

>100_bases
AACATTAAATCCCGGGGATGATTCCCTGGGATTTTGTTATAAATGCTTTTGTCCTTCCGGGCTAAAATTAGGTAAAATAT
TTTAGTTGAATTTTCCCTGC

Product: amino acid/peptide transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MSTNSSSLKQPRPFYMIFFLEMWERFGFYGLQAVLATFFVKSLGMSDAESFTIFGAFSAMVYGFVAIGGFIGDKVLGTKR
TIVLGAFTMMIGYILIGMATLDKSLVYIALAFVAVGNGLFKANPSSLLSKLYEKDDPRLDGAFTLYYMSVNIGSFISMIL
VPILGGKFGLSVGFYVCAAGLMLSLASFIFFRQLVEGIDSPAGLAPIHYRNFSLVLLGEAVLIGFSTYMLQNLTVAHWLL
LLVGIGVISIFFKEIFKSQGIERSKMIAAVILMVQAVVFFTLYQQMPTSLNFFAIKNVEHSILGIAVSNPETFQALNPFW
IVVASPLFAYLYAYFGKQGRDLSMPGKFALGMVLCAISFLILPLGTKFANSQGIVSVWWLVASYGFQSVGELLISGLGLS
MVAKLVPQRMVGFVMGAWFLTTAASGVIGGWVATLTAAPKGVTDPLQTLPIYSKVFLQIGEVTAVVAVIMIITVPILRRM
IEGNSQQNKKEQQAA

Sequences:

>Translated_495_residues
MSTNSSSLKQPRPFYMIFFLEMWERFGFYGLQAVLATFFVKSLGMSDAESFTIFGAFSAMVYGFVAIGGFIGDKVLGTKR
TIVLGAFTMMIGYILIGMATLDKSLVYIALAFVAVGNGLFKANPSSLLSKLYEKDDPRLDGAFTLYYMSVNIGSFISMIL
VPILGGKFGLSVGFYVCAAGLMLSLASFIFFRQLVEGIDSPAGLAPIHYRNFSLVLLGEAVLIGFSTYMLQNLTVAHWLL
LLVGIGVISIFFKEIFKSQGIERSKMIAAVILMVQAVVFFTLYQQMPTSLNFFAIKNVEHSILGIAVSNPETFQALNPFW
IVVASPLFAYLYAYFGKQGRDLSMPGKFALGMVLCAISFLILPLGTKFANSQGIVSVWWLVASYGFQSVGELLISGLGLS
MVAKLVPQRMVGFVMGAWFLTTAASGVIGGWVATLTAAPKGVTDPLQTLPIYSKVFLQIGEVTAVVAVIMIITVPILRRM
IEGNSQQNKKEQQAA
>Mature_494_residues
STNSSSLKQPRPFYMIFFLEMWERFGFYGLQAVLATFFVKSLGMSDAESFTIFGAFSAMVYGFVAIGGFIGDKVLGTKRT
IVLGAFTMMIGYILIGMATLDKSLVYIALAFVAVGNGLFKANPSSLLSKLYEKDDPRLDGAFTLYYMSVNIGSFISMILV
PILGGKFGLSVGFYVCAAGLMLSLASFIFFRQLVEGIDSPAGLAPIHYRNFSLVLLGEAVLIGFSTYMLQNLTVAHWLLL
LVGIGVISIFFKEIFKSQGIERSKMIAAVILMVQAVVFFTLYQQMPTSLNFFAIKNVEHSILGIAVSNPETFQALNPFWI
VVASPLFAYLYAYFGKQGRDLSMPGKFALGMVLCAISFLILPLGTKFANSQGIVSVWWLVASYGFQSVGELLISGLGLSM
VAKLVPQRMVGFVMGAWFLTTAASGVIGGWVATLTAAPKGVTDPLQTLPIYSKVFLQIGEVTAVVAVIMIITVPILRRMI
EGNSQQNKKEQQAA

Specific function: Proton-dependent permease that transports di- and tripeptides [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily [H]

Homologues:

Organism=Homo sapiens, GI226371746, Length=349, Percent_Identity=26.0744985673352, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4827008, Length=396, Percent_Identity=24.4949494949495, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1787922, Length=481, Percent_Identity=58.2120582120582, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI1789911, Length=481, Percent_Identity=54.2619542619543, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1790572, Length=474, Percent_Identity=28.4810126582279, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1786927, Length=482, Percent_Identity=27.5933609958506, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71987453, Length=366, Percent_Identity=23.224043715847, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28571098, Length=379, Percent_Identity=25.065963060686, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571102, Length=375, Percent_Identity=25.3333333333333, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571100, Length=375, Percent_Identity=25.3333333333333, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24639583, Length=355, Percent_Identity=25.6338028169014, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24639585, Length=344, Percent_Identity=25.5813953488372, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24639581, Length=344, Percent_Identity=25.5813953488372, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 53907; Mature: 53776

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS50850 MFS ; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNSSSLKQPRPFYMIFFLEMWERFGFYGLQAVLATFFVKSLGMSDAESFTIFGAFSAM
CCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHH
VYGFVAIGGFIGDKVLGTKRTIVLGAFTMMIGYILIGMATLDKSLVYIALAFVAVGNGLF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KANPSSLLSKLYEKDDPRLDGAFTLYYMSVNIGSFISMILVPILGGKFGLSVGFYVCAAG
CCCHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LMLSLASFIFFRQLVEGIDSPAGLAPIHYRNFSLVLLGEAVLIGFSTYMLQNLTVAHWLL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
LLVGIGVISIFFKEIFKSQGIERSKMIAAVILMVQAVVFFTLYQQMPTSLNFFAIKNVEH
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
SILGIAVSNPETFQALNPFWIVVASPLFAYLYAYFGKQGRDLSMPGKFALGMVLCAISFL
EEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
ILPLGTKFANSQGIVSVWWLVASYGFQSVGELLISGLGLSMVAKLVPQRMVGFVMGAWFL
HHHCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
TTAASGVIGGWVATLTAAPKGVTDPLQTLPIYSKVFLQIGEVTAVVAVIMIITVPILRRM
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEGNSQQNKKEQQAA
HCCCCCCCHHHHCCC
>Mature Secondary Structure 
STNSSSLKQPRPFYMIFFLEMWERFGFYGLQAVLATFFVKSLGMSDAESFTIFGAFSAM
CCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHH
VYGFVAIGGFIGDKVLGTKRTIVLGAFTMMIGYILIGMATLDKSLVYIALAFVAVGNGLF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KANPSSLLSKLYEKDDPRLDGAFTLYYMSVNIGSFISMILVPILGGKFGLSVGFYVCAAG
CCCHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LMLSLASFIFFRQLVEGIDSPAGLAPIHYRNFSLVLLGEAVLIGFSTYMLQNLTVAHWLL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
LLVGIGVISIFFKEIFKSQGIERSKMIAAVILMVQAVVFFTLYQQMPTSLNFFAIKNVEH
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
SILGIAVSNPETFQALNPFWIVVASPLFAYLYAYFGKQGRDLSMPGKFALGMVLCAISFL
EEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
ILPLGTKFANSQGIVSVWWLVASYGFQSVGELLISGLGLSMVAKLVPQRMVGFVMGAWFL
HHHCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
TTAASGVIGGWVATLTAAPKGVTDPLQTLPIYSKVFLQIGEVTAVVAVIMIITVPILRRM
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEGNSQQNKKEQQAA
HCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]