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The map label for this gene is yhcA [H]

Identifier: 134298470

GI number: 134298470

Start: 644766

End: 646169

Strand: Reverse

Name: yhcA [H]

Synonym: Dred_0599

Alternate gene names: 134298470

Gene position: 646169-644766 (Counterclockwise)

Preceding gene: 134298471

Following gene: 134298469

Centisome position: 17.91

GC content: 44.37

Gene sequence:

>1404_bases
ATGGAACCAAACGCTTCATTAAAAAAGTATACCTTGTTGGTGGCCTGCGGAGCATCCTTTTTAACCCCATTCACTGGCAG
TGCTATTAACCTAGCTATCCCTTCCATTGGTAAAGAATTTGGTAGCAGTGCCCTTTTGCTGGGCTGGGTGGCCACCAGTT
ATCTGTTAGCCTCTGCGGCTTTCCTGGTTCCCTTTGGTAGACTGGCAGACATTGTGGGCAGAAAAAAGATATTTATATTG
GGTATTAGCCTTTTTGGTCTCTTTTCCGGATTATGCGGTTTTGCCTGGTCCATTGAGTCGTTAATTGCCTTCCGGGTTCT
TCAGGGAATAGGCAGCGCTATGATTTTTGGGACCAGCATGGCTATCTTGACCTCAGTCTTTCCACCCCAGGAGCGAGGTA
AAGTACTGGGTATTTCCGTGGCTACGGTATACACTGGCCTTTCCCTAGGGCCGGTGTTGGGCGGCATTATGAACCACAAC
TTAGGTTGGCCATCCATTTTTTATTTTACCGCTGTCATCGCCCTAGCAGTTTTCTTGTTCACGGTGTGGAAATTAGAAGG
TGAATGGGCCGGTGCCCGGGGTGAAAAATTTGATTTAATGGGCTCTATTCTCTACTCCGTAGGACTGGTATCCTTCATGT
ATGGTATTTCATCCGTTGACTCTTCAGTCTGGGCCAAATATATCCTGCTGGTTGGTCTGGTAGTATTAATTGCCTTTGTC
AAATATGAAATGAAGGTTAAACAACCTGTGTTAAATCTTAGCCTATTCAGTAAAAATTTAACCTTTGCCTTTTCAAACTT
GGCAGCCCTTATAAACTATAGTGCTACCTTTGCCCTGGGCTTTTTACTGTCGATGTACTTGCAGGTGGTACTAGGTTATA
ATTCTCAAACGGCCGGGCTAATACTACTTTCACAACCTGTGATTATGGCGATCTTATCACCCTTTGCCGGAACTCTTTCC
GATCGGGTTGACCCCAGACTTGTATCTTCCTGGGGTATGTCCATTACCACATTGGGGTTATTTATTTTTTGTTTTCTCAG
TAAAACCACACCCATCTGGTTATTGATTTTAAACCTAGGACTGTTAGGTATTGGCTTTGCCCTCTTCTCATCACCCAATA
CCAACTCCGTAATGGGATCGGTGGAAAAAAGATTTTACGGCGTGGCGTCTTCCACCCTGGGCACCATGCGACTTACAGGC
CAAACCATCAGCATGGCCATTGTGACTTTACTGTTAACCATTTATGTGGGTAATGTCAAATTAAGTGAAACCTCTGCGGA
CATGCTAATAAAAGGTACTAAAATAGCATTTATAGTATTTACCATTATGTGTTTTGGGGGGATCTTTGCCTCCCTGGCCA
GGGGGAGTGTGAAAACGAATGCACAGCGATATGATCAAAAATAA

Upstream 100 bases:

>100_bases
AAACGTTCTCCCTCTGTAAAAATTTATATGATCAGTGTACATACATTAAGTGTTATGATAATATGGATTCACAATATAAA
ATGAAGGTAGGACAAGAGTG

Downstream 100 bases:

>100_bases
AGACAACAAAGATCTTTTCGATATTGAAAATAGCTTAGGCTTCCTAATATCGAAAACCCATCAGTACTTTTCCTTATCCT
TTAAAGAAAAACTAAATCCC

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MEPNASLKKYTLLVACGASFLTPFTGSAINLAIPSIGKEFGSSALLLGWVATSYLLASAAFLVPFGRLADIVGRKKIFIL
GISLFGLFSGLCGFAWSIESLIAFRVLQGIGSAMIFGTSMAILTSVFPPQERGKVLGISVATVYTGLSLGPVLGGIMNHN
LGWPSIFYFTAVIALAVFLFTVWKLEGEWAGARGEKFDLMGSILYSVGLVSFMYGISSVDSSVWAKYILLVGLVVLIAFV
KYEMKVKQPVLNLSLFSKNLTFAFSNLAALINYSATFALGFLLSMYLQVVLGYNSQTAGLILLSQPVIMAILSPFAGTLS
DRVDPRLVSSWGMSITTLGLFIFCFLSKTTPIWLLILNLGLLGIGFALFSSPNTNSVMGSVEKRFYGVASSTLGTMRLTG
QTISMAIVTLLLTIYVGNVKLSETSADMLIKGTKIAFIVFTIMCFGGIFASLARGSVKTNAQRYDQK

Sequences:

>Translated_467_residues
MEPNASLKKYTLLVACGASFLTPFTGSAINLAIPSIGKEFGSSALLLGWVATSYLLASAAFLVPFGRLADIVGRKKIFIL
GISLFGLFSGLCGFAWSIESLIAFRVLQGIGSAMIFGTSMAILTSVFPPQERGKVLGISVATVYTGLSLGPVLGGIMNHN
LGWPSIFYFTAVIALAVFLFTVWKLEGEWAGARGEKFDLMGSILYSVGLVSFMYGISSVDSSVWAKYILLVGLVVLIAFV
KYEMKVKQPVLNLSLFSKNLTFAFSNLAALINYSATFALGFLLSMYLQVVLGYNSQTAGLILLSQPVIMAILSPFAGTLS
DRVDPRLVSSWGMSITTLGLFIFCFLSKTTPIWLLILNLGLLGIGFALFSSPNTNSVMGSVEKRFYGVASSTLGTMRLTG
QTISMAIVTLLLTIYVGNVKLSETSADMLIKGTKIAFIVFTIMCFGGIFASLARGSVKTNAQRYDQK
>Mature_467_residues
MEPNASLKKYTLLVACGASFLTPFTGSAINLAIPSIGKEFGSSALLLGWVATSYLLASAAFLVPFGRLADIVGRKKIFIL
GISLFGLFSGLCGFAWSIESLIAFRVLQGIGSAMIFGTSMAILTSVFPPQERGKVLGISVATVYTGLSLGPVLGGIMNHN
LGWPSIFYFTAVIALAVFLFTVWKLEGEWAGARGEKFDLMGSILYSVGLVSFMYGISSVDSSVWAKYILLVGLVVLIAFV
KYEMKVKQPVLNLSLFSKNLTFAFSNLAALINYSATFALGFLLSMYLQVVLGYNSQTAGLILLSQPVIMAILSPFAGTLS
DRVDPRLVSSWGMSITTLGLFIFCFLSKTTPIWLLILNLGLLGIGFALFSSPNTNSVMGSVEKRFYGVASSTLGTMRLTG
QTISMAIVTLLLTIYVGNVKLSETSADMLIKGTKIAFIVFTIMCFGGIFASLARGSVKTNAQRYDQK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=304, Percent_Identity=24.0131578947368, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87081983, Length=398, Percent_Identity=27.6381909547739, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1790195, Length=421, Percent_Identity=29.4536817102138, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1789042, Length=314, Percent_Identity=31.2101910828025, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788710, Length=318, Percent_Identity=29.2452830188679, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87081738, Length=143, Percent_Identity=32.1678321678322, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790146, Length=154, Percent_Identity=29.8701298701299, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788392, Length=129, Percent_Identity=30.2325581395349, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324954, Length=254, Percent_Identity=29.1338582677165, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319770, Length=330, Percent_Identity=26.0606060606061, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323735, Length=323, Percent_Identity=25.6965944272446, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325455, Length=244, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50109; Mature: 50109

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPNASLKKYTLLVACGASFLTPFTGSAINLAIPSIGKEFGSSALLLGWVATSYLLASAA
CCCCCCHHHHEEHEECCHHHHCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHH
FLVPFGRLADIVGRKKIFILGISLFGLFSGLCGFAWSIESLIAFRVLQGIGSAMIFGTSM
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AILTSVFPPQERGKVLGISVATVYTGLSLGPVLGGIMNHNLGWPSIFYFTAVIALAVFLF
HHHHHCCCCHHCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
TVWKLEGEWAGARGEKFDLMGSILYSVGLVSFMYGISSVDSSVWAKYILLVGLVVLIAFV
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYEMKVKQPVLNLSLFSKNLTFAFSNLAALINYSATFALGFLLSMYLQVVLGYNSQTAGL
HHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
ILLSQPVIMAILSPFAGTLSDRVDPRLVSSWGMSITTLGLFIFCFLSKTTPIWLLILNLG
EEECCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLGIGFALFSSPNTNSVMGSVEKRFYGVASSTLGTMRLTGQTISMAIVTLLLTIYVGNVK
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCEE
LSETSADMLIKGTKIAFIVFTIMCFGGIFASLARGSVKTNAQRYDQK
ECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHCCCC
>Mature Secondary Structure
MEPNASLKKYTLLVACGASFLTPFTGSAINLAIPSIGKEFGSSALLLGWVATSYLLASAA
CCCCCCHHHHEEHEECCHHHHCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHH
FLVPFGRLADIVGRKKIFILGISLFGLFSGLCGFAWSIESLIAFRVLQGIGSAMIFGTSM
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AILTSVFPPQERGKVLGISVATVYTGLSLGPVLGGIMNHNLGWPSIFYFTAVIALAVFLF
HHHHHCCCCHHCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
TVWKLEGEWAGARGEKFDLMGSILYSVGLVSFMYGISSVDSSVWAKYILLVGLVVLIAFV
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYEMKVKQPVLNLSLFSKNLTFAFSNLAALINYSATFALGFLLSMYLQVVLGYNSQTAGL
HHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
ILLSQPVIMAILSPFAGTLSDRVDPRLVSSWGMSITTLGLFIFCFLSKTTPIWLLILNLG
EEECCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLGIGFALFSSPNTNSVMGSVEKRFYGVASSTLGTMRLTGQTISMAIVTLLLTIYVGNVK
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCEE
LSETSADMLIKGTKIAFIVFTIMCFGGIFASLARGSVKTNAQRYDQK
ECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]