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The map label for this gene is arsB [H]

Identifier: 134298431

GI number: 134298431

Start: 600743

End: 601795

Strand: Reverse

Name: arsB [H]

Synonym: Dred_0558

Alternate gene names: 134298431

Gene position: 601795-600743 (Counterclockwise)

Preceding gene: 134298432

Following gene: 134298429

Centisome position: 16.68

GC content: 47.29

Gene sequence:

>1053_bases
ATGGCAGAAAAAAGACTGTCTACCCTGGACCGTTTTCTAACCCTGTGGATTTTCCTAGCAATGGCCATTGGGGTAGGTCT
GGGTTATGTATTTCCCGGCATTGCCGATTGGTTAAACAGTATGTCCATTGGCACCACTTCCATTCCCATTGCTGTGGGTC
TGATTGTTATGATGTACCCACCCCTGGCAAAGGTGAAATATGAAGAAATGGGCAAAGCCTTCAAAAACGGTAAAGTCATG
GGGCTTTCCCTGGTACAAAACTGGATTATCGGCCCCACCCTGATGTTTGTGCTAGCCATTGCCTTCCTGCGGGATTATCC
TGATTATATGATTGGACTTATTTTAATTGGTCTTGCCCGCTGCATCGCAATGGTGATTGTTTGGAACGATTTGGCCAAAG
GGGACAATGAGTACGCCGCCGCATTGGTGGCGGTTAATTCCATTTTTCAAATGGTCTTTTACTCTATTTATGCTTACTTC
TTTATTACCCTGGTACCAGGCTGGCTGGGTATGGAAGCCATTGAAGTGCACGTCTCGATGGCGGAGGTAGCCAAGAGTGT
CCTCATTTACCTGGGCATTCCCTTTGCCGGTGGTATGCTAACCAGAGCTTTACTGGTACCCCGCAAGGGTAAGGAGTGGT
ATGAAAAGGAATTTGTACCTCGCATCAGCCCGTTGGCCCTTATTTCCCTACTATTCACCATCGTGATTATGTTCTCCCTG
AAGGGCAAATATATTGTGGAACTGCCTATGGATGTTGTTCGCATTGCCATCCCGCTCTTGATTTACTTTAGCATCATGTT
CTTCTTATCCTTCTTCATGAGCAAGCGAAACTGCGTCAACTACGGCCAAAGCACCACCCTGGCCTTTACCGCTGCCAGCA
ATAACTTTGAGCTAGCCATTGCGGTGGCTGTAGCGATCTTCGGTATCGAGTCCGGTGCAGCCTTTGCAGCAGTAATTGGC
CCTCTGATTGAGGTACCTGTGATGATTGCACTGGTGAATGTTGCTTTGGGCTTTAAGAAGAAATACTTTACTGCCAGTGG
TGCGGTAAAATAA

Upstream 100 bases:

>100_bases
TGTCAAACCCTCAGCCCTACGAGAGACCCCTAATTATTGTGAACTGATGGGCTTAAAAAAATCTGTCTGTGAAAAAGATG
AATAAGGAGGAATTCTGTAT

Downstream 100 bases:

>100_bases
CAGTCTCCTTATAAATAGCAAACCCGGAAAAGAACTTTACTCTGTTCTCTTCCGGGTTTTCATTTCAATCGCCCTGGCAA
TCACCGATTGCACTGCAGGC

Product: arsenical-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MAEKRLSTLDRFLTLWIFLAMAIGVGLGYVFPGIADWLNSMSIGTTSIPIAVGLIVMMYPPLAKVKYEEMGKAFKNGKVM
GLSLVQNWIIGPTLMFVLAIAFLRDYPDYMIGLILIGLARCIAMVIVWNDLAKGDNEYAAALVAVNSIFQMVFYSIYAYF
FITLVPGWLGMEAIEVHVSMAEVAKSVLIYLGIPFAGGMLTRALLVPRKGKEWYEKEFVPRISPLALISLLFTIVIMFSL
KGKYIVELPMDVVRIAIPLLIYFSIMFFLSFFMSKRNCVNYGQSTTLAFTAASNNFELAIAVAVAIFGIESGAAFAAVIG
PLIEVPVMIALVNVALGFKKKYFTASGAVK

Sequences:

>Translated_350_residues
MAEKRLSTLDRFLTLWIFLAMAIGVGLGYVFPGIADWLNSMSIGTTSIPIAVGLIVMMYPPLAKVKYEEMGKAFKNGKVM
GLSLVQNWIIGPTLMFVLAIAFLRDYPDYMIGLILIGLARCIAMVIVWNDLAKGDNEYAAALVAVNSIFQMVFYSIYAYF
FITLVPGWLGMEAIEVHVSMAEVAKSVLIYLGIPFAGGMLTRALLVPRKGKEWYEKEFVPRISPLALISLLFTIVIMFSL
KGKYIVELPMDVVRIAIPLLIYFSIMFFLSFFMSKRNCVNYGQSTTLAFTAASNNFELAIAVAVAIFGIESGAAFAAVIG
PLIEVPVMIALVNVALGFKKKYFTASGAVK
>Mature_349_residues
AEKRLSTLDRFLTLWIFLAMAIGVGLGYVFPGIADWLNSMSIGTTSIPIAVGLIVMMYPPLAKVKYEEMGKAFKNGKVMG
LSLVQNWIIGPTLMFVLAIAFLRDYPDYMIGLILIGLARCIAMVIVWNDLAKGDNEYAAALVAVNSIFQMVFYSIYAYFF
ITLVPGWLGMEAIEVHVSMAEVAKSVLIYLGIPFAGGMLTRALLVPRKGKEWYEKEFVPRISPLALISLLFTIVIMFSLK
GKYIVELPMDVVRIAIPLLIYFSIMFFLSFFMSKRNCVNYGQSTTLAFTAASNNFELAIAVAVAIFGIESGAAFAAVIGP
LIEVPVMIALVNVALGFKKKYFTASGAVK

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=327, Percent_Identity=37.6146788990826, Blast_Score=187, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 38516; Mature: 38385

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AEKRLSTLDRFLTLWIFLAMAIGVGLGYVFPGIADWLNSMSIGTTSIPIAVGLIVMMYP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
PLAKVKYEEMGKAFKNGKVMGLSLVQNWIIGPTLMFVLAIAFLRDYPDYMIGLILIGLAR
CHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
CIAMVIVWNDLAKGDNEYAAALVAVNSIFQMVFYSIYAYFFITLVPGWLGMEAIEVHVSM
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
AEVAKSVLIYLGIPFAGGMLTRALLVPRKGKEWYEKEFVPRISPLALISLLFTIVIMFSL
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
KGKYIVELPMDVVRIAIPLLIYFSIMFFLSFFMSKRNCVNYGQSTTLAFTAASNNFELAI
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHH
AVAVAIFGIESGAAFAAVIGPLIEVPVMIALVNVALGFKKKYFTASGAVK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]